WS18.5 Evaluation of the contributions of splicing and gating defects to dysfunction of G970R-CFTR von Fidler, M.C, Sullivan, J.C, Boj, S.F, Vries, R, Munck, A, Higgins, M, Moretto-Zita, M, Negulescu, P, Van Goor, F, De Boeck, K

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P16-26: Human kidney patient-derived organoids are a promising tool for modelling drug-induced nephrotoxicity and for assessing preclinical toxicity of immunotherapy von Merenda, A., Ehsani, N., Vries, R.G., Boj, S.F., Cantrill, C., Cabon, L., Gubler, M., Pott, J., Pourfarzad, F.

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EPS3.03 Patient-derived organoids as a platform for preclinical drug testing, identification of responsive mutations and personlized treatment diagnosis in cystic fibrosis von Frias, J., Ehsani, N., Statia, M., Fries, R.G.J., Boj, S.F., Pott, J.

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P024 Patient-derived organoids as a model for treatment diagnosis in cystic fibrosis – combinatory treatment with read-through agent, correctors and potentiator on rare mutations von Frias, J., Eshani, N., Statia, M., Vries, R.G.J., Boj, S.F., Pott, J.

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P11-12 Human Liver patient-derived organoids are a promising tool to study drug-induced liver injury and drug metabolism for improved preclinical toxicology assessment von Merenda, A., Derksen, M., Kourula, S., Van Heerden, M., Frazer-Mendelewska, E., Lai, K.W., Boj, S.F., Snoeys, J., Vries, R.G., Pourfarzad, F.

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Intestinal organoids as in vitro model system to assess safety and ADME properties of compounds von Derksen, M., Kourula, S., Roos, J.L., Frazer-Mendelewska, E., Lai, K.W., Jonkers, S., Theuns, V., Verboven, P., Huybrechts, T., van Asten, S., Kunze, A., Jardi, F., Monshouwer, M., Vries, R.G., Boj, S.F., Snoeys, J., Pourfarzad, F.

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HUB Organoids™ improve pre-clinical toxicology, metabolism, and pharmacokinetic studies for drug discovery and development von Derksen, M., Kourula, S., Jacobs, F., Lee Roos, J., Van Heerden, M., Frazer-Mendelewska, E., Ramos, E., Lai, K.W., Jonkers, S., Theuns, V., Verboven, P., Huybrechts, T., van Asten, S., Kunze, A., Jardi, F., Monshouwer, M., Vries, R.G., Boj, S.F., Snoeys, J., Pourfarzad, F.

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Engineering multicellular living systems: a Keystone symposia report von Cable, J., Arlotta, P., Parker, K.K., Hughes, A.J., Goodwin, K., Mummery, C.L., Kamm, R.D., Engle, S.J., Tagle, D.A., Boj, S.F., Stanton, A.E., Morishita, Y., Kemp, M.L., Norfleet, D.A., May, E.E., Lu, A., Bashir, R., Feinberg, A.W., Hull, S.M., Gonzalez, A.L., Blatchley, M.R., Pulido, N.M., Morizane, R., McDevitt, T.C., Mishra, D., Mulero-Russe, A.

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Expansion of Adult Human Pancreatic Tissue Yields Organoids Harboring Progenitor Cells with Endocrine Differentiation Potential von Loomans, C.J.M., Giuliani, N.W., Balak, J., Ringnalda, F., Gurp, L. van, Huch, M., Boj, S.F., Sato, T., Kester, L., Lopes, S.M.C.D., Roost, M.S., Bonner-Weir, S., Engelse, M.A., Rabelink, T.J., Heimberg, H., Vries, R.G.J., Oudenaarden, A. van, Carlotti, F., Clevers, H., Koning, E.J.P. de

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