Heterozygous Mutations in TREX1 Cause Familial Chilblain Lupus and Dominant Aicardi-Goutières Syndrome von Rice, Gillian, Newman, William G., Dean, John, Patrick, Teresa, Parmar, Rekha, Flintoff, Kim, Robins, Peter, Harvey, Scott, Hollis, Thomas, O’Hara, Ann, Herrick, Ariane L., Bowden, Andrew P., Perrino, Fred W., Lindahl, Tomas, Barnes, Deborah E., Crow, Yanick J.

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3D microfluidic ex vivo culture of organotypic tumor spheroids to model immune checkpoint blockade von Aref, Amir R, Campisi, Marco, Ivanova, Elena, Portell, Andrew, Larios, Dalia, Piel, Brandon P, Mathur, Natasha, Zhou, Chensheng, Coakley, Raven Vlahos, Bartels, Alan, Bowden, Michaela, Herbert, Zach, Hill, Sarah, Gilhooley, Sean, Carter, Jacob, Cañadas, Israel, Thai, Tran C, Kitajima, Shunsuke, Chiono, Valeria, Paweletz, Cloud P, Barbie, David A, Kamm, Roger D, Jenkins, Russell W

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Long-Term implications of early onset in bipolar disorder: data from the first 1000 participants in the systematic treatment enhancement program for bipolar disorder (STEP-BD) von Perlis, Roy H, Miyahara, Sachiko, Marangell, Lauren B, Wisniewski, Stephen R, Ostacher, Michael, DelBello, Melissa P, Bowden, Charles L, Sachs, Gary S, Nierenberg, Andrew A

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Mepolizumab effectiveness and identification of super-responders in severe asthma von Harvey, Erin S., Langton, David, Katelaris, Constance, Stevens, Sean, Farah, Claude S., Gillman, Andrew, Harrington, John, Hew, Mark, Kritikos, Vicky, Radhakrishna, Naghmeh, Bardin, Philip, Peters, Matthew, Reynolds, Paul N., Upham, John W., Baraket, Melissa, Bowler, Simon, Bowden, Jeffrey, Chien, Jimmy, Chung, Li Ping, Grainge, Christopher, Jenkins, Christine, Katsoulotos, Gregory P., Lee, Joy, McDonald, Vanessa M., Reddel, Helen K., Rimmer, Janet, Wark, Peter A. B., Gibson, Peter G.

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A Genome-Wide Association Study of IVGTT-Based Measures of First-Phase Insulin Secretion Refines the Underlying Physiology of Type 2 Diabetes Variants von Wood, Andrew R, Jonsson, Anna, Jackson, Anne U, Wang, Nan, van Leewen, Nienke, Palmer, Nicholette D, Kobes, Sayuko, Deelen, Joris, Boquete-Vilarino, Lorena, Paananen, Jussi, Stančáková, Alena, Boomsma, Dorret I, de Geus, Eco J C, Eekhoff, Elisabeth M W, Fritsche, Andreas, Kramer, Mark, Nijpels, Giel, Simonis-Bik, Annemarie, van Haeften, Timon W, Mahajan, Anubha, Boehnke, Michael, Bergman, Richard N, Tuomilehto, Jaakko, Collins, Francis S, Mohlke, Karen L, Banasik, Karina, Groves, Christopher J, McCarthy, Mark I, Pearson, Ewan R, Natali, Andrea, Mari, Andrea, Buchanan, Thomas A, Taylor, Kent D, Xiang, Anny H, Gjesing, Anette P, Grarup, Niels, Eiberg, Hans, Pedersen, Oluf, Chen, Yii-Derr, Laakso, Markku, Norris, Jill M, Smith, Ulf, Wagenknecht, Lynne E, Baier, Leslie, Bowden, Donald W, Hansen, Torben, Walker, Mark, Watanabe, Richard M, 't Hart, Leen M, Hanson, Robert L, Frayling, Timothy M

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Influence of Early Low‐Temperature and Later High‐Temperature Diagenesis on Magnetic Mineral Assemblages in Marine Sediments From the Nankai Trough von Kars, Myriam, Köster, Male, Henkel, Susann, Stein, Rüdiger, Schubotz, Florence, Zhao, Xiang, Bowden, Stephen A., Roberts, Andrew P., Kodama, Kazuto

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Physical Activity and Sedentary Time: Association with Metabolic Health and Liver Fat von BOWDEN DAVIES, KELLY A, SPRUNG, VICTORIA S, NORMAN, JULIETTE A, THOMPSON, ANDREW, MITCHELL, KATIE L, HARROLD, JO A, FINLAYSON, GRAHAM, GIBBONS, CATHERINE, WILDING, JOHN P H, KEMP, GRAHAM J, HAMER, MARK, CUTHBERTSON, DANIEL J

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A naturally protective epitope of limited variability as an influenza vaccine target von Thompson, Craig P., Lourenço, José, Walters, Adam A., Obolski, Uri, Edmans, Matthew, Palmer, Duncan S., Kooblall, Kreepa, Carnell, George W., O’Connor, Daniel, Bowden, Thomas A., Pybus, Oliver G., Pollard, Andrew J., Temperton, Nigel J., Lambe, Teresa, Gilbert, Sarah C., Gupta, Sunetra

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Metabolic syndrome is associated with reduced flow mediated dilation independent of obesity status von Sprung, Victoria S, Bowden Davies, Kelly A, Norman, Juliette A, Thompson, Andrew, Mitchell, Katie L, Wilding, John P H, Kemp, Graham J, Cuthbertson, Daniel J

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Retrospective age at onset of bipolar disorder and outcome during two-year follow-up: results from the STEP-BD study von Perlis, Roy H, Dennehy, Ellen B, Miklowitz, David J, DelBello, Melissa P, Ostacher, Michael, Calabrese, Joseph R, Ametrano, Rebecca M, Wisniewski, Stephen R, Bowden, Charles L, Thase, Michael E, Nierenberg, Andrew A, Sachs, Gary

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Anti-SARS-CoV-2 antibody responses are attenuated in patients with IBD treated with infliximab von Kennedy, Nicholas A, Goodhand, James R, Bewshea, Claire, Nice, Rachel, Chee, Desmond, Lin, Simeng, Chanchlani, Neil, Butterworth, Jeffrey, Cooney, Rachel, Croft, Nicholas M, Hart, Ailsa L, Irving, Peter M, Kok, Klaartje B, Lamb, Christopher A, Limdi, Jimmy K, Macdonald, Jonathan, McGovern, Dermot PB, Mehta, Shameer J, Murray, Charles D, Patel, Kamal V, Pollok, Richard CG, Raine, Timothy, Russell, Richard K, Selinger, Christian P, Smith, Philip J, Bowden, Jack, McDonald, Timothy J, Lees, Charlie W, Sebastian, Shaji, Powell, Nicholas, Ahmad, Tariq

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Short-term decreased physical activity with increased sedentary behaviour causes metabolic derangements and altered body composition: effects in individuals with and without a firs... von Bowden Davies, Kelly A., Sprung, Victoria S., Norman, Juliette A., Thompson, Andrew, Mitchell, Katie L., Halford, Jason C. G., Harrold, Jo A., Wilding, John P. H., Kemp, Graham J., Cuthbertson, Daniel J.

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Influence of land use and hydrologic variability on seasonal dissolved organic carbon and nitrate export: insights from a multi-year regional analysis for the northeastern USA von Seybold, Erin, Gold, Arthur J., Inamdar, Shreeram P., Adair, Carol, Bowden, W. B., Vaughan, Matthew C. H., Pradhanang, Soni M., Addy, Kelly, Shanley, James B., Vermilyea, Andrew, Levia, Delphis F., Wemple, Beverley C., Schroth, Andrew W.

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Landscape of multi-nucleotide variants in 125,748 human exomes and 15,708 genomes von Wang, Qingbo, Pierce-Hoffman, Emma, Cummings, Beryl B., Alföldi, Jessica, Francioli, Laurent C., Gauthier, Laura D., Hill, Andrew J., O’Donnell-Luria, Anne H., Karczewski, Konrad J., MacArthur, Daniel G.

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Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyte development and differentiation von Chu, Audrey Y, Deng, Xuan, Fisher, Virginia A, Drong, Alexander, Zhang, Yang, Feitosa, Mary F, Liu, Ching-Ti, Weeks, Olivia, Choh, Audrey C, Duan, Qing, Dyer, Thomas D, Eicher, John D, Guo, Xiuqing, Heard-Costa, Nancy L, Kacprowski, Tim, Kent, Jack W, Lange, Leslie A, Liu, Xinggang, Lohman, Kurt, Lu, Lingyi, Mahajan, Anubha, O'Connell, Jeffrey R, Parihar, Ankita, Peralta, Juan M, Smith, Albert V, Zhang, Yi, Homuth, Georg, Kissebah, Ahmed H, Kullberg, Joel, Laqua, René, Launer, Lenore J, Nauck, Matthias, Olivier, Michael, Peyser, Patricia A, Terry, James G, Wojczynski, Mary K, Yao, Jie, Bielak, Lawrence F, Blangero, John, Borecki, Ingrid B, Bowden, Donald W, Carr, John Jeffrey, Czerwinski, Stefan A, Ding, Jingzhong, Friedrich, Nele, Gudnason, Vilmunder, Harris, Tamara B, Ingelsson, Erik, Johnson, Andrew D, Kardia, Sharon L R, Langefeld, Carl D, Lind, Lars, Liu, Yongmei, Mitchell, Braxton D, Morris, Andrew P, Mosley, Thomas H, Rotter, Jerome I, Shuldiner, Alan R, Towne, Bradford, Völzke, Henry, Wallaschofski, Henri, Wilson, James G, Allison, Matthew, Lindgren, Cecilia M, Goessling, Wolfram, Cupples, L Adrienne, Steinhauser, Matthew L, Fox, Caroline S

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Methicillin Resistance Reduces the Virulence of Healthcare-Associated Methicillin-Resistant Staphylococcus aureus by Interfering With the agr Quorum Sensing System von Rudkin, Justine K., Edwards, Andrew M., Bowden, Maria G., Brown, Eric L., Pozzi, Clarissa, Waters, Elaine M., Chan, Weng C., Williams, Paul, O'Gara, James P., Massey, Ruth C.

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Priorities for the effective implementation of osteoarthritis management programs: an OARSI international consensus exercise von Eyles, Jillian P., Hunter, David J., Bennell, Kim L., Dziedzic, Krysia S., Hinman, Rana S., van der Esch, Martin, Holden, Melanie A., Bowden, Jocelyn L., Quicke, J., Skou, S.T., Risberg, M.A.G., Roos, E.M., Thorstensson, C., Hurley, M., Nelson, A., Jinks, C., Briggs, A., Egerton, T., Allen, K., Davis, A., Dowsey, M., Holm, I., Yu, S., Dahlberg, L., Peat, G., Chan, P.K., Miller, K., Scanzello, C., Østerås, N., Schipof, D., Pais, S., Berenbaum, F., Frost, H., Walsh, N., Crossley, K., Vlieland, T.V., van den Ende, E., Slater, H., Nero, H., Jönsson, T., Woolf, A., Mills, K., O'Donnell, J., Ross, M., Hao, L.J.

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Analysis of protein-coding genetic variation in 60,706 humans von Lek, Monkol, Karczewski, Konrad J., Minikel, Eric V., Samocha, Kaitlin E., Banks, Eric, Fennell, Timothy, O’Donnell-Luria, Anne H., Ware, James S., Hill, Andrew J., Cummings, Beryl B., Tukiainen, Taru, Birnbaum, Daniel P., Kosmicki, Jack A., Duncan, Laramie E., Estrada, Karol, Zhao, Fengmei, Zou, James, Pierce-Hoffman, Emma, Berghout, Joanne, Cooper, David N., Deflaux, Nicole, DePristo, Mark, Do, Ron, Flannick, Jason, Fromer, Menachem, Gauthier, Laura, Goldstein, Jackie, Gupta, Namrata, Howrigan, Daniel, Kiezun, Adam, Kurki, Mitja I., Moonshine, Ami Levy, Natarajan, Pradeep, Orozco, Lorena, Peloso, Gina M., Poplin, Ryan, Rivas, Manuel A., Ruano-Rubio, Valentin, Rose, Samuel A., Ruderfer, Douglas M., Shakir, Khalid, Stenson, Peter D., Stevens, Christine, Thomas, Brett P., Tiao, Grace, Tusie-Luna, Maria T., Weisburd, Ben, Won, Hong-Hee, Yu, Dongmei, Altshuler, David M., Ardissino, Diego, Boehnke, Michael, Danesh, John, Donnelly, Stacey, Elosua, Roberto, Florez, Jose C., Gabriel, Stacey B., Getz, Gad, Glatt, Stephen J., Hultman, Christina M., Kathiresan, Sekar, Laakso, Markku, McCarroll, Steven, McCarthy, Mark I., McGovern, Dermot, McPherson, Ruth, Neale, Benjamin M., Palotie, Aarno, Purcell, Shaun M., Saleheen, Danish, Scharf, Jeremiah M., Sklar, Pamela, Sullivan, Patrick F., Tuomilehto, Jaakko, Tsuang, Ming T., Watkins, Hugh C., Wilson, James G., Daly, Mark J., MacArthur, Daniel G.

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Short-Term Physical Inactivity Induces Endothelial Dysfunction von Davies, Kelly A. Bowden, Norman, Juliette A., Thompson, Andrew, Mitchell, Katie L., Harrold, Joanne A., Halford, Jason C. G., Wilding, John P. H., Kemp, Graham J., Cuthbertson, Daniel J., Sprung, Victoria S.

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Uncontrolled pain: a call for better study design von Hyndman, Timothy H, Bowden, Ross S, Woodward, Andrew P, Pang, Daniel S J, Hampton, Jordan O

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