Concurrent loss of the PTEN and RB1 tumor suppressors attenuates RAF dependence in melanomas harboring BRAF von Xing, F, Persaud, Y, Pratilas, C A, Taylor, B S, Janakiraman, M, She, Q-B, Gallardo, H, Liu, C, Merghoub, T, Hefter, B, Dolgalev, I, Viale, A, Heguy, A, De Stanchina, E, Cobrinik, D, Bollag, G, Wolchok, J, Houghton, A, Solit, D B

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Discovery of a novel Raf kinase inhibitor von Lyons, J F, Wilhelm, S, Hibner, B, Bollag, G

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A family of phosphodiesterase inhibitors discovered by cocrystallography and scaffold-based drug design von Zhang, Kam Y J, Card, Graeme L, Blasdel, Landy, England, Bruce P, Zhang, Chao, Suzuki, Yoshihisa, Gillette, Sam, Fong, Daniel, Ibrahim, Prabha N, Artis, Dean R, Bollag, Gideon, Milburn, Michael V, Kim, Sung-Hou, Schlessinger, Joseph

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The Raf kinase inhibitor PLX5568 slows cyst proliferation in rat polycystic kidney disease but promotes renal and hepatic fibrosis von Buchholz, Bjoern, Klanke, Bernd, Schley, Gunnar, Bollag, Gideon, Tsai, James, Kroening, Sven, Yoshihara, Daisuke, Wallace, Darren P., Kraenzlin, Bettina, Gretz, Norbert, Hirth, Peter, Eckardt, Kai-Uwe, Bernhardt, Wanja M.

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99 Proffered Paper: The Importance of Glycolysis for the Response and Resistance of BRAFV600E Human Melanoma Cells to Vemurafenib von Parmenter, T, Bollag, G, Hicks, R, Johnstone, R, McArthur, G

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372 Preclinical Characterization of RG7256, a Potent and Selective BRAF Inhibitor with Differentiation From Vemurafenib von Su, F, Xu, L, Higgings, B, Yang, H, Packman, K, Hilton, H, Schostack, K, Bollag, G, Tsai, J, Habets, G

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A novel serine kinase activated by rac1/CDC42Hs‐dependent autophosphorylation is related to PAK65 and STE20 von Martin, G.A., Bollag, G., McCormick, F., Abo, A.

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Structure-Guided Blockade of CSF1R Kinase in Tenosynovial Giant-Cell Tumor von Tap, William D, Wainberg, Zev A, Anthony, Stephen P, Ibrahim, Prabha N, Zhang, Chao, Healey, John H, Chmielowski, Bartosz, Staddon, Arthur P, Cohn, Allen Lee, Shapiro, Geoffrey I, Keedy, Vicki L, Singh, Arun S, Puzanov, Igor, Kwak, Eunice L, Wagner, Andrew J, Von Hoff, Daniel D, Weiss, Glen J, Ramanathan, Ramesh K, Zhang, Jiazhong, Habets, Gaston, Zhang, Ying, Burton, Elizabeth A, Visor, Gary, Sanftner, Laura, Severson, Paul, Nguyen, Hoa, Kim, Marie J, Marimuthu, Adhirai, Tsang, Garson, Shellooe, Rafe, Gee, Carolyn, West, Brian L, Hirth, Peter, Nolop, Keith, van de Rijn, Matt, Hsu, Henry H, Peterfy, Charles, Lin, Paul S, Tong-Starksen, Sandra, Bollag, Gideon

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BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis von WILHELM, Scott M, CARTER, Christopher, CAO, Yichen, SHUJATH, Jaleel, GAWLAK, Susan, EVELEIGH, Deepa, ROWLEY, Bruce, LI LIU, ADNANE, Lila, LYNCH, Mark, AUCLAIR, Daniel, TAYLOR, Ian, TANG, Liya, GEDRICH, Rich, VOZNESENSKY, Andrei, RIEDL, Bernd, POST, Leonard E, BOLLAG, Gideon, TRAIL, Pamela A, WILKIE, Dean, MCNABOLA, Angela, HONG RONG, CHEN, Charles, XIAOMEI ZHANG, VINCENT, Patrick, MCHUGH, Mark

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Germline KRAS mutations cause Noonan syndrome von Böll, Silke, Kratz, Christian P, Schubbert, Suzanne, Zhang, Kam Y J, Shannon, Kevin, West, Brian, Zenker, Martin, Bollag, Gideon, Musante, Luciana, Rauch, Anita, Klein, Cornelia, van der Burgt, Ineke, Nguyen, Hoa, Wehner, Lars-Erik, Rowe, Sara L, Sistermans, Erik, Niemeyer, Charlotte M, Kalscheuer, Vera

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Modulation of nutrient sensing nuclear hormone receptors promotes weight loss through appetite suppression in mice von Perreault, M, Will, S, Panza, D, Gareski, T, Harding, K, Kubasiak, D, Jalenak, M, Gartrell, K, Wang, S, Bollag, G, Artis, D.R, Ibrahim, P.N, Womack, P, Lin, J.J, Saiah, E, Mansour, T.S, Vlasuk, G.P, Erbe, D.V, Tobin, J.F

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529MO Activity, safety and circulating tumour DNA (ctDNA) dynamics of paradox breaker BRAF inhibitor PLX8394 in patients with advanced cancer von Gouda, M.A., Sherman, E.J., Gilcrease, G.W., Vaishampayan, U.N., Parikh, A., Feun, L., Kummar, S., Huang, H., Zhang, C., Severson, P., Inokuchi, K., Silverman, M., Bollag, G., Janku, F.

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Phosphodiesterase-4 as a potential drug target von Zhang, Kam YJ, Ibrahim, Prabha N, Gillette, Sam, Bollag, Gideon

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Regulation of Tiam1 Nucleotide Exchange Activity by Pleckstrin Domain Binding Ligands von Crompton, Anne M., Foley, Louise H., Wood, Alexander, Roscoe, William, Stokoe, David, McCormick, Frank, Symons, Marc, Bollag, Gideon

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Interim results from a phase 1/2 precision medicine study of PLX8394- a next generation BRAF inhibitor von Janku, F., Sherman, E.J., Parikh, A.R., Feun, L.G., Tsai, F., Allen, E., Zhang, C., Severson, P., Inokuchi, K., Walling, J., Averbuch, S., Tarcic, G., Bollag, G.

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A Glutamine Switch Mechanism for Nucleotide Selectivity by Phosphodiesterases von Zhang, Kam Y.J, Card, Graeme L, Suzuki, Yoshihisa, Artis, D.Richard, Fong, Daniel, Gillette, Sam, Hsieh, Davin, Neiman, Joshua, West, Brian L, Zhang, Chao, Milburn, Michael V, Kim, Sung-Hou, Schlessinger, Joseph, Bollag, Gideon

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Characterization of full‐length neurofibromin: tubulin inhibits Ras GAP activity von Bollag, G., McCormick, F., Clark, R.

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Structural Basis for the Activity of Drugs that Inhibit Phosphodiesterases von Card, Graeme L., England, Bruce P., Suzuki, Yoshihisa, Fong, Daniel, Powell, Ben, Lee, Byunghun, Luu, Catherine, Tabrizizad, Maryam, Gillette, Sam, Ibrahim, Prabha N., Artis, Dean R., Bollag, Gideon, Milburn, Michael V., Kim, Sung-Hou, Schlessinger, Joseph, Zhang, Kam Y.J.

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p115 RhoGEF, a GTPase activating protein for Gα12 and Gα13 von KOZASA, T, XUEJUN JIANG, HART, M. J, STERNWEIS, P. M, SINGER, W. D, GILMAN, A. G, BOLLAG, G, STERNWEIS, P. C

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cA Glutamine Switch Mechanism for Nucleotide Selectivity by Phosphodiesterases von Zhang, KYJ, Card, G L, Suzuki, Y, Artis, DR, Fong, D, Gillette, S, Hsieh, D, Neiman, J, West, B L, Zhang, C, Milburn, M V, Kim, S-H, Schlessinger, J, Bollag, G

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