The CLIPMERGE PGx Program: Clinical Implementation of Personalized Medicine Through Electronic Health Records and Genomics-Pharmacogenomics von Gottesman, O, Scott, S A, Ellis, S B, Overby, C L, Ludtke, A, Hulot, J-S, Hall, J, Chatani, K, Myers, K, Kannry, J L, Bottinger, E P

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Design and Anticipated Outcomes of the eMERGE-PGx Project: A Multicenter Pilot for Preemptive Pharmacogenomics in Electronic Health Record Systems von Rasmussen-Torvik, L J, Stallings, S C, Gordon, A S, Almoguera, B, Basford, M A, Bielinski, S J, Brautbar, A, Brilliant, M H, Carrell, D S, Connolly, J J, Crosslin, D R, Doheny, K F, Gallego, C J, Gottesman, O, Kim, D S, Leppig, K A, Li, R, Lin, S, Manzi, S, Mejia, A R, Pacheco, J A, Pan, V, Pathak, J, Perry, C L, Peterson, J F, Prows, C A, Ralston, J, Rasmussen, L V, Ritchie, M D, Sadhasivam, S, Scott, S A, Smith, M, Vega, A, Vinks, A A, Volpi, S, Wolf, W A, Bottinger, E, Chisholm, R L, Chute, C G, Haines, J L, Harley, J B, Keating, B, Holm, I A, Kullo, I J, Jarvik, G P, Larson, E B, Manolio, T, McCarty, C A, Nickerson, D A, Scherer, S E, Williams, M S, Roden, D M, Denny, J C

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Determining the effects and challenges of incorporating genetic testing into primary care management of hypertensive patients with African ancestry von Horowitz, C.R, Abul-Husn, N.S, Ellis, S, Ramos, M.A, Negron, R, Suprun, M, Zinberg, R.E, Sabin, T, Hauser, D, Calman, N, Bagiella, E, Bottinger, E.P

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Implementing Algorithm-Guided Warfarin Dosing in an Ethnically Diverse Patient Population Using Electronic Health Records and Preemptive CYP2C9 and VKORC1 Genetic Testing von Obeng, A Owusu, Kaszemacher, T, Abul-Husn, NS, Gottesman, O, Vega, A, Waite, E, Myers, K, Cho, J, Bottinger, EP, Ellis, SB, Scott, SA

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Genetic variation in the HLA region is associated with susceptibility to herpes zoster von Crosslin, D R, Carrell, D S, Burt, A, Kim, D S, Underwood, J G, Hanna, D S, Comstock, B A, Baldwin, E, de Andrade, M, Kullo, I J, Tromp, G, Kuivaniemi, H, Borthwick, K M, McCarty, C A, Peissig, P L, Doheny, K F, Pugh, E, Kho, A, Pacheco, J, Hayes, M G, Ritchie, M D, Verma, S S, Armstrong, G, Stallings, S, Denny, J C, Carroll, R J, Crawford, D C, Crane, P K, Mukherjee, S, Bottinger, E, Li, R, Keating, B, Mirel, D B, Carlson, C S, Harley, J B, Larson, E B, Jarvik, G P

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Endothelial mitochondrial oxidative stress determines podocyte depletion in segmental glomerulosclerosis von Daehn, Ilse, Casalena, Gabriella, Zhang, Taoran, Shi, Shaolin, Fenninger, Franz, Barasch, Nicholas, Yu, Liping, D'Agati, Vivette, Schlondorff, Detlef, Kriz, Wilhelm, Haraldsson, Borje, Bottinger, Erwin P

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Expression of a dominant-negative mutant TGF-β type II receptor in transgenic mice reveals essential roles for TGF-β in regulation of growth and differentiation in the exocrine pan... von Böttinger, Erwin P., Jakubczak, John L., Roberts, Ian S.D., Mumy, Michelle, Hemmati, Philipp, Bagnall, Kerri, Merlino, Glenn, Wakefield, Lalage M.

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Genetic Programs of Epithelial Cell Plasticity Directed by Transforming Growth Factor-β von Zavadil, Jiri, Bitzer, Markus, Liang, Dan, Yang, Yaw-Ching, Massimi, Aldo, Kneitz, Susanne, Piek, Ester, Böttinger, Erwin P.

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Implementing genomic medicine in the clinic: the future is here von Manolio, Teri A., Chisholm, Rex L., Ozenberger, Brad, Roden, Dan M., Williams, Marc S., Wilson, Richard, Bick, David, Bottinger, Erwin P., Brilliant, Murray H., Eng, Charis, Frazer, Kelly A., Korf, Bruce, Ledbetter, David H., Lupski, James R., Marsh, Clay, Mrazek, David, Murray, Michael F., O’Donnell, Peter H., Rader, Daniel J., Relling, Mary V., Shuldiner, Alan R., Valle, David, Weinshilboum, Richard, Green, Eric D., Ginsburg, Geoffrey S.

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Functional Characterization of Transforming Growth Factor β Signaling in Smad2- and Smad3-deficient Fibroblasts von Piek, Ester, Ju, Wen Jun, Heyer, Jörg, Escalante-Alcalde, Diana, Stewart, Colin L., Weinstein, Michael, Deng, Chuxia, Kucherlapati, Raju, Böttinger, Erwin P., Roberts, Anita B.

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Smad proteins and transforming growth factor-β signaling von Schiffer, Mario, Von Gersdorff, Gero, Bitzer, Markus, Susztak, Katalin, Böttinger, Erwin P.

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A clustering approach to improve our understanding of the genetic and phenotypic complexity of chronic kidney disease von Eoli, A., Ibing, S., Schurmann, C., Nadkarni, G. N., Heyne, H. O., Böttinger, E.

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Biology of TGF-β in knockout and transgenic mouse models von Böttinger, Erwin P., Letterio, John J., Roberts, Anita B.

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Genetic variation among 82 pharmacogenes: The PGRNseq data from the eMERGE network von Bush, WS, Crosslin, DR, Owusu-Obeng, A, Wallace, J, Almoguera, B, Basford, MA, Bielinski, SJ, Carrell, DS, Connolly, JJ, Crawford, D, Doheny, KF, Gallego, CJ, Gordon, AS, Keating, B, Kirby, J, Kitchner, T, Manzi, S, Mejia, AR, Pan, V, Perry, CL, Peterson, JF, Prows, CA, Ralston, J, Scott, SA, Scrol, A, Smith, M, Stallings, SC, Veldhuizen, T, Wolf, W, Volpi, S, Wiley, K, Li, R, Manolio, T, Bottinger, E, Brilliant, MH, Carey, D, Chisholm, RL, Chute, CG, Haines, JL, Hakonarson, H, Harley, JB, Holm, IA, Kullo, IJ, Jarvik, GP, Larson, EB, McCarty, CA, Williams, MS, Denny, JC, Rasmussen-Torvik, LJ, Roden, DM, Ritchie, MD

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TGF-beta and epithelial-to-mesenchymal transitions von Zavadil, Jiri, Böttinger, Erwin P

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Glucose-Induced Reactive Oxygen Species Cause Apoptosis of Podocytes and Podocyte Depletion at the Onset of Diabetic Nephropathy von SUSZTAK, Katalin, RAFF, Amanda C, SCHIFFER, Mario, BÖTTINGER, Erwin P

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Gene expression analysis on small numbers of invasive cells collected by chemotaxis from primary mammary tumors of the mouse von Wang, Weigang, Wyckoff, Jeffrey B, Wang, Yarong, Bottinger, Erwin P, Segall, Jeffrey E, Condeelis, John S

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Apoptosis in podocytes induced by TGF-beta and Smad7 von Schiffer, M, Bitzer, M, Roberts, I S, Kopp, J B, ten Dijke, P, Mundel, P, Böttinger, E P

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Glomerular Endothelial Mitochondrial Dysfunction Is Essential and Characteristic of Diabetic Kidney Disease Susceptibility von Qi, Haiying, Casalena, Gabriella, Shi, Shaolin, Yu, Liping, Ebefors, Kerstin, Sun, Yezhou, Zhang, Weijia, D'Agati, Vivette, Schlondorff, Detlef, Haraldsson, Börje, Böttinger, Erwin, Daehn, Ilse

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Novel regulators of kidney development from the tips of the ureteric bud von SCHMIDT-OTT, Kai M, JUN YANG, BOTTINGER, Erwin, BARASCH, Jonathan, XIA CHEN, WANG, Howard, PARAGAS, Neal, MORI, Kiyoshi, LI, Jau-Yi, LU, Benson, COSTANTINI, Frank, SCHIFFER, Mario

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