LAL (Lysosomal Acid Lipase) Promotes Reverse Cholesterol Transport In Vitro and In Vivo von Bowden, Kristin L, Dubland, Joshua A, Chan, Teddy, Xu, You-Hai, Grabowski, Gregory A, Du, Hong, Francis, Gordon A

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Lysosomal Acid Lipase Deficiency Impairs Regulation of ABCA1 Gene and Formation of High Density Lipoproteins in Cholesteryl Ester Storage Disease von Bowden, Kristin L., Bilbey, Nicolas J., Bilawchuk, Leanne M., Boadu, Emmanuel, Sidhu, Rohini, Ory, Daniel S., Du, Hong, Chan, Teddy, Francis, Gordon A.

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Lysosomal acid lipase promotes reverse cholesterol transport in vitro and in vivo von Bowden, Kristin L., Dubland, Joshua A., Chan, Teddy, Xu, You-Hai, Grabowski, Gregory A., Du, Hong, Francis, Gordon A.

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Reasons Patients Choose the Emergency Department over Primary Care: a Qualitative Metasynthesis von Vogel, Jody A., Rising, Kristin L., Jones, Jacqueline, Bowden, Marjorie L., Ginde, Adit A., Havranek, Edward P.

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Assessing the contribution of rare variants to complex trait heritability from whole-genome sequence data von Wainschtein, Pierrick, Jain, Deepti, Zheng, Zhili, Cupples, L. Adrienne, Shadyab, Aladdin H., McKnight, Barbara, Shoemaker, Benjamin M., Mitchell, Braxton D., Psaty, Bruce M., Kooperberg, Charles, Liu, Ching-Ti, Albert, Christine M., Roden, Dan, Chasman, Daniel I., Darbar, Dawood, Lloyd-Jones, Donald M., Arnett, Donna K., Regan, Elizabeth A., Boerwinkle, Eric, Rotter, Jerome I., O’Connell, Jeffrey R., Yanek, Lisa R., de Andrade, Mariza, Allison, Matthew A., McDonald, Merry-Lynn N., Chung, Mina K., Fornage, Myriam, Chami, Nathalie, Smith, Nicholas L., Ellinor, Patrick T., Vasan, Ramachandran S., Mathias, Rasika A., Loos, Ruth J. F., Rich, Stephen S., Lubitz, Steven A., Heckbert, Susan R., Redline, Susan, Guo, Xiuqing, Chen, Y. -D Ida, Laurie, Cecelia A., Hernandez, Ryan D., McGarvey, Stephen T., Goddard, Michael E., Laurie, Cathy C., North, Kari E., Lange, Leslie A., Weir, Bruce S., Yengo, Loic, Yang, Jian, Visscher, Peter M.

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Clonal haematopoiesis and risk of chronic liver disease von Wong, Waihay J., Emdin, Connor, Bick, Alexander G., Zekavat, Seyedeh M., Niroula, Abhishek, Pirruccello, James P., Dichtel, Laura, Griffin, Gabriel, Uddin, Md Mesbah, Gibson, Christopher J., Kovalcik, Veronica, Lin, Amy E., McConkey, Marie E., Vromman, Amelie, Sellar, Rob S., Kim, Peter G., Agrawal, Mridul, Weinstock, Joshua, Long, Michelle T., Yu, Bing, Banerjee, Rajarshi, Nicholls, Rowan C., Dennis, Andrea, Kelly, Matt, Loh, Po-Ru, McCarroll, Steve, Boerwinkle, Eric, Vasan, Ramachandran S., Jaiswal, Siddhartha, Johnson, Andrew D., Chung, Raymond T., Corey, Kathleen, Levy, Daniel, Ballantyne, Christie, Ebert, Benjamin L., Natarajan, Pradeep

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Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole-genome sequencing studies at scale von Li, Xihao, Li, Zilin, Zhou, Hufeng, Gaynor, Sheila M., Liu, Yaowu, Chen, Han, Sun, Ryan, Dey, Rounak, Arnett, Donna K., Aslibekyan, Stella, Ballantyne, Christie M., Bielak, Lawrence F., Blangero, John, Boerwinkle, Eric, Bowden, Donald W., Broome, Jai G., Conomos, Matthew P., Correa, Adolfo, Cupples, L. Adrienne, Curran, Joanne E., Freedman, Barry I., Guo, Xiuqing, Hindy, George, Irvin, Marguerite R., Kardia, Sharon L. R., Kathiresan, Sekar, Khan, Alyna T., Kooperberg, Charles L., Laurie, Cathy C., Liu, X. Shirley, Mahaney, Michael C., Manichaikul, Ani W., Martin, Lisa W., Mathias, Rasika A., McGarvey, Stephen T., Mitchell, Braxton D., Montasser, May E., Moore, Jill E., Morrison, Alanna C., O’Connell, Jeffrey R., Palmer, Nicholette D., Pampana, Akhil, Peralta, Juan M., Peyser, Patricia A., Psaty, Bruce M., Redline, Susan, Rice, Kenneth M., Rich, Stephen S., Smith, Jennifer A., Tiwari, Hemant K., Tsai, Michael Y., Vasan, Ramachandran S., Wang, Fei Fei, Weeks, Daniel E., Weng, Zhiping, Wilson, James G., Yanek, Lisa R., Neale, Benjamin M., Sunyaev, Shamil R., Abecasis, Gonçalo R., Rotter, Jerome I., Willer, Cristen J., Peloso, Gina M., Natarajan, Pradeep, Lin, Xihong

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A high-resolution HLA reference panel capturing global population diversity enables multi-ancestry fine-mapping in HIV host response von Luo, Yang, Kanai, Masahiro, Choi, Wanson, Li, Xinyi, Sakaue, Saori, Yamamoto, Kenichi, Ogawa, Kotaro, Gutierrez-Arcelus, Maria, Gregersen, Peter K., Stuart, Philip E., Elder, James T., Forer, Lukas, Schönherr, Sebastian, Fuchsberger, Christian, Smith, Albert V., Fellay, Jacques, Carrington, Mary, Haas, David W., Guo, Xiuqing, Palmer, Nicholette D., Chen, Yii-Der Ida, Rotter, Jerome I., Taylor, Kent D., Rich, Stephen S., Correa, Adolfo, Wilson, James G., Kathiresan, Sekar, Cho, Michael H., Metspalu, Andres, Esko, Tonu, Okada, Yukinori, Han, Buhm, McLaren, Paul J., Raychaudhuri, Soumya

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Genetic diversity fuels gene discovery for tobacco and alcohol use von Wang, Xingyan, Jang, Seon-Kyeong, Jiang, Yu, Khunsriraksakul, Chachrit, Addison, Clifton, Aliev, Fazil, Arnett, Donna K., Ashley-Koch, Allison E., Barr, R. Graham, Bielak, Lawrence F., Benjamin, Emelia J., Bis, Joshua C., Bjornsdottir, Gyda, Blangero, John, Chavan, Sameer, Chen, Yii-Der Ida, Chen, Zhengming, Cheng, Iona, Choquet, Hélène, Cole, John W., Cucca, Francesco, Dick, Danielle M., Fernandes Silva, Lilian, Fiorillo, Edoardo, Garrett, Melanie E., Glahn, David C., Gordon, Scott D., Gu, Dongfeng, Gudbjartsson, Daniel F., Hall, Michael E., Haller, Toomas, Harris, Kathleen Mullan, He, Jiang, Hewitt, John K., Hickie, Ian, Hidalgo, Bertha, Hokanson, John E., Hottenga, JoukeJan, Hwu, Chii-Min, Jee, Yon Ho, Joo, Yoonjung Y., Kamatani, Yoichiro, Kaplan, Robert C., Kelly, Tanika N., Kraft, Peter, Krauter, Kenneth, Laakso, Markku, Lasky-Su, Jessica, Li, Liming, Lloyd-Jones, Donald M., Mägi, Reedik, Manichaikul, Ani, Mathur, Ravi, Matoba, Nana, McArdle, Patrick F., Metspalu, Andres, Moll, Matthew, Montasser, May E., Nielsen, Jonas B., Oelsner, Elizabeth C., Orrù, Valeria, Palmer, Nicholette D., Park, S. Lani, Peters, Ulrike, Peters, Annette, Polderman, Tinca J. C., Rafaels, Nicholas, Reiner, Alex P., Roan, Carol, Rotter, Jerome I., Runarsdottir, Valgerdur, Saccone, Nancy L., Shadyab, Aladdin H., Shringarpure, Suyash S., Sicinski, Kamil, Smith, Jennifer A., Smith, Nicholas L., Sotoodehnia, Nona, Stallings, Michael C., Stefansson, Hreinn, Syed, Moin, Tal-Singer, Ruth, Telen, Marilyn J., Tiwari, Hemant, Wall, Tamara L., White, Wendy B., Whitfield, John B., Wiggins, Kerri L., Willemsen, Gonneke, Willer, Cristen J., Xu, Huichun, Yanek, Lisa R., Young, Kendra A., Yu, Bing, Zhao, Wei, Zöllner, Sebastian, Bierut, Laura J., Gagliano Taliun, Sarah A., Munafò, Marcus R., Liu, Dajiang J.

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Aberrant activation of TCL1A promotes stem cell expansion in clonal haematopoiesis von Weinstock, Joshua S., Gopakumar, Jayakrishnan, Burugula, Bala Bharathi, Jahn, Nikolaus, Belk, Julia A., Bouzid, Hind, Daniel, Bence, Miao, Zhuang, Ly, Nghi, Mack, Taralynn M., Luna, Sofia E., Prothro, Katherine P., Mitchell, Shaneice R., Laurie, Cecelia A., Broome, Jai G., Taylor, Kent D., Guo, Xiuqing, Sinner, Moritz F., von Falkenhausen, Aenne S., Shuldiner, Alan R., O’Connell, Jeffrey R., Lewis, Joshua P., Boerwinkle, Eric, Chami, Nathalie, Kenny, Eimear E., Loos, Ruth J. F., Fornage, Myriam, Hou, Lifang, Lloyd-Jones, Donald M., Redline, Susan, Cade, Brian E., Psaty, Bruce M., Bis, Joshua C., Brody, Jennifer A., Yun, Jeong H., Qiao, Dandi, Palmer, Nicholette D., Freedman, Barry I., Bowden, Donald W., Cho, Michael H., Vasan, Ramachandran S., Yanek, Lisa R., Becker, Lewis C., Kardia, Sharon L. R., Peyser, Patricia A., He, Jiang, Rienstra, Michiel, Van der Harst, Pim, Kaplan, Robert, Heckbert, Susan R., Smith, Nicholas L., Wiggins, Kerri L., Arnett, Donna K., Irvin, Marguerite R., Tiwari, Hemant, Cutler, Michael J., Knight, Stacey, Muhlestein, J. Brent, Correa, Adolfo, Raffield, Laura M., Gao, Yan, de Andrade, Mariza, Rotter, Jerome I., Rich, Stephen S., Konkle, Barbara A., Johnsen, Jill M., Wheeler, Marsha M., Smith, J. Gustav, Melander, Olle, Nilsson, Peter M., Custer, Brian S., Duggirala, Ravindranath, Curran, Joanne E., Blangero, John, Xiao, Shujie, Yang, Mao, Gu, C. Charles, Chen, Yii-Der Ida, Lee, Wen-Jane, Marcus, Gregory M., Kane, John P., Pullinger, Clive R., Shoemaker, M. Benjamin, Darbar, Dawood, Roden, Dan M., Kooperberg, Charles, Zhou, Ying, Manson, JoAnn E., Desai, Pinkal, Johnson, Andrew D., Mathias, Rasika A., Abecasis, Goncalo R., Kang, Hyun M., Satpathy, Ansuman T., Natarajan, Pradeep, Kitzman, Jacob O., Whitsel, Eric A., Reiner, Alexander P., Bick, Alexander G., Jaiswal, Siddhartha

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Assessment of the genetic and clinical determinants of fracture risk: genome wide association and mendelian randomisation study von Trajanoska, Katerina, Morris, John A, Oei, Ling, Zheng, Hou-Feng, Evans, David M, Kiel, Douglas P, Ohlsson, Claes, Richards, J Brent, Rivadeneira, Fernando

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The global dissemination of hospital clones of Enterococcus faecium von van Hal, Sebastiaan J, Willems, Rob J L, Gouliouris, Theodore, Ballard, Susan A, Coque, Teresa M, Hammerum, Anette M, Hegstad, Kristin, Westh, Hendrik T, Howden, Benjamin P, Malhotra-Kumar, Surbhi, Werner, Guido, Yanagihara, Katsunori, Earl, Ashlee M, Raven, Katherine E, Corander, Jukka, Bowden, Rory

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Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution von Justice, Anne E., Young, Kristin L., Lu, Yingchang, Turcot, Valérie, Winkler, Thomas W., Medina-Gomez, Carolina, Mudgal, Poorva, Ng, Maggie C. Y., Willems, Sara M., Abecasis, Goncalo, Allison, Matthew, Balkau, Beverley, Bastarache, Lisa, Bergmann, Sven, Bielak, Lawrence F., Blüher, Matthias, Boeing, Heiner, Bottinger, Erwin P., Bowden, Donald W., Butterworth, Adam S., Chambers, John C., Chen, Yii-Der Ida, Chowdhury, Rajiv, Chu, Audrey Y., Cox, Amanda J., Danesh, John, Denny, Josh C., Di Angelantonio, Emanuele, Drenos, Fotios, Dubé, Marie-Pierre, Evangelou, Evangelos, Ferrannini, Ele, Ferrieres, Jean, Florez, Jose C., Gan, Wei, Giedraitis, Vilmantas, Grove, Megan L., Howson, Joanna M. M., Ikram, M. Arfan, Ingelsson, Erik, Jackson, Anne U., Jarvik, Gail P., Kitajima, Hidetoshi, Krämer, Bernhard K., Laakso, Markku, Lamparter, David, Lee, Wen-Jane, Li, Huaixing, Li, Jin, Lin, Xu, Linneberg, Allan, Liu, Ching-Ti, MacGregor, Stuart, Männistö, Satu, Masca, Nicholas G. D., Moitry, Marie, Müller-Nurasyid, Martina, Munroe, Patricia B., Neville, Matt, Perola, Markus, Pers, Tune H., Reilly, Dermot F., Ridker, Paul M., Rivas, Manuel A., Robertson, Neil R., Rudan, Igor, Saleheen, Danish, Samani, Nilesh J., Schreiner, Pamela J., Scott, Robert A., Slater, Andrew J., Speliotes, Elizabeth K., Steinthorsdottir, Valgerdur, Sun, Liang, Taylor, Kent D., Thorleifsson, Gudmar, Tönjes, Anke, Tsafantakis, Emmanouil, Uusitupa, Matti, Vermeulen, Sita H., Vitart, Veronique, Vuckovic, Dragana, Wagenknecht, Lynne E., Walker, Mark, Wallentin, Lars, Waterworth, Dawn M., Wu, Ying, Zeggini, Eleftheria, Zhan, Xiaowei, Zhao, Jing Hua, Zhao, Wei, Zhou, Wei, Rivadeneira, Fernando, Pospisilik, J. Andrew, Mohlke, Karen L., Rotter, Jerome I., Hirschhorn, Joel N., Cupples, L. Adrienne, Loos, Ruth J. F., North, Kari E.

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Treatable inborn errors of metabolism presenting as cerebral palsy mimics: systematic literature review von Leach, Emma L, Shevell, Michael, Bowden, Kristin, Stockler-Ipsiroglu, Sylvia, van Karnebeek, Clara D M

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Whole Genome Sequence Analysis of the Plasma Proteome in Black Adults Provides Novel Insights Into Cardiovascular Disease von Katz, Daniel H., Tahir, Usman A., Bick, Alexander G., Pampana, Akhil, Ngo, Debby, Benson, Mark D., Yu, Zhi, Robbins, Jeremy M., Chen, Zsu-Zsu, Cruz, Daniel E., Deng, Shuliang, Farrell, Laurie, Sinha, Sumita, Schmaier, Alec A., Shen, Dongxiao, Gao, Yan, Hall, Michael E., Correa, Adolfo, Tracy, Russell P., Durda, Peter, Taylor, Kent D., Liu, Yongmei, Johnson, W. Craig, Guo, Xiuqing, Yao, Jie, Ida Chen, Yii-Der, Manichaikul, Ani W., Jain, Deepti, Bouchard, Claude, Sarzynski, Mark A., Rich, Stephen S., Rotter, Jerome I., Wang, Thomas J., Wilson, James G., Natarajan, Pradeep, Gerszten, Robert E.

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Whole genome sequence analysis of blood lipid levels in >66,000 individuals von Selvaraj, Margaret Sunitha, Li, Xihao, Li, Zilin, Pampana, Akhil, Zhang, David Y., Park, Joseph, Aslibekyan, Stella, Bis, Joshua C., Brody, Jennifer A., Cade, Brian E., Chuang, Lee-Ming, Chung, Ren-Hua, Curran, Joanne E., de las Fuentes, Lisa, de Vries, Paul S., Duggirala, Ravindranath, Freedman, Barry I., Graff, Mariaelisa, Guo, Xiuqing, Heard-Costa, Nancy, Hidalgo, Bertha, Hwu, Chii-Min, Irvin, Marguerite R., Kelly, Tanika N., Kral, Brian G., Lange, Leslie, Li, Xiaohui, Lisa, Martin, Lubitz, Steven A., Manichaikul, Ani W., Michael, Preuss, Montasser, May E., Morrison, Alanna C., Naseri, Take, O’Connell, Jeffrey R., Palmer, Nicholette D., Peyser, Patricia A., Reupena, Muagututia S., Smith, Jennifer A., Sun, Xiao, Taylor, Kent D., Tracy, Russell P., Tsai, Michael Y., Wang, Zhe, Wang, Yuxuan, Bao, Wei, Wilkins, John T., Yanek, Lisa R., Zhao, Wei, Arnett, Donna K., Blangero, John, Boerwinkle, Eric, Bowden, Donald W., Chen, Yii-Der Ida, Correa, Adolfo, Cupples, L. Adrienne, Dutcher, Susan K., Ellinor, Patrick T., Fornage, Myriam, Gabriel, Stacey, Germer, Soren, Gibbs, Richard, He, Jiang, Kaplan, Robert C., Kardia, Sharon L. R., Kim, Ryan, Kooperberg, Charles, Loos, Ruth J. F., Viaud-Martinez, Karine A, Mathias, Rasika A., McGarvey, Stephen T., Mitchell, Braxton D., Nickerson, Deborah, North, Kari E., Psaty, Bruce M., Redline, Susan, Reiner, Alexander P., Vasan, Ramachandran S., Rich, Stephen S., Willer, Cristen, Rotter, Jerome I., Rader, Daniel J., Lin, Xihong, Peloso, Gina M., Natarajan, Pradeep

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Genome sequencing unveils a regulatory landscape of platelet reactivity von Keramati, Ali R., Chen, Ming-Huei, Rodriguez, Benjamin A. T., Yanek, Lisa R., Bhan, Arunoday, Gaynor, Brady J., Ryan, Kathleen, Brody, Jennifer A., Zhong, Xue, Wei, Qiang, Kammers, Kai, Kanchan, Kanika, Iyer, Kruthika, Kowalski, Madeline H., Pitsillides, Achilleas N., Cupples, L. Adrienne, Li, Bingshan, Schlaeger, Thorsten M., Shuldiner, Alan R., O’Connell, Jeffrey R., Ruczinski, Ingo, Mitchell, Braxton D., Faraday, Nauder, Taub, Margaret A., Becker, Lewis C., Lewis, Joshua P., Mathias, Rasika A., Johnson, Andrew D.

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Whole Genome Association Study of the Plasma Metabolome Identifies Metabolites Linked to Cardiometabolic Disease in Black Individuals von Tahir, Usman A., Katz, Daniel H., Avila-Pachecho, Julian, Bick, Alexander G., Pampana, Akhil, Robbins, Jeremy M., Yu, Zhi, Chen, Zsu-Zsu, Benson, Mark D., Cruz, Daniel E., Ngo, Debby, Deng, Shuliang, Shi, Xu, Zheng, Shuning, Eisman, Aaron S., Farrell, Laurie, Hall, Michael E., Correa, Adolfo, Tracy, Russell P., Durda, Peter, Taylor, Kent D., Liu, Yongmei, Johnson, W. Craig, Guo, Xiuqing, Yao, Jie, Chen, Yii-Der Ida, Manichaikul, Ani W., Ruberg, Frederick L., Blaner, William S., Jain, Deepti, Bouchard, Claude, Sarzynski, Mark A., Rich, Stephen S., Rotter, Jerome I., Wang, Thomas J., Wilson, James G., Clish, Clary B., Natarajan, Pradeep, Gerszten, Robert E.

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Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness von Willems, Sara M., Wright, Daniel J., Day, Felix R., Trajanoska, Katerina, Joshi, Peter K., Morris, John A., Matteini, Amy M., Garton, Fleur C., Grarup, Niels, Oskolkov, Nikolay, Thalamuthu, Anbupalam, Mangino, Massimo, Liu, Jun, Demirkan, Ayse, Lek, Monkol, Xu, Liwen, Wang, Guan, Oldmeadow, Christopher, Gaulton, Kyle J., Lotta, Luca A., Miyamoto-Mikami, Eri, Rivas, Manuel A., White, Tom, Loh, Po-Ru, Aadahl, Mette, Amin, Najaf, Attia, John R., Austin, Krista, Benyamin, Beben, Brage, Søren, Cheng, Yu-Ching, Cięszczyk, Paweł, Derave, Wim, Eriksson, Karl-Fredrik, Eynon, Nir, Linneberg, Allan, Lucia, Alejandro, Massidda, Myosotis, Mitchell, Braxton D., Miyachi, Motohiko, Murakami, Haruka, Padmanabhan, Sandosh, Pandey, Ashutosh, Papadimitriou, Ioannis, Rajpal, Deepak K., Sale, Craig, Schnurr, Theresia M., Sessa, Francesco, Shrine, Nick, Tobin, Martin D., Varley, Ian, Wain, Louise V., Wray, Naomi R., Lindgren, Cecilia M., MacArthur, Daniel G., Waterworth, Dawn M., McCarthy, Mark I., Pedersen, Oluf, Khaw, Kay-Tee, Kiel, Douglas P., Pitsiladis, Yannis, Fuku, Noriyuki, Franks, Paul W., North, Kathryn N., van Duijn, Cornelia M., Mather, Karen A., Hansen, Torben, Hansson, Ola, Spector, Tim, Murabito, Joanne M., Richards, J. Brent, Rivadeneira, Fernando, Langenberg, Claudia, Perry, John R. B., Wareham, Nick J., Scott, Robert A.

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Genetic background influences survival of infections with Salmonella enterica serovar Typhimurium in the Collaborative Cross von Scoggin, Kristin, Lynch, Rachel, Gupta, Jyotsana, Nagarajan, Aravindh, Sheffield, Maxwell, Elsaadi, Ahmed, Bowden, Christopher, Aminian, Manuchehr, Peterson, Amy, Adams, L Garry, Kirby, Michael, Threadgill, David W, Andrews-Polymenis, Helene L

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