Partial gene suppression improves identification of cancer vulnerabilities when CRISPR-Cas9 knockout is pan-lethal von Krill-Burger, J. Michael, Dempster, Joshua M., Borah, Ashir A., Paolella, Brenton R., Root, David E., Golub, Todd R., Boehm, Jesse S., Hahn, William C., McFarland, James M., Vazquez, Francisca, Tsherniak, Aviad

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In vivo perturb-seq of cancer and microenvironment cells dissects oncologic drivers and radiotherapy responses in glioblastoma von Liu, S John, Zou, Christopher, Pak, Joanna, Morse, Alexandra, Pang, Dillon, Casey-Clyde, Timothy, Borah, Ashir A, Wu, David, Seo, Kyounghee, O'Loughlin, Thomas, Lim, Daniel A, Ozawa, Tomoko, Berger, Mitchel S, Kamber, Roarke A, Weiss, William A, Raleigh, David R, Gilbert, Luke A

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Lineage-specific canonical and non-canonical activity of EZH2 in advanced prostate cancer subtypes von Venkadakrishnan, Varadha Balaji, Presser, Adam G., Singh, Richa, Booker, Matthew A., Traphagen, Nicole A., Weng, Kenny, Voss, Nathaniel C. E., Mahadevan, Navin R., Mizuno, Kei, Puca, Loredana, Idahor, Osasenaga, Ku, Sheng-Yu, Bakht, Martin K., Borah, Ashir A., Herbert, Zachary T., Tolstorukov, Michael Y., Barbie, David A., Rickman, David S., Brown, Myles, Beltran, Himisha

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Repeat expansions confer WRN dependence in microsatellite-unstable cancers von van Wietmarschen, Niek, Sridharan, Sriram, Nathan, William J., Tubbs, Anthony, Chan, Edmond M., Callen, Elsa, Wu, Wei, Belinky, Frida, Tripathi, Veenu, Wong, Nancy, Foster, Kyla, Noorbakhsh, Javad, Garimella, Kiran, Cruz-Migoni, Abimael, Sommers, Joshua A., Huang, Yongqing, Borah, Ashir A., Smith, Jonathan T., Kalfon, Jeremie, Kesten, Nikolas, Fugger, Kasper, Walker, Robert L., Dolzhenko, Egor, Eberle, Michael A., Hayward, Bruce E., Usdin, Karen, Freudenreich, Catherine H., Brosh, Robert M., West, Stephen C., McHugh, Peter J., Meltzer, Paul S., Bass, Adam J., Nussenzweig, André

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A Ubiquitination Cascade Regulating the Integrated Stress Response and Survival in Carcinomas von Cervia, Lisa D, Shibue, Tsukasa, Borah, Ashir A, Gaeta, Benjamin, He, Linh, Leung, Lisa, Li, Naomi, Moyer, Sydney M, Shim, Brian H, Dumont, Nancy, Gonzalez, Alfredo, Bick, Nolan R, Kazachkova, Mariya, Dempster, Joshua M, Krill-Burger, John Michael, Piccioni, Federica, Udeshi, Namrata D, Olive, Meagan E, Carr, Steven A, Root, David E, McFarland, James M, Vazquez, Francisca, Hahn, William C

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Sparse dictionary learning recovers pleiotropy from human cell fitness screens von Pan, Joshua, Kwon, Jason J., Talamas, Jessica A., Borah, Ashir A., Vazquez, Francisca, Boehm, Jesse S., Tsherniak, Aviad, Zitnik, Marinka, McFarland, James M., Hahn, William C.

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Microenvironment drives cell state, plasticity, and drug response in pancreatic cancer von Raghavan, Srivatsan, Winter, Peter S., Navia, Andrew W., Williams, Hannah L., DenAdel, Alan, Lowder, Kristen E., Galvez-Reyes, Jennyfer, Kalekar, Radha L., Mulugeta, Nolawit, Kapner, Kevin S., Raghavan, Manisha S., Borah, Ashir A., Liu, Nuo, Väyrynen, Sara A., Costa, Andressa Dias, Ng, Raymond W.S., Wang, Junning, Hill, Emma K., Ragon, Dorisanne Y., Brais, Lauren K., Jaeger, Alex M., Spurr, Liam F., Li, Yvonne Y., Cherniack, Andrew D., Booker, Matthew A., Cohen, Elizabeth F., Tolstorukov, Michael Y., Wakiro, Isaac, Rotem, Asaf, Johnson, Bruce E., McFarland, James M., Sicinska, Ewa T., Jacks, Tyler E., Sullivan, Ryan J., Shapiro, Geoffrey I., Clancy, Thomas E., Perez, Kimberly, Rubinson, Douglas A., Ng, Kimmie, Cleary, James M., Crawford, Lorin, Manalis, Scott R., Nowak, Jonathan A., Wolpin, Brian M., Hahn, William C., Aguirre, Andrew J., Shalek, Alex K.

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Abstract P3-09-01: A ubiquitination cascade regulating the integrated stress response and survival in carcinomas von Cervia, Lisa D, Shibue, Tsukasa, Gaeta, Benjamin, Borah, Ashir A, Leung, Lisa, Li, Naomi, Dumont, Nancy, Gonzalez, Alfredo, Bick, Nolan, Kazachkova, Mariya, Dempster, Joshua M, Krill-Burger, John M, Piccioni, Federica, Udeshi, Namrata D, Olive, Meagan E, Carr, Steven A, Root, David E, McFarland, James M, Vazquez, Francisca, Hahn, William C

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Abstract 1897: Systematic methods to identify cancer vulnerabilities from genome-wide loss-of-function screens: An interactive framework for target discovery von Krill-Burger, John M., Borah, Ashir A., Paolella, Brenton R., McFarland, James M., Vazquez, Francisca

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Abstract PO-058: Transcriptional subtype-specific microenvironmental crosstalk and tumor cell plasticity in metastatic pancreatic cancer von Raghavan, Srivatsan, Winter, Peter S., Navia, Andrew W., Williams, Hannah L., DenAdel, Alan, Kalekar, Radha L., Galvez-Reyes, Jennyfer, Lowder, Kristen E., Mulugeta, Nolawit, Raghavan, Manisha S., Borah, Ashir A., Vayrynen, Sara A., Costa, Andressa Dias, Wang, Junning, Reilly, Emma, Ragon, Dorisanne Y., Brais, Lauren K., Jaeger, Alex M., Cleary, James M., Crawford, Lorin, Nowak, Jonathan A., Wolpin, Brian M., Hahn, William C., Aguirre, Andrew J., Shalek, Alex K.

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Repeat expansions confer WRN dependence in microsatellite-unstable cancers von van Wietmarschen, Niek, Sridharan, Sriram, Nathan, William J, Tubbs, Anthony, Chan, Edmond, Callen, Elsa, Wu, Wei, Belinky, Frida, Tripathi, Veenu, Wong, Nancy, Foster, Kyla, Noorbakhsh, Javad, Garimella, Kiran, Cruz-Migoni, Abimael, Sommers, Joshua A, Huang, Yongqing, Borah, Ashir A, Smith, Jonathan T, Kalfon, Jeremie, Kesten, Nikolas, Fugger, Kasper, Walker, Robert L, Dolzhenko, Egor, Eberle, Michael A, Hayward, Bruce E, Usdin, Karen, Freudenreich, Catherine H, Brosh, Robert M, West, Stephen C, McHugh, Peter J, Meltzer, Paul S, Bass, Adam, Nussenzweig, André

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Abstract 73: A ubiquitination cascade regulating the integrated stress response and survival in carcinomas von Cervia, Lisa D., Shibue, Tsukasa, Gaeta, Benjamin, Borah, Ashir A., Leung, Lisa, Li, Naomi, Dumont, Nancy, Gonzalez, Alfredo, Bick, Nolan, Kazachkova, Mariya, Dempster, Joshua M., Krill-Burger, John M., Piccioni, Federica, Udeshi, Namrata D., Olive, Meagan E., Carr, Steven A., Root, David E., McFarland, James M., Vazquez, Francisca, Hahn, William C.

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Sparse dictionary learning recovers pleiotropy from human cell fitness screens von Pan, Joshua, Kwon, Jason J, Talamas, Jessica A, Borah, Ashir A, Vazquez, Francisca, Boehm, Jesse S, Tsherniak, Aviad, Zitnik, Marinka, McFarland, James M, Hahn, William C

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Additional file 4 of Partial gene suppression improves identification of cancer vulnerabilities when CRISPR-Cas9 knockout is pan-lethal von Krill-Burger, J. Michael, Dempster, Joshua M., Borah, Ashir A., Paolella, Brenton R., Root, David E., Golub, Todd R., Boehm, Jesse S., Hahn, William C., McFarland, James M., Vazquez, Francisca, Tsherniak, Aviad

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Additional file 3 of Partial gene suppression improves identification of cancer vulnerabilities when CRISPR-Cas9 knockout is pan-lethal von Krill-Burger, J. Michael, Dempster, Joshua M., Borah, Ashir A., Paolella, Brenton R., Root, David E., Golub, Todd R., Boehm, Jesse S., Hahn, William C., McFarland, James M., Vazquez, Francisca, Tsherniak, Aviad

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Additional file 2 of Partial gene suppression improves identification of cancer vulnerabilities when CRISPR-Cas9 knockout is pan-lethal von Krill-Burger, J. Michael, Dempster, Joshua M., Borah, Ashir A., Paolella, Brenton R., Root, David E., Golub, Todd R., Boehm, Jesse S., Hahn, William C., McFarland, James M., Vazquez, Francisca, Tsherniak, Aviad

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Sparse dictionary learning recovers pleiotropy from human cell fitness screens von Pan, Joshua, Kwon, Jason J, Talamas, Jessica A, Borah, Ashir A, Vazquez, Francisca, Boehm, Jesse S, Tsherniak, Aviad, Zitnik, Marinka, McFarland, James M, Hahn, William C

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Abstract 4678: The role of EGR1 and AP1 in acute myeloid leukemia cell reprogramming toward cell cycle arrest and apoptosis von Roberts, Michael, Kageler, Lauren, Bendinelli, Kayla, Bonner, Shannon, Borah, Ashir, Forrester, Jeffrey

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A systematic search for RNA structural switches across the human transcriptome von Khoroshkin, Matvei, Asarnow, Daniel, Zhou, Shaopu, Navickas, Albertas, Winters, Aidan, Goudreau, Jackson, Zhou, Simon K., Yu, Johnny, Palka, Christina, Fish, Lisa, Borah, Ashir, Yousefi, Kian, Carpenter, Christopher, Ansel, K. Mark, Cheng, Yifan, Gilbert, Luke A., Goodarzi, Hani

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Abstract 1950: A ubiquitination cascade regulates the integrated stress response and epithelial cancer survival von Cervia, Lisa D., Shibue, Tsukasa, Gaeta, Benjamin, Borah, Ashir, Leung, Lisa, Li, Naomi, Dumont, Nancy, Gonzalez, Alfredo, Bick, Nolan, Kazachkova, Mariya, Dempster, Joshua, Krill-Burger, John M., Udeshi, Namrata, Olive, Meagan, Carr, Steven A., Root, David E., Piccioni, Federica, McFarland, James M., Vazquez, Francisca, Hahn, William C.

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