Epac: Defining a New Mechanism for cAMP Action von GLOERICH, Martijn, BOS, Johannes L

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GEFs and GAPs: Critical Elements in the Control of Small G Proteins von Bos, Johannes L., Rehmann, Holger, Wittinghofer, Alfred

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Epac: a new cAMP target and new avenues in cAMP research von Bos, Johannes L

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Specificity in Ras and Rap Signaling von Raaijmakers, Judith H., Bos, Johannes L.

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Targeting mutant RAS in patient-derived colorectal cancer organoids by combinatorial drug screening von Verissimo, Carla S, Overmeer, René M, Ponsioen, Bas, Drost, Jarno, Mertens, Sander, Verlaan-Klink, Ingrid, Gerwen, Bastiaan van, van der Ven, Marieke, Wetering, Marc van de, Egan, David A, Bernards, René, Clevers, Hans, Bos, Johannes L, Snippert, Hugo J

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Capturing cyclic nucleotides in action: snapshots from crystallographic studies von Rehmann, Holger, Wittinghofer, Alfred, Bos, Johannes L

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Drug-repurposing screen on patient-derived organoids identifies therapy-induced vulnerability in KRAS-mutant colon cancer von Mertens, Sander, Huismans, Maarten A., Verissimo, Carla S., Ponsioen, Bas, Overmeer, Rene, Proost, Natalie, van Tellingen, Olaf, van de Ven, Marieke, Begthel, Harry, Boj, Sylvia F., Clevers, Hans, Roodhart, Jeanine M.L., Bos, Johannes L., Snippert, Hugo J.G.

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Rasip1 mediates Rap1 regulation of Rho in endothelial barrier function through ArhGAP29 von Post, Anneke, Pannekoek, Willem-Jan, Ross, Sarah H., Verlaan, Ingrid, Brouwer, Patricia M., Bos, Johannes L.

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Rap1: a key regulator in cell-cell junction formation von Kooistra, Matthijs R.H, Dubé, Nadia, Bos, Johannes L

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Epac-Rap Signaling Reduces Cellular Stress and Ischemia-induced Kidney Failure von STOKMAN, Geurt, YU QIN, GENIESER, Hans-Gottfried, SCHWEDE, Frank, DE HEER, Emile, BOS, Johannes L, BAJEMA, Ingeborg M, VAN DE WATER, Bob, PRICE, Leo S

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Epac1 regulates integrity of endothelial cell junctions through VE-cadherin von Kooistra, Matthijs R.H., Corada, Monica, Dejana, Elisabetta, Bos, Johannes L.

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Amino Acids Mediate mTOR/Raptor Signaling through Activation of Class 3 Phosphatidylinositol 3OH-Kinase von Nobukuni, Takahiro, Joaquin, Manel, Roccio, Marta, Dann, Stephen G., Kim, So Young, Gulati, Pawan, Byfield, Maya P., Backer, Jonathan M., Natt, Francois, Bos, Johannes L., Fried J. T. Zwartkruis, Thomas, George, Schlessinger, Joseph

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Epac proteins: multi-purpose cAMP targets von Bos, Johannes L.

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FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK von Essers, Marieke AG, Weijzen, Sanne, de Vries-Smits, Alida MM, Saarloos, Ingrid, de Ruiter, Nancy D, Bos, Johannes L, Burgering, Boudewijn M T

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Ras Association-Domain Dimers Bring Proteins Together von Rehmann, Holger, Bos, Johannes L.

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cAMP regulates DEP domain-mediated binding of the guanine nucleotide exchange factor Epac1 to phosphatidic acid at the plasma membrane von Consonni, Sarah V, Gloerich, Martijn, Spanjaard, Emma, Bos, Johannes L

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Rap1 and Rap2 antagonistically control endothelial barrier resistance von Pannekoek, Willem-Jan, Linnemann, Jelena R, Brouwer, Patricia M, Bos, Johannes L, Rehmann, Holger

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Multiple Rap1 effectors control Epac1-mediated tightening of endothelial junctions von Pannekoek, Willem-Jan, Vliem, Marjolein J., Bos, Johannes L.

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Structure-guided design of selective Epac1 and Epac2 agonists von Schwede, Frank, Bertinetti, Daniela, Langerijs, Carianne N, Hadders, Michael A, Wienk, Hans, Ellenbroek, Johanne H, de Koning, Eelco J P, Bos, Johannes L, Herberg, Friedrich W, Genieser, Hans-Gottfried, Janssen, Richard A J, Rehmann, Holger

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Insulin Activation of Rheb, a Mediator of mTOR/S6K/4E-BP Signaling, Is Inhibited by TSC1 and 2 von Garami, Attila, Zwartkruis, Fried J.T, Nobukuni, Takahiro, Joaquin, Manel, Roccio, Marta, Stocker, Hugo, Kozma, Sara C, Hafen, Ernst, Bos, Johannes L, Thomas, George

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