Targeting 6-phosphogluconate dehydrogenase in the oxidative PPP sensitizes leukemia cells to antimalarial agent dihydroartemisinin von Elf, S, Lin, R, Xia, S, Pan, Y, Shan, C, Wu, S, Lonial, S, Gaddh, M, Arellano, M L, Khoury, H J, Khuri, F R, Lee, B H, Boggon, T J, Fan, J, Chen, J

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G-Protein Signaling through Tubby Proteins von Santagata, Sandro, Boggon, Titus J., Baird, Cheryl L., Gomez, Carlos A., Zhao, Jin, Shan, Wei Song, Myszka, David G., Shapiro, Lawrence

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Structure and regulation of Src family kinases von BOGGON, Titus J, ECK, Michael J

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Implication of Tubby Proteins as Transcription Factors by Structure-Based Functional Analysis von Boggon, Titus J., Shan, Wei-Song, Santagata, Sandro, Myers, Samuel C., Shapiro, Lawrence

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EGFR Mutation and Resistance of Non–Small-Cell Lung Cancer to Gefitinib von Kobayashi, Susumu, Boggon, Titus J, Dayaram, Tajhal, Jänne, Pasi A, Kocher, Olivier, Meyerson, Matthew, Johnson, Bruce E, Eck, Michael J, Tenen, Daniel G, Halmos, Balázs

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Disruption of the EGFR E884-R958 ion pair conserved in the human kinome differentially alters signaling and inhibitor sensitivity von Tang, Z, Jiang, S, Du, R, Petri, E T, El-Telbany, A, Chan, P S O, Kijima, T, Dietrich, S, Matsui, K, Kobayashi, M, Sasada, S, Okamoto, N, Suzuki, H, Kawahara, K, Iwasaki, T, Nakagawa, K, Kawase, I, Christensen, J G, Hirashima, T, Halmos, B, Salgia, R, Boggon, T J, Kern, J A, Ma, P C

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Synchrotron X-ray reciprocal-space mapping, topography and diffraction resolution studies of macromolecular crystal quality von Boggon, T. J., Helliwell, J. R., Judge, R. A., Olczak, A., Siddons, D. P., Snell, E. H., Stojanoff, V.

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Screening for phasing atoms in protein crystallography von Boggon, Titus J, Shapiro, Lawrence

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Structures of Lung Cancer-Derived EGFR Mutants and Inhibitor Complexes: Mechanism of Activation and Insights into Differential Inhibitor Sensitivity von Yun, Cai-Hong, Boggon, Titus J., Li, Yiqun, Woo, Michele S., Greulich, Heidi, Meyerson, Matthew, Eck, Michael J.

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Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis von Levine, Ross L., Wadleigh, Martha, Cools, Jan, Ebert, Benjamin L., Wernig, Gerlinde, Huntly, Brian J.P., Boggon, Titus J., Wlodarska, Iwona, Clark, Jennifer J., Moore, Sandra, Adelsperger, Jennifer, Koo, Sumin, Lee, Jeffrey C., Gabriel, Stacey, Mercher, Thomas, D’Andrea, Alan, Fröhling, Stefan, Döhner, Konstanze, Marynen, Peter, Vandenberghe, Peter, Mesa, Ruben A., Tefferi, Ayalew, Griffin, James D., Eck, Michael J., Sellers, William R., Meyerson, Matthew, Golub, Todd R., Lee, Stephanie J., Gilliland, D. Gary

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Identification of Driver and Passenger Mutations of FLT3 by High-Throughput DNA Sequence Analysis and Functional Assessment of Candidate Alleles von Fröhling, Stefan, Scholl, Claudia, Levine, Ross L., Loriaux, Marc, Boggon, Titus J., Bernard, Olivier A., Berger, Roland, Döhner, Hartmut, Döhner, Konstanze, Ebert, Benjamin L., Teckie, Sewit, Golub, Todd R., Jiang, Jingrui, Schittenhelm, Marcus M., Lee, Benjamin H., Griffin, James D., Stone, Richard M., Heinrich, Michael C., Deininger, Michael W., Druker, Brian J., Gilliland, D. Gary

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EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy von Paez, J. Guillermo, Jänne, Pasi A., Lee, Jeffrey C., Tracy, Sean, Greulich, Heidi, Gabriel, Stacey, Herman, Paula, Kaye, Frederic J., Lindeman, Neal, Boggon, Titus J., Naoki, Katsuhiko, Sasaki, Hidefumi, Fujii, Yoshitaka, Eck, Michael J., Sellers, William R., Johnson, Bruce E., Meyerson, Matthew

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Partial Improvement of Crystal Quality for Microgravity-Grown Apocrustacyanin C1 von Snell, E. H., Cassetta, A., Helliwell, J. R., Boggon, T. J., Chayen, N. E., Weckert, E., Hölzer, K., Schroer, K., Gordon, E. J., Zagalsky, P. F.

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C-Cadherin Ectodomain Structure and Implications for Cell Adhesion Mechanisms von Boggon, Titus J., Murray, John, Chappuis-Flament, Sophie, Wong, Ellen, Gumbiner, Barry M., Shapiro, Lawrence

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JAK2T875N is a novel activating mutation that results in myeloproliferative disease with features of megakaryoblastic leukemia in a murine bone marrow transplantation model von Mercher, Thomas, Wernig, Gerlinde, Moore, Sandra A., Levine, Ross L., Gu, Ting-Lei, Fröhling, Stefan, Cullen, Dana, Polakiewicz, Roberto D., Bernard, Olivier A., Boggon, Titus J., Lee, Benjamin H., Gilliland, D. Gary

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CCD Video Observation of Microgravity Crystallization of Lysozyme and Correlation with Accelerometer Data von Snell, E. H., Boggon, T. J., Helliwell, J. R., Moskowitz, M. E., Nadarajah, A.

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JAK3: A two-faced player in hematological disorders von Cornejo, Melanie G., Boggon, Titus J., Mercher, Thomas

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Lysozyme Crystal Growth Kinetics Monitored Using a Mach-Zehnder Interferometer von Snell, E. H., Helliwell, J. R., Boggon, T. J., Lautenschlager, P., Potthast, L.

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Crystal structure of the Jak3 kinase domain in complex with a staurosporine analog von Boggon, Titus J., Li, Yiqun, Manley, Paul W., Eck, Michael J.

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The Crystal Structure Analysis of d(CGCGAASSCGCG)2, a Synthetic DNA Dodecamer Duplex Containing Four 4′-Thio-2′-Deoxythymidine Nucleotides von Boggon, Titus J., Hancox, E. Louise, McAuley-Hecht, Katherine E., Connolly, Bernard A., Hunter, William N., Brown, Tom, Walker, Richard T., Leonard, Gordon A.

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