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    Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity von Schurmann, Claudia, Justice, Anne E., Bradfield, Jonathan P., Graff, Mariaelisa, Hendricks, Audrey E., Karaderi, Tugce, Locke, Adam E., Sivapalaratnam, Suthesh, Medina-Gomez, Carolina, Mudgal, Poorva, Aben, Katja K., Alam, Dewan S., Barroso, Inês, Bielak, Lawrence F., Boehnke, Michael, Boeing, Heiner, Böger, Carsten A., Bork-Jensen, Jette, Brandslund, Ivan, Campbell, Peter T., Cappellani, Stefania, Carey, David J., Cocca, Massimiliano, Corominas Galbany, Jordi, Crosslin, David S., Deary, Ian J., Edwards, Todd L., Ferrannini, Ele, Florez, Jose C., Gan, Wei, Gandin, Ilaria, Gibson, Jane, Giedraitis, Vilmantas, Grabe, Hans-Jörgen, Hakonarson, Hakon, Hernesniemi, Jussi, Huffman, Jennifer E., Ingelsson, Erik, Johansson, Stefan, Kahn, René S., Kanoni, Stavroula, Karaleftheri, Maria, Kim, Eric, Kooner, Jaspal S., Korhonen, Tellervo, Kuivaniemi, Helena, Kutalik, Zoltán, Li-Gao, Ruifang, McCarthy, Mark I., Medland, Sarah E., Meidtner, Karina, Moitry, Marie, Montgomery, Grant W., Mook-Kanamori, Dennis O., Moore, Carmel, Müller-Nurasyid, Martina, Nordestgaard, Børge G., Nyholt, Dale R., O’Connel, Jeffrey R., O’Donoghue, Michelle L., Owen, Katharine R., Padmanabhan, Sandosh, Pasterkamp, Gerard, Patel, Aniruddh P., Peloso, Gina M., Pennell, Craig E., Pers, Tune H., Person, Thomas N., Peyser, Patricia A., Raitakari, Olli T., Rauramaa, Rainer, Ridker, Paul M., Roberts, David J., Robertson, Neil R., Sheu, Wayne H.-H., Sim, Xueling, Slater, Andrew J., Smith, Albert V., Spector, Timothy D., Strauch, Konstantin, Teumer, Alexander, Thompson, Deborah J., Thorleifsson, Gudmar, van Setten, Jessica, Vanhala, Mauno, Vogt, Thomas F., Vuckovic, Dragana, Walker, Mark, Wang, Feijie, Wang, Yiqin, White, Harvey D., Willer, Cristen J., Wilson, James G., Yaghootkar, Hanieh, Yerges-Armstrong, Laura M., Young, Robin, Zeggini, Eleftheria, Zhou, Wei, Zondervan, Krina T, Borecki, Ingrid B.

    Veröffentlicht in Nature genetics

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    Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program von Taliun, Daniel, Kessler, Michael D., Carlson, Jedidiah, Taliun, Sarah A. Gagliano, Kang, Hyun Min, Pitsillides, Achilleas N., Emde, Anne-Katrin, Clarke, Wayne E., Shetty, Amol C., Wong, Quenna, Bobo, Dean M., Aguet, François, Albert, Christine, Aslibekyan, Stella, Barnard, John, Barr, R. Graham, Barwick, Lucas, Becker, Lewis C., Bielak, Lawrence F., Blangero, John, Bowden, Donald W., Burchard, Esteban G., Chalazan, Brandon, Chasman, Daniel I., Chen, Yii-Der Ida, Choi, Seung Hoan, Chung, Mina K., Curran, Joanne E., Daya, Michelle, Ellinor, Patrick T., Fatkin, Diane, Fingerlin, Tasha, Forer, Lukas, Franceschini, Nora, Germer, Soren, Gladwin, Mark T., Hall, Michael E., He, Jiang, Johnsen, Jill M., Johnson, Andrew D., Kardia, Sharon L. R., Klemmer, Robert, Kooperberg, Charles, Köttgen, Anna, Lange, Leslie A., Lin, Xihong, Lin, Keng-Han, Liu, Chunyu, Loos, Ruth J. F., Gerszten, Robert, Lunetta, Kathryn L., Mak, Angel C. Y., Manichaikul, Ani, Manning, Alisa K., Mathias, Rasika A., McManus, David D., McGarvey, Stephen T., Meigs, James B., Minear, Mollie A., Mitchell, Braxton D., Mohanty, Sanghamitra, Montasser, May E., Montgomery, Courtney, Morrison, Alanna C., Murabito, Joanne M., Natale, Andrea, Nelson, Sarah C., Palmer, Nicholette D., Pankratz, Nathan, Peyser, Patricia A., Post, Wendy S., Psaty, Bruce M., Rao, D. C., Reiner, Alexander P., Roden, Dan, Rotter, Jerome I., Schoenherr, Sebastian, Seo, Jeong-Sun, Sheu, Wayne H., Smith, Nicholas L., Smith, Jennifer A., Stilp, Adrienne M., Telen, Marilyn, Thornton, Timothy A., Tracy, Russell P., Van Den Berg, David J., Vasan, Ramachandran S., Vrieze, Scott, Weng, Lu-Chen, Zhao, Xutong, Boerwinkle, Eric, Gibbs, Richard, Rich, Stephen S., Silverman, Edwin K., Qasba, Pankaj, Gan, Weiniu, Zöllner, Sebastian, Wilson, James G., Laurie, Cathy C., Jaquish, Cashell E.

    Veröffentlicht in Nature (London)

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    Analysis of protein-coding genetic variation in 60,706 humans von Lek, Monkol, Karczewski, Konrad J., Minikel, Eric V., Samocha, Kaitlin E., Banks, Eric, Fennell, Timothy, O’Donnell-Luria, Anne H., Ware, James S., Hill, Andrew J., Cummings, Beryl B., Tukiainen, Taru, Birnbaum, Daniel P., Kosmicki, Jack A., Duncan, Laramie E., Estrada, Karol, Zhao, Fengmei, Zou, James, Pierce-Hoffman, Emma, Berghout, Joanne, Cooper, David N., Deflaux, Nicole, DePristo, Mark, Do, Ron, Flannick, Jason, Fromer, Menachem, Gauthier, Laura, Goldstein, Jackie, Gupta, Namrata, Howrigan, Daniel, Kiezun, Adam, Kurki, Mitja I., Moonshine, Ami Levy, Natarajan, Pradeep, Orozco, Lorena, Peloso, Gina M., Poplin, Ryan, Rivas, Manuel A., Ruano-Rubio, Valentin, Rose, Samuel A., Ruderfer, Douglas M., Shakir, Khalid, Stenson, Peter D., Stevens, Christine, Thomas, Brett P., Tiao, Grace, Tusie-Luna, Maria T., Weisburd, Ben, Won, Hong-Hee, Yu, Dongmei, Altshuler, David M., Ardissino, Diego, Boehnke, Michael, Danesh, John, Donnelly, Stacey, Elosua, Roberto, Florez, Jose C., Gabriel, Stacey B., Getz, Gad, Glatt, Stephen J., Hultman, Christina M., Kathiresan, Sekar, Laakso, Markku, McCarroll, Steven, McCarthy, Mark I., McGovern, Dermot, McPherson, Ruth, Neale, Benjamin M., Palotie, Aarno, Purcell, Shaun M., Saleheen, Danish, Scharf, Jeremiah M., Sklar, Pamela, Sullivan, Patrick F., Tuomilehto, Jaakko, Tsuang, Ming T., Watkins, Hugh C., Wilson, James G., Daly, Mark J., MacArthur, Daniel G.

    Veröffentlicht in Nature (London)

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    Aberrant activation of TCL1A promotes stem cell expansion in clonal haematopoiesis von Weinstock, Joshua S., Gopakumar, Jayakrishnan, Burugula, Bala Bharathi, Jahn, Nikolaus, Belk, Julia A., Bouzid, Hind, Daniel, Bence, Miao, Zhuang, Ly, Nghi, Mack, Taralynn M., Luna, Sofia E., Prothro, Katherine P., Mitchell, Shaneice R., Laurie, Cecelia A., Broome, Jai G., Taylor, Kent D., Guo, Xiuqing, Sinner, Moritz F., von Falkenhausen, Aenne S., Shuldiner, Alan R., O’Connell, Jeffrey R., Lewis, Joshua P., Boerwinkle, Eric, Chami, Nathalie, Kenny, Eimear E., Loos, Ruth J. F., Fornage, Myriam, Hou, Lifang, Lloyd-Jones, Donald M., Redline, Susan, Cade, Brian E., Psaty, Bruce M., Bis, Joshua C., Brody, Jennifer A., Yun, Jeong H., Qiao, Dandi, Palmer, Nicholette D., Freedman, Barry I., Bowden, Donald W., Cho, Michael H., Vasan, Ramachandran S., Yanek, Lisa R., Becker, Lewis C., Kardia, Sharon L. R., Peyser, Patricia A., He, Jiang, Rienstra, Michiel, Van der Harst, Pim, Kaplan, Robert, Heckbert, Susan R., Smith, Nicholas L., Wiggins, Kerri L., Arnett, Donna K., Irvin, Marguerite R., Tiwari, Hemant, Cutler, Michael J., Knight, Stacey, Muhlestein, J. Brent, Correa, Adolfo, Raffield, Laura M., Gao, Yan, de Andrade, Mariza, Rotter, Jerome I., Rich, Stephen S., Konkle, Barbara A., Johnsen, Jill M., Wheeler, Marsha M., Smith, J. Gustav, Melander, Olle, Nilsson, Peter M., Custer, Brian S., Duggirala, Ravindranath, Curran, Joanne E., Blangero, John, Xiao, Shujie, Yang, Mao, Gu, C. Charles, Chen, Yii-Der Ida, Lee, Wen-Jane, Marcus, Gregory M., Kane, John P., Pullinger, Clive R., Shoemaker, M. Benjamin, Darbar, Dawood, Roden, Dan M., Kooperberg, Charles, Zhou, Ying, Manson, JoAnn E., Desai, Pinkal, Johnson, Andrew D., Mathias, Rasika A., Abecasis, Goncalo R., Kang, Hyun M., Satpathy, Ansuman T., Natarajan, Pradeep, Kitzman, Jacob O., Whitsel, Eric A., Reiner, Alexander P., Bick, Alexander G., Jaiswal, Siddhartha

    Veröffentlicht in Nature (London)

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    Whole genome sequence analysis of blood lipid levels in >66,000 individuals von Selvaraj, Margaret Sunitha, Li, Xihao, Li, Zilin, Pampana, Akhil, Zhang, David Y., Park, Joseph, Aslibekyan, Stella, Bis, Joshua C., Brody, Jennifer A., Cade, Brian E., Chuang, Lee-Ming, Chung, Ren-Hua, Curran, Joanne E., de las Fuentes, Lisa, de Vries, Paul S., Duggirala, Ravindranath, Freedman, Barry I., Graff, Mariaelisa, Guo, Xiuqing, Heard-Costa, Nancy, Hidalgo, Bertha, Hwu, Chii-Min, Irvin, Marguerite R., Kelly, Tanika N., Kral, Brian G., Lange, Leslie, Li, Xiaohui, Lisa, Martin, Lubitz, Steven A., Manichaikul, Ani W., Michael, Preuss, Montasser, May E., Morrison, Alanna C., Naseri, Take, O’Connell, Jeffrey R., Palmer, Nicholette D., Peyser, Patricia A., Reupena, Muagututia S., Smith, Jennifer A., Sun, Xiao, Taylor, Kent D., Tracy, Russell P., Tsai, Michael Y., Wang, Zhe, Wang, Yuxuan, Bao, Wei, Wilkins, John T., Yanek, Lisa R., Zhao, Wei, Arnett, Donna K., Blangero, John, Boerwinkle, Eric, Bowden, Donald W., Chen, Yii-Der Ida, Correa, Adolfo, Cupples, L. Adrienne, Dutcher, Susan K., Ellinor, Patrick T., Fornage, Myriam, Gabriel, Stacey, Germer, Soren, Gibbs, Richard, He, Jiang, Kaplan, Robert C., Kardia, Sharon L. R., Kim, Ryan, Kooperberg, Charles, Loos, Ruth J. F., Viaud-Martinez, Karine A, Mathias, Rasika A., McGarvey, Stephen T., Mitchell, Braxton D., Nickerson, Deborah, North, Kari E., Psaty, Bruce M., Redline, Susan, Reiner, Alexander P., Vasan, Ramachandran S., Rich, Stephen S., Willer, Cristen, Rotter, Jerome I., Rader, Daniel J., Lin, Xihong, Peloso, Gina M., Natarajan, Pradeep

    Veröffentlicht in Nature communications

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    Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution von Justice, Anne E., Young, Kristin L., Lu, Yingchang, Turcot, Valérie, Winkler, Thomas W., Medina-Gomez, Carolina, Mudgal, Poorva, Ng, Maggie C. Y., Willems, Sara M., Abecasis, Goncalo, Allison, Matthew, Balkau, Beverley, Bastarache, Lisa, Bergmann, Sven, Bielak, Lawrence F., Blüher, Matthias, Boeing, Heiner, Bottinger, Erwin P., Bowden, Donald W., Butterworth, Adam S., Chambers, John C., Chen, Yii-Der Ida, Chowdhury, Rajiv, Chu, Audrey Y., Cox, Amanda J., Danesh, John, Denny, Josh C., Di Angelantonio, Emanuele, Drenos, Fotios, Dubé, Marie-Pierre, Evangelou, Evangelos, Ferrannini, Ele, Ferrieres, Jean, Florez, Jose C., Gan, Wei, Giedraitis, Vilmantas, Grove, Megan L., Howson, Joanna M. M., Ikram, M. Arfan, Ingelsson, Erik, Jackson, Anne U., Jarvik, Gail P., Kitajima, Hidetoshi, Krämer, Bernhard K., Laakso, Markku, Lamparter, David, Lee, Wen-Jane, Li, Huaixing, Li, Jin, Lin, Xu, Linneberg, Allan, Liu, Ching-Ti, MacGregor, Stuart, Männistö, Satu, Masca, Nicholas G. D., Moitry, Marie, Müller-Nurasyid, Martina, Munroe, Patricia B., Neville, Matt, Perola, Markus, Pers, Tune H., Reilly, Dermot F., Ridker, Paul M., Rivas, Manuel A., Robertson, Neil R., Rudan, Igor, Saleheen, Danish, Samani, Nilesh J., Schreiner, Pamela J., Scott, Robert A., Slater, Andrew J., Speliotes, Elizabeth K., Steinthorsdottir, Valgerdur, Sun, Liang, Taylor, Kent D., Thorleifsson, Gudmar, Tönjes, Anke, Tsafantakis, Emmanouil, Uusitupa, Matti, Vermeulen, Sita H., Vitart, Veronique, Vuckovic, Dragana, Wagenknecht, Lynne E., Walker, Mark, Wallentin, Lars, Waterworth, Dawn M., Wu, Ying, Zeggini, Eleftheria, Zhan, Xiaowei, Zhao, Jing Hua, Zhao, Wei, Zhou, Wei, Rivadeneira, Fernando, Pospisilik, J. Andrew, Mohlke, Karen L., Rotter, Jerome I., Hirschhorn, Joel N., Cupples, L. Adrienne, Loos, Ruth J. F., North, Kari E.

    Veröffentlicht in Nature genetics

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    Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction von Do, Ron, Stitziel, Nathan O., Won, Hong-Hee, Jørgensen, Anders Berg, Duga, Stefano, Angelica Merlini, Pier, Kiezun, Adam, Farrall, Martin, Goel, Anuj, Zuk, Or, Guella, Illaria, Asselta, Rosanna, Lange, Leslie A., Peloso, Gina M., Auer, Paul L., Girelli, Domenico, Martinelli, Nicola, Farlow, Deborah N., DePristo, Mark A., Roberts, Robert, Stewart, Alexander F. R., Saleheen, Danish, Danesh, John, Epstein, Stephen E., Sivapalaratnam, Suthesh, Kees Hovingh, G., Kastelein, John J., Samani, Nilesh J., Schunkert, Heribert, Erdmann, Jeanette, Shah, Svati H., Kraus, William E., Davies, Robert, Nikpay, Majid, Johansen, Christopher T., Wang, Jian, Hegele, Robert A., Hechter, Eliana, Marz, Winfried, Kleber, Marcus E., Huang, Jie, Johnson, Andrew D., Li, Mingyao, Burke, Greg L., Gross, Myron, Liu, Yongmei, Assimes, Themistocles L., Heiss, Gerardo, Lange, Ethan M., Folsom, Aaron R., Taylor, Herman A., Olivieri, Oliviero, Hamsten, Anders, Clarke, Robert, Reilly, Dermot F., Yin, Wu, Rivas, Manuel A., Donnelly, Peter, Rossouw, Jacques E., Psaty, Bruce M., Herrington, David M., Wilson, James G., Rich, Stephen S., Bamshad, Michael J., Tracy, Russell P., Adrienne Cupples, L., Rader, Daniel J., Reilly, Muredach P., Spertus, John A., Cresci, Sharon, Hartiala, Jaana, Wilson Tang, W. H., Hazen, Stanley L., Allayee, Hooman, Reiner, Alex P., Carlson, Christopher S., Kooperberg, Charles, Jackson, Rebecca D., Boerwinkle, Eric, Lander, Eric S., Schwartz, Stephen M., Siscovick, David S., McPherson, Ruth, Tybjaerg-Hansen, Anne, Abecasis, Goncalo R., Watkins, Hugh, Nickerson, Deborah A., Ardissino, Diego, Sunyaev, Shamil R., O'Donnell, Christopher J., Altshuler, David, Gabriel, Stacey, Kathiresan, Sekar

    Veröffentlicht in Nature (London)

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    Rare variants in long non-coding RNAs are associated with blood lipid levels in the TOPMed whole-genome sequencing study von Wang, Yuxuan, Selvaraj, Margaret Sunitha, Li, Xihao, Li, Zilin, Holdcraft, Jacob A., Arnett, Donna K., Bis, Joshua C., Blangero, John, Boerwinkle, Eric, Bowden, Donald W., Cade, Brian E., Carlson, Jenna C., Carson, April P., Chen, Yii-Der Ida, Curran, Joanne E., de Vries, Paul S., Dutcher, Susan K., Ellinor, Patrick T., Floyd, James S., Fornage, Myriam, Freedman, Barry I., Gabriel, Stacey, Germer, Soren, Gibbs, Richard A., Guo, Xiuqing, He, Jiang, Heard-Costa, Nancy, Hildalgo, Bertha, Hou, Lifang, Irvin, Marguerite R., Joehanes, Roby, Kaplan, Robert C., Kardia, Sharon LR, Kelly, Tanika N., Kim, Ryan, Kooperberg, Charles, Kral, Brian G., Levy, Daniel, Li, Changwei, Liu, Chunyu, Lloyd-Jone, Don, Loos, Ruth JF, Mahaney, Michael C., Martin, Lisa W., Mathias, Rasika A., Minster, Ryan L., Mitchell, Braxton D., Montasser, May E., Morrison, Alanna C., Murabito, Joanne M., Naseri, Take, O'Connell, Jeffrey R., Palmer, Nicholette D., Preuss, Michael H., Psaty, Bruce M., Raffield, Laura M., Rao, Dabeeru C., Redline, Susan, Reiner, Alexander P., Rich, Stephen S., Ruepena, Muagututi’a Sefuiva, Sheu, Wayne H.-H., Smith, Jennifer A., Smith, Albert, Tiwari, Hemant K., Tsai, Michael Y., Viaud-Martinez, Karine A., Wang, Zhe, Yanek, Lisa R., Zhao, Wei, Rotter, Jerome I., Lin, Xihong, Natarajan, Pradeep, Peloso, Gina M.


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