Structure-Based Design of Lipophilic Quinazoline Inhibitors of Thymidylate Synthase von Jones, Terence R, Varney, Michael D, Webber, Stephen E, Lewis, Kathleen K, Marzoni, Gifford P, Palmer, Cindy L, Kathardekar, Vinit, Welsh, Katharine M, Webber, Stephanie, Matthews, David A, Appelt, Krzysztof, Smith, Ward W, Janson, Cheryl A, Villafranca, J. E, Bacquet, Russell J, Howland, Eleanor F, Booth, Carol L. J, Herrmann, Steven M, Ward, Robert W, White, Jennifer, Moomaw, Ellen W, Bartlett, Charlotte A, Morse, Cathy A

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Construction of an altered proton donation mechanism in Escherichia coli dihydrofolate reductase von Howell, Elizabeth Ehrhardt, Warren, Mark S, Booth, Carol L. J, Villafranca, Jesus E, Kraut, Joseph

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Design of enzyme inhibitors using iterative protein crystallographic analysis von Appelt, Krzysztof, Bacquet, Russell J, Bartlett, Charlotte A, Booth, Carol L. J, Freer, Stephan T, Fuhry, Mary Ann M, Gehring, Michael R, Herrmann, Steven M, Howland, Eleanor F

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Structure-Based Design of Substituted Diphenyl Sulfones and Sulfoxides as Lipophilic Inhibitors of Thymidylate Synthase von Jones, Terence R, Webber, Stephen E, Varney, Michael D, Reddy, M. Rami, Lewis, Kathleen K, Kathardekar, Vinit, Mazdiyasni, Hormoz, Deal, Judith, Nguyen, Dzuy, Welsh, Katharine M, Webber, Stephanie, Johnston, Amanda, Matthews, David A, Smith, Ward W, Janson, Cheryl A, Bacquet, Russell J, Howland, Eleanor F, Booth, Carol L. J, Herrmann, Steven M, Ward, Robert W, White, Jennifer, Bartlett, Charlotte A, Morse, Cathy A

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The effects of lowering LDL cholesterol with simvastatin plus ezetimibe in patients with chronic kidney disease (Study of Heart and Renal Protection): a randomised placebo-controll... von Baigent, Colin, Prof, Landray, Martin J, FRCP, Reith, Christina, MRCP, Emberson, Jonathan, PhD, Wheeler, David C, FRCP, Tomson, Charles, DM, Wanner, Christoph, Prof, Krane, Vera, MD, Cass, Alan, Prof, Craig, Jonathan, Prof, Neal, Bruce, Prof, Jiang, Lixin, MD, Hooi, Lai Seong, FRCP, Levin, Adeera, Prof, Agodoa, Lawrence, Prof, Gaziano, Mike, Prof, Kasiske, Bertram, Prof, Walker, Robert, Prof, Massy, Ziad A, Prof, Feldt-Rasmussen, Bo, Prof, Krairittichai, Udom, MD, Ophascharoensuk, Vuddidhej, MD, Fellström, Bengt, Prof, Holdaas, Hallvard, MD, Tesar, Vladimir, Prof, Wiecek, Andrzej, Prof, Grobbee, Diederick, Prof, de Zeeuw, Dick, Prof, Grönhagen-Riska, Carola, Prof, Dasgupta, Tanaji, MRCP, Lewis, David, MRCP, Herrington, William, MRCP, Mafham, Marion, MD, Majoni, William, FRACP, Wallendszus, Karl, MSc, Grimm, Richard, Prof, Pedersen, Terje, Prof, Tobert, Jonathan, PhD, Armitage, Jane, Prof, Baxter, Alex, BA, Bray, Christopher, PhD, Chen, Yiping, DPhil, Chen, Zhengming, Prof, Hill, Michael, DPhil, Knott, Carol, MSc, Parish, Sarah, DPhil, Simpson, David, Sleight, Peter, Prof, Young, Alan, DPhil, Collins, Rory, Prof

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Altiratinib Inhibits Tumor Growth, Invasion, Angiogenesis, and Microenvironment-Mediated Drug Resistance via Balanced Inhibition of MET, TIE2, and VEGFR2 von Smith, Bryan D, Kaufman, Michael D, Leary, Cynthia B, Turner, Benjamin A, Wise, Scott C, Ahn, Yu Mi, Booth, R John, Caldwell, Timothy M, Ensinger, Carol L, Hood, Molly M, Lu, Wei-Ping, Patt, Tristan W, Patt, William C, Rutkoski, Thomas J, Samarakoon, Thiwanka, Telikepalli, Hanumaiah, Vogeti, Lakshminarayana, Vogeti, Subha, Yates, Karen M, Chun, Lawrence, Stewart, Lance J, Clare, Michael, Flynn, Daniel L

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Parent-mediated intervention versus no intervention for infants at high risk of autism: a parallel, single-blind, randomised trial von Green, Jonathan, Prof, Charman, Tony, Prof, Pickles, Andrew, Prof, Wan, Ming W, PhD, Elsabbagh, Mayada, PhD, Slonims, Vicky, PhD, Taylor, Carol, MA, McNally, Janet, MSc, Booth, Rhonda, PhD, Gliga, Teodora, PhD, Jones, Emily J H, PhD, Harrop, Clare, PhD, Bedford, Rachael, PhD, Johnson, Mark H, Prof

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Control of fibroblast fibronectin expression and alternative splicing via the PI3K/Akt/mTOR pathway von White, Eric S., Sagana, Rommel L., Booth, Adam J., Yan, Mei, Cornett, Ashley M., Bloomheart, Christopher A., Tsui, Jessica L., Wilke, Carol A., Moore, Bethany B., Ritzenthaler, Jeffrey D., Roman, Jesse, Muro, Andrés F.

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Topographic and hydrodynamic controls on barrier retreat and preservation: An example from Dogger Bank, North Sea von Emery, Andy R., Hodgson, David M., Barlow, Natasha L.M., Carrivick, Jonathan L., Cotterill, Carol J., Mellett, Claire L., Booth, Adam D.

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Mutations in ZIC2 in human holoprosencephaly: description of a Novel ZIC2 specific phenotype and comprehensive analysis of 157 individuals von Solomon, Benjamin D, Lacbawan, Felicitas, Mercier, Sandra, Clegg, Nancy J, Delgado, Mauricio R, Rosenbaum, Kenneth, Dubourg, Christèle, David, Veronique, Olney, Ann Haskins, Wehner, Lars-Erik, Hehr, Ute, Bale, Sherri, Paulussen, Aimee, Smeets, Hubert J, Hardisty, Emily, Tylki-Szymanska, Anna, Pronicka, Ewa, Clemens, Michelle, McPherson, Elizabeth, Hennekam, Raoul C M, Hahn, Jin, Stashinko, Elaine, Levey, Eric, Wieczorek, Dagmar, Roeder, Elizabeth, Schell-Apacik, Chayim Can, Booth, Carol W, Thomas, Ronald L, Kenwrick, Sue, Cummings, Derek A T, Bous, Sophia M, Keaton, Amelia, Balog, Joan Z, Hadley, Donald, Zhou, Nan, Long, Robert, Vélez, Jorge I, Pineda-Alvarez, Daniel E, Odent, Sylvie, Roessler, Erich, Muenke, Maximilian

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The JWST Early Release Science Program for the Direct Imaging and Spectroscopy of Exoplanetary Systems von Hinkley, Sasha, Carter, Aarynn L., Ray, Shrishmoy, Skemer, Andrew, Biller, Beth, Choquet, Elodie, Millar-Blanchaer, Maxwell A., Sallum, Stephanie, Miles, Brittany, Whiteford, Niall, Patapis, Polychronis, Perrin, Marshall, Pueyo, Laurent, Schneider, Glenn, Stapelfeldt, Karl, Wang, Jason, Ward-Duong, Kimberly, Bowler, Brendan P., Boccaletti, Anthony, H. Girard, Julien, Hines, Dean, Kalas, Paul, Kammerer, Jens, Kervella, Pierre, Leisenring, Jarron, Pantin, Eric, Zhou, Yifan, Meyer, Michael, Liu, Michael C., Bonnefoy, Mickael, Currie, Thayne, McElwain, Michael, Metchev, Stanimir, Wyatt, Mark, Absil, Olivier, Adams, Jea, Barman, Travis, Baraffe, Isabelle, Bonavita, Mariangela, Booth, Mark, Bryan, Marta, Chauvin, Gael, Chen, Christine, Danielski, Camilla, Furio, Matthew De, Factor, Samuel M., Fitzgerald, Michael P., Fortney, Jonathan J., Grady, Carol, Greenbaum, Alexandra, Henning, Thomas, Hoch, Kielan K. W., Janson, Markus, Kennedy, Grant, Kenworthy, Matthew, Kraus, Adam, Kuzuhara, Masayuki, Lagage, Pierre-Olivier, Lagrange, Anne-Marie, Launhardt, Ralf, Lazzoni, Cecilia, Lloyd, James, Marino, Sebastian, Marley, Mark, Martinez, Raquel, Marois, Christian, Matthews, Brenda, Matthews, Elisabeth C., Mawet, Dimitri, Mazoyer, Johan, Phillips, Mark, Petrus, Simon, Quanz, Sascha P., Quirrenbach, Andreas, Rameau, Julien, Rebollido, Isabel, Rickman, Emily, Samland, Matthias, Sargent, B., Schlieder, Joshua E., Sivaramakrishnan, Anand, Stone, Jordan M., Tamura, Motohide, Tremblin, Pascal, Uyama, Taichi, Vasist, Malavika, Vigan, Arthur, Wagner, Kevin, Ygouf, Marie

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Identification and Evaluations of Novel Insecticidal Proteins from Plants of the Class Polypodiopsida for Crop Protection against Key Lepidopteran Pests von Liu, Lu, Schepers, Eric, Lum, Amy, Rice, Janet, Yalpani, Nasser, Gerber, Ryan, Jiménez-Juárez, Nuria, Haile, Fikru, Pascual, Alejandra, Barry, Jennifer, Qi, Xiuli, Kassa, Adane, Heckert, Matthew J, Xie, Weiping, Ding, Changkui, Oral, Jarred, Nguyen, Minh, Le, James, Procyk, Lisa, Diehn, Scott H, Crane, Virginia C, Damude, Howard, Pilcher, Carol, Booth, Russ, Liu, Lu, Zhu, Genhai, Nowatzki, Timothy M, Nelson, Mark E, Lu, Albert L, Wu, Gusui

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Molecular and Clinical Analyses of Greig Cephalopolysyndactyly and Pallister-Hall Syndromes: Robust Phenotype Prediction from the Type and Position of GLI3 Mutations von Johnston, Jennifer J., Olivos-Glander, Isabelle, Killoran, Christina, Elson, Emma, Turner, Joyce T., Peters, Kathryn F., Abbott, Margaret H., Aughton, David J., Aylsworth, Arthur S., Bamshad, Michael J., Booth, Carol, Curry, Cynthia J., David, Albert, Dinulos, Mary Beth, Flannery, David B., Fox, Michelle A., Graham, John M., Grange, Dorothy K., Guttmacher, Alan E., Hannibal, Mark C., Henn, Wolfram, Hennekam, RaoulC.M., Holmes, Lewis B., Hoyme, H. Eugene, Leppig, Kathleen A., Lin, Angela E., MacLeod, Patrick, Manchester, David K., Marcelis, Carlo, Mazzanti, Laura, McCann, Emma, McDonald, Marie T., Mendelsohn, Nancy J., Moeschler, John B., Moghaddam, Billur, Neri, Giovanni, Newbury-Ecob, Ruth, Pagon, Roberta A., Phillips III, John A., Sadler, Laurie S., Stoler, Joan M., Tilstra, David, Walsh Vockley, Catherine M., Zackai, Elaine H., Zadeh, Touran M., Brueton, Louise, Black, Graeme Charles M., Biesecker, Leslie G.

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The JWST Early Release Science Program for Direct Observations of Exoplanetary Systems. V. Do Self-consistent Atmospheric Models Represent JWST Spectra? A Showcase with VHS 1256-12... von Petrus, Simon, Whiteford, Niall, Patapis, Polychronis, Biller, Beth A, Skemer, Andrew, Hinkley, Sasha, Suarez, Genaro, Palma-Bifani, Paulina, Morley, Caroline V, Tremblin, Pascal, Charnay, Benjamin, Vos, Johanna M, Wang, Jason J, Stone, Jordan M, Bonnefoy, Mickael, Chauvin, Gael, Miles, Brittany E, Carter, Aarynn L, Lueber, Anna, Helling, Christiane, Sutlieff, Ben J, Janson, Markus, Gonzales, Eileen C, Hoch, Kielan K.W, Absil, Olivier, Balmer, William O, Boccaletti, Anthony, Bonavita, Mariangela, Booth, Mark, Bowler, Brendan P, Briesemeister, Zackery W, Bryan, Marta L, Calissendorff, Per, Cantalloube, Faustine, Chen, Christine H, Choquet, Elodie, Christiaens, Valentin, Cugno, Gabriele, Currie, Thayne, Danielski, Camilla, De Furio, Matthew, Dupuy, Trent J, Factor, Samuel M, Faherty, Jacqueline K, Fitzgerald, Michael P, Fortney, Jonathan J, Franson, Kyle, Girard, Julien H, Grady, Carol A, Henning, Thomas, Hines, Dean C, Hood, Callie E, Howe, Alex R, Kalas, Paul, Kammerer, Jens, Kennedy, Grant M, Kenworthy, Matthew A, Kervella, Pierre, Kim, Minjae, Kitzmann, Daniel, Kraus, Adam L, Kuzuhara, Masayuki, Lagage, Pierre-Olivier, Lagrange, Anne-Marie, Lawson, Kellen, Lazzoni, Cecilia, Leisenring, Jarron M, Lew, Ben W.P, Liu, Michael C, Liu, Pengyu, Llop-Sayson, Jorge, Lloyd, James P, Macintosh, Bruce, Malin, Mathilde, Manjavacas, Elena, Marino, Sebastian, Marley, Mark S, Marois, Christian, Martinez, Raquel A, Matthews, Elisabeth C, Matthews, Brenda C, Mawet, Dimitri, Mazoyer, Johan, McElwain, Michael W, Metchev, Stanimir, Meyer, Michael R, Millar-Blanchaer, Maxwell A, Molliere, Paul, Moran, Sarah E, Mukherjee, Sagnick, Pantin, Eric, Perrin, Marshall D, Pueyo, Laurent, Quanz, Sascha P, Quirrenbach, Andreas, Ray, Shrishmoy, Rebollido, Isabel, Redai, Jea Adams, Ren, Bin B, Rickman, Emily

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The JWST Early Release Science Program for Direct Observations of Exoplanetary Systems. IV. NIRISS Aperture Masking Interferometry Performance and Lessons Learned von Sallum, Steph, Kammerer, Jens, Sivaramakrishnan, Anand, Greebaum, Alexandra Z., Thatte, Deepashri, De Furio, Matthew, Factor, Samuel M., Meyer, Michael R., Carter, Aarynn, Hinkley, Sasha, Skemer, Andrew, Perrin, Marshall D., Kraus, Adam L., Absil, Olivier, Balmer, William O., Betti, Sarah K., Boccaletti, Anthony, Bonnefoy, Mickael, Booth, Mark, Bowler, Brendan P., Briesemeister, Zackery W., Bryan, Marta L., Cantalloube, Faustine, Chauvin, Gael, Choquet, Elodie, Christiaens, Valentin, Cugno, Gabriele, Currie, Thayne, Danielski, Camilla, Faherty, Jacqueline K., Fitzgerald, Michael P., Fortney, Jonathan J., Franson, Kyle, Girard, Julien H., Grady, Carol A., Gonzales, Eileen C., Henning, Thomas, Hines, Dean C., Hoch, Kielan K. W., Hood, Callie E., Janson, Markus, Kennedy, Grant M., Kenworthy, Matthew A., Kervella, Pierre, Kitzmann, Daniel, Lagrange, Anne-Marie, Lagage, Pierre-Olivier, Lawson, Kellen, Lazzoni, Cecilia, Liu, Michael C., Liu, Pengyu, Llop-Sayson, Jorge, Lloyd, James P., Lueber, Anna, Macintosh, Bruce, Manjavacas, Elena, Marino, Sebastian, Marley, Mark S., Marois, Christian, Martinez, Raquel A., Matthews, Brenda C., Matthews, Elisabeth C., Mawet, Dimitri, Mazoyer, Johan, McElwain, Michael W., Metchev, Stanimir, Miles, Brittany E., Millar-Blanchaer, Maxwell A., Moran, Sarah E., Morley, Caroline V., Mukherjee, Sagnick, Palma-Bifani, Paulina, Pantin, Eric, Patapis, Polychronis, Petrus, Simon, Quanz, Sascha P., Rebollido, Isabel, Redai, Jea Adams, Ren, Bin B., Rickman, Emily, Samland, Matthias, Schneider, Glenn, Stapelfeldt, Karl R., Sutlieff, Ben J., Tamura, Motohide, Tan, Xianyu, Theissen, Christopher A., Uyama, Taichi, Vasist, Malavika, Vos, Johanna M., Wagner, Kevin, Ward-Duong, Kimberly, Whiteford, Niall, Wolff, Schuyler G., Worthen, Kadin, Ygouf, Marie, Zhang, Xi, Zhang, Zhoujian, Zhou, Yifan, Zurlo, Alice

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The JWST Early Release Science Program for Direct Observations of Exoplanetary Systems I: High-contrast Imaging of the Exoplanet HIP 65426 b from 2 to 16 μm von Carter, Aarynn L, Hinkley, Sasha, Kammerer, Jens, Skemer, Andrew, Biller, Beth A, Leisenring, Jarron M, Millar-Blanchaer, Maxwell A, Petrus, Simon, Stone, Jordan M, Ward-Duong, Kimberly, Wang, Jason J, Girard, Julien H, Hines, Dean C, Perrin, Marshall D, Pueyo, Laurent, Balmer, William O, Bonavita, Mariangela, Bonnefoy, Mickael, Chauvin, Gael, Choquet, Elodie, Christiaens, Valentin, Danielski, Camilla, Kennedy, Grant M, Matthews, Elisabeth C, Miles, Brittany E, Patapis, Polychronis, Ray, Shrishmoy, Rickman, Emily, Sallum, Steph, Stapelfeldt, Karl R, Whiteford, Niall, Zhou, Yifan, Absil, Olivier, Boccaletti, Anthony, Booth, Mark, Bowler, Brendan P, Chen, Christine H, Currie, Thayne, Fortney, Jonathan J, Grady, Carol A, Greebaum, Alexandra Z, Henning, Thomas, Hoch, Kielan K.W, Janson, Markus, Kalas, Paul, Kenworthy, Matthew A, Kervella, Pierre, Kraus, Adam L, Lagage, Pierre-Olivier, Liu, Michael C, Macintosh, Bruce, Marino, Sebastian, Marley, Mark S, Marois, Christian, Matthews, Brenda C, Mawet, Dimitri, McElwain, Michael W, Metchev, Stanimir, Meyer, Michael R, Molliere, Paul, Moran, Sarah E, Morley, Caroline, Mukherjee, Sagnick, Pantin, Eric, Quirrenbach, Andreas, Rebollido, Isabel, Ren, Bin B, Schneider, Glenn, Vasist, Malavika, Worthen, Kadin, Wyatt, Mark C, Briesemeister, Zackery W, Bryan, Marta L, Calissendorff, Per, Cantalloube, Faustine, Cugno, Gabriele, De Furio, Matthew, Dupuy, Trent J, Factor, Samuel M, Faherty, Jacqueline K, Fitzgerald, Michael P, Franson, Kyle, Gonzales, Eileen C, Hood, Callie E, Howe, Alex R, Kuzuhara, Masayuki, Lagrange, Anne-Marie, Lawson, Kellen, Lazzoni, Cecilia, Lew, Ben W.P, Liu, Pengyu, Llop-Sayson, Jorge, Lloyd, James P, Martinez, Raquel A, Mazoyer, Johan, Palma-Bifani, Paulina, Quanz, Sascha P, Redai, Jea Adams, Samland, Matthias, Schlieder, Joshua E

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The JWST Early-release Science Program for Direct Observations of Exoplanetary Systems II: A 1 to 20 μm Spectrum of the Planetary-mass Companion VHS 1256-1257 b von Miles, Brittany E, Biller, Beth A, Patapis, Polychronis, Worthen, Kadin, Rickman, Emily, Hoch, Kielan K.W, Skemer, Andrew, Perrin, Marshall D, Whiteford, Niall, Chen, Christine H, Sargent, B, Mukherjee, Sagnick, Morley, Caroline V, Moran, Sarah E, Bonnefoy, Mickael, Petrus, Simon, Carter, Aarynn L, Choquet, Elodie, Hinkley, Sasha, Ward-Duong, Kimberly, Leisenring, Jarron M, Millar-Blanchaer, Maxwell A, Pueyo, Laurent, Ray, Shrishmoy, Sallum, Steph, Stapelfeldt, Karl R, Stone, Jordan M, Wang, Jason J, Absil, Olivier, Balmer, William O, Boccaletti, Anthony, Bonavita, Mariangela, Booth, Mark, Bowler, Brendan P, Chauvin, Gael, Christiaens, Valentin, Currie, Thayne, Danielski, Camilla, Fortney, Jonathan J, Girard, Julien H, Grady, Carol A, Greenbaum, Alexandra Z, Henning, Thomas, Hines, Dean C, Janson, Markus, Kalas, Paul, Kammerer, Jens, Kennedy, Grant M, Kenworthy, Matthew A, Kervella, Pierre, Lagage, Pierre-Olivier, Lew, Ben W.P, Liu, Michael C, Macintosh, Bruce, Marino, Sebastian, Marley, Mark S, Marois, Christian, Matthews, Elisabeth C, Matthews, Brenda C, Mawet, Dimitri, McElwain, Michael W, Metchev, Stanimir, Meyer, Michael R, Molliere, Paul, Pantin, Eric, Quirrenbach, Andreas, Rebollido, Isabel, Ren, Bin B, Schneider, Glenn, Vasist, Malavika, Wyatt, Mark C, Zhou, Yifan, Briesemeister, Zackery W, Bryan, Marta L, Calissendorff, Per, Cantalloube, Faustine, Cugno, Gabriele, De Furio, Matthew, Dupuy, Trent J, Factor, Samuel M, Faherty, Jacqueline K, Fitzgerald, Michael P, Franson, Kyle, Gonzales, Eileen C, Hood, Callie E, Howe, Alex R, Kraus, Adam L, Kuzuhara, Masayuki, Lagrange, Anne-Marie, Lawson, Kellen, Lazzoni, Cecilia, Liu, Pengyu, Llop-Sayson, Jorge, Lloyd, James P, Martinez, Raquel A, Mazoyer, Johan, Quanz, Sascha P, Redai, Jea Adams, Samland, Matthias, Schlieder, Joshua E

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The challenge of determining appropriate care in the era of patient-centered care and rising health care costs von Coulter, Ian, Herman, Patricia, Ryan, Gery, Hilton, Lara, Hays, Ron D.

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Predictors of HIV sero-status among drug injectors at three Ukraine sites von BOOTH, Robert E, KWIATKOWSKI, Carol F, BREWSTER, John T, SINITSYNA, Larisa, DVORYAK, Sergey

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Micro-geographical variation in exposure to Schistosoma mansoni and malaria, and exacerbation of splenomegaly in Kenyan school-aged children von Booth, Mark, Vennervald, Birgitte J, Kenty, LeeCarol, Butterworth, Anthony E, Kariuki, Henry C, Kadzo, Hilda, Ireri, Edmund, Amaganga, Clifford, Kimani, Gachuhi, Mwatha, Joseph K, Otedo, Amos, Ouma, John H, Muchiri, Eric, Dunne, David W

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