Analysis of 589,306 genomes identifies individuals resilient to severe Mendelian childhood diseases von Chen, Rong, Shi, Lisong, Hakenberg, Jörg, Naughton, Brian, Sklar, Pamela, Zhang, Jianguo, Zhou, Hanlin, Tian, Lifeng, Prakash, Om, Lemire, Mathieu, Sleiman, Patrick, Cheng, Wei-yi, Chen, Wanting, Shah, Hardik, Shen, Yulan, Fromer, Menachem, Omberg, Larsson, Deardorff, Matthew A, Zackai, Elaine, Bobe, Jason R, Levin, Elissa, Hudson, Thomas J, Groop, Leif, Wang, Jun, Hakonarson, Hakon, Wojcicki, Anne, Diaz, George A, Edelmann, Lisa, Schadt, Eric E, Friend, Stephen H

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Extensive sequencing of seven human genomes to characterize benchmark reference materials von Zook, Justin M., Catoe, David, McDaniel, Jennifer, Vang, Lindsay, Spies, Noah, Sidow, Arend, Weng, Ziming, Liu, Yuling, Mason, Christopher E., Alexander, Noah, Henaff, Elizabeth, McIntyre, Alexa B.R., Chandramohan, Dhruva, Chen, Feng, Jaeger, Erich, Moshrefi, Ali, Pham, Khoa, Stedman, William, Liang, Tiffany, Saghbini, Michael, Dzakula, Zeljko, Hastie, Alex, Cao, Han, Deikus, Gintaras, Schadt, Eric, Sebra, Robert, Bashir, Ali, Truty, Rebecca M., Chang, Christopher C., Gulbahce, Natali, Zhao, Keyan, Ghosh, Srinka, Hyland, Fiona, Fu, Yutao, Chaisson, Mark, Xiao, Chunlin, Trow, Jonathan, Sherry, Stephen T., Zaranek, Alexander W., Ball, Madeleine, Bobe, Jason, Estep, Preston, Church, George M., Marks, Patrick, Kyriazopoulou-Panagiotopoulou, Sofia, Zheng, Grace X.Y., Schnall-Levin, Michael, Ordonez, Heather S., Mudivarti, Patrice A., Giorda, Kristina, Sheng, Ying, Rypdal, Karoline Bjarnesdatter, Salit, Marc

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Harvard Personal Genome Project: lessons from participatory public research von Ball, Madeleine P, Bobe, Jason R, Chou, Michael F, Clegg, Tom, Estep, Preston W, Lunshof, Jeantine E, Vandewege, Ward, Zaranek, Alexander, Church, George M

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Recent Progress in Lyme Disease and Remaining Challenges von Bobe, Jason R, Jutras, Brandon L, Horn, Elizabeth J, Embers, Monica E, Bailey, Allison, Moritz, Robert L, Zhang, Ying, Soloski, Mark J, Ostfeld, Richard S, Marconi, Richard T, Aucott, John, Ma'ayan, Avi, Keesing, Felicia, Lewis, Kim, Ben Mamoun, Choukri, Rebman, Alison W, McClune, Mecaila E, Breitschwerdt, Edward B, Reddy, Panga Jaipal, Maggi, Ricardo, Yang, Frank, Nemser, Bennett, Ozcan, Aydogan, Garner, Omai, Di Carlo, Dino, Ballard, Zachary, Joung, Hyou-Arm, Garcia-Romeu, Albert, Griffiths, Roland R, Baumgarth, Nicole, Fallon, Brian A

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public resource facilitating clinical use of genomes von Ball, Madeleine P, Thakuria, Joseph V, Zaranek, Alexander Wait, Clegg, Tom, Rosenbaum, Abraham M, Wu, Xiaodi, Angrist, Misha, Bhak, Jong, Bobe, Jason, Callow, Matthew J, Cano, Carlos, Chou, Michael F, Chung, Wendy K, Douglas, Shawn M, Estep, Preston W, Gore, Athurva, Hulick, Peter, Labarga, Alberto, Lee, Je-Hyuk, Lunshof, Jeantine E, Kim, Byung Chul, Kim, Jong-Il, Li, Zhe, Murray, Michael F, Nilsen, Geoffrey B, Peters, Brock A, Raman, Anugraha M, Rienhoff, Hugh Y, Robasky, Kimberly, Wheeler, Matthew T, Vandewege, Ward, Vorhaus, Daniel B, Yang, Joyce L, Yang, Luhan, Aach, John, Ashley, Euan A, Drmanac, Radoje, Kim, Seong-Jin, Li, Jin Billy, Peshkin, Leonid, Seidman, Christine E, Seo, Jeong-Sun, Zhang, Kun, Rehm, Heidi L, Church, George M

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Exploring the Potential for Collaborative Use of an App-Based Platform for n-of-1 Trials Among Healthcare Professionals That Treat Patients With Insomnia von Bobe, Jason R, De Freitas, Jessica K, Glicksberg, Benjamin S

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APPLaUD: access for patients and participants to individual level uninterpreted genomic data von Thorogood, Adrian, Bobe, Jason, Prainsack, Barbara, Middleton, Anna, Scott, Erick, Nelson, Sarah, Corpas, Manuel, Bonhomme, Natasha, Rodriguez, Laura Lyman, Murtagh, Madeleine, Kleiderman, Erika

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Predicting Lyme Disease From Patients' Peripheral Blood Mononuclear Cells Profiled With RNA-Sequencing von Clarke, Daniel J B, Rebman, Alison W, Bailey, Allison, Wojciechowicz, Megan L, Jenkins, Sherry L, Evangelista, John E, Danieletto, Matteo, Fan, Jinshui, Eshoo, Mark W, Mosel, Michael R, Robinson, William, Ramadoss, Nitya, Bobe, Jason, Soloski, Mark J, Aucott, John N, Ma'ayan, Avi

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Ten simple rules for open human health research von Bafeta, Aïda, Bobe, Jason, Clucas, Jon, Gonsalves, Pattie Pramila, Gruson-Daniel, Célya, Hudson, Kathy L, Klein, Arno, Krishnakumar, Anirudh, McCollister-Slipp, Anna, Lindner, Ariel B, Misevic, Dusan, Naslund, John A, Nebeker, Camille, Nikolaidis, Aki, Pasquetto, Irene, Sanchez, Gabriela, Schapira, Matthieu, Scheininger, Tohar, Schoeller, Félix, Sólon Heinsfeld, Anibal, Taddei, François

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Measuring the Effects of Caffeine and L-Theanine on Cognitive Performance: A Protocol for Self-Directed, Mobile N-of-1 Studies von Golden, Eddye, Johnson, Matthew, Jones, Michael, Viglizzo, Ryan, Bobe, Jason, Zimmerman, Noah

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Factors Associated With Trial Completion and Adherence in App-Based N-of-1 Trials: Protocol for a Randomized Trial Evaluating Study Duration, Notification Level, and Meaningful Eng... von Bobe, Jason R, Buros, Jacqueline, Golden, Eddye, Johnson, Matthew, Jones, Michael, Percha, Bethany, Viglizzo, Ryan, Zimmerman, Noah

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'Your DNA, Your Say': global survey gathering attitudes toward genomics: design, delivery and methods von Middleton, Anna, Niemiec, Emilia, Prainsack, Barbara, Bobe, Jason, Farley, Lauren, Steed, Claire, Smith, James, Bevan, Paul, Bonhomme, Natasha, Kleiderman, Erika, Thorogood, Adrian, Schickhardt, Christoph, Garattini, Chiara, Vears, Danya, Littler, Katherine, Banner, Natalie, Scott, Erick, Kovalevskaya, Nadezda V, Levin, Elissa, Morley, Katherine I, Howard, Heidi Carmen

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A 72-Year-Old Patient with Longstanding, Untreated Familial Hypercholesterolemia but no Coronary Artery Calcification: A Case Report von Johnson, Kipp W, Dudley, Joel T, Bobe, Jason R

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American Gut: an Open Platform for Citizen Science Microbiome Research von McDonald, Daniel, Hyde, Embriette, Debelius, Justine W, Morton, James T, Gonzalez, Antonio, Ackermann, Gail, Aksenov, Alexander A, Behsaz, Bahar, Brennan, Caitriona, Chen, Yingfeng, DeRight Goldasich, Lindsay, Dorrestein, Pieter C, Dunn, Robert R, Fahimipour, Ashkaan K, Gaffney, James, Gilbert, Jack A, Gogul, Grant, Green, Jessica L, Hugenholtz, Philip, Humphrey, Greg, Huttenhower, Curtis, Jackson, Matthew A, Janssen, Stefan, Jeste, Dilip V, Jiang, Lingjing, Kelley, Scott T, Knights, Dan, Kosciolek, Tomasz, Ladau, Joshua, Leach, Jeff, Marotz, Clarisse, Meleshko, Dmitry, Melnik, Alexey V, Metcalf, Jessica L, Mohimani, Hosein, Montassier, Emmanuel, Navas-Molina, Jose, Nguyen, Tanya T, Peddada, Shyamal, Pevzner, Pavel, Pollard, Katherine S, Rahnavard, Gholamali, Robbins-Pianka, Adam, Sangwan, Naseer, Shorenstein, Joshua, Smarr, Larry, Song, Se Jin, Spector, Timothy, Swafford, Austin D, Thackray, Varykina G, Thompson, Luke R, Tripathi, Anupriya, Vázquez-Baeza, Yoshiki, Vrbanac, Alison, Wischmeyer, Paul, Wolfe, Elaine, Zhu, Qiyun, Knight, Rob

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CAGI, the Critical Assessment of Genome Interpretation, establishes progress and prospects for computational genetic variant interpretation methods von Jain, Shantanu, Bakolitsa, Constantina, Brenner, Steven E., Radivojac, Predrag, Moult, John, Repo, Susanna, Hoskins, Roger A., Andreoletti, Gaia, Barsky, Daniel, Chellapan, Ajithavalli, Chu, Hoyin, Dabbiru, Navya, Kollipara, Naveen K., Ly, Melissa, Neumann, Andrew J., Pal, Lipika R., Odell, Eric, Pandey, Gaurav, Peters-Petrulewicz, Robin C., Srinivasan, Rajgopal, Yee, Stephen F., Yeleswarapu, Sri Jyothsna, Zuhl, Maya, Adebali, Ogun, Patra, Ayoti, Beer, Michael A., Hosur, Raghavendra, Peng, Jian, Bernard, Brady M., Berry, Michael, Dong, Shengcheng, Boyle, Alan P., Adhikari, Aashish, Chen, Jingqi, Hu, Zhiqiang, Wang, Robert, Wang, Yaqiong, Miller, Maximilian, Wang, Yanran, Bromberg, Yana, Turina, Paola, Capriotti, Emidio, Han, James J., Ozturk, Kivilcim, Carter, Hannah, Babbi, Giulia, Bovo, Samuele, Di Lena, Pietro, Martelli, Pier Luigi, Savojardo, Castrense, Casadio, Rita, Cline, Melissa S., De Baets, Greet, Bonache, Sandra, Díez, Orland, Gutiérrez-Enríquez, Sara, Fernández, Alejandro, Montalban, Gemma, Ootes, Lars, Özkan, Selen, Padilla, Natàlia, Riera, Casandra, De la Cruz, Xavier, Diekhans, Mark, Huwe, Peter J., Wei, Qiong, Xu, Qifang, Dunbrack, Roland L., Gotea, Valer, Elnitski, Laura, Margolin, Gennady, Fariselli, Piero, Kulakovskiy, Ivan V., Makeev, Vsevolod J., Penzar, Dmitry D., Vorontsov, Ilya E., Favorov, Alexander V., Forman, Julia R., Hasenahuer, Marcia, Fornasari, Maria S., Parisi, Gustavo, Avsec, Ziga, Çelik, Muhammed H., Nguyen, Thi Yen Duong, Gagneur, Julien, Shi, Fang-Yuan, Edwards, Matthew D., Guo, Yuchun, Tian, Kevin, Zeng, Haoyang, Gifford, David K., Göke, Jonathan, Zaucha, Jan, Gough, Julian, Ritchie, Graham R. S., Frankish, Adam, Mudge, Jonathan M., Harrow, Jennifer, Young, Erin L., Yu, Yao

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Members of the public in the USA, UK, Canada and Australia expressing genetic exceptionalism say they are more willing to donate genomic data von Middleton, Anna, Milne, Richard, Howard, Heidi, Niemiec, Emilia, Robarts, Lauren, Critchley, Christine, Nicol, Dianne, Prainsack, Barbara, Atutornu, Jerome, Vears, Danya F, Smith, James, Steed, Claire, Bevan, Paul, Scott, Erick R, Bobe, Jason, Goodhand, Peter, Kleiderman, Erika, Thorogood, Adrian, Morley, Katherine I

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Open Humans: A platform for participant-centered research and personal data exploration von Greshake Tzovaras, Bastian, Angrist, Misha, Arvai, Kevin, Dulaney, Mairi, Estrada-Galiñanes, Vero, Gunderson, Beau, Head, Tim, Lewis, Dana, Nov, Oded, Shaer, Orit, Tzovara, Athina, Bobe, Jason, Price Ball, Mad

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Members of the public in the USA, UK, Canada and Australia expressing genetic exceptionalism say they are more willing to donate genomic data von Middleton, Anna, Milne, Richard, Howard, Heidi, Niemiec, Emilia, Robarts, Lauren, Critchley, Christine, Nicol, Dianne, Prainsack, Barbara, Atutornu, Jerome, Vears, Danya F, Smith, James, Steed, Claire, Bevan, Paul, Scott, Erick R, Bobe, Jason, Goodhand, Peter, Kleiderman, Erika, Thorogood, Adrian, Morley, Katherine I

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Matching phenotypes to whole genomes: Lessons learned from four iterations of the personal genome project community challenges von Cai, Binghuang, Li, Biao, Kiga, Nikki, Thusberg, Janita, Bergquist, Timothy, Chen, Yun‐Ching, Niknafs, Noushin, Carter, Hannah, Tokheim, Collin, Beleva‐Guthrie, Violeta, Douville, Christopher, Bhattacharya, Rohit, Yeo, Hui Ting Grace, Fan, Jean, Sengupta, Sohini, Kim, Dewey, Cline, Melissa, Turner, Tychele, Diekhans, Mark, Zaucha, Jan, Pal, Lipika R., Cao, Chen, Yu, Chen‐Hsin, Yin, Yizhou, Carraro, Marco, Giollo, Manuel, Ferrari, Carlo, Leonardi, Emanuela, Tosatto, Silvio C.E., Bobe, Jason, Ball, Madeleine, Hoskins, Roger A., Repo, Susanna, Church, George, Brenner, Steven E., Moult, John, Gough, Julian, Stanke, Mario, Karchin, Rachel, Mooney, Sean D.

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Open Humans: A platform for participant-centered research and personal data exploration von Tzovaras, Bastian Greshake, Angrist, Misha, Arvai, Kevin, Dulaney, Mairi, Estrada-Galiñanes, Vero, Gunderson, Beau, Head, Tim, Lewis, Dana, Nov, Oded, Shaer, Orit, Tzovara, Athina, Bobe, Jason, Ball, Mad Price

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