Relapse or Eradication of Cancer Is Predicted by Peptide-Major Histocompatibility Complex Affinity von Engels, Boris, Engelhard, Victor H., Sidney, John, Sette, Alessandro, Binder, David C., Liu, Rebecca B., Kranz, David M., Meredith, Stephen C., Rowley, Donald A., Schreiber, Hans

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IL-15 in tumor microenvironment causes rejection of large established tumors by T cells in a noncognate T cell receptor-dependent manner von Liu, Rebecca Berlant, Engels, Boris, Schreiber, Karin, Ciszewski, Cezary, Schietinger, Andrea, Schreiber, Hans, Jabri, Bana

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Densely Granulated Murine NK Cells Eradicate Large Solid Tumors von LIU, Rebecca B, ENGELS, Boris, JABRI, Bana, SCHREIBER, Hans, ARINA, Ainhoa, SCHREIBER, Karin, HYJEK, Elizabeth, SCHIETINGER, Andrea, BINDER, David C, BUTZ, Eric, KRAUSZ, Thomas, ROWLEY, Donald A

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CAR'TCR-T cells co-expressing CD33-CAR and dNPM1-TCR as superior dual-targeting approach for AML treatment von Teppert, Karin, Yonezawa Ogusuku, Isabella Elias, Brandes, Caroline, Herbel, Vera, Winter, Nora, Werchau, Niels, Khorkova, Svetlana, Wöhle, Christian, Jelveh, Nojan, Bisdorf, Kevin, Engels, Boris, Schaser, Thomas, Anders, Kathleen, Künkele, Annette, Lock, Dominik

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The Antitumorigenic Response of Neural Precursors Depends on Subventricular Proliferation and Age von Walzlein, Joo‐Hee, Synowitz, Michael, Engels, Boris, Markovic, Darko S., Gabrusiewicz, Konrad, Nikolaev, Evgeni, Yoshikawa, Kazuaki, Kaminska, Bozena, Kempermann, Gerd, Uckert, Wolfgang, Kaczmarek, Leszek, Kettenmann, Helmut, Glass, Rainer

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Tumour ischaemia by interferon-γ resembles physiological blood vessel regression von Kammertoens, Thomas, Friese, Christian, Arina, Ainhoa, Idel, Christian, Briesemeister, Dana, Rothe, Michael, Ivanov, Andranik, Szymborska, Anna, Patone, Giannino, Kunz, Severine, Sommermeyer, Daniel, Engels, Boris, Leisegang, Matthias, Textor, Ana, Fehling, Hans Joerg, Fruttiger, Marcus, Lohoff, Michael, Herrmann, Andreas, Yu, Hua, Weichselbaum, Ralph, Uckert, Wolfgang, Hübner, Norbert, Gerhardt, Holger, Beule, Dieter, Schreiber, Hans, Blankenstein, Thomas

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Engineered CAR T Cells Targeting the Cancer-Associated Tn-Glycoform of the Membrane Mucin MUC1 Control Adenocarcinoma von Posey, Avery D., Schwab, Robert D., Boesteanu, Alina C., Steentoft, Catharina, Mandel, Ulla, Engels, Boris, Stone, Jennifer D., Madsen, Thomas D., Schreiber, Karin, Haines, Kathleen M., Cogdill, Alexandria P., Chen, Taylor J., Song, Decheng, Scholler, John, Kranz, David M., Feldman, Michael D., Young, Regina, Keith, Brian, Schreiber, Hans, Clausen, Henrik, Johnson, Laura A., June, Carl H.

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Targeting stroma to treat cancers von Engels, Boris, Rowley, Donald A, Schreiber, Hans

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Antigen-independent activation enhances the efficacy of 4-1BB-costimulated CD22 CAR T cells von Singh, Nathan, Frey, Noelle V., Engels, Boris, Barrett, David M., Shestova, Olga, Ravikumar, Pranali, Cummins, Katherine D., Lee, Yong Gu, Pajarillo, Raymone, Chun, Inkook, Shyu, Amy, Highfill, Steven L., Price, Andrew, Zhao, Linlin, Peng, Liaomin, Granda, Brian, Ramones, Melissa, Lu, Xueqing Maggie, Christian, David A., Perazzelli, Jessica, Lacey, Simon F., Roy, Nathan H., Burkhardt, Janis K., Colomb, Florent, Damra, Mohammad, Abdel-Mohsen, Mohamed, Liu, Ting, Liu, Dongfang, Standley, Daron M., Young, Regina M., Brogdon, Jennifer L., Grupp, Stephan A., June, Carl H., Maude, Shannon L., Gill, Saar, Ruella, Marco

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Pancreatic cancer therapy with combined mesothelin-redirected chimeric antigen receptor T cells and cytokine-armed oncolytic adenoviruses von Watanabe, Keisuke, Luo, Yanping, Da, Tong, Guedan, Sonia, Ruella, Marco, Scholler, John, Keith, Brian, Young, Regina M, Engels, Boris, Sorsa, Suvi, Siurala, Mikko, Havunen, Riikka, Tähtinen, Siri, Hemminki, Akseli, June, Carl H

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A Novel Autologous CAR-T Therapy, YTB323, with Preserved T-Cell Stemness Shows Enhanced CAR T-Cell Efficacy in Preclinical and Early Clinical Development von Dickinson, Michael J, Barba, Pere, Jager, Ulrich, Shah, Nirav N, Blaise, Didier, Briones, Javier, Shune, Leyla, Boissel, Nicolas, Bondanza, Attilio, Mariconti, Luisa, Marchal, Anne-Laure, Quinn, David S, Yang, Jennifer, Price, Andrew, Sohoni, Akash, Treanor, Louise M, Orlando, Elena J, Mataraza, Jennifer, Davis, Jaclyn, Lu, Darlene, Zhu, Xu, Engels, Boris, Moutouh-de Parseval, Laure, Brogdon, Jennifer L, Moschetta, Michele, Flinn, Ian W

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Eradication of Large Solid Tumors by Gene Therapy with a T-Cell Receptor Targeting a Single Cancer-Specific Point Mutation von Leisegang, Matthias, Engels, Boris, Schreiber, Karin, Yew, Poh Yin, Kiyotani, Kazuma, Idel, Christian, Arina, Ainhoa, Duraiswamy, Jaikumar, Weichselbaum, Ralph R, Uckert, Wolfgang, Nakamura, Yusuke, Schreiber, Hans

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Two cases of severe pulmonary toxicity from highly active mesothelin-directed CAR T cells von Haas, Andrew R., Golden, Ryan J., Litzky, Leslie A., Engels, Boris, Zhao, Linlin, Xu, Fangmin, Taraszka, John A., Ramones, Melissa, Granda, Brian, Chang, Wan-Jung, Jadlowsky, Julie, Shea, Kim-Marie, Runkle, Adam, Chew, Anne, Dowd, Emily, Gonzalez, Vanessa, Chen, Fang, Liu, Xiaojun, Fang, Chongyun, Jiang, Shuguang, Davis, Megan M., Sheppard, Neil C., Zhao, Yangbing, Fraietta, Joseph A., Lacey, Simon F., Plesa, Gabriela, Melenhorst, J. Joseph, Mansfield, Keith, Brogdon, Jennifer L., Young, Regina M., Albelda, Steven M., June, Carl H., Tanyi, Janos L.

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Ibrutinib before Apheresis May Improve Tisagenlecleucel Manufacturing in Relapsed/Refractory Adult Diffuse Large B-Cell Lymphoma: Initial Results from a Phase 1b Study von Chavez, Julio C., Locke, Frederick L., Napier, Ellen, Simon, Carl, Lewandowski, Andrew, Awasthi, Rakesh, Engels, Boris, Georgala, Petrina, Bondanza, Attilio, Schuster, Stephen J.

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Preservation of T-Cell Stemness with a Novel Expansionless CAR-T Manufacturing Process, Which Reduces Manufacturing Time to Less Than Two Days, Drives Enhanced CAR-T Cell Efficacy von Engels, Boris, Zhu, Xu, Yang, Jennifer, Price, Andrew, Sohoni, Akash, Stein, Andrew M, Parent, Lana, Greene, Michael, Niederst, Matthew, Whalen, Jeanne, Orlando, Elena J, Treanor, Louise M, Brogdon, Jennifer L

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Abstract 510: Impact of tisagenlecleucel product attributes on clinical outcomes in pediatric and young adult patients with relapsed or refractory acute lymphoblastic leukemia (r/r... von Gershgorin, Irina, Waldron, Edward R., Grupp, Stephan A., Levine, John E., Pulsipher, Michael A., Davies, Stella M., Myers, G. Doug, Jeschke, Margit, Engels, Boris, del Corral, Chris, Baruchel, Andre

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CD22-Targeted CAR-Modified T-Cells Safely Induce Remissions in Children and Young Adults with Relapsed, CD19-Negative B-ALL after Treatment with CD19-Targeted CAR T-Cells von Myers, Regina M., DiNofia, Amanda M., Li, Yimei, Diorio, Caroline, Aplenc, Richard, Baniewicz, Diane, Brogdon, Jennifer L, Callahan, Colleen, Engels, Boris, Fraietta, Joseph A., Gonzalez, Vanessa, Iannone, Emma, Leahy, Allison Barz, Liu, Hongyan, McClory, Susan E., Rheingold, Susan R., Shinehouse, Laura, Wertheim, Gerald, Wray, Lisa, Frey, Noelle V., Maude, Shannon L., Grupp, Stephan A.

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A First-in-Human Study of YTB323, a Novel, Autologous CD19-Directed CAR-T Cell Therapy Manufactured Using the Novel T-Charge TM platform, for the Treatment of Patients (Pts) with R... von Flinn, Ian W., Jaeger, Ulrich, Shah, Nirav N., Blaise, Didier, Briones, Javier, Shune, Leyla, Boissel, Nicolas, Bondanza, Attilio, Lu, Darlene, Zhu, Xu, Engels, Boris, Brogdon, Jennifer L, Mataraza, Jennifer, Davis, Jaclyn, Marchal, Anne Laure, Mariconti, Luisa, Moschetta, Michele, Parseval, Laure Moutouh-de, Barba, Pere, Dickinson, Michael

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CART22-65s Co-Administered with huCART19 in Adult Patients with Relapsed or Refractory ALL von Frey, Noelle V, Gill, Saar, Hwang, Wei-Ting, Luger, Selina M., Martin, Mary Ellen, McCurdy, Shannon R., Loren, Alison W., Pratz, Keith W., Perl, Alexander E., Barber-Rotenberg, Julie, Marshall, Amy, Ruella, Marco, Lacey, Simon F, Fraietta, Joseph, Fesnak, Andrew, O'brien, Megan, Schanne, Theresa, Brogdon, Jennifer L, Engels, Boris, Levine, Bruce L, June, Carl H, Porter, David L, Hexner, Elizabeth O.

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Redirecting T lymphocyte specificity by T cell receptor gene transfer – A new era for immunotherapy von Engels, Boris, Uckert, Wolfgang

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