2.242 BRAIN AND PERIPHERAL LEVODOPA PHARMACOKINETICS IN THE CYNOMOLGUS MONKEY FOLLOWING ADMINISTRATION OF OPICAPONE, A NOVEL CATECHOL-O-METHYLTRANSFERASE INHIBITOR von Bonifacio, M.J, Sutcliffe, J.S, Torrão, L, Wright, L, Soares-da-Silva, P

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2.241 COMPUTATION OF BINDING AFFINITY OF CATECHOL-O-METHYLTRANSFERASE-OPICAPONE COMPLEXES von Palma, N, Bonifacio, M.J, Loureiro, A.I, Soares-da-Silva, P

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2.243 OPICAPONE: CHARACTERIZATION OF A NOVEL PERIPHERAL LONG-ACTING CATECHOL- O -METHYLTRANSFERASE INHIBITOR von Bonifacio, M.J, Torrão, L, Loureiro, A.I, Wright, L.C, Soares-da-Silva, P

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Optimization of fermentation conditions for the production of human soluble catechol-O-methyltransferase by Escherichia coli using artificial neural network von Silva, R., Ferreira, S., Bonifácio, M.J., Dias, J.M.L., Queiroz, J.A., Passarinha, L.A.

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A novel prokaryotic expression system for biosynthesis of recombinant human membrane-bound catechol- O-methyltransferase von Pedro, A.Q., Bonifácio, M.J., Queiroz, J.A., Maia, C.J., Passarinha, L.A.

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Potential drug toxicity of nitrocatechol COMT inhibitors in HepaRG von Bonifacio, M.J., Sousa, F., Soares-da-Silva, P.

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Analysis of hSCOMT adsorption in bioaffinity chromatography with immobilized amino acids: The influence of pH and ionic strength von Costa, S.R., Bonifácio, M.J., Queiroz, J.A., Passarinha, L.A.

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Recovery of biological active catechol‐O‐methyltransferase isoforms from Q‐sepharose von Correia, F. F, Santos, F. M, Pedro, A. Q, Bonifácio, M. J, Queiroz, J. A, Passarinha, L. A

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Development of fed-batch profiles for efficient biosynthesis of catechol-O-methyltransferase von Espírito Santo, G.M., Pedro, A.Q., Oppolzer, D., Bonifácio, M.J., Queiroz, J.A., Silva, F., Passarinha, L.A.

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Opicapone improves the effects of l-dopa on the mptp-induced parkinson’s-like syndrome in cynomolgus monkeys von Bonifácio, M.J., Sousa, F., Soares-da-Silva, P.

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P.190 Mexazolam main metabolite chlorordiazepam affinity to different GABAa a3 receptor subtypes. A comparison with Alprazolam von Fernandes, H., Batalha, V.L., Bonifácio, M.J., Vieira-Coelho, M.A., Soares-da-Silva, P.

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Brain and peripheral pharmacokinetics of levodopa in the cynomolgus monkey following administration of opicapone, a third generation nitrocatechol COMT inhibitor von Bonifácio, M.J., Sutcliffe, J.S., Torrão, L., Wright, L.C., Soares-da-Silva, P.

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Application of a Fed-Batch Bioprocess for the Heterologous Production of hSCOMT in Escherichia coli von Passarinha, L.A., CICS, Universidade da Beira Interior, Covilha, Portugal, Bonifacio, M.J., Departamento de Investigacao e Desenvolvimento, Sao Mamede do Coronado, Portugal, Queiroz, J.A., CICS, Universidade da Beira Interior, Covilha, Portugal

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A new approach on the purification of recombinant human soluble catechol- O-methyltransferase from an Escherichia coli extract using hydrophobic interaction chromatography von Passarinha, L.A., Bonifácio, M.J., Soares-da-Silva, P., Queiroz, J.A.

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Application of a Fed-Batch Bioprocess for the Heterologous Production of hSCOMT in Escherichia coli von Passarinha, L.A, Bonifacio, M.J, Queiroz, J.A

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Comparative Study of ortho- and meta-Nitrated Inhibitors of Catechol-O-methyltransferase: Interactions with the Active Site and Regioselectivity of O-Methylation von Palma, P.N., Rodrigues, M.L., Archer, M., Bonifácio, M.J., Loureiro, A.I., Learmonth, D.A., Carrondo, M.A., Soares-da-Silva, P.

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Implementation of new strategies for COMT isolation, stability and laboratory storage von Passarinha, L., Nunes, V., Queiroz, J., Bonifácio, M.J.

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A super lithium-rich red-clump star in the open cluster Trumpler 5 von Monaco, L., Boffin, H. M. J., Bonifacio, P., Villanova, S., Carraro, G., Caffau, E., Steffen, M., Ahumada, J. A., Beletsky, Y., Beccari, G.

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A combined risk score enhances prediction of type 1 diabetes among susceptible children von Ferrat, Lauric A., Vehik, Kendra, Sharp, Seth A., Lernmark, Åke, Rewers, Marian J., She, Jin-Xiong, Ziegler, Anette-G., Toppari, Jorma, Akolkar, Beena, Krischer, Jeffrey P., Weedon, Michael N., Oram, Richard A., Hagopian, William A.

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Low-Energy Argon Broad Ion Beam and Narrow Ion Beam Milling of In Situ Lift-Out FIB Specimens von Campin, M.J., Bonifacio, C.S., Fischione, P.E.

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