Tumor suppressor p53: Biology, signaling pathways, and therapeutic targeting von Borrero, Liz J. Hernandez, El-Deiry, Wafik S.

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A subset of CB002 xanthine analogs bypass p53-signaling to restore a p53 transcriptome and target an S-phase cell cycle checkpoint in tumors with mutated-p53 von Borrero, Liz Hernandez, Dicker, David T., Santiago, John, Sanders, Jennifer, Tian, Xiaobing, Ahsan, Nagib, Lev, Avital, Zhou, Lanlan, El-Deiry, Wafik S.

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Bcl-2 Protein Targeting by the p53/p21 Complex-Letter von Hernandez Borrero, Liz J, Sikder, Rahmat, Lulla, Amriti, Gokare, Prashanth, Del Valle, Paulo R, Tian, Xiaobing, Zhang, Shengliang, Abbosh, Philip H, El-Deiry, Wafik S

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Small-molecule CB002 restores p53 pathway signaling and represses colorectal cancer cell growth von Richardson, Colby, Zhang, Shengliang, Hernandez Borrero, Liz J, El-Deiry, Wafik S

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Targeting the Integrated Stress Response in Cancer Therapy von Tian, Xiaobing, Zhang, Shengliang, Zhou, Lanlan, Seyhan, Attila A., Hernandez Borrero, Liz, Zhang, Yiqun, El-Deiry, Wafik S.

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Advanced Strategies for Therapeutic Targeting of Wild-Type and Mutant p53 in Cancer von Zhang, Shengliang, Carlsen, Lindsey, Hernandez Borrero, Liz, Seyhan, Attila A, Tian, Xiaobing, El-Deiry, Wafik S

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CB002, a novel p53 tumor suppressor pathway-restoring small molecule induces tumor cell death through the pro-apoptotic protein NOXA von Hernandez-Borrero, Liz J, Zhang, Shengliang, Lulla, Amriti, Dicker, David T, El-Deiry, Wafik S

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Abstract 327: Anti-tumor effect and destabilization of R175H-mutant p53 by CB002, a p53-pathway restoring small molecule that stimulates autophagy von Hernandez Borrero, Liz J., Zhang, Shengliang, Dicker, David, El-Deiry, Wafik

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Therapeutic Targeting of Autophagy in Pancreatic Ductal Adenocarcinoma von Raufi, Alexander G., Liguori, Nicholas R., Carlsen, Lindsey, Parker, Cassandra, Hernandez Borrero, Liz, Zhang, Shengliang, Tian, Xiaobing, Louie, Anna, Zhou, Lanlan, Seyhan, Attila A., El-Deiry, Wafik S.

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Synergistic anti-tumor activity, reduced pERK, and immuno-stimulatory cytokine profiles with 5-FU or ONC212 plus KRAS G12D inhibitor MRTX1133 in CRC and pancreatic cancer cells ind... von Tajiknia, Vida, Pinho-Schwermann, Maximilian, Srinivasan, Praveen R, Hernandez Borrero, Liz, Zhang, Leiqing, Huntington, Kelsey E, El-Deiry, Wafik S

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Pan-drug and drug-specific mechanisms of 5-FU, irinotecan (CPT-11), oxaliplatin, and cisplatin identified by comparison of transcriptomic and cytokine responses of colorectal cance... von Carlsen, Lindsey, Schorl, Christoph, Huntington, Kelsey, Hernandez-Borrero, Liz, Jhaveri, Aakash, Zhang, Shengliang, Zhou, Lanlan, El-Deiry, Wafik S.

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Abstract 165: Establishment and characterization of Vogelgram-mimic colorectal cancer organoids as a laboratory tool von Zhang, Leiqing, Carlsen, Lindsey, Zhou, Lanlan, Borrero, Liz Hernandez, El-Deiry, Wafik S.

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Abstract 2643: Small molecule identification for the restoration of p53 pathway through p73 and by degradation of mutant p53 von Hernandez Borrero, Liz J., Zhao, Shengliang, Dicker, David T., El-Deiry, Wafik

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Abstract 6349: A subgroup of potent CB002 xanthine derivatives define a novel class of anti-cancer drugs that restore the p53 pathway in tumors with mutated p53 and target an S-pha... von Borrero, Liz Janice Hernandez, Dicker, David T., El-Deiry, Wafik S.

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Abstract 3878: Newly identified p53-pathway restoring small molecule, CB002 analog #4 induces apoptosis and appears non-toxic in vivo von Borrero, Liz J. Hernandez, Lev, Avital, Zhou, Lanlan, Dicker, David T., El-Deiry, Wafik S.

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Abstract 4457: Post exposure suppression of radiation pneumonitis by TRAIL pathway agonists TLY012 and ONC201 von Strandberg, Jillian R., Louie, Anna, Hahn, Marina, Srinivasan, Praveen, George, Andrew, Cruz, Arielle De La, Zhang, Leiqing, Borrero, Liz Hernandez, Huntington, Kelsey, Azzoli, Christopher, Abbas, Abbas E., Zhou, Lanlan, Lee, Seulki, El-Deiry, Wafik S.

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Abstract 4828: Newly identified p53 pathway-restoring compound CB002 and its derivatives sensitize colorectal and multiple myeloma cancer cell lines to front-line cancer therapies von Borrero, Liz J. Hernandez, Dicker, David T., El-Deiry, Wafik S.

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Synergistic Effect of Quinacrine with Chemotherapeutics or TRAIL in Hematopoietic Malignant Cells von Wang, Wenge, Lulla, Amriti R., Hernandez-Borrero, Liz J., Dicker, David T., Teye, Emmanuel K., Talekar, Mala K., Dolloff, Nathan G., Pu, Jeffrey J., El-Deiry, Wafik S.

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Abstract 5178: CB002, a novel p53 pathway-restoring compound that induces apoptosis through the pro-apototic protein NOXA von Borrero, Liz J. Hernandez, Zhang, Shengliang, Dicker, David T., El-Deiry, Wafik S.

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Caspase-Dependent Anti-Tumor Effects of ONC201/TIC10 on Acute Myeloid Leukemia (AML) and Multiple Myeloma (MM) von Lulla, Amriti R., Kline, Christina Leah B, Hernandez-Borrero, Liz J., Prabhu, Varun Vijay, Wagner, Jessica M, Dicker, David T., Dolloff, Nathan G., Barth, Brian M, Pu, Jeffrey J, Claxton, David F., Allen, Joshua E., El-Deiry, Wafik S.

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