Structure-Based Design of a Novel SMYD3 Inhibitor that Bridges the SAM-and MEKK2-Binding Pockets von Van Aller, Glenn S., Graves, Alan P., Elkins, Patricia A., Bonnette, William G., McDevitt, Patrick J., Zappacosta, Francesca, Annan, Roland S., Dean, Tony W., Su, Dai-Shi, Carpenter, Christopher L., Mohammad, Helai P., Kruger, Ryan G.

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A DNA Hypomethylation Signature Predicts Antitumor Activity of LSD1 Inhibitors in SCLC von Mohammad, Helai P., Smitheman, Kimberly N., Kamat, Chandrashekhar D., Soong, David, Federowicz, Kelly E., Van Aller, Glenn S., Schneck, Jess L., Carson, Jeffrey D., Liu, Yan, Butticello, Michael, Bonnette, William G., Gorman, Shelby A., Degenhardt, Yan, Bai, Yuchen, McCabe, Michael T., Pappalardi, Melissa B., Kasparec, Jiri, Tian, Xinrong, McNulty, Kenneth C., Rouse, Meagan, McDevitt, Patrick, Ho, Thau, Crouthamel, Michelle, Hart, Timothy K., Concha, Nestor O., McHugh, Charles F., Miller, William H., Dhanak, Dashyant, Tummino, Peter J., Carpenter, Christopher L., Johnson, Neil W., Hann, Christine L., Kruger, Ryan G.

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Fragment-Guided Discovery of Pyrazole Carboxylic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2 Related Factor 2 (KEAP1:NRF2) Protein−Protei... von Norton, David, Bonnette, William G, Callahan, James F, Carr, Maria G, Griffiths-Jones, Charlotte M, Heightman, Tom D, Kerns, Jeffrey K, Nie, Hong, Rich, Sharna J, Richardson, Caroline, Rumsey, William, Sanchez, Yolanda, Verdonk, Marcel L, Willems, Henriëtte M. G, Wixted, William E, Woolford, Alison J.-A, Wu, Zining, Davies, Thomas G

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Gut-Restricted Selective Cyclooxygenase‑2 (COX-2) Inhibitors for Chemoprevention of Colorectal Cancer von Zhang, Zhuming, Ghosh, Avijit, Connolly, Peter J, King, Peter, Wilde, Thomas, Wang, Jianyao, Dong, Yawei, Li, Xueliang, Liao, Daohong, Chen, Hao, Tian, Gaochao, Suarez, Javier, Bonnette, William G, Pande, Vineet, Diloreto, Karen A, Shi, Yifan, Patel, Shefali, Pietrak, Beth, Szewczuk, Lawrence, Sensenhauser, Carlo, Dallas, Shannon, Edwards, James P, Bachman, Kurtis E, Evans, David C

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Development of a high-content imaging assay for screening compound aggregation von Jiang, Yong, Hoffman, Ann, Quinque, Geoffrey, Bonnette, William G., Szewczuk, Lawrence M., Holbert, Marc A., Gross, Jeffrey

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Modular Protein Ligation: A New Paradigm as a Reagent Platform for Pre-Clinical Drug Discovery von Matico, Rosalie, Szewczuk, Lawrence M., Pietrak, Beth, Chen, Stephanie, Dul, Ed, Bonnette, William G., Meinhold, Derrick W., Quinque, Geoffrey, Totoritis, Rachel, Lewis, Tia, Grimes, Maggie, Fornwald, Daniel, McCormick, Patricia M., Schaber, Michael, Jiang, Yong, Bledsoe, Randy, Holbert, Marc A.

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A High-Throughput Dose-Response Cellular Thermal Shift Assay for Rapid Screening of Drug Target Engagement in Living Cells, Exemplified Using SMYD3 and IDO1 von McNulty, Dean E., Bonnette, William G., Qi, Hongwei, Wang, Liping, Ho, Thau F., Waszkiewicz, Anna, Kallal, Lorena A., Nagarajan, Raman P., Stern, Melissa, Quinn, Amy M., Creasy, Caretha L., Su, Dai-Shi, Graves, Alan P., Annan, Roland S., Sweitzer, Sharon M., Holbert, Marc A.

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