Biflavonoid-Induced Disruption of Hydrogen Bonds Leads to Amyloid-β Disaggregation von Windsor, Peter K, Plassmeyer, Stephen P, Mattock, Dominic S, Bradfield, Jonathan C, Choi, Erika Y, Miller, 3rd, Bill R, Han, Byung Hee

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ANGPT2 Genetic Variant Is Associated with Trauma-associated Acute Lung Injury and Altered Plasma Angiopoietin-2 Isoform Ratio von MEYER, Nuala J, MINGYAO LI, APLENC, Richard, ABRAMOVA, Helen, ATOCHINA-VASSERMAN, Elena N, BEERS, Michael F, CALFEE, Carolyn S, COHEN, Mitchell J, PITTET, Jean-Francois, CHRISTIANI, David C, O'KEEFE, Grant E, WARE, Lorraine B, RUI FENG, MAY, Addison K, WURFEL, Mark M, HAKONARSON, Hakon, CHRISTIE, Jason D, BRADFIELD, Jonathan, GALLOP, Robert, BELLAMY, Scarlett, FUCHS, Barry D, LANKEN, Paul N, ALBELDA, Steven M, RUSHEFSKI, Melanie

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Type I IFNs facilitate innate immune control of the opportunistic bacteria Burkholderia cenocepacia in the macrophage cytosol von Dorrington, Michael G, Bradfield, Clinton J, Lack, Justin B, Lin, Bin, Liang, Jonathan J, Starr, Tregei, Ernst, Orna, Gross, Julia L, Sun, Jing, Miller, Alexandra H, Steele-Mortimer, Olivia, Fraser, Iain D C

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Biphasic JNK signaling reveals distinct MAP3K complexes licensing inflammasome formation and pyroptosis von Bradfield, Clinton J., Liang, Jonathan J., Ernst, Orna, John, Sinu P., Sun, Jing, Ganesan, Sundar, de Jesus, Adriana A., Bryant, Clare E., Goldbach-Mansky, Raphaela, Fraser, Iain D. C.

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Genetic correlations among psychiatric and immune‐related phenotypes based on genome‐wide association data von Tylee, Daniel S., Sun, Jiayin, Hess, Jonathan L., Tahir, Muhammad A., Sharma, Esha, Malik, Rainer, Worrall, Bradford B., Levine, Andrew J., Martinson, Jeremy J., Nejentsev, Sergey, Speed, Doug, Fischer, Annegret, Mick, Eric, Walker, Brian R., Crawford, Andrew, Grant, Struan F. A., Polychronakos, Constantin, Bradfield, Jonathan P., Sleiman, Patrick M. A., Hakonarson, Hakon, Ellinghaus, Eva, Elder, James T., Tsoi, Lam C., Trembath, Richard C., Barker, Jonathan N., Franke, Andre, Dehghan, Abbas, Faraone, Stephen V., Glatt, Stephen J.

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A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci von Bradfield, Jonathan P, Qu, Hui-Qi, Wang, Kai, Zhang, Haitao, Sleiman, Patrick M, Kim, Cecilia E, Mentch, Frank D, Qiu, Haijun, Glessner, Joseph T, Thomas, Kelly A, Frackelton, Edward C, Chiavacci, Rosetta M, Imielinski, Marcin, Monos, Dimitri S, Pandey, Rahul, Bakay, Marina, Grant, Struan F A, Polychronakos, Constantin, Hakonarson, Hakon

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Interferon-induced guanylate-binding proteins in inflammasome activation and host defense von Kim, Bae-Hoon, Chee, Jonathan D, Bradfield, Clinton J, Park, Eui-Soon, Kumar, Pradeep, MacMicking, John D

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Genetic Discrimination Between LADA and Childhood-Onset Type 1 Diabetes Within the MHC von Mishra, Rajashree, Åkerlund, Mikael, Cousminer, Diana L, Ahlqvist, Emma, Bradfield, Jonathan P, Chesi, Alessandra, Hodge, Kenyaita M, Guy, Vanessa C, Brillon, David J, Pratley, Richard E, Rickels, Michael R, Vella, Adrian, Ovalle, Fernando, Harris, Ronald I, Melander, Olle, Varvel, Stephen, Hakonarson, Hakon, Froguel, Phillippe, Lonsdale, John T, Mauricio, Didac, Schloot, Nanette C, Khunti, Kamlesh, Greenbaum, Carla J, Yderstræde, Knud B, Tuomi, Tiinamaija, Voight, Benjamin F, Schwartz, Stanley, Boehm, Bernhard O, Groop, Leif, Leslie, Richard David, Grant, Struan F A

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Transcriptional Basis for Rhythmic Control of Hunger and Metabolism within the AgRP Neuron von Cedernaes, Jonathan, Huang, Wenyu, Ramsey, Kathryn Moynihan, Waldeck, Nathan, Cheng, Lei, Marcheva, Biliana, Omura, Chiaki, Kobayashi, Yumiko, Peek, Clara Bien, Levine, Daniel C., Dhir, Ravindra, Awatramani, Raj, Bradfield, Christopher A., Wang, Xiaozhong A., Takahashi, Joseph S., Mokadem, Mohamad, Ahima, Rexford S., Bass, Joseph

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High-resolution mapping and analysis of copy number variations in the human genome: a data resource for clinical and research applications von Shaikh, Tamim H, Gai, Xiaowu, Perin, Juan C, Glessner, Joseph T, Xie, Hongbo, Murphy, Kevin, O'Hara, Ryan, Casalunovo, Tracy, Conlin, Laura K, D'Arcy, Monica, Frackelton, Edward C, Geiger, Elizabeth A, Haldeman-Englert, Chad, Imielinski, Marcin, Kim, Cecilia E, Medne, Livija, Annaiah, Kiran, Bradfield, Jonathan P, Dabaghyan, Elvira, Eckert, Andrew, Onyiah, Chioma C, Ostapenko, Svetlana, Otieno, F George, Santa, Erin, Shaner, Julie L, Skraban, Robert, Smith, Ryan M, Elia, Josephine, Goldmuntz, Elizabeth, Spinner, Nancy B, Zackai, Elaine H, Chiavacci, Rosetta M, Grundmeier, Robert, Rappaport, Eric F, Grant, Struan F A, White, Peter S, Hakonarson, Hakon

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Relative contribution of type 1 and type 2 diabetes loci to the genetic etiology of adult-onset, non-insulin-requiring autoimmune diabetes von Mishra, Rajashree, Chesi, Alessandra, Cousminer, Diana L, Hawa, Mohammad I, Bradfield, Jonathan P, Hodge, Kenyaita M, Guy, Vanessa C, Hakonarson, Hakon, Mauricio, Didac, Schloot, Nanette C, Yderstræde, Knud B, Voight, Benjamin F, Schwartz, Stanley, Boehm, Bernhard O, Leslie, Richard David, Grant, Struan F A

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genome-wide association study identifies KIAA0350 as a type 1 diabetes gene von HAKONARSON, Hakon, GRANT, Struan F. A, LAWSON, Margaret L, ROBINSON, Luke J, SKRABAN, Robert, YANG LU, CHIAVACCI, Rosetta M, STANLEY, Charles A, KIRSCH, Susan E, RAPPAPORT, Eric F, ORANGE, Jordan S, MONOS, Dimitri S, BRADFIELD, Jonathan P, DEVOTO, Marcella, QU, Hui-Qi, POLYCHRONAKOS, Constantin, MARCHAND, Luc, KIM, Cecilia E, GLESSNER, Joseph T, GRABS, Rosemarie, CASALUNOVO, Tracy, TABACK, Shayne P, FRACKELTON, Edward C

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Polycyclic aromatic hydrocarbons (PAHs) present in ambient urban dust drive proinflammatory T cell and dendritic cell responses via the aryl hydrocarbon receptor (AHR) in vitro von O'Driscoll, Chelsea A, Gallo, Madeline E, Hoffmann, Erica J, Fechner, John H, Schauer, James J, Bradfield, Christopher A, Mezrich, Joshua D

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First Genome-Wide Association Study of Latent Autoimmune Diabetes in Adults Reveals Novel Insights Linking Immune and Metabolic Diabetes von Cousminer, Diana L, Ahlqvist, Emma, Mishra, Rajashree, Andersen, Mette K, Chesi, Alessandra, Hawa, Mohammad I, Davis, Asa, Hodge, Kenyaita M, Bradfield, Jonathan P, Zhou, Kaixin, Guy, Vanessa C, Åkerlund, Mikael, Wod, Mette, Fritsche, Lars G, Vestergaard, Henrik, Snyder, James, Højlund, Kurt, Linneberg, Allan, Käräjämäki, Annemari, Brandslund, Ivan, Kim, Cecilia E, Witte, Daniel, Sørgjerd, Elin Pettersen, Brillon, David J, Pedersen, Oluf, Beck-Nielsen, Henning, Grarup, Niels, Pratley, Richard E, Rickels, Michael R, Vella, Adrian, Ovalle, Fernando, Melander, Olle, Harris, Ronald I, Varvel, Stephen, Grill, Valdemar E R, Hakonarson, Hakon, Froguel, Philippe, Lonsdale, John T, Mauricio, Didac, Schloot, Nanette C, Khunti, Kamlesh, Greenbaum, Carla J, Åsvold, Bjørn Olav, Yderstræde, Knud B, Pearson, Ewan R, Schwartz, Stanley, Voight, Benjamin F, Hansen, Torben, Tuomi, Tiinamaija, Boehm, Bernhard O, Groop, Leif, Leslie, R David, Grant, Struan F A

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Duplication of the SLIT3 locus on 5q35.1 predisposes to major depressive disorder von Glessner, Joseph T, Wang, Kai, Sleiman, Patrick M A, Zhang, Haitao, Kim, Cecilia E, Flory, James H, Bradfield, Jonathan P, Imielinski, Marcin, Frackelton, Edward C, Qiu, Haijun, Mentch, Frank, Grant, Struan F A, Hakonarson, Hakon

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Association analysis of the FTO gene with obesity in children of Caucasian and African ancestry reveals a common tagging SNP von Grant, Struan F A, Li, Mingyao, Bradfield, Jonathan P, Kim, Cecilia E, Annaiah, Kiran, Santa, Erin, Glessner, Joseph T, Casalunovo, Tracy, Frackelton, Edward C, Otieno, F George, Shaner, Julie L, Smith, Ryan M, Imielinski, Marcin, Eckert, Andrew W, Chiavacci, Rosetta M, Berkowitz, Robert I, Hakonarson, Hakon

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Common variations in BARD1 influence susceptibility to high-risk neuroblastoma von Devoto, Marcella, Hakonarson, Hakon, Maris, John M, Capasso, Mario, Hou, Cuiping, Asgharzadeh, Shahab, Glessner, Joseph T, Attiyeh, Edward F, Mosse, Yael P, Kim, Cecilia, Diskin, Sharon J, Cole, Kristina A, Bosse, Kristopher, Diamond, Maura, Laudenslager, Marci, Winter, Cynthia, Bradfield, Jonathan P, Scott, Richard H, Jagannathan, Jayanti, Garris, Maria, McConville, Carmel, London, Wendy B, Seeger, Robert C, Grant, Struan F A, Li, Hongzhe, Rahman, Nazneen, Rappaport, Eric

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Diverse Genome-wide Association Studies Associate the IL12/IL23 Pathway with Crohn Disease von Wang, Kai, Zhang, Haitao, Kugathasan, Subra, Annese, Vito, Bradfield, Jonathan P., Russell, Richard K., Sleiman, Patrick M.A., Imielinski, Marcin, Glessner, Joseph, Hou, Cuiping, Wilson, David C., Walters, Thomas, Kim, Cecilia, Frackelton, Edward C., Lionetti, Paolo, Barabino, Arrigo, Van Limbergen, Johan, Guthery, Stephen, Denson, Lee, Piccoli, David, Li, Mingyao, Dubinsky, Marla, Silverberg, Mark, Griffiths, Anne, Grant, Struan F.A., Satsangi, Jack, Baldassano, Robert, Hakonarson, Hakon

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The aryl hydrocarbon receptor controls cell-fate decisions in B cells von Vaidyanathan, Bharat, Chaudhry, Ashutosh, Yewdell, William T, Angeletti, Davide, Yen, Wei-Feng, Wheatley, Adam K, Bradfield, Christopher A, McDermott, Adrian B, Yewdell, Jonathan W, Rudensky, Alexander Y, Chaudhuri, Jayanta

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Rare Genetic Variants of Large Effect Influence Risk of Type 1 Diabetes von Forgetta, Vincenzo, Manousaki, Despoina, Istomine, Roman, Ross, Stephanie, Tessier, Marie-Catherine, Marchand, Luc, Li, Min, Qu, Hui-Qi, Bradfield, Jonathan P, Grant, Struan F A, Hakonarson, Hakon, Paterson, Andrew D, Piccirillo, Ciriaco, Polychronakos, Constantin, Richards, J Brent

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