Crystal structure of the Arabidopsis SPIRAL2 C-terminal domain reveals a p80-Katanin-like domain von Bolhuis, Derek L, Dixit, Ram, Slep, Kevin C

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A structure-based designed small molecule depletes hRpn13Pru and a select group of KEN box proteins von Lu, Xiuxiu, Chandravanshi, Monika, Sabbasani, Venkata R., Gaikwad, Snehal, Hughitt, V. Keith, Gyabaah-Kessie, Nana, Scroggins, Bradley T., Das, Sudipto, Myint, Wazo, Clapp, Michelle E., Schwieters, Charles D., Dyba, Marzena A., Bolhuis, Derek L., Koscielniak, Janusz W., Andresson, Thorkell, Emanuele, Michael J., Brown, Nicholas G., Matsuo, Hiroshi, Chari, Raj, Citrin, Deborah E., Mock, Beverly A., Swenson, Rolf E., Walters, Kylie J.

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Proteomic analysis reveals a PLK1-dependent G2/M degradation program and a role for AKAP2 in coordinating the mitotic cytoskeleton von Mouery, Ryan D., Lukasik, Kimberly, Hsu, Carolyn, Bonacci, Thomas, Bolhuis, Derek L., Wang, Xianxi, Mills, C. Allie, Toomer, E. Drew, Canterbury, Owen G., Robertson, Kevin C., Branigan, Timothy B., Brown, Nicholas G., Herring, Laura E., Gupton, Stephanie L., Emanuele, Michael J.

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In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators von Franks, Jennifer L., Martinez-Chacin, Raquel C., Wang, Xianxi, Tiedemann, Rochelle L., Bonacci, Thomas, Choudhury, Rajarshi, Bolhuis, Derek L., Enrico, Taylor P., Mouery, Ryan D., Damrauer, Jeffrey S., Yan, Feng, Harrison, Joseph S., Ben Major, M., Hoadley, Katherine A., Suzuki, Aussie, Rothbart, Scott B., Brown, Nicholas G., Emanuele, Michael J.

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Cryo-EM structure of the plant 26S proteasome von Kandolf, Susanne, Grishkovskaya, Irina, Belačić, Katarina, Bolhuis, Derek L., Amann, Sascha, Foster, Brent, Imre, Richard, Mechtler, Karl, Schleiffer, Alexander, Tagare, Hemant D., Zhong, Ellen D., Meinhart, Anton, Brown, Nicholas G., Haselbach, David

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Cryo‐EM structure of the chain‐elongating E3 ubiquitin ligase UBR5 von Hodáková, Zuzana, Grishkovskaya, Irina, Brunner, Hanna L, Bolhuis, Derek L, Belačić, Katarina, Schleiffer, Alexander, Kotisch, Harald, Brown, Nicholas G, Haselbach, David

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Enabling Genetic Code Expansion and Peptide Macrocyclization in mRNA Display via a Promiscuous Orthogonal Aminoacyl-tRNA Synthetase von Iskandar, Sabrina E., Pelton, Jarrett M., Wick, Elizaveta T., Bolhuis, Derek L., Baldwin, Albert S., Emanuele, Michael J., Brown, Nicholas G., Bowers, Albert A.

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The anaphase-promoting complex controls a ubiquitination-phosphoprotein axis in chromatin during neurodevelopment von Ledvin, Leya, Gassaway, Brandon M, Tawil, Jonathan, Urso, Olivia, Pizzo, Donald, Welsh, Kaeli A, Bolhuis, Derek L, Fisher, Daniel, Bonni, Azad, Gygi, Steven P, Brown, Nicholas G, Ferguson, Cole J

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Examining the mechanistic relationship of APC/C CDH1 and its interphase inhibitor EMI1 von Bolhuis, Derek L, Martinez-Chacin, Raquel C, Welsh, Kaeli A, Bodrug, Tatyana, Cui, Liying, Emanuele, Michael J, Brown, Nicholas G

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Examining the mechanistic relationship of APC/CCDH1 and its interphase inhibitor EMI1 von Bolhuis, Derek L., Martinez‐Chacin, Raquel C., Welsh, Kaeli A., Bodrug, Tatyana, Cui, Liying, Emanuele, Michael J., Brown, Nicholas G.

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Functional conservation and divergence of the helix‐turn‐helix motif of E2 ubiquitin‐conjugating enzymes von Welsh, Kaeli A, Bolhuis, Derek L, Nederstigt, Anneroos E, Boyer, Joshua, Temple, Brenda R S, Bonacci, Thomas, Gu, Li, Ordureau, Alban, Harper, J Wade, Steimel, Joshua P, Zhang, Qi, Emanuele, Michael J, Harrison, Joseph S, Brown, Nicholas G

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Ubiquitin chain-elongating enzyme UBE2S activates the RING E3 ligase APC/C for substrate priming von Martinez-Chacin, Raquel C., Bodrug, Tatyana, Bolhuis, Derek L., Kedziora, Katarzyna M., Bonacci, Thomas, Ordureau, Alban, Gibbs, Morgan E., Weissmann, Florian, Qiao, Renping, Grant, Gavin D., Cook, Jeanette G., Peters, Jan-Michael, Wade Harper, J., Emanuele, Michael J., Brown, Nicholas G.

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AtomNet-Aided OTUD7B Inhibitor Discovery and Validation von Chen, Jianfeng, Bolhuis, Derek L, Laggner, Christian, Kong, Deyu, Yu, Le, Wang, Xiaodong, Emanuele, Michael J, Brown, Nicholas G, Liu, Pengda

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Time-resolved cryo-EM (TR-EM) analysis of substrate polyubiquitination by the RING E3 anaphase-promoting complex/cyclosome (APC/C) von Bodrug, Tatyana, Welsh, Kaeli A., Bolhuis, Derek L., Paulаkonis, Ethan, Martinez-Chacin, Raquel C., Liu, Bei, Pinkin, Nicholas, Bonacci, Thomas, Cui, Liying, Xu, Pengning, Roscow, Olivia, Amann, Sascha Josef, Grishkovskaya, Irina, Emanuele, Michael J., Harrison, Joseph S., Steimel, Joshua P., Hahn, Klaus M., Zhang, Wei, Zhong, Ellen D., Haselbach, David, Brown, Nicholas G.

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Protein engineering of a ubiquitin-variant inhibitor of APC/C identifies a cryptic K48 ubiquitin chain binding site von Watson, Edmond R., Grace, Christy R. R., Zhang, Wei, Miller, Darcie J., Davidson, Iain F., Prabu, J. Rajan, Yu, Shanshan, Bolhuis, Derek L., Kulko, Elizaveta T., Vollrath, Ronnald, Haselbach, David, Stark, Holger, Peters, Jan-Michael, Brown, Nicholas G., Sidhu, Sachdev S., Schulman, Brenda A.

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Crystal structure of the Arabidopsis SPIRAL2 C-terminal domain reveals a p80-Katanin-like domain von Derek L. Bolhuis, Ram Dixit, Kevin C. Slep

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A structure-based designed small molecule depletes hRpn13 Pru and a select group of KEN box proteins von Lu, Xiuxiu, Chandravanshi, Monika, Sabbasani, Venkata R, Gaikwad, Snehal, Hughitt, V Keith, Gyabaah-Kessie, Nana, Scroggins, Bradley T, Das, Sudipto, Myint, Wazo, Clapp, Michelle E, Schwieters, Charles D, Dyba, Marzena A, Bolhuis, Derek L, Koscielniak, Janusz W, Andresson, Thorkell, Emanuele, Michael J, Brown, Nicholas G, Matsuo, Hiroshi, Chari, Raj, Citrin, Deborah E, Mock, Beverly A, Swenson, Rolf E, Walters, Kylie J

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Linezolid pharmacokinetics in MDR-TB: a systematic review, meta-analysis and Monte Carlo simulation von Millard, James, Pertinez, Henry, Bonnett, Laura, Hodel, Eva Maria, Dartois, Véronique, Johnson, John L, Caws, Maxine, Tiberi, Simon, Bolhuis, Mathieu, Alffenaar, Jan-Willem C, Davies, Geraint, Sloan, Derek J

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Darwin's mistake: Explaining the discontinuity between human and nonhuman minds. Authors' reply von PENN, Derek C, HOLYOAK, Keith J, GARDNER, R. Allen, GENTNER, Dedre, CHRISTIE, Stella, HALFORD, Graeme S, PHILLIPS, Steven, WILSON, William H, HALLINAN, Elizabeth V, KUHLMEIER, Valerie A, HERMAN, Louis M, UYEYAMA, Robert K, POVINELLI, Daniel J, PACK, Adam A, LUPYAN, Gary, MARKMAN, Arthur B, STILWELL, C. Hunt, MCGONIGLE, Brendan, CHALMERS, Margaret, PEPPERBERG, Irene M, RENDALL, Drew, VOKEY, John R, NOTMAN, Hugh, BARRETT, Louise, SHATZ, Marilyn, SIEGAL, Michael, VARLEY, Rosemary, SUDDENDORF, Thomas, TETZLAFF, Michael, CARRUTHERS, Peter, THOMPSON, Roger K. R, FLEMMING, Timothy M, TOMLINSON, Marc T, LOVE, Bradlev C, BERMUDEZ, José Luis, WASSERMAN, Edward A, WYNNE, Clive D. L, BOLHUIS, Johan J, BICKERTON, Derek, BRIDGEMAN, Bruce, BURGHARDT, Gordon M, EMERY, Nathan J, CLAYTON, Nicola S

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