Identification and Characterization of a Peptide That Specifically Binds the Human, Broadly Neutralizing Anti-Human Immunodeficiency Virus Type 1 Antibody b12 von Zwick, M B, Bonnycastle, L L, Menendez, A, Irving, M B, Barbas, 3rd, C F, Parren, P W, Burton, D R, Scott, J K

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The Maltose-Binding Protein as a Scaffold for Monovalent Display of Peptides Derived from Phage Libraries von Zwick, Michael B., Bonnycastle, Lori L.C., Noren, Karen A., Venturini, Sara, Leong, Edward, Barbas, Carlos F., Noren, Christopher J., Scott, Jamie K.

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Epitope Mapping of a Function-blocking β1 Integrin Antibody by Phage Display von Ryan, Sarah T., Chi-Rosso, Gloria, Bonnycastle, Lori L. C., Scott, Jamie K., Koteliansky, Victor, Pollard, Stuart, Gotwals, Philip J.

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SARS-CoV-2 infection induces beta cell transdifferentiation von Tang, Xuming, Uhl, Skyler, Zhang, Tuo, Xue, Dongxiang, Li, Bo, Vandana, J. Jeya, Acklin, Joshua A., Bonnycastle, Lori L., Narisu, Narisu, Erdos, Michael R., Bram, Yaron, Chandar, Vasuretha, Chong, Angie Chi Nok, Lacko, Lauretta A., Min, Zaw, Lim, Jean K., Borczuk, Alain C., Xiang, Jenny, Naji, Ali, Collins, Francis S., Evans, Todd, Liu, Chengyang, tenOever, Benjamin R., Schwartz, Robert E., Chen, Shuibing

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The genetic regulatory signature of type 2 diabetes in human skeletal muscle von Scott, Laura J., Erdos, Michael R., Huyghe, Jeroen R., Welch, Ryan P., Beck, Andrew T., Wolford, Brooke N., Chines, Peter S., Didion, John P., Narisu, Narisu, Stringham, Heather M., Taylor, D. Leland, Jackson, Anne U., Vadlamudi, Swarooparani, Bonnycastle, Lori L., Kinnunen, Leena, Saramies, Jouko, Sundvall, Jouko, Albanus, Ricardo D'Oliveira, Kiseleva, Anna, Hensley, John, Crawford, Gregory E., Jiang, Hui, Wen, Xiaoquan, Watanabe, Richard M., Lakka, Timo A., Mohlke, Karen L., Laakso, Markku, Tuomilehto, Jaakko, Koistinen, Heikki A., Boehnke, Michael, Collins, Francis S., Parker, Stephen C. J.

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Systematic comparison of three genomic enrichment methods for massively parallel DNA sequencing von Teer, Jamie K, Bonnycastle, Lori L, Chines, Peter S, Hansen, Nancy F, Aoyama, Natsuyo, Swift, Amy J, Abaan, Hatice Ozel, Albert, Thomas J, Margulies, Elliott H, Green, Eric D, Collins, Francis S, Mullikin, James C, Biesecker, Leslie G

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Genome-wide association studies of metabolites in Finnish men identify disease-relevant loci von Yin, Xianyong, Chan, Lap Sum, Bose, Debraj, Jackson, Anne U., VandeHaar, Peter, Locke, Adam E., Fuchsberger, Christian, Stringham, Heather M., Welch, Ryan, Yu, Ketian, Fernandes Silva, Lilian, Service, Susan K., Zhang, Daiwei, Hector, Emily C., Young, Erica, Ganel, Liron, Das, Indraniel, Abel, Haley, Erdos, Michael R., Bonnycastle, Lori L., Kuusisto, Johanna, Stitziel, Nathan O., Hall, Ira M., Wagner, Gregory R., Kang, Jian, Morrison, Jean, Burant, Charles F., Collins, Francis S., Ripatti, Samuli, Palotie, Aarno, Freimer, Nelson B., Mohlke, Karen L., Scott, Laura J., Wen, Xiaoquan, Fauman, Eric B., Laakso, Markku, Boehnke, Michael

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Re-sequencing expands our understanding of the phenotypic impact of variants at GWAS loci von Service, Susan K, Teslovich, Tanya M, Fuchsberger, Christian, Ramensky, Vasily, Yajnik, Pranav, Koboldt, Daniel C, Larson, David E, Zhang, Qunyuan, Lin, Ling, Welch, Ryan, Ding, Li, McLellan, Michael D, O'Laughlin, Michele, Fronick, Catrina, Fulton, Lucinda L, Magrini, Vincent, Swift, Amy, Elliott, Paul, Jarvelin, Marjo-Riitta, Kaakinen, Marika, McCarthy, Mark I, Peltonen, Leena, Pouta, Anneli, Bonnycastle, Lori L, Collins, Francis S, Narisu, Narisu, Stringham, Heather M, Tuomilehto, Jaakko, Ripatti, Samuli, Fulton, Robert S, Sabatti, Chiara, Wilson, Richard K, Boehnke, Michael, Freimer, Nelson B

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A genomic mutational constraint map using variation in 76,156 human genomes von Chen, Siwei, Francioli, Laurent C., Goodrich, Julia K., Collins, Ryan L., Kanai, Masahiro, Wang, Qingbo, Alföldi, Jessica, Watts, Nicholas A., Vittal, Christopher, Gauthier, Laura D., Poterba, Timothy, Wilson, Michael W., Tarasova, Yekaterina, Phu, William, Grant, Riley, Yohannes, Mary T., Koenig, Zan, Farjoun, Yossi, Banks, Eric, Donnelly, Stacey, Gabriel, Stacey, Gupta, Namrata, Ferriera, Steven, Tolonen, Charlotte, Novod, Sam, Bergelson, Louis, Roazen, David, Ruano-Rubio, Valentin, Covarrubias, Miguel, Llanwarne, Christopher, Petrillo, Nikelle, Wade, Gordon, Jeandet, Thibault, Munshi, Ruchi, Tibbetts, Kathleen, O’Donnell-Luria, Anne, Solomonson, Matthew, Seed, Cotton, Martin, Alicia R., Talkowski, Michael E., Rehm, Heidi L., Daly, Mark J., Tiao, Grace, Neale, Benjamin M., MacArthur, Daniel G., Karczewski, Konrad J.

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Functional interrogation of twenty type 2 diabetes-associated genes using isogenic human embryonic stem cell-derived β-like cells von Xue, Dongxiang, Narisu, Narisu, Taylor, D Leland, Zhang, Meili, Grenko, Caleb, Taylor, Henry J, Yan, Tingfen, Tang, Xuming, Sinha, Neelam, Zhu, Jiajun, Vandana, J Jeya, Nok Chong, Angie Chi, Lee, Angela, Mansell, Erin C, Swift, Amy J, Erdos, Michael R, Zhong, Aaron, Bonnycastle, Lori L, Zhou, Ting, Chen, Shuibing, Collins, Francis S

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The mutational constraint spectrum quantified from variation in 141,456 humans von Karczewski, Konrad J., Francioli, Laurent C., Tiao, Grace, Cummings, Beryl B., Alföldi, Jessica, Wang, Qingbo, Collins, Ryan L., Laricchia, Kristen M., Ganna, Andrea, Birnbaum, Daniel P., Gauthier, Laura D., Brand, Harrison, Solomonson, Matthew, Watts, Nicholas A., Rhodes, Daniel, Singer-Berk, Moriel, England, Eleina M., Seaby, Eleanor G., Kosmicki, Jack A., Walters, Raymond K., Tashman, Katherine, Farjoun, Yossi, Banks, Eric, Poterba, Timothy, Wang, Arcturus, Seed, Cotton, Whiffin, Nicola, Chong, Jessica X., Samocha, Kaitlin E., Pierce-Hoffman, Emma, Zappala, Zachary, O’Donnell-Luria, Anne H., Minikel, Eric Vallabh, Weisburd, Ben, Lek, Monkol, Ware, James S., Vittal, Christopher, Armean, Irina M., Bergelson, Louis, Cibulskis, Kristian, Connolly, Kristen M., Covarrubias, Miguel, Donnelly, Stacey, Ferriera, Steven, Gabriel, Stacey, Gentry, Jeff, Gupta, Namrata, Jeandet, Thibault, Kaplan, Diane, Llanwarne, Christopher, Munshi, Ruchi, Novod, Sam, Petrillo, Nikelle, Roazen, David, Ruano-Rubio, Valentin, Saltzman, Andrea, Schleicher, Molly, Soto, Jose, Tibbetts, Kathleen, Tolonen, Charlotte, Wade, Gordon, Talkowski, Michael E., Neale, Benjamin M., Daly, Mark J., MacArthur, Daniel G.

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Single-cell transcriptomic profiling of human pancreatic islets reveals genes responsive to glucose exposure over 24 h von Grenko, Caleb M., Taylor, Henry J., Bonnycastle, Lori L., Xue, Dongxiang, Lee, Brian N., Weiss, Zoe, Yan, Tingfen, Swift, Amy J., Mansell, Erin C., Lee, Angela, Robertson, Catherine C., Narisu, Narisu, Erdos, Michael R., Chen, Shuibing, Collins, Francis S., Taylor, D. Leland

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Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits von Randall, Joshua C, Winkler, Thomas W, Kutalik, Zoltán, Berndt, Sonja I, Jackson, Anne U, Monda, Keri L, Kilpeläinen, Tuomas O, Esko, Tõnu, Mägi, Reedik, Li, Shengxu, Workalemahu, Tsegaselassie, Feitosa, Mary F, Croteau-Chonka, Damien C, Day, Felix R, Fall, Tove, Ferreira, Teresa, Gustafsson, Stefan, Locke, Adam E, Mathieson, Iain, Scherag, Andre, Vedantam, Sailaja, Wood, Andrew R, Liang, Liming, Steinthorsdottir, Valgerdur, Thorleifsson, Gudmar, Dermitzakis, Emmanouil T, Dimas, Antigone S, Karpe, Fredrik, Min, Josine L, Nicholson, George, Clegg, Deborah J, Person, Thomas, Krohn, Jon P, Bauer, Sabrina, Buechler, Christa, Eisinger, Kristina, Bonnefond, Amélie, Froguel, Philippe, Hottenga, Jouke-Jan, Prokopenko, Inga, Waite, Lindsay L, Harris, Tamara B, Smith, Albert Vernon, Shuldiner, Alan R, McArdle, Wendy L, Caulfield, Mark J, Munroe, Patricia B, Grönberg, Henrik, Chen, Yii-Der Ida, Li, Guo, Beckmann, Jacques S, Johnson, Toby, Thorsteinsdottir, Unnur, Teder-Laving, Maris, Khaw, Kay-Tee, Wareham, Nicholas J, Zhao, Jing Hua, Amin, Najaf, Oostra, Ben A, Kraja, Aldi T, Province, Michael A, Cupples, L Adrienne, Heard-Costa, Nancy L, Kaprio, Jaakko, Ripatti, Samuli, Surakka, Ida, Collins, Francis S, Saramies, Jouko, Tuomilehto, Jaakko, Jula, Antti, Salomaa, Veikko, Erdmann, Jeanette, Hengstenberg, Christian, Loley, Christina, Schunkert, Heribert, Lamina, Claudia, Wichmann, H Erich, Albrecht, Eva, Gieger, Christian, Hicks, Andrew A, Johansson, Asa, Pramstaller, Peter P, Kathiresan, Sekar, Speliotes, Elizabeth K, Penninx, Brenda, Hartikainen, Anna-Liisa, Jarvelin, Marjo-Riitta, Gyllensten, Ulf, Boomsma, Dorret I, Campbell, Harry, Wilson, James F, Chanock, Stephen J, Farrall, Martin, Goel, Anuj, Medina-Gomez, Carolina, Rivadeneira, Fernando, Estrada, Karol, Uitterlinden, André G, Hofman, Albert, Zillikens, M Carola

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Newly identified loci that influence lipid concentrations and risk of coronary artery disease von Willer, Cristen J, Sanna, Serena, Jackson, Anne U, Scuteri, Angelo, Bonnycastle, Lori L, Clarke, Robert, Heath, Simon C, Timpson, Nicholas J, Najjar, Samer S, Stringham, Heather M, Strait, James, Duren, William L, Maschio, Andrea, Busonero, Fabio, Mulas, Antonella, Albai, Giuseppe, Swift, Amy J, Morken, Mario A, Narisu, Narisu, Bennett, Derrick, Parish, Sarah, Shen, Haiqing, Galan, Pilar, Meneton, Pierre, Hercberg, Serge, Zelenika, Diana, Chen, Wei-Min, Li, Yun, Scott, Laura J, Scheet, Paul A, Sundvall, Jouko, Watanabe, Richard M, Nagaraja, Ramaiah, Ebrahim, Shah, Lawlor, Debbie A, Ben-Shlomo, Yoav, Davey-Smith, George, Shuldiner, Alan R, Collins, Rory, Bergman, Richard N, Uda, Manuela, Tuomilehto, Jaakko, Cao, Antonio, Collins, Francis S, Lakatta, Edward, Lathrop, G Mark, Boehnke, Michael, Schlessinger, David, Mohlke, Karen L, Abecasis, Gonçalo R

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Integrating transcriptomics, metabolomics, and GWAS helps reveal molecular mechanisms for metabolite levels and disease risk von Yin, Xianyong, Bose, Debraj, Kwon, Annie, Hanks, Sarah C., Jackson, Anne U., Stringham, Heather M., Welch, Ryan, Oravilahti, Anniina, Fernandes Silva, Lilian, Locke, Adam E., Fuchsberger, Christian, Service, Susan K., Erdos, Michael R., Bonnycastle, Lori L., Kuusisto, Johanna, Stitziel, Nathan O., Hall, Ira M., Morrison, Jean, Ripatti, Samuli, Palotie, Aarno, Freimer, Nelson B., Collins, Francis S., Mohlke, Karen L., Scott, Laura J., Fauman, Eric B., Burant, Charles, Boehnke, Michael, Laakso, Markku, Wen, Xiaoquan

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Noncoding variants alter GATA2 expression in rhombomere 4 motor neurons and cause dominant hereditary congenital facial paresis von Tenney, Alan P., Di Gioia, Silvio Alessandro, Webb, Bryn D., Chan, Wai-Man, de Boer, Elke, Garnai, Sarah J., Barry, Brenda J., Ray, Tammy, Kosicki, Michael, Robson, Caroline D., Zhang, Zhongyang, Collins, Thomas E., Gelber, Alon, Pratt, Brandon M., Fujiwara, Yuko, Varshney, Arushi, Lek, Monkol, Warburton, Peter E., Van Ryzin, Carol, Lehky, Tanya J., Zalewski, Christopher, King, Kelly A., Brewer, Carmen C., Thurm, Audrey, Snow, Joseph, Facio, Flavia M., Narisu, Narisu, Bonnycastle, Lori L., Swift, Amy, Chines, Peter S., Bell, Jessica L., Mohan, Suresh, Whitman, Mary C., Staffieri, Sandra E., Elder, James E., Demer, Joseph L., Torres, Alcy, Rachid, Elza, Al-Haddad, Christiane, Boustany, Rose-Mary, Mackey, David A., Brady, Angela F., Fenollar-Cortés, María, Fradin, Melanie, Kleefstra, Tjitske, Padberg, George W., Raskin, Salmo, Sato, Mario Teruo, Orkin, Stuart H., Parker, Stephen C. J., Hadlock, Tessa A., Vissers, Lisenka E. L. M., van Bokhoven, Hans, Jabs, Ethylin Wang, Collins, Francis S., Pennacchio, Len A., Manoli, Irini, Engle, Elizabeth C.

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Genetic effects on liver chromatin accessibility identify disease regulatory variants von Currin, Kevin W., Erdos, Michael R., Narisu, Narisu, Rai, Vivek, Vadlamudi, Swarooparani, Perrin, Hannah J., Idol, Jacqueline R., Yan, Tingfen, Albanus, Ricardo D’Oliveira, Broadaway, K. Alaine, Etheridge, Amy S., Bonnycastle, Lori L., Orchard, Peter, Didion, John P., Chaudhry, Amarjit S., Barnabas, Beatrice B., Black, Sean, Bouffard, Gerard G., Brooks, Shelise Y., Coleman, Holly, Dekhtyar, Lyudmila, Han, Joel, Ho, Shi-ling, Kim, Juyun, Legaspi, Richelle, Maduro, Quino L., Masiello, Catherine A., McDowell, Jennifer C., Montemayor, Casandra, Mullikin, James C., Park, Morgan, Riebow, Nancy L., Schandler, Karen, Schmidt, Brian, Sison, Christina, Stantripop, Sirintorn, Thomas, James W., Thomas, Pamela J., Vemulapalli, Meghana, Young, Alice C., Innocenti, Federico, Schuetz, Erin G., Scott, Laura J., Parker, Stephen C.J., Collins, Francis S., Mohlke, Karen L.

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A structural variation reference for medical and population genetics von Collins, Ryan L., Brand, Harrison, Karczewski, Konrad J., Zhao, Xuefang, Alföldi, Jessica, Francioli, Laurent C., Khera, Amit V., Lowther, Chelsea, Gauthier, Laura D., Wang, Harold, Watts, Nicholas A., Solomonson, Matthew, O’Donnell-Luria, Anne, Baumann, Alexander, Munshi, Ruchi, Walker, Mark, Whelan, Christopher W., Huang, Yongqing, Brookings, Ted, Sharpe, Ted, Stone, Matthew R., Valkanas, Elise, Fu, Jack, Tiao, Grace, Laricchia, Kristen M., Ruano-Rubio, Valentin, Stevens, Christine, Gupta, Namrata, Cusick, Caroline, Margolin, Lauren, Taylor, Kent D., Lin, Henry J., Rich, Stephen S., Post, Wendy S., Chen, Yii-Der Ida, Rotter, Jerome I., Nusbaum, Chad, Philippakis, Anthony, Lander, Eric, Gabriel, Stacey, Neale, Benjamin M., Kathiresan, Sekar, Daly, Mark J., Banks, Eric, MacArthur, Daniel G., Talkowski, Michael E.

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Adipose tissue eQTL meta-analysis highlights the contribution of allelic heterogeneity to gene expression regulation and cardiometabolic traits von Brotman, Sarah M., El-Sayed Moustafa, Julia S., Guan, Li, Broadaway, K. Alaine, Wang, Dongmeng, Jackson, Anne U., Welch, Ryan, Currin, Kevin W., Tomlinson, Max, Vadlamudi, Swarooparani, Stringham, Heather M., Roberts, Amy L., Lakka, Timo A., Oravilahti, Anniina, Fernandes Silva, Lilian, Narisu, Narisu, Erdos, Michael R., Yan, Tingfen, Bonnycastle, Lori L., Raulerson, Chelsea K., Raza, Yasrab, Yan, Xinyu, Parker, Stephen C. J., Kuusisto, Johanna, Pajukanta, Päivi, Tuomilehto, Jaakko, Collins, Francis S., Boehnke, Michael, Love, Michael I., Koistinen, Heikki A., Laakso, Markku, Mohlke, Karen L., Small, Kerrin S., Scott, Laura J.

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Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function von Pattaro, Cristian, Teumer, Alexander, Tin, Adrienne, Sorice, Rossella, Foster, Meredith, Johnson, Andrew D., Nalls, Michael, Dehghan, Abbas, Dieffenbach, Aida Karina, Nolte, Ilja M., van der Most, Peter J., Shuldiner, Alan R., Morrison, Alanna C., Hofman, Albert, Lupo, Antonio, Robino, Antonietta, Johansson, Åsa, Freedman, Barry I., Mitchell, Braxton D., Hayward, Caroline, Shaffer, Christian M., Toniolo, Daniela, Lu, Yingchang, Siscovick, David S., Ruderfer, Douglas, Atkinson, Elizabeth J., Boerwinkle, Eric, Rivadeneira, Fernando, Hu, Frank B., Navis, Gerjan J., Curhan, Gary C., Ehret, George B., Coassin, Stefan, Thun, Gian-Andri, Eiriksdottir, Gudny, Wichmann, H-Erich, Brenner, Hermann, Ford, Ian, Guessous, Idris, Rudan, Igor, Heid, Iris M., Kolcic, Ivana, Persico, Ivana, Jukema, J. Wouter, Wilson, James F., Divers, Jasmin, Stafford, Jeanette M., Smith, Jennifer A., Wang, Jie Jin, Viikari, Jorma, Coresh, Josef, Butterbach, Katja, Lohman, Kurt, Portas, Laura, Lyytikäinen, Leo-Pekka, Yengo, Loic, Ferrucci, Luigi, Cavalieri, Margherita, Haun, Margot, Pirastu, Mario, McEvoy, Mark A., Woodward, Mark, Adam, Martin, Nauck, Matthias, Stumvoll, Michael, Sale, Michele M., Boban, Mladen, Bochud, Murielle, Verweij, Niek, Probst-Hensch, Nicole, Soranzo, Nicole, Gottesman, Omri, Polasek, Ozren, Ridker, Paul M., Mitchell, Paul, Muntner, Paul, Meisinger, Christa, Smit, Johannes H., Wild, Philipp S., Biffar, Reiner, Carroll, Robert J., Penninx, Brenda W., Scott, Rodney J., Katz, Ronit, Hwang, Shih-Jen, Kloiber, Stefan, Rosas, Sylvia E., Harris, Tamara B., Aspelund, Thor, Nikopensius, Tiit, Chen, Wei-Min, Igl, Wilmar, Lieb, Wolfgang, Loos, Ruth J. F., Liu, Yongmei, Parsa, Afshin, Hamet, Pavel, Tremblay, Johanne, Goessling, Wolfram, Fox, Caroline S.

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