SHOC2–MRAS–PP1 complex positively regulates RAF activity and contributes to Noonan syndrome pathogenesis von Young, Lucy C., Hartig, Nicole, del Río, Isabel Boned, Sari, Sibel, Ringham-Terry, Benjamin, Wainwright, Joshua R., Jones, Greg G., McCormick, Frank, Rodriguez-Viciana, Pablo

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SHOC2 phosphatase-dependent RAF dimerization mediates resistance to MEK inhibition in RAS-mutant cancers von Jones, Greg G., del Río, Isabel Boned, Sari, Sibel, Sekerim, Aysen, Young, Lucy C., Hartig, Nicole, Areso Zubiaur, Itziar, El-Bahrawy, Mona A., Hynds, Rob E., Lei, Winnie, Molina-Arcas, Miriam, Downward, Julian, Rodriguez-Viciana, Pablo

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SHOC2 complex-driven RAF dimerization selectively contributes to ERK pathway dynamics von del Río, Isabel Boned, Young, Lucy C., Sari, Sibel, Jones, Greg G., Ringham-Terry, Benjamin, Hartig, Nicole, Rejnowicz, Ewa, Lei, Winnie, Bhamra, Amandeep, Surinova, Silvia, Rodriguez-Viciana, Pablo

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Localized immune surveillance of primary melanoma in the skin deciphered through executable modeling von Howell, Rowan, Davies, James, Clarke, Matthew A, Appios, Anna, Mesquita, Inês, Jayal, Yashoda, Ringham-Terry, Ben, Boned Del Rio, Isabel, Fisher, Jasmin, Bennett, Clare L

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Abstract PR05: Selective contribution of the SHOC2 phosphatase complex to ERK pathway dynamics highlights its potential as a therapeutic target von Boned del Rio, Isabel, Young, Lucy C., Sari, Sibel, Jones, Greg G., Bhamra, Amandeep, Surinova, Silvia, Rodriguez-Viciana, Pablo

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Abstract B26: The SHOC2 phosphatase complex as a therapeutic target for ERK-pathway inhibition in RAS-driven tumors von Jones, Greg G., Del Rio, Isabel Boned, Sari, Sibel, Sekerim, Aysen, Young, Lucy C., Hartig, Nicole, El-Bahrawy, Mona A., Molina-Arcas, Miriam, Downward, Julian, Rodriguez-Viciana, Pablo

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Abstract A19: Conditional inactivation of SHOC2 in adult mice to study its role in tissue homeostasis von Sari, Sibel, Boned del Rio, Isabel, Jones, Greg, Henry, Jake, De Las Nieves Amalia Peltzer, Maria, Posor, York, Quezada, Sergio, Rodriguez-Viciana, Pablo

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Therapeutic potential of SHOC2 via its selective contribution of the ERK pathway activation von Boned del Río, Isabel

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