P-selectin-targeted nanocarriers induce active crossing of the blood–brain barrier via caveolin-1-dependent transcytosis von Tylawsky, Daniel E., Kiguchi, Hiroto, Vaynshteyn, Jake, Gerwin, Jeffrey, Shah, Janki, Islam, Taseen, Boyer, Jacob A., Boué, Daniel R., Snuderl, Matija, Greenblatt, Matthew B., Shamay, Yosi, Raju, G. Praveen, Heller, Daniel A.

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Regulation of PTEN translation by PI3K signaling maintains pathway homeostasis von Mukherjee, Radha, Vanaja, Kiran G., Boyer, Jacob A., Gadal, Sunyana, Solomon, Hilla, Chandarlapaty, Sarat, Levchenko, Andre, Rosen, Neal

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Combined inhibition of KRASG12C and mTORC1 kinase is synergistic in non-small cell lung cancer von Kitai, Hidenori, Choi, Philip H., Yang, Yu C., Boyer, Jacob A., Whaley, Adele, Pancholi, Priya, Thant, Claire, Reiter, Jason, Chen, Kevin, Markov, Vladimir, Taniguchi, Hirokazu, Yamaguchi, Rui, Ebi, Hiromichi, Evans, James, Jiang, Jingjing, Lee, Bianca, Wildes, David, de Stanchina, Elisa, Smith, Jacqueline A. M., Singh, Mallika, Rosen, Neal

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Editor's Highlight: Ah Receptor Activation Potentiates Neutrophil Chemoattractant (C-X-C Motif) Ligand 5 Expression in Keratinocytes and Skin von Smith, Kayla J, Boyer, Jacob A, Muku, Gulsum E, Murray, Iain A, Gowda, Krishne, Desai, Dhimant, Amin, Shantu G, Glick, Adam B, Perdew, Gary H

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Aryl Hydrocarbon Receptor Activation Synergistically Induces Lipopolysaccharide-Mediated Expression of Proinflammatory Chemokine (c-c motif) Ligand 20 von Lahoti, Tejas S, Boyer, Jacob A, Kusnadi, Ann, Muku, Gulsum E, Murray, Iain A, Perdew, Gary H

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Senolytic CAR T cells reverse senescence-associated pathologies von Amor, Corina, Feucht, Judith, Leibold, Josef, Ho, Yu-Jui, Zhu, Changyu, Alonso-Curbelo, Direna, Mansilla-Soto, Jorge, Boyer, Jacob A., Li, Xiang, Giavridis, Theodoros, Kulick, Amanda, Houlihan, Shauna, Peerschke, Ellinor, Friedman, Scott L., Ponomarev, Vladimir, Piersigilli, Alessandra, Sadelain, Michel, Lowe, Scott W.

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Author Correction: Senolytic CAR T cells reverse senescence-associated pathologies von Amor, Corina, Feucht, Judith, Leibold, Josef, Ho, Yu-Jui, Zhu, Changyu, Alonso-Curbelo, Direna, Mansilla-Soto, Jorge, Boyer, Jacob A., Li, Xiang, Giavridis, Theodoros, Kulick, Amanda, Houlihan, Shauna, Peerschke, Ellinor, Friedman, Scott L., Ponomarev, Vladimir, Piersigilli, Alessandra, Sadelain, Michel, Lowe, Scott W.

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Selective inhibitors of mTORC1 activate 4EBP1 and suppress tumor growth von Lee, Bianca J., Boyer, Jacob A., Burnett, G. Leslie, Thottumkara, Arun P., Tibrewal, Nidhi, Wilson, Stacy L., Hsieh, Tientien, Marquez, Abby, Lorenzana, Edward G., Evans, James W., Hulea, Laura, Kiss, Gert, Liu, Hui, Lee, Dong, Larsson, Ola, McLaughlan, Shannon, Topisirovic, Ivan, Wang, Zhengping, Wang, Zhican, Zhao, Yongyuan, Wildes, David, Aggen, James B., Singh, Mallika, Gill, Adrian L., Smith, Jacqueline A. M., Rosen, Neal

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Allelic variants of the aryl hydrocarbon receptor differentially influence UVB-mediated skin inflammatory responses in SKH1 mice von Smith, Kayla J., Murray, Iain A., Boyer, Jacob A., Perdew, Gary H.

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Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction von Amor, Corina, Fernández-Maestre, Inés, Chowdhury, Saria, Ho, Yu-Jui, Nadella, Sandeep, Graham, Courtenay, Carrasco, Sebastian E, Nnuji-John, Emmanuella, Feucht, Judith, Hinterleitner, Clemens, Barthet, Valentin J A, Boyer, Jacob A, Mezzadra, Riccardo, Wereski, Matthew G, Tuveson, David A, Levine, Ross L, Jones, Lee W, Sadelain, Michel, Lowe, Scott W

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Author Correction: Selective inhibitors of mTORC1 activate 4EBP1 and suppress tumor growth von Lee, Bianca J., Boyer, Jacob A., Burnett, G. Leslie, Thottumkara, Arun P., Tibrewal, Nidhi, Wilson, Stacy L., Hsieh, Tientien, Marquez, Abby, Lorenzana, Edward G., Evans, James W., Hulea, Laura, Kiss, Gert, Liu, Hui, Lee, Dong, Larsson, Ola, McLaughlan, Shannon, Topisirovic, Ivan, Wang, Zhengping, Wang, Zhican, Zhao, Yongyuan, Wildes, David, Aggen, James B., Singh, Mallika, Gill, Adrian L., Smith, Jacqueline A. M., Rosen, Neal

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Author Correction: Selective inhibitors of mTORC1 activate 4EBP1 and suppress tumor growth von Lee, Bianca J., Boyer, Jacob A., Burnett, G. Leslie, Thottumkara, Arun P., Tibrewal, Nidhi, Wilson, Stacy L., Hsieh, Tientien, Marquez, Abby, Lorenzana, Edward G., Evans, James W., Hulea, Laura, Kiss, Gert, Liu, Hui, Lee, Dong, Larsson, Ola, McLaughlan, Shannon, Topisirovic, Ivan, Wang, Zhengping, Wang, Zhican, Zhao, Yongyuan, Wildes, David, Aggen, James B., Singh, Mallika, Gill, Adrian L., Smith, Jacqueline A. M., Rosen, Neal

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A Druggable FOXA1-Glucocorticoid Receptor Transcriptional Axis Drives Tumor Growth in a Subset of Non-Small Cell Lung Cancer von Dorso, M., Patel, Payal T., Pankov, Aleksandr, Boyer, Jacob A., Soni, Rajesh K., Del Priore, Isabella S., Hayatt, Omar, Kulick, Amanda, Hagen, Connor J., de Stanchina, Elisa, Junttila, Melissa R., Daemen, Anneleen, Friedman, Lori S., Hendrickson, Ronald C., Chandarlapaty, Sarat

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Abstract 1090: Regulation of PTEN translation by PI3K signaling maintains pathway homeostasis von Mukherjee, Radha, Vanaja, Kiran Gireesan, Boyer, Jacob A., Qiu, Juan, Chen, Xiaoping, de Stanchina, Elisa, Chandarlapaty, Sarat, Levchenko, Andre, Rosen, Neal

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Selective inhibitors of mTORC1 activate 4EBP1 and suppress tumor growth (Jun, 10.1038/s41589-021-00813-7, 2021) von Lee, Bianca J., Boyer, Jacob A., Burnett, G. Leslie, Thottumkara, Arun P., Tibrewal, Nidhi, Wilson, Stacy L., Hsieh, Tientien, Marquez, Abby, Lorenzana, Edward G., Evans, James W., Hulea, Laura, Kiss, Gert, Liu, Hui, Lee, Dong, Larsson, Ola, McLaughlan, Shannon, Topisirovic, Ivan, Wang, Zhengping, Wang, Zhican, Zhao, Yongyuan, Wildes, David, Aggen, James B., Singh, Mallika, Gill, Adrian L., Smith, Jacqueline A. M., Rosen, Neal

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Selective inhibitors of mTORC1 activate 4EBP1 and suppress tumor growth (vol 17, pg 1065, 2021) von Lee, Bianca J., Boyer, Jacob A., Burnett, G. Leslie, Thottumkara, Arun P., Tibrewal, Nidhi, Wilson, Stacy L., Hsieh, Tientien, Marquez, Abby, Lorenzana, Edward G., Evans, James W., Hulea, Laura, Kiss, Gert, Liu, Hui, Lee, Dong, Larsson, Ola, McLaughlan, Shannon, Topisirovic, Ivan, Wang, Zhengping, Wang, Zhican, Zhao, Yongyuan, Wildes, David, Aggen, James B., Singh, Mallika, Gill, Adrian L., Smith, Jacqueline A. M., Rosen, Neal

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Abstract 835: Estrogen receptor expression and ER dependent breast tumor growth are dependent on translation initiation factor EIF4A von Boyer, Jacob A., Dorso, Madeline A., Amor, Corina, Reiter, Jason, Xu, Jianing, de Stanchina, Elisa, Wendel, Hans-Guido, Chandarlapaty, Sarat, Rosen, Neal

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Abstract 2422: Migration of V600E-expressing cells is suppressed by ERK-dependent feedback inhibition of RAC1 and rescued in melanoma by secondary mutations von Gadal, Sunyana, Boyer, Jacob A., Li, Hongyan, Fan, Ning, Chan, Eric, Romin, Yevgeniy, De Stanchina, Elisa, Yeager, Rona, Bosenberg, Marcus, Todorova, Katia M., Rosen, Neal

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Combined inhibition of KRAS G12C and mTORC1 kinase is synergistic in non-small cell lung cancer von Kitai, Hidenori, Choi, Philip H, Yang, Yu C, Boyer, Jacob A, Whaley, Adele, Pancholi, Priya, Thant, Claire, Reiter, Jason, Chen, Kevin, Markov, Vladimir, Taniguchi, Hirokazu, Yamaguchi, Rui, Ebi, Hiromichi, Evans, James, Jiang, Jingjing, Lee, Bianca, Wildes, David, de Stanchina, Elisa, Smith, Jacqueline A M, Singh, Mallika, Rosen, Neal

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Systematic review and meta-analysis of gait mechanics in young and older adults von Boyer, Katherine A., Johnson, Russell T., Banks, Jacob J., Jewell, Carl, Hafer, Jocelyn F.

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