Nitric Oxide-Mediated Posttranslational Modifications: Impacts at the Synapse von Bradley, Sophie A., Steinert, Joern

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Design of Next-Generation G Protein-Coupled Receptor Drugs: Linking Novel Pharmacology and In Vivo Animal Models von Bradley, Sophie J, Tobin, Andrew B

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Fine Tuning Muscarinic Acetylcholine Receptor Signaling Through Allostery and Bias von van der Westhuizen, Emma T., Choy, K. H. Christopher, Valant, Celine, McKenzie-Nickson, Simon, Bradley, Sophie J., Tobin, Andrew B., Sexton, Patrick M., Christopoulos, Arthur

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The use of chemogenetic approaches to study the physiological roles of muscarinic acetylcholine receptors in the central nervous system von Bradley, Sophie J., Tobin, Andrew B., Prihandoko, Rudi

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Inhibition of neuroinflammatory nitric oxide signaling suppresses glycation and prevents neuronal dysfunction in mouse prion disease von Bourgognon, Julie-Myrtille, Spiers, Jereme G., Robinson, Sue W., Scheiblich, Hannah, Glynn, Paul, Ortori, Catharine, Bradley, Sophie J., Tobin, Andrew B., Steinert, Joern R.

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M1 muscarinic allosteric modulators slow prion neurodegeneration and restore memory loss von Bradley, Sophie J, Bourgognon, Julie-Myrtille, Sanger, Helen E, Verity, Nicholas, Mogg, Adrian J, White, David J, Butcher, Adrian J, Moreno, Julie A, Molloy, Colin, Macedo-Hatch, Timothy, Edwards, Jennifer M, Wess, Jurgen, Pawlak, Robert, Read, David J, Sexton, Patrick M, Broad, Lisa M, Steinert, Joern R, Mallucci, Giovanna R, Christopoulos, Arthur, Felder, Christian C, Tobin, Andrew B

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Targeting the Type 5 Metabotropic Glutamate Receptor: A Potential Therapeutic Strategy for Neurodegenerative Diseases? von Budgett, Rebecca F, Bakker, Geor, Sergeev, Eugenia, Bennett, Kirstie A, Bradley, Sophie J

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From structure to clinic: Design of a muscarinic M1 receptor agonist with potential to treatment of Alzheimer's disease von Brown, Alastair J. H., Bradley, Sophie J., Marshall, Fiona H., Bown, Giles A., Bennett, Kirstie A., Brown, Jason, Cansfield, Julie E., Cross, David M., de Graaf, Chris, Hudson, Brian D., Dwomoh, Louis, Dias, Joao M., Errey, James C., Hurrell, Edward, Liptrot, Jan, Mattedi, Giulio, Molloy, Colin, Nathan, Pradeep J., Okrasa, Krzysztof, Osborne, Greg, Patel, Jayesh C., Pickworth, Mark, Robertson, Nathan, Shahabi, Shahram, Bundgaard, Christoffer, Phillips, Keith, Broad, Lisa M., Goonawardena, Anushka V., Morairty, Stephen R., Browning, Michael, Perini, Francesca, Dawson, Gerard R., Deakin, John F. W., Smith, Robert T., Sexton, Patrick M., Warneck, Julie, Vinson, Mary, Tasker, Tim, Tehan, Benjamin G., Teobald, Barry, Christopoulos, Arthur, Langmead, Christopher J., Jazayeri, Ali, Cooke, Robert M., Rucktooa, Prakash, Congreve, Miles S., Weir, Malcolm, Tobin, Andrew B.

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Chemogenetics defines receptor-mediated functions of short chain free fatty acids von Bolognini, Daniele, Barki, Natasja, Butcher, Adrian J., Hudson, Brian D., Sergeev, Eugenia, Molloy, Colin, Moss, Catherine E., Bradley, Sophie J., Le Gouill, Christian, Bouvier, Michel, Tobin, Andrew B., Milligan, Graeme

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Characterisation and comparison of temporal release profiles of nitric oxide generating donors von Bradley, Sophie A., Steinert, Joern R.

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Biased M1 muscarinic receptor mutant mice show accelerated progression of prion neurodegenerative disease von Scarpa, Miriam, Molloy, Colin, Jenkins, Laura, Strellis, Bethany, Budgett, Rebecca F., Hesse, Sarah, Dwomoh, Louis, Marsango, Sara, Tejeda, Gonzalo S., Rossi, Mario, Ahmed, Zeshan, Milligan, Graeme, Hudson, Brian D., Tobin, Andrew B., Bradley, Sophie J.

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Alterations in neuronal metabolism contribute to the pathogenesis of prion disease von Bourgognon, Julie-Myrtille, Spiers, Jereme G., Scheiblich, Hannah, Antonov, Alexey, Bradley, Sophie J., Tobin, Andrew B., Steinert, Joern R.

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The M 1 muscarinic receptor is present in situ as a ligand-regulated mixture of monomers and oligomeric complexes von Marsango, Sara, Jenkins, Laura, Pediani, John D, Bradley, Sophie J, Ward, Richard J, Hesse, Sarah, Biener, Gabriel, Stoneman, Michael R, Tobin, Andrew B, Raicu, Valerica, Milligan, Graeme

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M1 muscarinic receptor activation reduces the molecular pathology and slows the progression of prion-mediated neurodegenerative disease von Dwomoh, Louis, Rossi, Mario, Scarpa, Miriam, Khajehali, Elham, Molloy, Colin, Herzyk, Pawel, Mistry, Shailesh N, Bottrill, Andrew R, Sexton, Patrick M, Christopoulos, Arthur, Conn, Jeffrey, Lindsley, Craig W, Bradley, Sophie J, Tobin, Andrew B

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Biased M1-muscarinic-receptor-mutant mice inform the design of next-generation drugs von Bradley, Sophie J., Molloy, Colin, Valuskova, Paulina, Dwomoh, Louis, Scarpa, Miriam, Rossi, Mario, Finlayson, Lisa, Svensson, Kjell A., Chernet, Eyassu, Barth, Vanessa N., Gherbi, Karolina, Sykes, David A., Wilson, Caroline A., Mistry, Rajendra, Sexton, Patrick M., Christopoulos, Arthur, Mogg, Adrian J., Rosethorne, Elizabeth M., Sakata, Shuzo, John Challiss, R. A., Broad, Lisa M., Tobin, Andrew B.

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Muscarinic acetylcholine receptors in the central nervous system von Bradley, Sophie J., Tobin, Andrew B., Prihandoko, Rudi

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Mapping physiological G protein-coupled receptor signaling pathways reveals a role for receptor phosphorylation in airway contraction von Bradley, Sophie J., Wiegman, Coen H., Iglesias, Max Maza, Kong, Kok Choi, Butcher, Adrian J., Plouffe, Bianca, Goupil, Eugénie, Bourgognon, Julie-Myrtille, Macedo-Hatch, Timothy, LeGouill, Christian, Russell, Kirsty, Laporte, Stéphane A., König, Gabriele M., Kostenis, Evi, Bouvier, Michel, Chung, Kian Fan, Amrani, Yassine, Tobin, Andrew B.

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The M1 muscarinic receptor is present in situ as a ligand-regulated mixture of monomers and oligomeric complexes von Marsango, Sara, Jenkins, Laura, Pediani, John D, Bradley, Sophie J, Ward, Richard J, Hesse, Sarah, Biener, Gabriel, Stoneman, Michael R, Tobin, Andrew B, Raicu, Valerica, Milligan, Graeme

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DREADD Agonist 21 Is an Effective Agonist for Muscarinic-Based DREADDs in Vitro and in Vivo von Thompson, Karen J, Khajehali, Elham, Bradley, Sophie J, Navarrete, Jovana S, Huang, Xi Ping, Slocum, Samuel, Jin, Jian, Liu, Jing, Xiong, Yan, Olsen, Reid H. J, Diberto, Jeffrey F, Boyt, Kristen M, Pina, Melanie M, Pati, Dipanwita, Molloy, Colin, Bundgaard, Christoffer, Sexton, Patrick M, Kash, Thomas L, Krashes, Michael J, Christopoulos, Arthur, Roth, Bryan L, Tobin, Andrew B

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M 1 muscarinic receptor activation reduces the molecular pathology and slows the progression of prion-mediated neurodegenerative disease von Dwomoh, Louis, Rossi, Mario, Scarpa, Miriam, Khajehali, Elham, Molloy, Colin, Herzyk, Pawel, Mistry, Shailesh N, Bottrill, Andrew R, Sexton, Patrick M, Christopoulos, Arthur, Conn, Jeffrey, Lindsley, Craig W, Bradley, Sophie J, Tobin, Andrew B

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