AZD1152, a Selective Inhibitor of Aurora B Kinase, Inhibits Human Tumor Xenograft Growth by Inducing Apoptosis von WILKINSON, Robert W, ODEDRA, Rajesh, BYTH, Kate F, BARRASS, Nigel C, MUNDT, Kirsten E, FOOTE, Kevin M, HERON, Nicola M, JUNG, Frederic H, MORTLOCK, Andrew A, BOYLE, F. Thomas, GREEN, Stephen, HEATON, Simon P, WEDGE, Stephen R, KEEN, Nicholas J, CRAFTER, Claire, FOSTER, John R, BRADY, Madeleine C, BIGLEY, Alison, BROWN, Elaine

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Synthesis of (S)-(-)-N-acetylcolchinol using intramolecular biaryl oxidative coupling von Besong, Gilbert, Jarowicki, Krzysztof, Kocienski, Philip J, Sliwinski, Eric, Boyle, F Thomas

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Structure-based design of a potent purine-based cyclin-dependent kinase inhibitor von Newell, David R, Davies, Thomas G, Bentley, Johanne, Arris, Christine E, Boyle, F. Thomas, Curtin, Nicola J, Endicott, Jane A, Gibson, Ashleigh E, Golding, Bernard T, Griffin, Roger J, Hardcastle, Ian R, Jewsbury, Philip, Johnson, Louise N, Mesguiche, Veronique, Noble, Martin E.M, Tucker, Julie A, Wang, Lan, Whitfield, Hayley J

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Probing the ATP ribose-binding domain of cyclin-dependent kinases 1 and 2 with O(6)-substituted guanine derivatives von Gibson, Ashleigh E, Arris, Christine E, Bentley, Johanne, Boyle, F Thomas, Curtin, Nicola J, Davies, Thomas G, Endicott, Jane A, Golding, Bernard T, Grant, Sharon, Griffin, Roger J, Jewsbury, Philip, Johnson, Louise N, Mesguiche, Veronique, Newell, David R, Noble, Martin E M, Tucker, Julie A, Whitfield, Hayley J

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Structure-Based design of 2-Arylamino-4-cyclohexylmethyl-5-nitroso-6-aminopyrimidine inhibitors of cyclin-Dependent kinases 1 and 2 von Sayle, Kerry L., Bentley, Johanne, Boyle, F.Thomas, Calvert, A.Hilary, Cheng, Yuzhu, Curtin, Nicola J., Endicott, Jane A., Golding, Bernard T., Hardcastle, Ian R., Jewsbury, Philip, Mesguiche, Veronique, Newell, David R., Noble, Martin E.M., Parsons, Rachel J., Pratt, David J., Wang, Lan Z., Griffin, Roger J.

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Design and Synthesis of Cyclopenta[g]quinazoline-Based Antifolates as Inhibitors of Thymidylate Synthase and Potential Antitumor Agents von Bavetsias, Vassilios, Marriott, Jonathan H, Melin, Camille, Kimbell, Rosemary, Matusiak, Zbigniew S, Boyle, F. Thomas, Jackman, Ann L

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4-Alkoxy-2,6-diaminopyrimidine derivatives: inhibitors of cyclin dependent kinases 1 and 2 von Mesguiche, Veronique, Parsons, Rachel J, Arris, Christine E, Bentley, Johanne, Boyle, F.Thomas, Curtin, Nicola J, Davies, Thomas G, Endicott, Jane A, Gibson, Ashleigh E, Golding, Bernard T, Griffin, Roger J, Jewsbury, Philip, Johnson, Louise N, Newell, David R, Noble, Martin E.M, Wang, Lan Z, Hardcastle, Ian R

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Solid-phase synthesis of c(RGDfK) derivatives: on-resin cyclisation and lysine functionalisation von McCusker, Catherine F, Kocienski, Philip J, Boyle, F.Thomas, Schätzlein, Andreas G

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Cancer therapy: a move to the molecular level von Thomas Boyle, F., F. Costello, Gerard

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A synthesis of (a R,7 S)-(−)- N-acetylcolchinol and its conjugate with a cyclic RGD peptide von Besong, Gilbert, Billen, Denis, Dager, Indu, Kocienski, Philip, Sliwinski, Eric, Tai, Lik Ren, Boyle, F. Thomas

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N2-Substituted O6-Cyclohexylmethylguanine Derivatives:  Potent Inhibitors of Cyclin-Dependent Kinases 1 and 2 von HARDCASTLE, Ian R., ARRIS, Christine E., BENTLEY, Johanne, BOYLE, F. Thomas, CHEN, Yuzhu, CURTIN, Nicola J., ENDICOTT, Jane A., GIBSON, Ashleigh E., GOLDING, Bernard T., GRIFFIN, Roger J., JEWSBURY, Philip, MENYEROL, Jerome, MESGUICHE, Veronique, NEWELL, David R., NOBLE, Martin E. M., PRATT, David J., WANG, Lan-Zhen, WHITFIELD, Hayley J.

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N 2 -Substituted O 6 -Cyclohexylmethylguanine Derivatives:  Potent Inhibitors of Cyclin-Dependent Kinases 1 and 2 von Hardcastle, Ian R., Arris, Christine E., Bentley, Johanne, Boyle, F. Thomas, Chen, Yuzhu, Curtin, Nicola J., Endicott, Jane A., Gibson, Ashleigh E., Golding, Bernard T., Griffin, Roger J., Jewsbury, Philip, Menyerol, Jerome, Mesguiche, Veronique, Newell, David R., Noble, Martin E. M., Pratt, David J., Wang, Lan-Zhen, Whitfield, Hayley J.

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Synthetic studies on the pederin family of antitumour agents. Syntheses of mycalamide B, theopederin D and pederin von Kocienski, Philip, Narquizian, Robert, Raubo, Piotr, Smith, Christopher, Farrugia, Louis J., Muir, Kenneth, Boyle, F. Thomas

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Identification of Novel Purine and Pyrimidine Cyclin-Dependent Kinase Inhibitors with Distinct Molecular Interactions and Tumor Cell Growth Inhibition Profiles von Arris, Christine E, Boyle, F. Thomas, Calvert, A. Hilary, Curtin, Nicola J, Endicott, Jane A, Garman, Elspeth F, Gibson, Ashleigh E, Golding, Bernard T, Grant, Sharon, Griffin, Roger J, Jewsbury, Philip, Johnson, Louise N, Lawrie, Alison M, Newell, David R, Noble, Martin E. M, Sausville, Edward A, Schultz, Robert, Yu, Wyatt

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Probing the ATP Ribose-Binding Domain of Cyclin-Dependent Kinases 1 and 2 with O6-Substituted Guanine Derivatives von GIBSON, Ashleigh E., ARRIS, Christine E., BENTLEY, Johanne, BOYLE, F. Thomas, CURTIN, Nicola J., DAVIES, Thomas G., ENDICOTT, Jane A., GOLDING, Bernard T., GRANT, Sharon, GRIFFIN, Roger J., JEWSBURY, Philip, JOHNSON, Louise N., MESGUICHE, Veronique, NEWELL, David R., NOBLE, Martin E. M., TUCKER, Julie A., WHITFIELD, Hayley J.

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Synthesis and Structure-Activity Relationships of a Novel Antifungal Agent, ICI 195,739 von BOYLE, F. THOMAS, GILMAN, DAVID J., GRAVESTOCK, MICHAEL B., WARDLEWORTH, J. MICHAEL

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Carrier- and receptor-mediated transport of folate antagonists targeting folate-dependent enzymes: correlates of molecular-structure and biological activity von Westerhof, G R, Schornagel, J H, Kathmann, I, Jackman, A L, Rosowsky, A, Forsch, R A, Hynes, J B, Boyle, F T, Peters, G J, Pinedo, H M

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Cellular pharmacology and in vivo activity of a new anticancer agent, ZD9331: a water-soluble, nonpolyglutamatable, quinazoline-based inhibitor of thymidylate synthase von JACKMAN, A. L, KIMBELL, R, AHERNE, G. W, BRUNTON, L, JANSEN, G, STEPHENS, T. C, SMITH, M. N, WARDLEWORTH, J. M, BOYLE, F. T

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Applications of the spiroannulation of tetralins with alkynes; towards new anti-estrogenic compounds von Boyle, F. Thomas, Hares, Owen, Matusiak, Zbigniew S., Li, Warren, Whiting, Donald A.

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Design and Synthesis of Potent Non-Polyglutamatable Quinazoline Antifolate Thymidylate Synthase Inhibitors von Marsham, Peter R, Wardleworth, J. Michael, Boyle, F. Thomas, Hennequin, Laurent F, Kimbell, Rosemary, Brown, Melody, Jackman, Ann L

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