Discovery of Inducible Nitric Oxide Synthase (iNOS) Inhibitor Development Candidate KD7332, Part 1: Identification of a Novel, Potent, and Selective Series of Quinolinone iNOS Dime... von Bonnefous, Céline, Payne, Joseph E, Roppe, Jeffrey, Zhuang, Hui, Chen, Xiaohong, Symons, Kent T, Nguyen, Phan M, Sablad, Marciano, Rozenkrants, Natasha, Zhang, Yan, Wang, Li, Severance, Daniel, Walsh, John P, Yazdani, Nahid, Shiau, Andrew K, Noble, Stewart A, Rix, Peter, Rao, Tadimeti S, Hassig, Christian A, Smith, Nicholas D

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ARN-509: A Novel Antiandrogen for Prostate Cancer Treatment von CLEGG, Nicola J, WONGVIPAT, John, APARICIO, Anna, DOROW, Steven, ARORA, Vivek, GANG SHAO, JING QIAN, HONG ZHAO, GUANGBIN YANG, CHUNYAN CAO, SENSINTAFFAR, John, WASIELEWSKA, Teresa, JOSEPH, James D, HERBERT, Mark R, BONNEFOUS, Celine, DARIMONT, Beatrice, SCHER, Howard I, SMITH-JONES, Peter, KLANG, Mark, SMITH, Nicholas D, DE STANCHINA, Elisa, NIAN WU, OUERFELLI, Ouathek, TRAN, Chris, RIX, Peter J, HEYMAN, Richard A, JUNG, Michael E, SAWYERS, Charles L, HAGER, Jeffrey H, OUK, Samedy, DILHAS, Anna, YU CHEN, GRILLOT, Kate, BISCHOFF, Eric D, LING CAI

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KLYP956 Is a Non-Imidazole-Based Orally Active Inhibitor of Nitric-Oxide Synthase Dimerization von Symons, Kent T, Massari, Mark E, Nguyen, Phan M, Lee, Tom T, Roppe, Jeffrey, Bonnefous, Céline, Payne, Joseph E, Smith, Nicholas D, Noble, Stewart A, Sablad, Marciano, Rozenkrants, Natasha, Zhang, Yan, Rao, Tadimeti S, Shiau, Andrew K, Hassig, Christian A

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Discovery of Dual Inducible/Neuronal Nitric Oxide Synthase (iNOS/nNOS) Inhibitor Development Candidate 4-((2-Cyclobutyl-1H-imidazo[4,5-b]pyrazin-1-yl)methyl)-7,8-difluoroquinolin-2... von Payne, Joseph E, Bonnefous, Céline, Symons, Kent T, Nguyen, Phan M, Sablad, Marciano, Rozenkrants, Natasha, Zhang, Yan, Wang, Li, Yazdani, Nahid, Shiau, Andrew K, Noble, Stewart A, Rix, Peter, Rao, Tadimeti S, Hassig, Christian A, Smith, Nicholas D

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The selective estrogen receptor downregulator GDC-0810 is efficacious in diverse models of ER+ breast cancer von Joseph, James D, Darimont, Beatrice, Zhou, Wei, Arrazate, Alfonso, Young, Amy, Ingalla, Ellen, Walter, Kimberly, Blake, Robert A, Nonomiya, Jim, Guan, Zhengyu, Kategaya, Lorna, Govek, Steven P, Lai, Andiliy G, Kahraman, Mehmet, Brigham, Dan, Sensintaffar, John, Lu, Nhin, Shao, Gang, Qian, Jing, Grillot, Kate, Moon, Michael, Prudente, Rene, Bischoff, Eric, Lee, Kyoung-Jin, Bonnefous, Celine, Douglas, Karensa L, Julien, Jackaline D, Nagasawa, Johnny Y, Aparicio, Anna, Kaufman, Josh, Haley, Benjamin, Giltnane, Jennifer M, Wertz, Ingrid E, Lackner, Mark R, Nannini, Michelle A, Sampath, Deepak, Schwarz, Luis, Manning, Henry Charles, Tantawy, Mohammed Noor, Arteaga, Carlos L, Heyman, Richard A, Rix, Peter J, Friedman, Lori, Smith, Nicholas D, Metcalfe, Ciara, Hager, Jeffrey H

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Heteroaromatic-aminomethyl quinolones: Potent and selective iNOS inhibitors von Durón, Sergio G., Lindstrom, Andrew, Bonnefous, Céline, Zhang, Hui, Chen, Xiaohong, Symons, Kent T., Sablad, Marciano, Rozenkrants, Natasha, Zhang, Yan, Wang, Li, Yazdani, Nahid, Shiau, Andrew K., Noble, Stewart A., Rix, Peter, Rao, Tadimeti S., Hassig, Christian A., Smith, Nicholas D.

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KD5170, a novel mercaptoketone-based histone deacetylase inhibitor that exhibits broad spectrum antitumor activity in vitro and in vivo von Hassig, Christian A, Symons, Kent T, Guo, Xin, Nguyen, Phan-Manh, Annable, Tami, Wash, Paul L, Payne, Joseph E, Jenkins, David A, Bonnefous, Céline, Trotter, Carol, Wang, Yan, Anzola, John V, Milkova, Elena L, Hoffman, Timothy Z, Dozier, Sara J, Wiley, Brandon M, Saven, Alan, Malecha, James W, Davis, Robert L, Muhammad, Jerry, Shiau, Andrew K, Noble, Stewart A, Rao, Tadimeti S, Smith, Nicholas D, Hager, Jeffrey H

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α-Mercaptoketone based histone deacetylase inhibitors von Wash, Paul L., Hoffman, Timothy Z., Wiley, Brandon M., Bonnefous, Céline, Smith, Nicholas D., Sertic, Michael S., Lawrence, Charles M., Symons, Kent T., Nguyen, Phan-Manh, Lustig, Kevin D., Guo, Xin, Annable, Tami, Noble, Stewart A., Hager, Jeffrey H., Hassig, Christian A., Malecha, James W.

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Six-Membered Ring Chelate Complexes of Ru(II):  Structural and Photophysical Effects von Abrahamsson, Maria, Becker, Hans-Christian, Hammarström, Leif, Bonnefous, Celine, Chamchoumis, Charles, Thummel, Randolph P

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Synthesis, characterization, and first successful monkey imaging studies of metabotropic glutamate receptor subtype 5 (mGluR5) PET radiotracers von Hamill, Terence G., Krause, Stephen, Ryan, Christine, Bonnefous, Celine, Govek, Steve, Seiders, T. Jon, Cosford, Nicholas D.P., Roppe, Jeffrey, Kamenecka, Ted, Patel, Shil, Gibson, Raymond E., Sanabria, Sandra, Riffel, Kerry, Eng, Waisi, King, Christopher, Yang, Xiaoqing, Green, Mitchell D., O'malley, Stacey S., Hargreaves, Richard, Burns, H. Donald

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Correction: The selective estrogen receptor downregulator GDC-0810 is efficacious in diverse models of ER+ breast cancer von Joseph, James D, Darimont, Beatrice, Zhou, Wei, Arrazate, Alfonso, Young, Amy, Ingalla, Ellen, Walter, Kimberly, Blake, Robert A, Nonomiya, Jim, Guan, Zhengyu, Kategaya, Lorna, Govek, Steven P, Lai, Andiliy G, Kahraman, Mehmet, Brigham, Dan, Sensintaffar, John, Lu, Nhin, Shao, Gang, Qian, Jing, Grillot, Kate, Moon, Michael, Prudente, Rene, Bischoff, Eric, Lee, Kyoung-Jin, Bonnefous, Celine, Douglas, Karensa L, Julien, Jackaline D, Nagasawa, Johnny Y, Aparicio, Anna, Kaufman, Josh, Haley, Benjamin, Giltnane, Jennifer M, Wertz, Ingrid E, Lackner, Mark R, Nannini, Michelle A, Sampath, Deepak, Schwarz, Luis, Manning, Henry Charles, Tantawy, Mohammed Noor, Arteaga, Carlos L, Heyman, Richard A, Rix, Peter J, Friedman, Lori, Smith, Nicholas D, Metcalfe, Ciara, Hager, Jeffrey H

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Identification of KD5170 : A novel mercaptoketone-based histone deacetylase inhibitor von PAYNE, Joseph E, BONNEFOUS, Céline, SHIAU, Andrew K, MALECHA, James W, NOBLE, Stewart A, HAGER, Jeffrey H, SMITH, Nicholas D, HASSIG, Christian A, SYMONS, Kent T, XIN GUO, NGUYEN, Phan-Manh, ANNABLE, Tami, WASH, Paul L, HOFFMAN, Timothy Z, RAO, Tadimeti S

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Identification of GDC-0810 (ARN-810), an Orally Bioavailable Selective Estrogen Receptor Degrader (SERD) that Demonstrates Robust Activity in Tamoxifen-Resistant Breast Cancer Xeno... von Lai, Andiliy, Kahraman, Mehmet, Govek, Steven, Nagasawa, Johnny, Bonnefous, Celine, Julien, Jackie, Douglas, Karensa, Sensintaffar, John, Lu, Nhin, Lee, Kyoung-jin, Aparicio, Anna, Kaufman, Josh, Qian, Jing, Shao, Gang, Prudente, Rene, Moon, Michael J, Joseph, James D, Darimont, Beatrice, Brigham, Daniel, Grillot, Kate, Heyman, Richard, Rix, Peter J, Hager, Jeffrey H, Smith, Nicholas D

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Cyclometalated Complexes of Ru(II) with 2-Aryl Derivatives of Quinoline and 1,10-Phenanthroline von Bonnefous, Céline, Chouai, Abdellatif, Thummel, Randolph P

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Identification of an Orally Bioavailable Chromene-Based Selective Estrogen Receptor Degrader (SERD) That Demonstrates Robust Activity in a Model of Tamoxifen-Resistant Breast Cance... von Nagasawa, Johnny, Govek, Steven, Kahraman, Mehmet, Lai, Andiliy, Bonnefous, Celine, Douglas, Karensa, Sensintaffar, John, Lu, Nhin, Lee, KyoungJin, Aparicio, Anna, Kaufman, Josh, Qian, Jing, Shao, Gang, Prudente, Rene, Joseph, James D, Darimont, Beatrice, Brigham, Daniel, Maheu, Kate, Heyman, Richard, Rix, Peter J, Hager, Jeffrey H, Smith, Nicholas D

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Dipyridyl amides: potent metabotropic glutamate subtype 5 (mGlu5) receptor antagonists von Bonnefous, Céline, Vernier, Jean-Michel, Hutchinson, John H., Chung, Janice, Reyes-Manalo, Grace, Kamenecka, Theodore

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Biphenyl-indanones: Allosteric potentiators of the metabotropic glutamate subtype 2 receptor von Bonnefous, Céline, Vernier, Jean-Michel, Hutchinson, John H., Gardner, Michael F., Cramer, Merryl, James, Joyce K., Rowe, Blake A., Daggett, Lorrie P., Schaffhauser, Hervé, Kamenecka, Theodore M.

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Maximizing ER‑α Degradation Maximizes Activity in a Tamoxifen-Resistant Breast Cancer Model: Identification of GDC-0927 von Kahraman, Mehmet, Govek, Steven P, Nagasawa, Johnny Y, Lai, Andiliy, Bonnefous, Celine, Douglas, Karensa, Sensintaffar, John, Liu, Nhin, Lee, KyoungJin, Aparicio, Anna, Kaufman, Josh, Qian, Jing, Shao, Gang, Prudente, Rene, Joseph, James D, Darimont, Beatrice, Brigham, Daniel, Heyman, Richard, Rix, Peter J, Hager, Jeffrey H, Smith, Nicholas D

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Optimization of an indazole series of selective estrogen receptor degraders: Tumor regression in a tamoxifen-resistant breast cancer xenograft von Govek, Steven P., Nagasawa, Johnny Y., Douglas, Karensa L., Lai, Andiliy G., Kahraman, Mehmet, Bonnefous, Celine, Aparicio, Anna M., Darimont, Beatrice D., Grillot, Katherine L., Joseph, James D., Kaufman, Joshua A., Lee, Kyoung-Jin, Lu, Nhin, Moon, Michael J., Prudente, Rene Y., Sensintaffar, John, Rix, Peter J., Hager, Jeffrey H., Smith, Nicholas D.

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Selective estrogen receptor degraders with novel structural motifs induce regression in a tamoxifen-resistant breast cancer xenograft von Govek, Steven P., Bonnefous, Celine, Julien, Jackaline D., Nagasawa, Johnny Y., Kahraman, Mehmet, Lai, Andiliy G., Douglas, Karensa L., Aparicio, Anna M., Darimont, Beatrice D., Grillot, Katherine L., Joseph, James D., Kaufman, Joshua A., Lee, Kyoung-Jin, Lu, Nhin, Moon, Michael J., Prudente, Rene Y., Sensintaffar, John, Rix, Peter J., Hager, Jeffrey H., Smith, Nicholas D.

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