Discovery of N-(3-Fluorophenyl)-1-[(4-([(3S)-3-methyl-1-piperazinyl]methyl)phenyl)acetyl]-4-piperidinamine (GSK962040), the First Small Molecule Motilin Receptor Agonist Clinical C... von Westaway, Susan M, Brown, Samantha L, Fell, Stephen C. M, Johnson, Christopher N, MacPherson, David T, Mitchell, Darren J, Myatt, James W, Stanway, Steven J, Seal, Jon T, Stemp, Geoffrey, Thompson, Mervyn, Lawless, Kirk, McKay, Fiona, Muir, Alison I, Barford, Jonathan M, Cluff, Chermaine, Mahmood, Sadhia R, Matthews, Kim L, Mohamed, Shiyam, Smith, Beverley, Stevens, Alexander J, Bolton, Victoria J, Jarvie, Emma M, Sanger, Gareth J

Volltext

The discovery of biaryl carboxamides as novel small molecule agonists of the motilin receptor von Westaway, Susan M., Brown, Samantha L., Conway, Elizabeth, Heightman, Tom D., Johnson, Christopher N., Lapsley, Kate, Macdonald, Gregor J., MacPherson, David T., Mitchell, Darren J., Myatt, James W., Seal, Jon T., Stanway, Steven J., Stemp, Geoffrey, Thompson, Mervyn, Celestini, Paolo, Colombo, Andrea, Consonni, Alessandra, Gagliardi, Stefania, Riccaboni, Mauro, Ronzoni, Silvano, Briggs, Michael A., Matthews, Kim L., Stevens, Alexander J., Bolton, Victoria J., Boyfield, Izzy, Jarvie, Emma M., Stratton, Sharon C., Sanger, Gareth J.

Volltext

The discovery and optimisation of benzazepine sulfonamide and sulfones as potent agonists of the motilin receptor von Bailey, James M., Scott, Jackie S., Basilla, Jonathan B., Bolton, Victoria J., Boyfield, Izzy, Evans, David G., Fleury, Etienne, Heightman, Tom D., Jarvie, Emma M., Lawless, Kirk, Matthews, Kim L., McKay, Fiona, Mok, Hindy, Muir, Alison, Orlek, Barry S., Sanger, Gareth J., Stemp, Geoffrey, Stevens, Alexander J., Thompson, Mervyn, Ward, John, Vaidya, Kalindi, Westaway, Susan M.

Volltext

T1381 Inhibition of Colonic Motility and Defecation By RS-127445 Suggests Involvement of the 5-HT2b Receptor in Large Bowel Physiology von Sanger, Gareth J, Bassil, Anna K, Bolton, Victoria J, Taylor, Colleen M, Gray, Karen, Winchester, Wendy J, Lee, Kevin

Volltext

T1381 Inhibition of Colonic Motility and Defecation By RS-127445 Suggests Involvement of the 5-HT 2b Receptor in Large Bowel Physiology von Sanger, Gareth J., Bassil, Anna K., Bolton, Victoria J., Taylor, Colleen M., Gray, Karen, Winchester, Wendy J., Lee, Kevin

Volltext

Discovery of N-(3-Fluorophenyl)-1-[4-([(3S)-3-methyl-1-piperazinyl]methyl)phenylacetyl]-4-piperidinamine (GSK962040), the First Small Molecule Motilin Receptor Agonist Clinical Can... von WESTAWAY, Susan M, BROWN, Samantha L, THOMPSON, Mervyn, LAWLESS, Kirk, MCKAY, Fiona, MUIR, Alison I, BARFORD, Jonathan M, CLUFF, Chermaine, MAHMOOD, Sadhia R, MATTHEWS, Kim L, MOHAMED, Shiyam, SMITH, Beverley, FELL, Stephen C. M, STEVENS, Alexander J, BOLTON, Victoria J, JARVIE, Emma M, SANGER, Gareth J, JOHNSON, Christopher N, MACPHERSON, David T, MITCHELL, Darren J, MYATT, James W, STANWAY, Steven J, SEAL, Jon T, STEMP, Geoffrey

Volltext

Convalescent human IgG, but not IgM, from COVID-19 survivors confers dose-dependent protection against SARS-CoV-2 replication and disease in hamsters von King, Hannah A D, Dussupt, Vincent, Mendez-Rivera, Letzibeth, Slike, Bonnie M, Tran, Ursula, Jackson, Nathan D, Barkei, Erica, Zemil, Michelle, Tourtellott-Fogt, Emily, Kuklis, Caitlin H, Soman, Sandrine, Ahmed, Aslaa, Porto, Maciel, Kitajewski, Christopher, Spence, Brittany, Benetiene, Dalia, Wieczorek, Lindsay, Kar, Swagata, Gromowski, Gregory, Polonis, Victoria R, Krebs, Shelly J, Modjarrad, Kayvon, Bolton, Diane L

Volltext

The Risk of Ovarian Cancer Increases with an Increase in the Lifetime Number of Ovulatory Cycles: An Analysis from the Ovarian Cancer Cohort Consortium (OC3) von Trabert, Britton, Tworoger, Shelley S., O'Brien, Katie M., Townsend, Mary K., Fortner, Renee T., Iversen, Edwin S., Hartge, Patricia, White, Emily, Amiano, Pilar, Arslan, Alan A., Bernstein, Leslie, Brinton, Louise A., Buring, Julie E., Dossus, Laure, Fraser, Gary E., Gaudet, Mia M., Giles, Graham G., Gram, Inger T., Harris, Holly R., Bolton, Judith Hoffman, Idahl, Annika, Jones, Michael E., Kaaks, Rudolf, Kirsh, Victoria A., Knutsen, Synnove F., Kvaskoff, Marina, Lacey, James, Lee, I-Min, Milne, Roger L., Onland-Moret, N. Charlotte, Overvad, Kim, Patel, Alpa, Peters, Ulrike, Poynter, Jenny N., Riboli, Elio, Robien, Kim, Rohan, Thomas E., Sandler, Dale P., Schairer, Catherine, Schouten, Leo J., Setiawan, Veronica W., Swerdlow, Anthony J., Travis, Ruth C., Trichopoulou, Antonia, van den Brandt, Piet A., Visvanathan, Kala, Wilkens, Lynne R., Wolk, Alicja, Zeleniuch-Jacquotte, Anne, Wentzensen, Nicolas

Volltext

Contemporary HIV-1 consensus Env with AI-assisted redesigned hypervariable loops promote antibody binding von Bai, Hongjun, Lewitus, Eric, Li, Yifan, Thomas, Paul V., Zemil, Michelle, Merbah, Mélanie, Peterson, Caroline E., Thuraisamy, Thujitha, Rees, Phyllis A., Hajduczki, Agnes, Dussupt, Vincent, Slike, Bonnie, Mendez-Rivera, Letzibeth, Schmid, Annika, Kavusak, Erin, Rao, Mekhala, Smith, Gabriel, Frey, Jessica, Sims, Alicea, Wieczorek, Lindsay, Polonis, Victoria, Krebs, Shelly J., Ake, Julie A., Vasan, Sandhya, Bolton, Diane L., Joyce, M. Gordon, Townsley, Samantha, Rolland, Morgane

Volltext

Measuring disease-specific quality of life in rare populations: a practical approach to cross-cultural translation von Price, Victoria E, Klaassen, Robert J, Bolton-Maggs, Paula H B, Grainger, John D, Curtis, Christine, Wakefield, Cindy, Dufort, Gustavo, Riedlinger, Arne, Soltner, Christophe, Blanchette, Victor S, Young, Nancy L

Volltext

A Simple Clinical Tool for Stratifying Risk of Clinically Significant CKD after Nephrectomy: Development and Multinational Validation von Ellis, Robert J., Del Vecchio, Sharon J., Gallagher, Kevin M. J., Aliano, Danielle N., Barber, Neil, Bolton, Damien M., Chew, Etienne T. S., Coombes, Jeff S., Coory, Michael D., Davis, Ian D., Donaldson, James F., Francis, Ross S., Giles, Graham G., Gobe, Glenda C., Hawley, Carmel M., Johnson, David W., Laird, Alexander, Leung, Steve, Malki, Manar, Marco, David J. T., McNeill, Alan S., Neale, Rachel E., Ng, Keng L., Phipps, Simon, Stewart, Grant D., White, Victoria M., Wood, Simon T., Jordan, Susan J.

Volltext

Plasmacytoid dendritic cells sense HIV replication before detectable viremia following treatment interruption von Mitchell, Julie L., Takata, Hiroshi, Muir, Roshell, Colby, Donn J., Kroon, Eugene, Crowell, Trevor A., Sacdalan, Carlo, Pinyakorn, Suteeraporn, Puttamaswin, Suwanna, Benjapornpong, Khunthalee, Trichavaroj, Rapee, Tressler, Randall L., Fox, Lawrence, Polonis, Victoria R., Bolton, Diane L., Maldarelli, Frank, Lewin, Sharon R., Haddad, Elias K., Phanuphak, Praphan, Robb, Merlin L., Michael, Nelson L., de Souza, Mark, Phanuphak, Nittaya, Ananworanich, Jintanat, Trautmann, Lydie

Volltext

Circulating high sensitivity C reactive protein concentrations and risk of lung cancer: nested case-control study within Lung Cancer Cohort Consortium von Muller, David C, Larose, Tricia L, Hodge, Allison, Guida, Florence, Langhammer, Arnulf, Grankvist, Kjell, Meyer, Klaus, Cai, Qiuyin, Arslan, Alan A, Zeleniuch-Jacquotte, Anne, Albanes, Demetrius, Giles, Graham G, Sesso, Howard D, Lee, I-Min, Gaziano, J Michael, Yuan, Jian-Min, Hoffman Bolton, Judith, Buring, Julie E, Visvanathan, Kala, Le Marchand, Loic, Purdue, Mark P, Caporaso, Neil E, Midttun, Øivind, Ueland, Per M, Prentice, Ross L, Weinstein, Stephanie J, Stevens, Victoria L, Zheng, Wei, Blot, William J, Shu, Xiao-Ou, Zhang, Xuehong, Xiang, Yong-Bing, Koh, Woon-Puay, Hveem, Kristian, Thomson, Cynthia A, Pettinger, Mary, Engström, Gunnar, Brunnström, Hans, Milne, Roger L, Stampfer, Meir J, Han, Jiali, Johansson, Mikael, Brennan, Paul, Severi, Gianluca, Johansson, Mattias

Volltext

Early Antiretroviral Therapy and Mortality among HIV-Infected Infants von Violari, Avy, Cotton, Mark F, Gibb, Diana M, Babiker, Abdel G, Steyn, Jan, Madhi, Shabir A, Jean-Philippe, Patrick, McIntyre, James A

Volltext

Ovarian Cancer Risk Factors by Histologic Subtype: An Analysis From the Ovarian Cancer Cohort Consortium von Wentzensen, Nicolas, Poole, Elizabeth M, Trabert, Britton, White, Emily, Arslan, Alan A, Patel, Alpa V, Setiawan, V Wendy, Visvanathan, Kala, Weiderpass, Elisabete, Adami, Hans-Olov, Black, Amanda, Bernstein, Leslie, Brinton, Louise A, Buring, Julie, Butler, Lesley M, Chamosa, Saioa, Clendenen, Tess V, Dossus, Laure, Fortner, Renee, Gapstur, Susan M, Gaudet, Mia M, Gram, Inger T, Hartge, Patricia, Hoffman-Bolton, Judith, Idahl, Annika, Jones, Michael, Kaaks, Rudolf, Kirsh, Victoria, Koh, Woon-Puay, Lacey, Jr, James V, Lee, I-Min, Lundin, Eva, Merritt, Melissa A, Onland-Moret, N Charlotte, Peters, Ulrike, Poynter, Jenny N, Rinaldi, Sabina, Robien, Kim, Rohan, Thomas, Sandler, Dale P, Schairer, Catherine, Schouten, Leo J, Sjöholm, Louise K, Sieri, Sabina, Swerdlow, Anthony, Tjonneland, Anna, Travis, Ruth, Trichopoulou, Antonia, van den Brandt, Piet A, Wilkens, Lynne, Wolk, Alicja, Yang, Hannah P, Zeleniuch-Jacquotte, Anne, Tworoger, Shelley S

Volltext

Device-assessed sleep and physical activity in individuals recovering from a hospital admission for COVID-19: a multicentre study von Plekhanova, Tatiana, Rowlands, Alex V, Evans, Rachael A, Edwardson, Charlotte L, Bishop, Nicolette C, Bolton, Charlotte E, Chalmers, James D, Davies, Melanie J, Daynes, Enya, Dempsey, Paddy C, Docherty, Annemarie B, Elneima, Omer, Greening, Neil J, Greenwood, Sharlene A, Hall, Andrew P, Harris, Victoria C, Harrison, Ewen M, Henson, Joseph, Ho, Ling-Pei, Horsley, Alex, Houchen-Wolloff, Linzy, Khunti, Kamlesh, Leavy, Olivia C, Lone, Nazir I, Marks, Michael, Maylor, Ben, McAuley, Hamish J. C, Nolan, Claire M, Poinasamy, Krisnah, Quint, Jennifer K, Raman, Betty, Richardson, Matthew, Sargeant, Jack A, Saunders, Ruth M, Sereno, Marco, Shikotra, Aarti, Singapuri, Amisha, Steiner, Michael, Stensel, David J, Wain, Louise V, Whitney, Julie, Wootton, Dan G, Brightling, Christopher E, Man, William D-C, Singh, Sally J, Yates, Tom

Volltext

Outcome of the First wwPDB/CCDC/D3R Ligand Validation Workshop von Adams, Paul D., Aertgeerts, Kathleen, Bauer, Cary, Bell, Jeffrey A., Berman, Helen M., Bhat, Talapady N., Blaney, Jeff M., Bolton, Evan, Bricogne, Gerard, Brown, David, Burley, Stephen K., Case, David A., Clark, Kirk L., Darden, Tom, Emsley, Paul, Feher, Victoria A., Feng, Zukang, Groom, Colin R., Harris, Seth F., Hendle, Jorg, Holder, Thomas, Joachimiak, Andrzej, Kleywegt, Gerard J., Krojer, Tobias, Marcotrigiano, Joseph, Mark, Alan E., Markley, John L., Miller, Matthew, Minor, Wladek, Montelione, Gaetano T., Murshudov, Garib, Nakagawa, Atsushi, Nakamura, Haruki, Nicholls, Anthony, Nicklaus, Marc, Nolte, Robert T., Padyana, Anil K., Peishoff, Catherine E., Pieniazek, Susan, Read, Randy J., Shao, Chenghua, Sheriff, Steven, Smart, Oliver, Soisson, Stephen, Spurlino, John, Stouch, Terry, Svobodova, Radka, Tempel, Wolfram, Terwilliger, Thomas C., Tronrud, Dale, Velankar, Sameer, Ward, Suzanna C., Warren, Gregory L., Westbrook, John D., Williams, Pamela, Yang, Huanwang, Young, Jasmine

Volltext

Efficacy and breadth of adjuvanted SARS-CoV-2 receptor-binding domain nanoparticle vaccine in macaques von King, Hannah A. D., Joyce, M. Gordon, Lakhal-Naouar, Ines, Ahmed, Aslaa, Cincotta, Camila Macedo, Subra, Caroline, Peachman, Kristina K., Hack, Holly R., Chen, Rita E., Thomas, Paul V., Chen, Wei-Hung, Sankhala, Rajeshwer S., Hajduczki, Agnes, Martinez, Elizabeth J., Peterson, Caroline E., Chang, William C., Choe, Misook, Smith, Clayton, Headley, Jarrett A., Elyard, Hanne A., Cook, Anthony, Anderson, Alexander, Wuertz, Kathryn McGuckin, Dong, Ming, Swafford, Isabella, Case, James B., Currier, Jeffrey R., Lal, Kerri G., Amare, Mihret F., Dussupt, Vincent, Molnar, Sebastian, Daye, Sharon P., Zeng, Xiankun, Barkei, Erica K., Alfson, Kendra, Staples, Hilary M., Carrion, Ricardo, Krebs, Shelly J., Paquin-Proulx, Dominic, Karasavvas, Nicos, Polonis, Victoria R., Jagodzinski, Linda L., Vasan, Sandhya, Scott, Paul T., Huang, Yaoxing, Nair, Manoj S., Ho, David D., de Val, Natalia, Diamond, Michael S., Lewisi, Mark G., Rao, Mangala, Matyas, Gary R., Gromowski, Gregory D., Peel, Sheila A., Michael, Nelson L., Modjarrad, Kayvon, Bolton, Diane L.

Volltext

Diverse array of neutralizing antibodies elicited upon Spike Ferritin Nanoparticle vaccination in rhesus macaques von Sankhala, Rajeshwer S., Lal, Kerri G., Jensen, Jaime L., Dussupt, Vincent, Mendez-Rivera, Letzibeth, Bai, Hongjun, Wieczorek, Lindsay, Mayer, Sandra V., Zemil, Michelle, Wagner, Danielle A., Townsley, Samantha M., Hajduczki, Agnes, Chang, William C., Chen, Wei-Hung, Donofrio, Gina C., Jian, Ningbo, King, Hannah A. D., Lorang, Cynthia G., Martinez, Elizabeth J., Rees, Phyllis A., Peterson, Caroline E., Schmidt, Fabian, Hart, Tricia J., Duso, Debra K., Kummer, Lawrence W., Casey, Sean P., Williams, Jazmean K., Kannan, Shruthi, Slike, Bonnie M., Smith, Lauren, Swafford, Isabella, Thomas, Paul V., Tran, Ursula, Currier, Jeffrey R., Bolton, Diane L., Davidson, Edgar, Doranz, Benjamin J., Hatziioannou, Theodora, Bieniasz, Paul D., Paquin-Proulx, Dominic, Reiley, William W., Rolland, Morgane, Sullivan, Nancy J., Vasan, Sandhya, Collins, Natalie D., Modjarrad, Kayvon, Gromowski, Gregory D., Polonis, Victoria R., Michael, Nelson L., Krebs, Shelly J., Joyce, M. Gordon

Volltext

Is high vitamin B12 status a cause of lung cancer? von Fanidi, Anouar, Carreras‐Torres, Robert, Larose, Tricia L., Yuan, Jian‐Min, Stevens, Victoria L., Weinstein, Stephanie J., Albanes, Demetrius, Prentice, Ross, Pettinger, Mary, Cai, Qiuyin, Blot, William J., Arslan, Alan A., Zeleniuch‐Jacquotte, Anne, McCullough, Marjorie L., Le Marchand, Loic, Wilkens, Lynne R., Haiman, Christopher A., Zhang, Xuehong, Stampfer, Meir J., Smith‐Warner, Stephanie A., Giovannucci, Edward, Giles, Graham G., Hodge, Allison M., Severi, Gianluca, Johansson, Mikael, Grankvist, Kjell, Langhammer, Arnulf, Brumpton, Ben M., Wang, Renwei, Gao, Yu‐Tang, Ericson, Ulrika, Bojesen, Stig E., Arnold, Susanne M., Koh, Woon‐Puay, Shu, Xiao‐Ou, Xiang, Yong‐Bing, Li, Honglan, Zheng, Wei, Lan, Qing, Visvanathan, Kala, Hoffman‐Bolton, Judith, Ueland, Per M., Midttun, Øivind, Caporaso, Neil E., Purdue, Mark, Freedman, Neal D., Buring, Julie E., Lee, I‐Min, Sesso, Howard D., Michael Gaziano, J., Manjer, Jonas, Relton, Caroline L., Hung, Rayjean J., Amos, Chris I., Johansson, Mattias, Brennan, Paul

Volltext