mTOR regulates metabolic adaptation of APCs in the lung and controls the outcome of allergic inflammation von Sinclair, Charles, Bommakanti, Gayathri, Gardinassi, Luiz, Loebbermann, Jens, Johnson, Matthew Joseph, Hakimpour, Paul, Hagan, Thomas, Benitez, Lydia, Todor, Andrei, Machiah, Deepa, Oriss, Timothy, Ray, Anuradha, Bosinger, Steven, Ravindran, Rajesh, Li, Shuzhao, Pulendran, Bali

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Lamprey Variable Lymphocyte Receptor Monoclonal Antibodies for Whole-Cell Surface Antigens von Bommakanti, Gayathri

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Design of an HA2-based Escherichia coli expressed influenza immunogen that protects mice from pathogenic challenge von Bommakanti, Gayathri, Citron, Michael P., Hepler, Robert W., Callahan, Cheryl, Heidecker, Gwendolyn J., Najar, Tariq Ahmad, Lu, Xianghan, Joyce, Joseph G., Shiver, John W., Casimiro, Danilo R., Meulen, Jan ter, Liang, Xiaoping, Varadarajan, Raghavan, Kim, Peter S.

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Design of Escherichia coli-Expressed Stalk Domain Immunogens of H1N1 Hemagglutinin That Protect Mice from Lethal Challenge von BOMMAKANTI, Gayathri, XIANGHAN LU, CITRON, Michael P, AHMAD NAJAR, Tariq, HEIDECKER, Gwendolyn J, MEULEN, Jan Ter, VARADARAJAN, Raghavan, XIAOPING LIANG

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STAT3 Antisense Oligonucleotide Remodels the Suppressive Tumor Microenvironment to Enhance Immune Activation in Combination with Anti-PD-L1 von Proia, Theresa A., Singh, Maneesh, Woessner, Richard, Carnevalli, Larissa, Bommakanti, Gayathri, Magiera, Lukasz, Srinivasan, Srimathi, Grosskurth, Shaun, Collins, Mike, Womack, Chris, Griffin, Matthew, Ye, Minwei, Cantin, Susan, Russell, Deanna, Xie, Mingchao, Hughes, Adina, Deng, Nanhua, Mele, Deanna A., Fawell, Stephen, Barry, Simon, Reimer, Corinne, Barrett, J. Carl, McCoon, Patricia

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Ancient BCMA -like Genes Herald B Cell Regulation in Lampreys von Das, Sabyasachi, Sutoh, Yoichi, Cancro, Michael P, Rast, Jonathan P, Han, Qifeng, Bommakanti, Gayathri, Cooper, Max D, Hirano, Masayuki

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Accelerated Discovery of Carbamate Cbl‑b Inhibitors Using Generative AI Models and Structure-Based Drug Design von Quinn, Taylor R., Giblin, Kathryn A., Thomson, Clare, Boerth, Jeffrey A., Bommakanti, Gayathri, Braybrooke, Erin, Chan, Christina, Chinn, Alex J., Code, Erin, Cui, Caifeng, Fan, Yukai, Grimster, Neil P., Kohara, Keishi, Lamb, Michelle L., Ma, Lina, Mfuh, Adelphe M., Robb, Graeme R., Robbins, Kevin J., Schimpl, Marianne, Tang, Haoran, Ware, Jamie, Wrigley, Gail L., Xue, Lin, Zhang, Yun, Zhu, Huimin, Hughes, Samantha J.

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Discovery, Optimization, and Biological Evaluation of Arylpyridones as Cbl‑b Inhibitors von Mfuh, Adelphe M., Boerth, Jeffrey A., Bommakanti, Gayathri, Chan, Christina, Chinn, Alex J., Code, Erin, Fricke, Patrick J., Giblin, Kathryn A., Gohlke, Andrea, Hansel, Catherine, Hariparsad, Niresh, Hughes, Samantha J., Jin, Meizhong, Kantae, Vasudev, Kavanagh, Stefan L., Lamb, Michelle L., Lane, Jordan, Moore, Rachel, Puri, Taranee, Quinn, Taylor R., Reddy, Iswarya, Robb, Graeme R., Robbins, Kevin J., Gancedo Rodrigo, Miguel, Schimpl, Marianne, Singh, Baljinder, Singh, Meha, Tang, Haoran, Thomson, Clare, Walsh, Jarrod J., Ware, Jamie, Watson, Iain D. G., Ye, Min-Wei, Wrigley, Gail L., Zhang, Andrew X., Zhang, Yun, Grimster, Neil P.

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1405 A CRISPR-Cas9 screen identifies novel epigenetic regulators of T cell exhaustion von Bommakanti, Gayathri, Jaensch, Elizabeth, Gorthi, Aparna, Tan, Sin Lih, Brucklacher-Waldert, Verena, Criscione, Steven, Mele, Deanna

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Critical roles for mTOR signaling in DC homeostasis and function (INC6P.306) von Sinclair, Charles, Loebbermann, Jens, Ravindran, Rajesh, Johnson, Matthew, Bommakanti, Gayathri, Li, Shuzhao, PULENDRAN, BALI

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Discovery of a Novel Benzodiazepine Series of Cbl‑b Inhibitors for the Enhancement of Antitumor Immunity von Boerth, Jeffrey A., Chinn, Alex J., Schimpl, Marianne, Bommakanti, Gayathri, Chan, Christina, Code, Erin L., Giblin, Kathryn A., Gohlke, Andrea, Hansel, Catherine S., Jin, Meizhong, Kavanagh, Stefan L., Lamb, Michelle L., Lane, Jordan S., Larner, Carrie J. B., Mfuh, Adelphe M., Moore, Rachel K., Puri, Taranee, Quinn, Taylor R., Ye, Minwei, Robbins, Kevin J., Gancedo-Rodrigo, Miguel, Tang, Haoran, Walsh, Jarrod, Ware, Jamie, Wrigley, Gail L., Reddy, Iswarya Karapa, Zhang, Yun, Grimster, Neil P.

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Degradation of IKZF1 prevents epigenetic progression of T cell exhaustion in an antigen-specific assay von Tay, Tristan, Bommakanti, Gayathri, Jaensch, Elizabeth, Gorthi, Aparna, Karapa Reddy, Iswarya, Hu, Yan, Zhang, Ruochi, Doshi, Aatman S., Tan, Sin Lih, Brucklacher-Waldert, Verena, Prickett, Laura, Kurasawa, James, Overstreet, Michael Glen, Criscione, Steven, Buenrostro, Jason Daniel, Mele, Deanna A.

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Abstract A56: Releasing the brake on T-cell activation through inhibition of HPK1 von Grimster, Neil, Drew, Lisa, Fawell, Stephen, Mele, Deanna A, Bommakanti, Gayathri, Shen, Minhui, Xu, Kevin, Song, Kun, Ziegler, Rob, Kettle, Jason, Mfuh, Adelphe, Sheilds, Jason

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Abstract 3453: First disclosure of a highly potent and selective HPK1 inhibitor that rescues T cell exhaustion von Mele, Deanna A., Grimster, Neil, Bommakanti, Gayathri, Shields, Jason, Morrill, Lucas, Giblin, Kathryn, SanMartin, Maryann, Wang, Yanjun, Ye, Minwei, KarapaReddy, Iswarya, Song, Kun, Proia, Theresa, Hariparsad, Niresh, Richards, Ryan, Luheshi, Nadia, Barry, Simon T., Fawell, Stephen

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