Novel strategies exploiting interleukin-12 in cancer immunotherapy von Cirella, Assunta, Luri-Rey, Carlos, Di Trani, Claudia Augusta, Teijeira, Alvaro, Olivera, Irene, Bolaños, Elixabet, Castañón, Eduardo, Palencia, Belen, Brocco, Davide, Fernández-Sendin, Myriam, Aranda, Fernando, Berraondo, Pedro, Melero, Ignacio

Volltext

Abscopal Effects of Radiotherapy Are Enhanced by Combined Immunostimulatory mAbs and Are Dependent on CD8 T Cells and Crosspriming von Rodriguez-Ruiz, María E, Rodriguez, Inmaculada, Garasa, Saray, Barbes, Benigno, Solorzano, Jose Luis, Perez-Gracia, Jose Luis, Labiano, Sara, Sanmamed, Miguel F, Azpilikueta, Arantza, Bolaños, Elixabet, Sanchez-Paulete, Alfonso R, Aznar, M Angela, Rouzaut, Ana, Schalper, Kurt A, Jure-Kunkel, Maria, Melero, Ignacio

Volltext

CD137 (4-1BB) costimulation of CD8+ T cells is more potent when provided in cis than in trans with respect to CD3-TCR stimulation von Otano, Itziar, Azpilikueta, Arantza, Glez-Vaz, Javier, Alvarez, Maite, Medina-Echeverz, José, Cortés-Domínguez, Ivan, Ortiz-de-Solorzano, Carlos, Ellmark, Peter, Fritzell, Sara, Hernandez-Hoyos, Gabriela, Nelson, Michelle Hase, Ochoa, María Carmen, Bolaños, Elixabet, Cuculescu, Doina, Jaúregui, Patricia, Sanchez-Gregorio, Sandra, Etxeberria, Iñaki, Rodriguez-Ruiz, María E., Sanmamed, Miguel F., Teijeira, Álvaro, Berraondo, Pedro, Melero, Ignacio

Volltext

Focusing and sustaining the antitumor CTL effector killer response by agonist anti-CD137 mAb von Weigelin, Bettina, Elixabet Bolaños, Alvaro Teijeira, Ivan Martinez-Forero, Sara Labiano, Arantza Azpilikueta, Aizea Morales-Kastresana, Josñé I. Quetglas, Esther Wagena, Alfonso Rodrñéíguez Sñéíánchez-Paulete, Lieping Chen, Peter Friedl, Ignacio Melero

Volltext

Intratumor Adoptive Transfer of IL-12 mRNA Transiently Engineered Antitumor CD8+ T Cells von Etxeberria, Iñaki, Bolaños, Elixabet, Quetglas, Jose I., Gros, Alena, Villanueva, Alberto, Palomero, Jara, Sánchez-Paulete, Alfonso R., Piulats, Jose María, Matias-Guiu, Xavier, Olivera, Irene, Ochoa, Maria C., Labiano, Sara, Garasa, Saray, Rodriguez, Inmaculada, Vidal, August, Mancheño, Uxua, Hervás-Stubbs, Sandra, Azpilikueta, Arantza, Otano, Itziar, Aznar, M. Angela, Sanmamed, Miguel F., Inogés, Susana, Berraondo, Pedro, Teijeira, Álvaro, Melero, Ignacio

Volltext

Immunotherapeutic effects of intratumoral nanoplexed poly I:C von Aznar, M Angela, Planelles, Lourdes, Perez-Olivares, Mercedes, Molina, Carmen, Garasa, Saray, Etxeberría, Iñaki, Perez, Guiomar, Rodriguez, Inmaculada, Bolaños, Elixabet, Lopez-Casas, Pedro, Rodriguez-Ruiz, Maria E, Perez-Gracia, Jose L, Marquez-Rodas, Ivan, Teijeira, Alvaro, Quintero, Marisol, Melero, Ignacio

Volltext

TGFβ Blockade Enhances Radiotherapy Abscopal Efficacy Effects in Combination with Anti-PD1 and Anti-CD137 Immunostimulatory Monoclonal Antibodies von Rodríguez-Ruiz, María E, Rodríguez, Inmaculada, Mayorga, Lina, Labiano, Tania, Barbes, Benigno, Etxeberria, Iñaki, Ponz-Sarvise, Mariano, Azpilikueta, Arantza, Bolaños, Elixabet, Sanmamed, Miguel F, Berraondo, Pedro, Calvo, Felipe A, Barcelos-Hoff, Mary Helen, Perez-Gracia, Jose L, Melero, Ignacio

Volltext

Deciphering CD137 (4‐1BB) signaling in T‐cell costimulation for translation into successful cancer immunotherapy von Sanchez‐Paulete, Alfonso R., Labiano, Sara, Rodriguez‐Ruiz, Maria E., Azpilikueta, Arantza, Etxeberria, Iñaki, Bolaños, Elixabet, Lang, Valérie, Rodriguez, Manuel, Aznar, M. Angela, Jure‐Kunkel, Maria, Melero, Ignacio

Volltext

Intratumoral Immunotherapy with XCL1 and sFlt3L Encoded in Recombinant Semliki Forest Virus-Derived Vectors Fosters Dendritic Cell-Mediated T-cell Cross-Priming von Sánchez-Paulete, Alfonso R, Teijeira, Álvaro, Quetglas, José I, Rodríguez-Ruiz, María E, Sánchez-Arráez, Álvaro, Labiano, Sara, Etxeberria, Iñaki, Azpilikueta, Arantza, Bolaños, Elixabet, Ballesteros-Briones, María Cristina, Casares, Noelia, Quezada, Sergio A, Berraondo, Pedro, Sancho, David, Smerdou, Cristian, Melero, Ignacio

Volltext

Cellular cytotoxicity is a form of immunogenic cell death von Minute, Luna, Teijeira, Alvaro, Sanchez-Paulete, Alfonso R, Ochoa, Maria C, Alvarez, Maite, Otano, Itziar, Etxeberrria, Iñaki, Bolaños, Elixabet, Azpilikueta, Arantza, Garasa, Saray, Casares, Noelia, Luis Perez Gracia, Jose, Rodriguez-Ruiz, Maria E, Berraondo, Pedro, Melero, Ignacio

Volltext

Engineering bionic T cells: signal 1, signal 2, signal 3, reprogramming and the removal of inhibitory mechanisms von Etxeberria, Iñaki, Olivera, Irene, Bolaños, Elixabet, Cirella, Asunta, Teijeira, Álvaro, Berraondo, Pedro, Melero, Ignacio

Volltext

Exploiting TCR Recognition of Shared Hotspot Oncogene-encoded Neoantigens von Olivera, Irene, Etxeberria, Iñaki, Bolaños, Elixabet, Gato-Cañas, María, Melero, Ignacio

Volltext

A Therapeutically Actionable Protumoral Axis of Cytokines Involving IL-8, TNFα, and IL-1β von Olivera, Irene, Sanz-Pamplona, Rebeca, Bolaños, Elixabet, Rodriguez, Inmaculada, Etxeberria, Iñaki, Cirella, Assunta, Egea, Josune, Garasa, Saray, Migueliz, Itziar, Eguren-Santamaria, Iñaki, Sanmamed, Miguel F, Glez-Vaz, Javier, Azpilikueta, Arantza, Alvarez, Maite, Ochoa, María C, Malacrida, Beatrice, Propper, David, de Andrea, Carlos E, Berraondo, Pedro, Balkwill, Frances R, Teijeira, Álvaro, Melero, Ignacio

Volltext

Antitumor efficacy and reduced toxicity using an anti-CD137 Probody therapeutic von Etxeberria, Iñaki, Bolaños, Elixabet, Teijeira, Alvaro, Garasa, Saray, Yanguas, Alba, Azpilikueta, Arantza, Kavanaugh, William M., Vasiljeva, Olga, Belvin, Marcia, Howng, Bruce, Irving, Bryan, Tipton, Kimberly, West, James, Mei, Li, Korman, Alan J., Sega, Emanuela, Olivera, Irene, Cirella, Assunta, Ochoa, Maria C., Rodriguez, Maria E., Melero, Ana, Sanmamed, Miguel F., Engelhardt, John J., Melero, Ignacio

Volltext

Short-term cultured tumor fragments to study immunotherapy combinations based on CD137 (4-1BB) agonism von Eguren-Santamaría, Iñaki, Rodríguez, Inmaculada, Herrero-Martin, Claudia, Fernández de Piérola, Eva, Azpilikueta, Arantza, Sánchez-Gregorio, Sandra, Bolaños, Elixabet, Gomis, Gabriel, Molero-Glez, Paula, Chacón, Enrique, Mínguez, José Ángel, Chiva, Santiago, Diez-Caballero, Fernando, de Andrea, Carlos, Teijeira, Álvaro, Sanmamed, Miguel F., Melero, Ignacio

Volltext

Combined Immunostimulatory Monoclonal Antibodies Extend Survival in an Aggressive Transgenic Hepatocellular Carcinoma Mouse Model von MORALES-KASTRESANA, Aizea, SANMAMED, Miguel F, AZPILIKUETA, Arantza, BOLANOS, Elixabet, JURE-KUNKEL, Maria, GÜTGEMANN, Ines, MELERO, Ignacio, RODRIGUEZ, Inmaculada, PALAZON, Asis, MARTINEZ-FORERO, Ivan, LABIANO, Sara, HERVAS-STUBBS, Sandra, SANGRO, Bruno, OCHOA, Carmen, ROUZAUT, Ana

Volltext

Intratumoral neoadjuvant immunotherapy based on the BO-112 viral RNA mimetic von Alvarez, Maite, Molina, Carmen, Garasa, Saray, Ochoa, Maria C, Rodriguez-Ruiz, Maria E, Gomis, Gabriel, Cirella, Assunta, Olivera, Irene, Glez-Vaz, Javier, Gonzalez-Gomariz, Jose, Luri-Rey, Carlos, Azpilikueta, Arantza, Bolaños, Elixabet, Teijeira, Alvaro, Berraondo, Pedro, Quintero, Marisol, Melero, Ignacio

Volltext

Intratumoral immunotherapy with mRNAs encoding chimeric protein constructs encompassing IL-12, CD137 agonists, and TGF-β antagonists von Cirella, Assunta, Bolaños, Elixabet, Luri-Rey, Carlos, Di Trani, Claudia Augusta, Olivera, Irene, Gomis, Gabriel, Glez-Vaz, Javier, Pinci, Beatrice, Garasa, Saray, Sánchez-Gregorio, Sandra, Azpilikueta, Arantza, Eguren-Santamaria, Iñaki, Valencia, Karmele, Palencia, Belén, Alvarez, Maite, Ochoa, Maria C., Teijeira, Álvaro, Berraondo, Pedro, Melero, Ignacio

Volltext

Intratumoral injection of IL-12-encoding mRNA targeted to CSF1R and PD-L1 exerts potent anti-tumor effects without substantial systemic exposure von Di Trani, Claudia Augusta, Cirella, Assunta, Arrizabalaga, Leire, Alvarez, Maite, Bella, Ángela, Fernandez-Sendin, Myriam, Russo-Cabrera, Joan Salvador, Gomar, Celia, Ardaiz, Nuria, Teijeira, Alvaro, Bolaños, Elixabet, González-Gomariz, José, Otano, Itziar, Aranda, Fernando, Palencia, Belén, Segués, Aina, Huang, Shuyu, van Duijnhoven, Sander M.J., van Elsas, Andrea, Melero, Ignacio, Berraondo, Pedro

Volltext

Virotherapy with a Semliki Forest Virus-Based Vector Encoding IL12 Synergizes with PD-1/PD-L1 Blockade von Quetglas, José I, Labiano, Sara, Aznar, M Ángela, Bolaños, Elixabet, Azpilikueta, Arantza, Rodriguez, Inmaculada, Casales, Erkuden, Sánchez-Paulete, Alfonso R, Segura, Víctor, Smerdou, Cristian, Melero, Ignacio

Volltext