Evaluation of PXL065 – deuterium-stabilized (R)-pioglitazone in patients with NASH: A phase II randomized placebo-controlled trial (DESTINY-1) von Harrison, Stephen A., Thang, Carole, Bolze, Sébastien, Dewitt, Sheila, Hallakou-Bozec, Sophie, Dubourg, Julie, Bedossa, Pierre, Cusi, Kenneth, Ratziu, Vlad, Grouin, Jean-Marie, Moller, David E., Fouqueray, Pascale

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Imeglimin normalizes glucose tolerance and insulin sensitivity and improves mitochondrial function in liver of a high-fat, high-sucrose diet mice model von Vial, Guillaume, Chauvin, Marie-Agnès, Bendridi, Nadia, Durand, Annie, Meugnier, Emmanuelle, Madec, Anne-Marie, Bernoud-Hubac, Nathalie, Pais de Barros, Jean-Paul, Fontaine, Éric, Acquaviva, Cécile, Hallakou-Bozec, Sophie, Bolze, Sébastien, Vidal, Hubert, Rieusset, Jennifer

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Absence of QTc prolongation in a thorough QT study with imeglimin, a first in class oral agent for type 2 diabetes mellitus von Dubourg, Julie, Perrimond-Dauchy, Sandrine, Felices, Mathieu, Bolze, Sébastien, Voiriot, Pascal, Fouqueray, Pascale

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Imeglimin lowers glucose primarily by amplifying glucose-stimulated insulin secretion in high-fat-fed rodents von Perry, Rachel J, Cardone, Rebecca L, Petersen, Max C, Zhang, Dongyan, Fouqueray, Pascale, Hallakou-Bozec, Sophie, Bolze, Sébastien, Shulman, Gerald I, Petersen, Kitt Falk, Kibbey, Richard G

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Beneficial Effects of the Direct AMP-Kinase Activator PXL770 in In Vitro and In Vivo Models of X-Linked Adrenoleukodystrophy von Monternier, Pierre-Axel, Parasar, Parveen, Theurey, Pierre, Gluais Dagorn, Pascale, Kaur, Navtej, Nagaraja, Tavarekere N, Fouqueray, Pascale, Bolze, Sébastien, Moller, David E., Singh, Jaspreet, Hallakou-Bozec, Sophie

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In Vitro Investigation, Pharmacokinetics, and Disposition of Imeglimin, a Novel Oral Antidiabetic Drug, in Preclinical Species and Humans von Clémence, Chevalier, Fouqueray, Pascale, Sébastien, Bolze

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Deuterium‐Stabilized (R)‐Pioglitazone (PXL065) Is Responsible for Pioglitazone Efficacy in NASH yet Exhibits Little to No PPARγ Activity von Jacques, Vincent, Bolze, Sébastien, Hallakou‐Bozec, Sophie, Czarnik, Anthony W., Divakaruni, Ajit S., Fouqueray, Pascale, Murphy, Anne N., Van der Ploeg, Lex H.T., DeWitt, Sheila

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Direct AMPK Activation Corrects NASH in Rodents Through Metabolic Effects and Direct Action on Inflammation and Fibrogenesis von Gluais‐Dagorn, Pascale, Foretz, Marc, Steinberg, Gregory R., Batchuluun, Battsetseg, Zawistowska‐Deniziak, Anna, Lambooij, Joost M., Guigas, Bruno, Carling, David, Monternier, Pierre‐Axel, Moller, David E., Bolze, Sebastien, Hallakou‐Bozec, Sophie

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Imeglimin: A Clinical Pharmacology Review von Chevalier, Clémence, Fouqueray, Pascale, Bolze, Sébastien

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Imeglimin amplifies glucose-stimulated insulin release from diabetic islets via a distinct mechanism of action von Hallakou-Bozec, Sophie, Kergoat, Micheline, Fouqueray, Pascale, Bolze, Sébastien, Moller, David E

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Mechanism of action of Imeglimin: A novel therapeutic agent for type 2 diabetes von Hallakou‐Bozec, Sophie, Vial, Guillaume, Kergoat, Micheline, Fouqueray, Pascale, Bolze, Sébastien, Borel, Anne‐Laure, Fontaine, Eric, Moller, David E.

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Imeglimin Does Not Induce Clinically Relevant Pharmacokinetic Interactions When Combined with Either Metformin or Sitagliptin in Healthy Subjects von Fouqueray, Pascale, Perrimond-Dauchy, Sandrine, Bolze, Sébastien

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Analysis of drug transporter expression in human intestinal Caco-2 cells by real-time PCR von Maubon, Nathalie, Le Vee, Marc, Fossati, Lina, Audry, Mathilde, Le Ferrec, Eric, Bolze, Sebastien, Fardel, Olivier

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Pharmacokinetics of Imeglimin in Caucasian and Japanese Healthy Subjects von Fouqueray, Pascale, Chevalier, Clémence, Bolze, Sébastien

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Pharmacokinetics of Imeglimin in Subjects with Moderate Hepatic Impairment von Chevalier, Clémence, Dubourg, Julie, Bolze, Sébastien, Fouqueray, Pascale

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Imeglimin preserves islet β‐cell mass in Type 2 diabetic ZDF rats von Hallakou‐Bozec, Sophie, Kergoat, Micheline, Moller, David E., Bolze, Sébastien

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Lack of Drug–Drug Interaction Between Cimetidine, a Renal Transporter Inhibitor, and Imeglimin, a Novel Oral Antidiabetic Drug, in Healthy Volunteers von Chevalier, Clémence, Perrimond-Dauchy, Sandrine, Dubourg, Julie, Fouqueray, Pascale, Bolze, Sébastien

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Phase 2 trial with imeglimin in patients with Type 2 diabetes indicates effects on insulin secretion and sensitivity von Theurey, Pierre, Thang, Carole, Pirags, Valdis, Mari, Andrea, Pacini, Giovanni, Bolze, Sébastien, Hallakou‐Bozec, Sophie, Fouqueray, Pascale

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Imeglimin population pharmacokinetics and dose adjustment predictions for renal impairment in Japanese and Western patients with type 2 diabetes von Tomita, Yoshiko, Hansson, Emma, Mazuir, Florent, Wellhagen, Gustaf J, Ooi, Qing Xi, Mezzalana, Enrica, Kitamura, Atsushi, Nemoto, Daisuke, Bolze, Sébastien

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Reduced lactic acidosis risk with Imeglimin: Comparison with Metformin von Theurey, Pierre, Vial, Guillaume, Fontaine, Eric, Monternier, Pierre‐Axel, Fouqueray, Pascale, Bolze, Sébastien, Moller, David E., Hallakou‐Bozec, Sophie

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