Combined Targeting of JAK2 and Bcl-2/Bcl-xL to Cure Mutant JAK2-Driven Malignancies and Overcome Acquired Resistance to JAK2 Inhibitors von Waibel, Michaela, Solomon, Vanessa S., Knight, Deborah A., Ralli, Rachael A., Kim, Sang-Kyu, Banks, Kellie-Marie, Vidacs, Eva, Virely, Clemence, Sia, Keith C.S., Bracken, Lauryn S., Collins-Underwood, Racquel, Drenberg, Christina, Ramsey, Laura B., Meyer, Sara C., Takiguchi, Megumi, Dickins, Ross A., Levine, Ross, Ghysdael, Jacques, Dawson, Mark A., Lock, Richard B., Mullighan, Charles G., Johnstone, Ricky W.

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AKR1C3 is a biomarker of sensitivity to PR-104 in preclinical models of T-cell acute lymphoblastic leukemia von Moradi Manesh, Donya, El-Hoss, Jad, Evans, Kathryn, Richmond, Jennifer, Toscan, Cara E., Bracken, Lauryn S., Hedrick, Ashlee, Sutton, Rosemary, Marshall, Glenn M., Wilson, William R., Kurmasheva, Raushan T., Billups, Catherine, Houghton, Peter J., Smith, Malcolm A., Carol, Hernan, Lock, Richard B.

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Evaluation of the in vitro and in vivo efficacy of the JAK inhibitor AZD1480 against JAK-mutated acute lymphoblastic leukemia von Suryani, Santi, Bracken, Lauryn S, Harvey, Richard C, Sia, Keith C S, Carol, Hernan, Chen, I-Ming, Evans, Kathryn, Dietrich, Philipp A, Roberts, Kathryn G, Kurmasheva, Raushan T, Billups, Catherine A, Mullighan, Charles G, Willman, Cheryl L, Loh, Mignon L, Hunger, Stephen P, Houghton, Peter J, Smith, Malcolm A, Lock, Richard B

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ZEB2 drives immature T-cell lymphoblastic leukaemia development via enhanced tumour-initiating potential and IL-7 receptor signalling von Goossens, Steven, Radaelli, Enrico, Blanchet, Odile, Durinck, Kaat, Van der Meulen, Joni, Peirs, Sofie, Taghon, Tom, Tremblay, Cedric S., Costa, Magdaline, Ghahremani, Morvarid Farhang, De Medts, Jelle, Bartunkova, Sonia, Haigh, Katharina, Schwab, Claire, Farla, Natalie, Pieters, Tim, Matthijssens, Filip, Van Roy, Nadine, Best, J. Adam, Deswarte, Kim, Bogaert, Pieter, Carmichael, Catherine, Rickard, Adam, Suryani, Santi, Bracken, Lauryn S., Alserihi, Raed, Canté-Barrett, Kirsten, Haenebalcke, Lieven, Clappier, Emmanuelle, Rondou, Pieter, Slowicka, Karolina, Huylebroeck, Danny, Goldrath, Ananda W., Janzen, Viktor, McCormack, Matthew P., Lock, Richard B., Curtis, David J., Harrison, Christine, Berx, Geert, Speleman, Frank, Meijerink, Jules P. P., Soulier, Jean, Van Vlierberghe, Pieter, Haigh, Jody J.

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Up-regulation of Survivin during Immortalization of Human Myofibroblasts Is Linked to Repression of Tumor Suppressor p16INK4a Protein and Confers Resistance to Oxidative Stress von Kan, Chin-Yi, Petti, Carlotta, Bracken, Lauryn, Maritz, Michelle, Xu, Ning, O'Brien, Rosemary, Yang, Chen, Liu, Tao, Yuan, Jun, Lock, Richard B., MacKenzie, Karen L.

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An assessment of the transparency of contemporary technology education research employing interview-based methodologies von Buckley, Jeffrey, Adams, Latif, Aribilola, Ifeoluwapo, Arshad, Iram, Azeem, Muhammad, Bracken, Lauryn, Breheny, Colette, Buckley, Ciara, Chimello, Ismael, Fagan, Alison, Fitzpatrick, Daniel P., Garza Herrera, Diana, Gomes, Guilherme Daniel, Grassick, Shaun, Halligan, Elaine, Hirway, Amit, Hyland, Tomás, Imtiaz, Muhammad Babar, Khan, Muhammad Bilal, Lanzagorta Garcia, Eduardo, Lennon, Paul, Manaf, Eyman, Meng, Jing, Mohd Sufian, Mohd Sufino Zuhaily, Moraes, Adrielle, Osterwald, Katja Magdalena, Platonava, Anastasia, Reid, Clodagh, Renard, Michèle, Rodriguez-Barroso, Laura G., Simonassi-Paiva, Bianca, Singh, Maulshree, Szank, Tomasz, Tahir, Mehwish, Vijayakumar, Sowmya, Ward, Cormac, Yan, Xinyu, Zainol, Ismin, Zhang, Lin

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Abstract 3276: Evaluation of the Bcl-2 inhibitor ABT-199 in xenograft models of acute lymphoblastic leukemia by the pediatric preclinical testing program von Suryani, Santi, Evans, Kathryn, Richmond, Jennifer, Robbins, Alissa, Bracken, Lauryn, Kurmasheva, Raushan, Houghton, Peter J., Smith, Malcolm A., Lock, Richard B.

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Up-regulation of survivin during immortalization of human myofibroblasts is linked to repression of tumor suppressor p16(INK4a) protein and confers resistance to oxidative stress von Kan, Chin-Yi, Petti, Carlotta, Bracken, Lauryn, Maritz, Michelle, Xu, Ning, O'Brien, Rosemary, Yang, Chen, Liu, Tao, Yuan, Jun, Lock, Richard B, MacKenzie, Karen L

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Abstract 2196: Upregulation of survivin during immortalization is linked to repression of p16INK4a and confers resistance to oxidative stress von Petti, Carlotta, Kan, Chin-Yi, Dietrich, Philipp A., Lauryn, Bracken, Xu, Ning, Yuan, Jun, Liu, Tao, MacKenzie, Karen L.

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Dual Inhibition of JAK/STAT and MAPK Pathways Results in Synergistic Cell Killing of JAK-Mutated Pediatric Acute Lymphoblastic Leukemia von Suryani, Santi, Sia, Keith CS, Bracken, Lauryn, Carol, Hernan, Evans, Kathryn, Kurmasheva, Raushan, Houghton, Peter J., Smith, Malcolm A., Lock, Richard B.

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ZEB2 drives immature T-cell lymphoblastic leukaemia development via enhanced tumour-initiating potential and IL-7 receptor signalling von Goossens, Steven, Radaelli, Enrico, Blanchet, Odile, Durinck, Kaat, Van der Meulen, Joni, Peirs, Sofie, Taghon, Tom, Tremblay, Cedric S, Costa, Magdaline, Farhang Ghahremani, Morvarid, De Medts, Jelle, Bartunkova, Sonia, Haigh, Katharina, Schwab, Claire, Farla, Natalie, Pieters, Tim, Matthijssens, Filip, Van Roy, Nadine, Best, J. Adam, Deswarte, Kim, Bogaert, Pieter, Carmichael, Catherine, Rickard, Adam, Suryani, Santi, Bracken, Lauryn S, Alserihi, Raed, Canté-Barrett, Kirsten, Haenebalcke, Lieven, Clappier, Emmanuelle, Rondou, Pieter, Slowicka, Karolina, Huylebroeck, Danny, Goldrath, Ananda W, Janzen, Viktor, McCormack, Matthew P, Lock, Richard B, Curtis, David J, Harrison, Christine, Berx, Geert, Speleman, Frank, Meijerink, Jules P.P, Soulier, Jean, Van Vlierberghe, Pieter, Haigh, Jody J

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ZEB2 drives immature T-cell lymphoblastic leukaemia development via enhanced tumour-initiating potential and IL-7 receptor signalling von Goossens, Steven, Radaelli, Enrico, Blanchet, Odile, Durinck, Kaat, Van der Meulen, Joni, Peirs, Sofie, Taghon, Tom, Tremblay, Cedric S, Costa, Magdaline, Ghahremani, Morvarid Farhang, De Medts, Jelle, Bartunkova, Sona, Haigh, Katharina, Schwab, Claire, Farla, Natalie, Pieters, Tim, Matthijssens, Filip, Van Roy, Nadine, Best, J Adam, Deswarte, Kim, Bogaert, Pieter, Carmichael, Catherine, Rickard, Adam, Suryani, Santi, Bracken, Lauryn S, Alserihi, Raed, Cante-Barret, Kirsten, Haenebalcke, Lieven, Clappier, Emmanuelle, Rondou, Pieter, Slowicka, Karolina, Huylebroeck, Danny, Goldrath, Ananda W, Janzen, Viktor, McCormack, Matthew P, Lock, Richard B, Curtis, David J, Harrison, Christine, Berx, Geert, Speleman, Franki, Meijerink, Jules PP, Soulier, Jean, Van Vlierberghe, Pieter, Haigh, Jody

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