DNA Damage Response and Repair Gene Alterations Are Associated with Improved Survival in Patients with Platinum-Treated Advanced Urothelial Carcinoma von Teo, Min Yuen, Bambury, Richard M, Zabor, Emily C, Jordan, Emmet, Al-Ahmadie, Hikmat, Boyd, Mariel E, Bouvier, Nancy, Mullane, Stephanie A, Cha, Eugene K, Roper, Nitin, Ostrovnaya, Irina, Hyman, David M, Bochner, Bernard H, Arcila, Maria E, Solit, David B, Berger, Michael F, Bajorin, Dean F, Bellmunt, Joaquim, Iyer, Gopakumar, Rosenberg, Jonathan E

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Contribution of systemic and somatic factors to clinical response and resistance to PD-L1 blockade in urothelial cancer: An exploratory multi-omic analysis von Snyder, Alexandra, Nathanson, Tavi, Funt, Samuel A, Ahuja, Arun, Buros Novik, Jacqueline, Hellmann, Matthew D, Chang, Eliza, Aksoy, Bulent Arman, Al-Ahmadie, Hikmat, Yusko, Erik, Vignali, Marissa, Benzeno, Sharon, Boyd, Mariel, Moran, Meredith, Iyer, Gopa, Robins, Harlan S, Mardis, Elaine R, Merghoub, Taha, Hammerbacher, Jeff, Rosenberg, Jonathan E, Bajorin, Dean F

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Multicenter Prospective Phase II Trial of Neoadjuvant Dose-Dense Gemcitabine Plus Cisplatin in Patients With Muscle-Invasive Bladder Cancer von Iyer, Gopa, Balar, Arjun V, Milowsky, Matthew I, Bochner, Bernard H, Dalbagni, Guido, Donat, S Machele, Herr, Harry W, Huang, William C, Taneja, Samir S, Woods, Michael, Ostrovnaya, Irina, Al-Ahmadie, Hikmat, Arcila, Maria E, Riches, Jamie C, Meier, Andreas, Bourque, Caitlin, Shady, Maha, Won, Helen, Rose, Tracy L, Kim, William Y, Kania, Brooke E, Boyd, Mariel E, Cipolla, Catharine K, Regazzi, Ashley M, Delbeau, Daniela, McCoy, Asia S, Vargas, Hebert Alberto, Berger, Michael F, Solit, David B, Rosenberg, Jonathan E, Bajorin, Dean F

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A phase 2 trial of buparlisib in patients with platinum‐resistant metastatic urothelial carcinoma von McPherson, Victor, Reardon, Brendan, Bhayankara, Aravind, Scott, Sasinya N., Boyd, Mariel E., Garcia‐Grossman, Ilana R., Regazzi, Ashley M., McCoy, Asia S., Kim, Philip H., Al‐Ahmadie, Hikmat, Ostrovnaya, Irina, Roth, Andrew J., Farooki, Azeez, Berger, Michael F., Rosenberg, Jonathan E., Solit, David B., Van Allen, Eliezer, Milowsky, Matthew I., Bajorin, Dean F., Iyer, Gopa

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Real‐world progression, treatment, and survival outcomes during rapid adoption of immunotherapy for advanced non–small cell lung cancer von Khozin, Sean, Miksad, Rebecca A., Adami, Johan, Boyd, Mariel, Brown, Nicholas R., Gossai, Anala, Kaganman, Irene, Kuk, Deborah, Rockland, Jillian M., Pazdur, Richard, Torres, Aracelis Z., Zhi, Jizu, Abernethy, Amy P.

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Phase I Study of Everolimus in Combination with Gemcitabine and Split-Dose Cisplatin in Advanced Urothelial Carcinoma von Abida, Wassim, Milowsky, Matthew I., Ostrovnaya, Irina, Gerst, Scott R., Rosenberg, Jonathan E., Voss, Martin H., Apolo, Andrea B., Regazzi, Ashley M., McCoy, Asia S., Boyd, Mariel E., Bajorin, Dean F.

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Technology-enabled clinical trials: Intentional capture of source data (IDC) in the electronic-health record (EHR) and direct transfer to trial database (electronic data capture [E... von Royce, Trevor Joseph, Falk, Sam, Xiao, Forrest, Boyd, Mariel, Bramwell, Lindsay, Shelley, Addison, Sutton, Lauren, Morgan, Ruth M., Mader, Patricia, Taiclet, Teresa, Alve, Abigail

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Genomic landscape of defective DNA damage response and repair mechanisms (DDR) across cancer types von Teo, MinYuen, Zabor, Emily Craig, Iyer, Gopa, Bambury, Richard, Boyd, Mariel Elena, Rosenberg, Jonathan E.

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A Phase II Trial of Buparlisib in Patients with Platinum-Resistant Metastatic Urothelial Carcinoma von McPherson, Victor, Reardon, Brendan, Bhayankara, Aravind, Scott, Sasinya N., Boyd, Mariel E., Garcia-Grossman, Ilana R., Regazzi, Ashley M., McCoy, Asia S., Kim, Philip H., Al-Ahmadie, Hikmat, Ostrovnaya, Irina, Roth, Andrew J., Farooki, Azeez, Berger, Michael F., Rosenberg, Jonathan E., Solit, David B., Van Allen, Eliezer, Milowsky, Matthew I, Bajorin, Dean F., Iyer, Gopa

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Muscle invasive bladder cancer (MIBC) demonstrates neoadjuvant cisplatin-based chemotherapy (NAC) related changes in molecular subtype and immune infiltration von Funt, Samuel Aaron, Solovyov, Alexander, Faltas, Bishoy Morris, Iyer, Gopa, Boyd, Mariel Elena, Cipolla, Catharine Kline, Regazzi, Ashley Marie, Teo, Min Yuen, Lee, Chung-Han, Al-Ahmadie, Hikmat, Rosenberg, Jonathan E., Greenbaum, Benjamin, Bajorin, Dean F.

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Abstract 2918: Analysis of matched pre and post cisplatin-treated muscle-invasive bladder cancer reveals a candidate cisplatin mutational signature von Liu, David, Keliher, Daniel, Abbosh, Philip, Mouw, Kent, Miao, Diana, Boyd, Mariel, Hoffman-Censits, Jean, Iyer, Gopa, Tolaney, Sara, Kim, Jaegil, Getz, Gad, Carter, Scott, Bellmunt, Joaquim, Plimack, Elizabeth R., Rosenberg, Jonathan E., Allen, Eliezer M. Van

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Health Related Quality of Life in Patients with Biliary Atresia Surviving with their Native Liver von Sundaram, Shikha S., MD, MSCI, Alonso, Estella M., MD, Haber, Barbara, MD, Magee, John C., MD, Fredericks, Emily, PhD, Kamath, Binita, MD, Kerkar, Nanda, MD, Rosenthal, Philip, MD, Shepherd, Ross, MD, Limbers, Christine, PhD, Varni, James W., PhD, Robuck, Patricia, PhD, Sokol, Ronald J., MD

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Genomic evolution in muscle-invasive bladder cancer resistant to neoadjuvant chemotherapy von Liu, David, Abbosh, Philip, Miao, Diana, Boyd, Mariel Elena, Hoffman-Censits, Jean H., Iyer, Gopa, Tolaney, Sara M., Mouw, Kent William, Carter, Scott L., Bellmunt, Joaquim, Plimack, Elizabeth R., Rosenberg, Jonathan E., Van Allen, Eliezer Mendel

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Correlation of peripheral and intratumoral T-cell receptor (TCR) clonality with clinical outcomes in patients with metastatic urothelial cancer (mUC) treated with atezolizumab von Funt, Samuel, Snyder Charen, Alexandra, Yusko, Erik, Vignali, Marissa, Benzeno, Sharon, Boyd, Mariel Elena, Moran, Meredith Maisie, Kania, Brooke Elizabeth, Cipolla, Catharine Kline, Regazzi, Ashley Marie, Robins, Harlan, Iyer, Gopa, Rosenberg, Jonathan E., Bajorin, Dean F.

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Phase I trial of gemcitabine and split-dose cisplatin plus everolimus (RAD001) in patients with advanced urothelial cancer von Abida, Wassim, Milowsky, Matthew I., Ostrovnaya, Irina, Gerst, Scott R., Rosenberg, Jonathan E., Regazzi, Ashley Marie, McCoy, Asia S., Boyd, Mariel Elena, Bajorin, Dean F.

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Evaluation of monocytic myeloid-derived suppressor cell (M-MDSC) frequency in patients with metastatic urothelial carcinoma (mUC) von Funt, Samuel, Mu, Zhenyu, Cipolla, Catharine Kline, Kania, Brooke Elizabeth, Zheng, Junting, Boyd, Mariel Elena, Snyder Charen, Alexandra, Callahan, Margaret K., Autio, Karen A., Regazzi, Ashley Marie, Moran, Meredith Maisie, Ostrovnaya, Irina, Iyer, Gopa, Wong, Phillip, Lesokhin, Alexander M., Rosenberg, Jonathan E., Bajorin, Dean F.

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Correlation of DNA damage response (DDR) gene alterations with response to neoadjuvant (neo) dose-dense gemcitabine and cisplatin (ddGC) in urothelial carcinoma (UC) von Iyer, Gopa, Balar, Arjun Vasant, Milowsky, Matthew I., Huang, William C., Woods, Michael, Donat, S. Machele, Herr, Harry W., Dalbagni, Guido, Bochner, Bernard H., Ostrovnaya, Irina, Al-Ahmadie, Hikmat, Rose, Tracy Lynn, Riches, Jamie Cathleen, Kania, Brooke Elizabeth, Boyd, Mariel Elena, Regazzi, Ashley Marie, McCoy, Asia S., Drier, Anthony, Rosenberg, Jonathan E., Bajorin, Dean F.

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Phase 2 study of the pan-isoform PI3 kinase inhibitor BKM120 in metastatic urothelial carcinoma patients von Iyer, Gopa, Tully, Christopher Michael, Garcia-Grossman, Ilana Rebecca, Scott, Sasinya N., Boyd, Mariel Elena, McCoy, Asia S., Berger, Michael F., Al-Ahmadie, Hikmat, Solit, David B., Rosenberg, Jonathan E., Bajorin, Dean F.

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Association of somatic mutations in DNA damage repair (DDR) genes with efficacy of platinum-based chemotherapy in advanced urothelial carcinoma von Bambury, Richard Martin, Jordan, Emmet, Zabor, Emily Craig, Bouvier, Nancy, Al-Ahmadie, Hikmat, Boyd, Mariel Elena, Mullane, Stephanie A., Cha, Eugene K., Ostrovnaya, Irina, Hyman, David Michael, Bochner, Bernard H., Arcila, Maria E., Solit, David B., Bajorin, Dean F., Bellmunt, Joaquim, Berger, Michael F., Iyer, Gopa, Rosenberg, Jonathan E.

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Comparison of genetic alterations from the bladder cancer genome atlas (TCGA) and a prospective set of high-grade urothelial carcinoma tumors using a CLIA laboratory next generatio... von Iyer, Gopa, Bagrodia, Aditya, Cha, Eugene K., Boyd, Mariel Elena, Zehir, Ahmet, Cheng, Donavan T, Hyman, David Michael, Bambury, Richard Martin, Arcila, Maria E., Ladanyi, Marc, Viale, Agnes, Al-Ahmadie, Hikmat, Berger, Michael F., Bochner, Bernard H., Rosenberg, Jonathan E., Bajorin, Dean F., Solit, David B.

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