The therapeutic potential of Aurora kinases targeting in glioblastoma: from preclinical research to translational oncology von de Almeida Magalhães, Taciani, de Sousa, Graziella Ribeiro, Alencastro Veiga Cruzeiro, Gustavo, Tone, Luiz Gonzaga, Valera, Elvis Terci, Borges, Kleiton Silva

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SHOC2 scaffold protein modulates daunorubicin-induced cell death through p53 modulation in lymphoid leukemia cells von Silveira, Vanessa Silva, Borges, Kleiton Silva, Santos, Verena Silva, Ruckert, Mariana Tannús, Vieira, Gabriela Maciel, Vasconcelos, Elton José Rosas, Nagano, Luis Fernando Peinado, Tone, Luiz Gonzaga, Scrideli, Carlos Alberto

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Wnt/β-catenin activation cooperates with loss of p53 to cause adrenocortical carcinoma in mice von Borges, Kleiton Silva, Pignatti, Emanuele, Leng, Sining, Kariyawasam, Dulanjalee, Ruiz-Babot, Gerard, Ramalho, Fernando Silva, Taketo, Makoto Mark, Carlone, Diana L., Breault, David T.

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Inhibition of Aurora kinase A activity enhances the antitumor response of beta-catenin blockade in human adrenocortical cancer cells von Maria, Andrea Gutierrez, Silva Borges, Kleiton, Lira, R.C.P., Hassib Thomé, Carolina, Berthon, Annabel, Drougat, Ludivine, Kiseljak-Vassiliades, Katja, Wierman, Margaret E., Faucz, Fabio R., Faça, Vitor Marcel, Tone, Luiz Gonzaga, Stratakis, Constantine A.

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Activation of Hedgehog signaling by the oncogenic RELA fusion reveals a primary cilia-dependent vulnerability in supratentorial ependymoma von de Almeida Magalhães, Taciani, Alencastro Veiga Cruzeiro, Gustavo, Ribeiro de Sousa, Graziella, Englinger, Bernhard, Fernando Peinado Nagano, Luis, Ancliffe, Mathew, Rodrigues da Silva, Keteryne, Jiang, Li, Gojo, Johannes, Cherry Liu, Yulu, Carline, Brooke, Kuchibhotla, Mani, Pinto Saggioro, Fabiano, Kazue Nagahashi Marie, Suely, Mieko Oba-Shinjo, Sueli, Andres Yunes, José, Gomes de Paula Queiroz, Rosane, Alberto Scrideli, Carlos, Endersby, Raelene, Filbin, Mariella G, Silva Borges, Kleiton, Salic, Adrian, Gonzaga Tone, Luiz, Valera, Elvis Terci

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Notch pathway in ependymoma RELA-fused subgroup: upregulation and association with cancer stem cells markers expression von de Almeida Magalhães, Taciani, Cruzeiro, Gustavo Alencastro Veiga, de Sousa, Graziella Ribeiro, da Silva, Keteryne Rodrigues, Lira, Régia Caroline Peixoto, Scrideli, Carlos Alberto, Tone, Luiz Gonzaga, Valera, Elvis Terci, Borges, Kleiton Silva

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Molecular characterization of Wnt pathway and function of β-catenin overexpression in medulloblastoma cell lines von Geron, Lenisa, Salomão, Karina Bezerra, Borges, Kleiton Silva, Andrade, Augusto Faria, Corrêa, Carolina Alves Pereira, Scrideli, Carlos Alberto, Tone, Luiz Gonzaga

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Frequency of the TP53 p.R337H mutation in a Brazilian cohort of pediatric patients with solid tumors von Feitosa, José Antonio da Silva, das Chagas, Pablo Ferreira, de Sousa, Graziella Ribeiro, Queiroz, Rosane Gomes de Paula, Cruzeiro, Gustavo Alencastro Veiga, Tone, Luiz Gonzaga, Borges, Kleiton Silva, Valera, Elvis Terci

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The TP53 p.R337H mutation is uncommon in a Brazilian cohort of pediatric patients diagnosed with ependymoma von de Almeida Magalhães, Taciani, Borges, Kleiton Silva, de Sousa, Graziella Ribeiro, Brandalise, Silvia Regina, Seidinger, Ana Luiza, Scrideli, Carlos Alberto, Oba-Shinjo, Sueli Mieko, Yunes, José Andrés, Tone, Luiz Gonzaga

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The DNA methyltransferase inhibitor zebularine exerts antitumor effects and reveals BATF2 as a poor prognostic marker for childhood medulloblastoma von Andrade, Augusto Faria, Borges, Kleiton Silva, Suazo, Veridiana Kiill, Geron, Lenisa, Corrêa, Carolina Alves Pereira, Castro-Gamero, Angel Mauricio, de Vasconcelos, Elton José Rosas, de Oliveira, Ricardo Santos, Neder, Luciano, Yunes, José Andres, dos Santos Aguiar, Simone, Scrideli, Carlos Alberto, Tone, Luiz Gonzaga

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Inhibition of Aurora kinases enhances chemosensitivity to temozolomide and causes radiosensitization in glioblastoma cells von Borges, Kleiton Silva, Castro-Gamero, Angel Maurício, Moreno, Daniel Antunes, da Silva Silveira, Vanessa, Brassesco, Maria Sol, de Paula Queiroz, Rosane Gomes, de Oliveira, Harley Francisco, Carlotti, Carlos Gilberto, Scrideli, Carlos Alberto, Tone, Luiz Gonzaga

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Antiproliferative effects of Tubi-bee propolis in glioblastoma cell lines von Borges, Kleiton Silva, Brassesco, María Sol, Scrideli, Carlos Alberto, Soares, Ademilson Espencer Egea, Tone, Luiz Gonzaga

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Wnt/[beta]-catenin activation cooperates with loss of p53 to cause adrenocortical carcinoma in mice von Borges, Kleiton Silva, Pignatti, Emanuele, Leng, Sining, Kariyawasam, Dulanjalee, Ruiz-Babot, Gerard, Ramalho, Fernando Silva, Taketo, Makoto Mark

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Identifying prognostic hub genes and key pathways in pediatric adrenocortical tumors through RNA sequencing and Co-expression analysis von Veronez, Luciana Chain, Xavier, Alcides Euzebio Tavares, Nagano, Luiz Fernando, Correa, Carolina Alves Pereira, Borges, Kleiton Silva, Santos, Paula, Baroni, Mirella, Silva Queiroz, Rosane de Paula, Antonini, Sonir Roberto Rauber, Yunes, José Andres, Brandalise, Silvia Regina, Molina, Carlos Augusto Fernandes, Pinto, Emilia Modolo, Valera, Elvis Terci, Tone, Luiz Gonzaga, Scrideli, Carlos Alberto

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Extracellular carriers control lipid-dependent secretion, delivery, and activity of WNT morphogens von de Almeida Magalhaes, Taciani, Liu, Jingjing, Chan, Charlene, Borges, Kleiton Silva, Zhang, Jiuchun, Kane, Andrew J, Wierbowski, Bradley M, Ge, Yunhui, Liu, Zhiwen, Mannam, Prabhath, Zeve, Daniel, Weiss, Ron, Breault, David T, Huang, Pengxiang, Salic, Adrian

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Purification and Biochemical Characterization of Native and Pegylated Form of L-Asparaginase from Aspergillus terreus and Evaluation of Its Antiproliferative Activity von Battiston Loureiro, Claudio, Silva Borges, Kleiton, Faria Andrade, Augusto, Gonzaga Tone, Luiz, Said, Suraia

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Abstract A30: Alisertib acts synergistically with sonidegib by modulating primary cilia assembly in a pediatric RELA ependymoma cell line von de Almeida Magalhães, Taciani, Cruzeiro, Gustavo Alencastro Veiga, Borges, Kleiton Silva, Yulu, Cherry Liu, de Souza, Graziella Ribeiro, da Silva, Keteryne Rodrigues, Scridelli, Carlos Alberto, Salic, Adrian, Tone, Luiz Gonzaga

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Anticancer activity of 7-epiclusianone, a benzophenone from Garcinia brasiliensis, in glioblastoma von Sales, Leilane, Pezuk, Julia Alejandra, Borges, Kleiton Silva, Brassesco, María Sol, Scrideli, Carlos Alberto, Tone, Luiz Gonzaga, dos Santos, Marcelo Henrique, Ionta, Marisa, de Oliveira, Jaqueline Carvalho

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Panobinostat (LBH589) increase survival in adult xenografic model of acute lymphoblastic leukemia with t(4;11) but promotes antagonistic effects in combination with MTX and 6MP von Moreno, Daniel Antunes, Junior, Howard Lopes Ribeiro, Laranjeira, Angelo Brunelli Albertoni, Cruzeiro, Gustavo Alencastro Veiga, Borges, Kleiton Silva, Salomão, Karina Bezerra, Ramalho, Fernando Silva, Yunes, José Andres, Silva, Cleide Lúcia Araújo, Rego, Eduardo Magalhães, Scrideli, Carlos Alberto, Tone, Luiz Gonzaga

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Effects of ethanolic extract and cernumidine compound obtained from Solanum cernuum’s Vell. leaves on benign prostatic hyperplasia von Mariza Abreu Miranda, Claudia Sares, Augusto Faria Andrade, Kleiton Silva Borges, James Dewey McChesney, Jairo Kenupp Bastos, Rodolfo Borges dos Reis

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