Phase I Study of RO4929097, a Gamma Secretase Inhibitor of Notch Signaling, in Patients With Refractory Metastatic or Locally Advanced Solid Tumors von TOLCHER, Anthony W, MESSERSMITH, Wells A, BOYLAN, John F, XU, Zhi-Xin, KA WANG, KOEHLER, Astrid, SONG, James, MIDDLETON, Steven A, DEUTSCH, Jonathan, DEMARIO, Mark, KURZROCK, Razelle, WHELER, Jennifer J, MIKULSKI, Stanislaw M, PAPADOPOULOS, Kyriakos P, KWAK, Eunice L, GIBBON, Darlene G, PATNAIK, Amita, FALCHOOK, Gerald S, DASARI, Arvind, SHAPIRO, Geoffrey I

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BRAFV600E negatively regulates the AKT pathway in melanoma cell lines von Chen, Brenden, Tardell, Christine, Higgins, Brian, Packman, Kathryn, Boylan, John F, Niu, Huifeng

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The Systemic Inflammatory Response to Cardiac Surgery von Warltier, David C., Laffey, John G., Boylan, John F., Cheng, Davy C. H.

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Discovery of siRNA Lipid Nanoparticles to Transfect Suspension Leukemia Cells and Provide In Vivo Delivery Capability von He, Wei, Bennett, Michael J, Luistro, Leopoldo, Carvajal, Daisy, Nevins, Thomas, Smith, Melissa, Tyagi, Gaurav, Cai, James, Wei, Xin, Lin, Tai-An, Heimbrook, David C, Packman, Kathryn, Boylan, John F

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The novel gamma secretase inhibitor RO4929097 reduces the tumor initiating potential of melanoma von Huynh, Chanh, Poliseno, Laura, Segura, Miguel F, Medicherla, Ratna, Haimovic, Adele, Menendez, Silvia, Shang, Shulian, Pavlick, Anna, Shao, Yongzhao, Darvishian, Farbod, Boylan, John F, Osman, Iman, Hernando, Eva

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Inactivation of mirk/dyrk1b kinase targets quiescent pancreatic cancer cells von Ewton, Daina Z, Hu, Jing, Vilenchik, Maria, Deng, Xiaobing, Luk, Kin-Chun, Polonskaia, Ann, Hoffman, Ann F, Zipf, Karen, Boylan, John F, Friedman, Eileen A

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The Discovery of a Dual TTK Protein Kinase/CDC2-Like Kinase (CLK2) Inhibitor for the Treatment of Triple Negative Breast Cancer Initiated from a Phenotypic Screen von Riggs, Jennifer R, Nagy, Mark, Elsner, Jan, Erdman, Paul, Cashion, Dan, Robinson, Dale, Harris, Roy, Huang, Dehua, Tehrani, Lida, Deyanat-Yazdi, Gordafaried, Narla, Rama Krishna, Peng, Xiaohui, Tran, Tam, Barnes, Leo, Miller, Terra, Katz, Jason, Tang, Yang, Chen, Ming, Moghaddam, Mehran F, Bahmanyar, Sogole, Pagarigan, Barbra, Delker, Silvia, LeBrun, Laurie, Chamberlain, Philip P, Calabrese, Andrew, Canan, Stacie S, Leftheris, Katerina, Zhu, Dan, Boylan, John F

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Synthetic Lethal Strategy Identifies a Potent and Selective TTK and CLK1/2 Inhibitor for Treatment of Triple-Negative Breast Cancer with a Compromised G1–S Checkpoint von Zhu, Dan, Xu, Shuichan, Deyanat-Yazdi, Gordafaried, Peng, Sophie X., Barnes, Leo A., Narla, Rama Krishna, Tran, Tam, Mikolon, David, Ning, Yuhong, Shi, Tao, Jiang, Ning, Raymon, Heather K., Riggs, Jennifer R., Boylan, John F.

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Preclinical Profile of a Potent γ-Secretase Inhibitor Targeting Notch Signaling with In vivo Efficacy and Pharmacodynamic Properties von LUISTRO, Leopoldo, WEI HE, LINN, Michael, FLOHR, Alexander, JAKOB-RØTNE, Roland, JACOBSEN, Helmut, GLENN, Kelli, HEIMBROOK, David, BOYLAN, John F, SMITH, Melissa, PACKMAN, Kathryn, VILENCHIK, Maria, CARVAJAL, Daisy, ROBERTS, John, CAI, James, BERKOFSKY-FESSLER, Windy, HILTON, Holly

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Structure-Guided Optimization Provides a Series of TTK Protein Inhibitors with Potent Antitumor Activity von Elsner, Jan, Cashion, Dan, Robinson, Dale, Bahmanyar, Sogole, Tehrani, Lida, Fultz, Kimberly E, Narla, Rama Krishna, Peng, Xiaohui, Tran, Tam, Apuy, Julius, LeBrun, Laurie, Leftheris, Katerina, Boylan, John F, Zhu, Dan, Riggs, Jennifer R

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Synthetic Lethal Strategy Identifies a Potent and Selective TTK and CLK1/2 Inhibitor for Treatment of Triple-Negative Breast Cancer with a Compromised G 1 -S Checkpoint von Zhu, Dan, Xu, Shuichan, Deyanat-Yazdi, Gordafaried, Peng, Sophie X, Barnes, Leo A, Narla, Rama Krishna, Tran, Tam, Mikolon, David, Ning, Yuhong, Shi, Tao, Jiang, Ning, Raymon, Heather K, Riggs, Jennifer R, Boylan, John F

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Design and Optimization Leading to an Orally Active TTK Protein Kinase Inhibitor with Robust Single Agent Efficacy von Riggs, Jennifer R, Elsner, Jan, Cashion, Dan, Robinson, Dale, Tehrani, Lida, Nagy, Mark, Fultz, Kimberly E, Krishna Narla, Rama, Peng, Xiaohui, Tran, Tam, Kulkarni, Ashutosh, Bahmanyar, Sogole, Condroski, Kevin, Pagarigan, Barbra, Fenalti, Gustavo, LeBrun, Laurie, Leftheris, Katerina, Zhu, Dan, Boylan, John F

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Identification of the MEK1(F129L) Activating Mutation as a Potential Mechanism of Acquired Resistance to MEK Inhibition in Human Cancers Carrying the B-Raf V600E Mutation von HUISHENG WANG, DAOUTI, Sherif, HUIFENG NIU, LI, Wen-Hui, YANG WEN, RIZZO, Christine, HIGGINS, Brian, PACKMAN, Kathryn, ROSEN, Neal, BOYLAN, John F, HEIMBROOK, David

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What do we treat when we treat ARDS? von Yoshida, Takeshi, Boylan, John F., Kavanagh, Brian P.

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Inhibition of the NOTCH pathway using γ-secretase inhibitor RO4929097 has limited antitumor activity in established glial tumors von Dantas-Barbosa, Carmela, Bergthold, Guillaume, Daudigeos-Dubus, Estelle, Blockus, Heike, Boylan, John F, Ferreira, Celine, Puget, Stephanie, Abely, Michel, Vassal, Gilles, Grill, Jacques, Geoerger, Birgit

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The name of the game: no transfusion (or nontransfusion) by cookbook von Boylan, John F, Kavanagh, Brian P

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Fatal Fibrinolysis During Orthotopic Liver Transplantation in Patients Receiving Solvent/Detergent-Treated Plasma (Octaplas) von Magner, John J., MB, FCARCSI, Crowley, Kieran J., MB, FFARCSI, Boylan, John F., MB, FRCPC

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Cyclin-Dependent Kinase Inhibitors:  Useful Targets in Cell Cycle Regulation von Sielecki, Thais M, Boylan, John F, Benfield, Pamela A, Trainor, George L

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SKIP3, a novel Drosophila tribbles ortholog, is overexpressed in human tumors and is regulated by hypoxia von BOWERS, Alex J, SCULLY, Sheila, BOYLAN, John F

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Synthesis and Evaluation of Indenopyrazoles as Cyclin-Dependent Kinase Inhibitors. 3. Structure Activity Relationships at C3 von Yue, Eddy W, Higley, C. Anne, DiMeo, Susan V, Carini, David J, Nugiel, David A, Benware, Carrie, Benfield, Pamela A, Burton, Catherine R, Cox, Sarah, Grafstrom, Robert H, Sharp, Diane M, Sisk, Lisa M, Boylan, John F, Muckelbauer, Jodi K, Smallwood, Angela M, Chen, Haiying, Chang, Chong-Hwan, Seitz, Steven P, Trainor, George L

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