Early assessment of minimal residual disease in AML by flow cytometry during aplasia identifies patients at increased risk of relapse von Köhnke, T, Sauter, D, Ringel, K, Hoster, E, Laubender, R P, Hubmann, M, Bohlander, S K, Kakadia, P M, Schneider, S, Dufour, A, Sauerland, M-C, Berdel, W E, Büchner, T, Wörmann, B, Braess, J, Hiddemann, W, Spiekermann, K, Subklewe, M

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BH3 mimetic ABT-737 neutralizes resistance to FLT3 inhibitor treatment mediated by FLT3-independent expression of BCL2 in primary AML blasts von KOHL, T. M, HELLINGER, C, AHMED, F, BUSKE, C, HIDDEMANN, W, BOHLANDER, S. K, SPIEKERMANN, K

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An eight-gene expression signature for the prediction of survival and time to treatment in chronic lymphocytic leukemia von Herold, T, Jurinovic, V, Metzeler, K H, Boulesteix, A-L, Bergmann, M, Seiler, T, Mulaw, M, Thoene, S, Dufour, A, Pasalic, Z, Schmidberger, M, Schmidt, M, Schneider, S, Kakadia, P M, Feuring-Buske, M, Braess, J, Spiekermann, K, Mansmann, U, Hiddemann, W, Buske, C, Bohlander, S K

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Identification of recurring tumor-specific somatic mutations in acute myeloid leukemia by transcriptome sequencing von Greif, P A, Eck, S H, Konstandin, N P, Benet-Pagès, A, Ksienzyk, B, Dufour, A, Vetter, A T, Popp, H D, Lorenz-Depiereux, B, Meitinger, T, Bohlander, S K, Strom, T M

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Genomic 5-hydroxymethylcytosine levels correlate with TET2 mutations and a distinct global gene expression pattern in secondary acute myeloid leukemia von Konstandin, N, Bultmann, S, Szwagierczak, A, Dufour, A, Ksienzyk, B, Schneider, F, Herold, T, Mulaw, M, Kakadia, P M, Schneider, S, Spiekermann, K, Leonhardt, H, Bohlander, S K

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P438: ARYL HYDROCARBON RECEPTOR SIGNALLING IN NORMAL HAEMATOPOIETIC (HSC) AND LEUKEMIA STEM CELLS (LSC): DIFFERENTIAL EFFECT OF AHR ANTAGONIST ON LSC COMPARED TO HSC von Oryshchuk, A., Desai, R., Kakadiya, P., Bohlander, S.

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CALM/AF10-positive leukemias show upregulation of genes involved in chromatin assembly and DNA repair processes and of genes adjacent to the breakpoint at 10p12 von Mulaw, M A, Krause, A J, Deshpande, A J, Krause, L F, Rouhi, A, La Starza, R, Borkhardt, A, Buske, C, Mecucci, C, Ludwig, W-D, Lottaz, C, Bohlander, S K

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CCAAT/enhancer-binding protein alpha (CEBPA) gene haploinsufficiency does not alter hematopoiesis or induce leukemia in Lck-CALM/AF10 transgenic mice von Lange, A P, Almeida, L Y, Araújo Silva, C L, Scheucher, P S, Chahud, F, Krause, A, Bohlander, S K, Rego, E M

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A four-gene LincRNA expression signature predicts risk in multiple cohorts of acute myeloid leukemia patients von Beck, D, Thoms, J A I, Palu, C, Herold, T, Shah, A, Olivier, J, Boelen, L, Huang, Y, Chacon, D, Brown, A, Babic, M, Hahn, C, Perugini, M, Zhou, X, Huntly, B J, Schwarzer, A, Klusmann, J-H, Berdel, W E, Wörmann, B, Büchner, T, Hiddemann, W, Bohlander, S K, To, L B, Scott, H S, Lewis, I D, D'Andrea, R J, Wong, J W H, Pimanda, J E

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Elevated PIN1 expression by C EBPα-p30 blocks C EBPα-induced granulocytic differentiation through c-Jun in AML von Pulikkan, J A, Dengler, V, Peer Zada, A A, Kawasaki, A, Geletu, M, Pasalic, Z, Bohlander, S K, Ryo, A, Tenen, D G, Behre, G

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The clathrin-binding domain of CALM and the OM-LZ domain of AF10 are sufficient to induce acute myeloid leukemia in mice von Deshpande, A J, Rouhi, A, Lin, Y, Stadler, C, Greif, P A, Arseni, N, Opatz, S, Quintanilla-Fend, L, Holzmann, K, Hiddemann, W, Döhner, K, Döhner, H, Xu, G, Armstrong, S A, Bohlander, S K, Buske, C

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ETV6: A versatile player in leukemogenesis von Bohlander, Stefan K.

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The target cell of transformation is distinct from the leukemia stem cell in murine CALM/AF10 leukemia models von Dutta, S, Krause, A, Vosberg, S, Herold, T, Ksienzyk, B, Quintanilla-Martinez, L, Tizazu, B, Chopra, M, Graf, A, Krebs, S, Blum, H, Greif, P A, Vetter, A, Metzeler, K, Rothenberg-Thurley, M, Schneider, M R, Dahlhoff, M, Spiekermann, K, Zimber-Strobl, U, Wolf, E, Bohlander, S K

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Somatic mutations in acute promyelocytic leukemia (APL) identified by exome sequencing von Greif, P A, Yaghmaie, M, Konstandin, N P, Ksienzyk, B, Alimoghaddam, K, Ghavamzadeh, A, Hauser, A, Graf, A, Krebs, S, Blum, H, Bohlander, S K

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The leukemogenic CALM AF10 fusion protein alters the subcellular localization of the lymphoid regulator Ikaros von Greif, P A, Tizazu, B, Krause, A, Kremmer, E, Bohlander, S K

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The homeobox gene CDX2 is aberrantly expressed and associated with an inferior prognosis in patients with acute lymphoblastic leukemia von Thoene, S, Rawat, V P S, Heilmeier, B, Hoster, E, Metzeler, K H, Herold, T, Hiddemann, W, Gökbuget, N, Hoelzer, D, Bohlander, S K, Feuring-Buske, M, Buske, C

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Proteomics of acute myeloid leukaemia: cytogenetic risk groups differ specifically in their proteome, interactome and post-translational protein modifications von Balkhi, M Y, Trivedi, A K, Geletu, M, Christopeit, M, Bohlander, S K, Behre, H M, Behre, G

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Proteomic identification of the MYST domain histone acetyltransferase TIP60 (HTATIP) as a co-activator of the myeloid transcription factor C EBPα von Bararia, D, Trivedi, A K, Zada, A A Peer, Greif, P A, Mulaw, M A, Christopeit, M, Hiddemann, W, Bohlander, S K, Behre, G

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A novel ABL1 fusion to the SH2 containing inositol phosphatase-1 (SHIP1) in acute lymphoblastic leukemia (ALL) von Kakadia, P M, Tizazu, B, Mellert, G, Harbott, J, Röttgers, S, Quentmeier, H, Spiekermann, K, Bohlander, S K

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P748: SINGLE CELL GENOTYPING OF MATCHED BONE MARROW AND PERIPHERAL BLOOD CELLS IN TREATMENT NAIVE AND AZA‐TREATED MDS AND CMML von Schnegg‐Kaufmann, A., Thoms, J., Bhuyan, G. S., Henry, H., Vaughan, L., Rutherford, K., Kakadia, P., Johansson, E., Failes, T., Greg, A., Koval, J., Lindeman, R., Warburton, P., Rodriguez‐Meira, A., Mead, A., Unnikrishnan, A., Bohlander, S., Pappaemmanuil, E., Faridani, O., Jolly, C., Zanini, F., Pimanda, J.

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