An Expanded View of Complex Traits: From Polygenic to Omnigenic von Boyle, Evan A., Li, Yang I., Pritchard, Jonathan K.

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Detection of human adaptation during the past 2000 years von Field, Yair, Boyle, Evan A, Telis, Natalie, Gao, Ziyue, Gaulton, Kyle J., Golan, David, Yengo, Loic, Rocheleau, Ghislain, Froguel, Philippe, McCarthy, Mark I., Pritchard, Jonathan K.

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Saturation editing of genomic regions by multiplex homology-directed repair von Findlay, Gregory M., Boyle, Evan A., Hause, Ronald J., Klein, Jason C., Shendure, Jay

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Genome-scale measurement of off-target activity using Cas9 toxicity in high-throughput screens von Morgens, David W., Wainberg, Michael, Boyle, Evan A., Ursu, Oana, Araya, Carlos L., Tsui, C. Kimberly, Haney, Michael S., Hess, Gaelen T., Han, Kyuho, Jeng, Edwin E., Li, Amy, Snyder, Michael P., Greenleaf, William J., Kundaje, Anshul, Bassik, Michael C.

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High‐resolution mapping of cancer cell networks using co‐functional interactions von Boyle, Evan A, Pritchard, Jonathan K, Greenleaf, William J

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Enhancer connectome in primary human cells identifies target genes of disease-associated DNA elements von Mumbach, Maxwell R, Satpathy, Ansuman T, Boyle, Evan A, Dai, Chao, Gowen, Benjamin G, Cho, Seung Woo, Nguyen, Michelle L, Rubin, Adam J, Granja, Jeffrey M, Kazane, Katelynn R, Wei, Yuning, Nguyen, Trieu, Greenside, Peyton G, Corces, M Ryan, Tycko, Josh, Simeonov, Dimitre R, Suliman, Nabeela, Li, Rui, Xu, Jin, Flynn, Ryan A, Kundaje, Anshul, Khavari, Paul A, Marson, Alexander, Corn, Jacob E, Quertermous, Thomas, Greenleaf, William J, Chang, Howard Y

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MIPgen: optimized modeling and design of molecular inversion probes for targeted resequencing von Boyle, Evan A, O'Roak, Brian J, Martin, Beth K, Kumar, Akash, Shendure, Jay

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High-throughput biochemical profiling reveals sequence determinants of dCas9 off-target binding and unbinding von Boyle, Evan A., Andreasson, Johan O. L., Chircus, Lauren M., Sternberg, Samuel H., Wu, Michelle J., Guegler, Chantal K., Doudna, Jennifer A., Greenleaf, William J.

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Mammalian target of rapamycin pathway mutations cause hemimegalencephaly and focal cortical dysplasia von D'Gama, Alissa M., Geng, Ying, Couto, Javier A., Martin, Beth, Boyle, Evan A., LaCoursiere, Christopher M., Hossain, Amer, Hatem, Nicole E., Barry, Brenda J., Kwiatkowski, David J., Vinters, Harry V., Barkovich, A. James, Shendure, Jay, Mathern, Gary W., Walsh, Christopher A., Poduri, Annapurna

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Expanded palette of RNA base editors for comprehensive RBP-RNA interactome studies von Medina-Munoz, Hugo C., Kofman, Eric, Jagannatha, Pratibha, Boyle, Evan A., Yu, Tao, Jones, Krysten L., Mueller, Jasmine R., Lykins, Grace D., Doudna, Andrew T., Park, Samuel S., Blue, Steven M., Ranzau, Brodie L., Kohli, Rahul M., Komor, Alexis C., Yeo, Gene W.

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Junior scientists spotlight social bonds in seminars for diversity, equity, and inclusion in STEM von Boyle, Evan A, Goldberg, Gabriela, Schmok, Jonathan C, Burgado, Jillybeth, Izidro Layng, Fabiana, Grunwald, Hannah A, Balotin, Kylie M, Cuoco, Michael S, Chang, Keng-Chi, Ecklu-Mensah, Gertrude, Arakaki, Aleena K S, Ahmed, Noorsher, Garcia Arceo, Ximena, Jagannatha, Pratibha, Pekar, Jonathan, Iyer, Mallika, Yeo, Gene W

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Caspase-8, association with Alzheimer's Disease and functional analysis of rare variants von Rehker, Jan, Rodhe, Johanna, Nesbitt, Ryan R, Boyle, Evan A, Martin, Beth K, Lord, Jenny, Karaca, Ilker, Naj, Adam, Jessen, Frank, Helisalmi, Seppo, Soininen, Hilkka, Hiltunen, Mikko, Ramirez, Alfredo, Scherer, Martin, Farrer, Lindsay A, Haines, Jonathan L, Pericak-Vance, Margaret A, Raskind, Wendy H, Cruchaga, Carlos, Schellenberg, Gerard D, Joseph, Bertrand, Brkanac, Zoran

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Deep sequencing of multiple regions of glial tumors reveals spatial heterogeneity for mutations in clinically relevant genes von Kumar, Akash, Boyle, Evan A, Tokita, Mari, Mikheev, Andrei M, Sanger, Michelle C, Girard, Emily, Silber, John R, Gonzalez-Cuyar, Luis F, Hiatt, Joseph B, Adey, Andrew, Lee, Choli, Kitzman, Jacob O, Born, Donald E, Silbergeld, Daniel L, Olson, James M, Rostomily, Robert C, Shendure, Jay

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Protocol to process crosslinking and immunoprecipitation data into annotated binding sites von Xu, Shuhao, Nguyen, Grady G., Naritomi, Jack T., Kopalle, Hema M., Yee, Brian A., Rothamel, Katherine L., Boyle, Evan A., Yeo, Gene W.

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Large-scale evaluation of the ability of RNA-binding proteins to activate exon inclusion von Schmok, Jonathan C., Jain, Manya, Street, Lena A., Tankka, Alex T., Schafer, Danielle, Her, Hsuan-Lin, Elmsaouri, Sara, Gosztyla, Maya L., Boyle, Evan A., Jagannatha, Pratibha, Luo, En-Ching, Kwon, Ester J., Jovanovic, Marko, Yeo, Gene W.

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A germline homozygous mutation in the base-excision repair gene NTHL1 causes adenomatous polyposis and colorectal cancer von Weren, Robbert D A, Ligtenberg, Marjolijn J L, Kets, C Marleen, de Voer, Richarda M, Verwiel, Eugène T P, Spruijt, Liesbeth, van Zelst-Stams, Wendy A G, Jongmans, Marjolijn C, Gilissen, Christian, Hehir-Kwa, Jayne Y, Hoischen, Alexander, Shendure, Jay, Boyle, Evan A, Kamping, Eveline J, Nagtegaal, Iris D, Tops, Bastiaan B J, Nagengast, Fokko M, Geurts van Kessel, Ad, van Krieken, J Han J M, Kuiper, Roland P, Hoogerbrugge, Nicoline

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Author Correction: Large-scale evaluation of the ability of RNA-binding proteins to activate exon inclusion von Schmok, Jonathan C., Jain, Manya, Street, Lena A., Tankka, Alex T., Schafer, Danielle, Her, Hsuan-Lin, Elmsaouri, Sara, Gosztyla, Maya L., Boyle, Evan A., Jagannatha, Pratibha, Luo, En-Ching, Kwon, Ester J., Jovanovic, Marko, Yeo, Gene W.

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Deactivated CRISPR Associated Protein 9 for Minor-Allele Enrichment in Cell-Free DNA von Aalipour, Amin, Dudley, Jonathan C, Park, Seung-Min, Murty, Surya, Chabon, Jacob J, Boyle, Evan A, Diehn, Maximilian, Gambhir, Sanjiv S

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KIAA0586 is Mutated in Joubert Syndrome von Bachmann-Gagescu, Ruxandra, Phelps, Ian G., Dempsey, Jennifer C., Sharma, Vivek A., Ishak, Gisele E., Boyle, Evan A., Wilson, Meredith, Marques Lourenço, Charles, Arslan, Mutluay, Shendure, Jay, Doherty, Dan

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Quantification of Cas9 binding and cleavage across diverse guide sequences maps landscapes of target engagement von Boyle, Evan A, Becker, Winston R, Bai, Hua B, Chen, Janice S, Doudna, Jennifer A, Greenleaf, William J

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