20 Years of Medicinal Chemistry - Always Look at the Bright Side (of Life) von Boss, Christoph

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Our Exciting Journey to ACT-451840 von Boss, Christoph, Wittlin, Sergio

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The Discovery of N‑[5-(4-Bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]‑N′‑propylsulfamide (Macitentan), an Orally Active, Potent Dual Endothelin Receptor Ant... von Bolli, Martin H, Boss, Christoph, Binkert, Christoph, Buchmann, Stephan, Bur, Daniel, Hess, Patrick, Iglarz, Marc, Meyer, Solange, Rein, Josiane, Rey, Markus, Treiber, Alexander, Clozel, Martine, Fischli, Walter, Weller, Thomas

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The Use of Physiology-Based Pharmacokinetic and Pharmacodynamic Modeling in the Discovery of the Dual Orexin Receptor Antagonist ACT-541468 von Treiber, Alexander, de Kanter, Ruben, Roch, Catherine, Gatfield, John, Boss, Christoph, von Raumer, Markus, Schindelholz, Benno, Muehlan, Clemens, van Gerven, Joop, Jenck, Francois

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From bosentan (Tracleer®) to macitentan (Opsumit®): The medicinal chemistry perspective von Boss, Christoph, Bolli, Martin H., Gatfield, John

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Biomedical Application of Orexin/Hypocretin Receptor Ligands in Neuroscience von Boss, Christoph, Brisbare-Roch, Catherine, Jenck, Francois

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Recent trends in orexin research—2010 to 2015 von Boss, Christoph, Roch, Catherine

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The Screening Compound Collection: A Key Asset for Drug Discovery von Boss, Christoph, Hazemann, Julien, Kimmerlin, Thierry, von Korff, Modest, Lüthi, Urs, Peter, Oliver, Sander, Thomas, Siegrist, Romain

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Orexin Receptor Antagonists: A New Concept In CNS Disorders? von Gatfield, John, Brisbare-Roch, Catherine, Jenck, Francois, Boss, Christoph

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Structure-Activity Relationship, Biological, and Pharmacological Characterization of the Proline Sulfonamide ACT-462206: a Potent, Brain-Penetrant Dual Orexin 1/Orexin 2 Receptor A... von Boss, Christoph, Roch-Brisbare, Catherine, Steiner, Michel A., Treiber, Alexander, Dietrich, Hendrik, Jenck, Francois, von Raumer, Markus, Sifferlen, Thierry, Brotschi, Christine, Heidmann, Bibia, Williams, Jodi T., Aissaoui, Hamed, Siegrist, Romain, Gatfield, John

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X-ray Structure of Plasmepsin II Complexed with a Potent Achiral Inhibitor von Prade, Lars, Jones, Andrew F., Boss, Christoph, Richard-Bildstein, Sylvia, Meyer, Solange, Binkert, Christoph, Bur, Daniel

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Design and Preparation of Potent, Nonpeptidic, Bioavailable Renin Inhibitors von Bezençon, Olivier, Bur, Daniel, Weller, Thomas, Richard-Bildstein, Sylvia, Remeň, Luboš, Sifferlen, Thierry, Corminboeuf, Olivier, Grisostomi, Corinna, Boss, Christoph, Prade, Lars, Delahaye, Stéphane, Treiber, Alexander, Strickner, Panja, Binkert, Christoph, Hess, Patrick, Steiner, Beat, Fischli, Walter

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Structure–activity relationship studies and sleep-promoting activity of novel 1-chloro-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine derivatives as dual orexin receptor antagonists. Par... von Sifferlen, Thierry, Koberstein, Ralf, Cottreel, Emmanuelle, Boller, Amandine, Weller, Thomas, Gatfield, John, Brisbare-Roch, Catherine, Jenck, Francois, Boss, Christoph

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Synthesis, structure–activity relationship studies, and identification of novel 5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine derivatives as dual orexin receptor antagonists. Part 1 von Sifferlen, Thierry, Koberstein, Ralf, Cottreel, Emmanuelle, Boller, Amandine, Weller, Thomas, Gatfield, John, Brisbare-Roch, Catherine, Jenck, Francois, Boss, Christoph

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Achiral, Cheap, and Potent Inhibitors of Plasmepsins I, II, and IV von Boss, Christoph, Corminboeuf, Olivier, Grisostomi, Corinna, Meyer, Solange, Jones, Andrew F., Prade, Lars, Binkert, Christoph, Fischli, Walter, Weller, Thomas, Bur, Daniel

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Discovery and Characterization of ACT-335827, an Orally Available, Brain Penetrant Orexin Receptor Type 1 Selective Antagonist von Steiner, Michel A., Gatfield, John, Brisbare-Roch, Catherine, Dietrich, Hendrik, Treiber, Alexander, Jenck, Francois, Boss, Christoph

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Discovery of Nivasorexant (ACT-539313): The First Selective Orexin‑1 Receptor Antagonist (SO1RA) Investigated in Clinical Trials von Williams, Jodi T., Bolli, Martin H., Brotschi, Christine, Sifferlen, Thierry, Steiner, Michel A., Treiber, Alexander, Gatfield, John, Boss, Christoph

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Orexin Receptor Antagonism: A New Principle in Neuroscience von Boss, Christoph, Brisbare-Roch, Catherine, Jenck, Francois, Aissaoui, Hamed, Koberstein, Ralf, Sifferlen, Thierry, Weller, Thomas

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Design, Synthesis, and Optimization of Indole Acetic Acid Derivatives as Potent and Selective CRTH2 Receptor Antagonists: Discovery of ACT‐774312 von Aissaoui, Hamed, Holdener, Martin, Gnerre, Carmela, Niggemann, Kerstin, Reber, Stefan, Richard, Sylvia, Siegrist, Romain, Boss, Christoph

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CYP3A4 Catalyzes the Rearrangement of the Dual Orexin Receptor Antagonist Daridorexant to 4‐Hydroxypiperidinol Metabolites von Treiber, Alexander, Aissaoui, Hamed, Delahaye, Stéphane, Glutz, Sven, Grimont, Julien, Müller, Claus, Seeland, Swen, Siefken, Valérie, Boss, Christoph

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