Mapping interindividual variability of toxicodynamics using high-throughput transcriptomics and primary human hepatocytes from fifty donors von Niemeijer, M.C., Więcek, W., Fu, S., Huppelschoten, S., Bouwman, R.J.P., Baze, A., Parmentier, C., Richert, L., Paules, R.S., Bois, F.Y., Water, B. van de

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Human-induced pluripotent stem cell reporters for high-content screening of stress response activation identifying target organ-specific toxicities von Danilyuk, T.Y., Niemeijer, M.C., Wijaya, L.S., Snijders, K., Berk, L. van der, Braak, S.J. ter, Callegaro, G., Bouwman, R.J.P., Water, B. van de

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Towards an advanced testing strategy for genotoxicity using image-based 2D and 3D HepG2 DNA damage response fluorescent protein reporters von Braak, S.J. ter, Niemeijer, M.C., Wolters, L., Le Dévédec, S.E., Bouwman, R.J.P., Water, B. van de

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Evaluation of an imaging-based in vitro screening platform for estrogenic activity with OECD reference chemicals von Duijndam, B.H.A., Tedeschi, M., Stel, W. van der, Hoorn, T. van den, Burg, B. van der, Bouwman, R.J.P., Laan, J.W. van der, Water, B. van der

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Systematic screening identifies ABCG2 as critical factor underlying synergy of kinase inhibitors with transcriptional CDK inhibitors von Noord, V.E. van der, Stel, W. van der, Louwerens, G., Verhoeven, D., Kuiken, H.J., Lieftink, C., Grandits, M., Ecker, G.F., Beijersbergen, R.L., Bouwman, R.J.P., Le Dévédec, S.E., Water, B. van de

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New approach methodologies to facilitate and improve the hazard assessment of non-genotoxic carcinogens-a PARC project von Audebert, M., Assmann, A.S., Azqueta, A., Babica, P., Benfenati, E., Bortoli, S., Bouwman, R.J.P., Braeuning, A., Burgdorf, T., Coumoul, X., Debizet, K., Dusinska, M., Ertych, N., Fahrer, J., Fetz, V., Le Hégarat, L., López de Cerain, A., Heusinkveld, H.J., Hogeveen, K., Jacobs, M.N., Luijten, M., Raitano, G., Recoules, C., Rundén-Pran, E., Saleh, M., Sovadinová, I., Stampar, M., Thibol, L., Tomkiewicz, C., Vettorazzi, A., Water, B. van de, El Yamani, N., Zegura, B., Oelgeschläger, M.

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Physiologically relevant estrogen receptor alpha pathway reporters for single-cell imaging-based carcinogenic hazard assessment of estrogenic compounds von Duijndam, B., Goudriaan, A., Stel, W. van der, Le Dévédec, S.E., Bouwman, R.J.P., Laan, J.W. van der, Water, B. van de

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Combined inhibition of EZH2 and ATM is synthetic lethal in BRCA1-deficient breast cancer von Ratz, L., Brambillasca, C.S., Bartke, L., Huetzen, M.A., Goergens, J., Leidecker, O., Jachimowicz, R.D., Ven, M. van de, Proost, N., Siteur, B., Korte-Grimmerink, R. de, Bouwman, R.J.P., Pulver, E.M., Bruijn, R. de, Isensee, J., Hucho, T., Pandey, G., Lohuizen, M., Mallmann, P., Reinhardt, H.C., Jonkers, J.M.M., Puppe, J.

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Integration of temporal single cell cellular stress response activity with logic-ODE modeling reveals activation of ATF4-CHOP axis as a critical predictor of drug-induced liver inj... von Wijaya, L.S., Trairatphisan, P., Gabor, A., Niemeijer, M.C., Keet, J., Alcalà Morera, A., Snijders, K.E., Wink, S., Yang, H., Schildknecht, S., Stevens, J.L., Bouwman, R.J.P., Kamp, H., Hengstler, J., Beltman, J.B., Leist, M., Le Dévédec, S.E., Saez-Rodriguez, J., Water, B. van de

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Sevoflurane-induced cardioprotection depends on PKC-α activation via production of reactive oxygen species von Bouwman, R.A., Musters, R.J.P., van Beek-Harmsen, B.J., de Lange, J.J., Lamberts, R.R., Loer, S.A., Boer, C.

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The mechanism of sevoflurane-induced cardioprotection is independent of the applied ischaemic stimulus in rat trabeculae von Bouwman, R.A., van't Hof, F.N.G., de Ruijter, W., van Beek-Harmsen, B.J., Musters, R.J.P., de Lange, J.J., Boer, C.

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