Discovery of a new series of potent prostacyclin receptor agonists with in vivo activity in rat von Tran, Thuy-Anh, Shin, Young-Jun, Kramer, Bryan, Choi, Juyi, Zou, Ning, Vallar, Pureza, Martens, Peter, Douglas Boatman, P., Adams, John W., Ramirez, Juan, Shi, Yunqing, Morgan, Michael, Unett, David J., Chang, Steve, Shu, Hsin-Hui, Tung, Shiu-Feng, Semple, Graeme

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Nicotinic Acid Receptor Agonists von Boatman, P. Douglas, Richman, Jeremy G, Semple, Graeme

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Discovery of 2‑(((1r,4r)‑4-(((4-Chlorophenyl)­(phenyl)­carbamoyl)­oxy)­methyl)­cyclohexyl)­methoxy)­acetate (Ralinepag): An Orally Active Prostacyclin Receptor Agonist for the Trea... von Tran, Thuy-Anh, Kramer, Bryan, Shin, Young-Jun, Vallar, Pureza, Boatman, P. Douglas, Zou, Ning, Sage, Carleton R, Gharbaoui, Tawfik, Krishnan, Ashwin, Pal, Biman, Shakya, Sagar R, Garrido Montalban, Antonio, Adams, John W, Ramirez, Juan, Behan, Dominic P, Shifrina, Anna, Blackburn, Anthony, Leakakos, Tina, Shi, Yunqing, Morgan, Michael, Sadeque, Abu, Chen, Weichao, Unett, David J, Gaidarov, Ibragim, Chen, Xiaohua, Chang, Steve, Shu, Hsin-Hui, Tung, Shiu-Feng, Semple, Graeme

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Inhibition of Mas G-protein signaling improves coronary blood flow, reduces myocardial infarct size, and provides long-term cardioprotection von Zhang, Tong, Li, Zhuangjie, Dang, Huong, Chen, Ruoping, Liaw, Chen, Tran, Thuy-Anh, Boatman, P Douglas, Connolly, Daniel T, Adams, John W

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(1aR,5aR)1a,3,5,5a-Tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalene-4-carboxylic Acid (MK-1903): A Potent GPR109a Agonist that Lowers Free Fatty Acids in Humans von Boatman, P. Douglas, Lauring, Brett, Schrader, Thomas O, Kasem, Michelle, Johnson, Benjamin R, Skinner, Philip, Jung, Jae-Kyu, Xu, Jerry, Cherrier, Martin C, Webb, Peter J, Semple, Graeme, Sage, Carleton R, Knudsen, Jens, Chen, Ruoping, Luo, Wen-Lin, Caro, Luzelena, Cote, Josee, Lai, Eseng, Wagner, John, Taggart, Andrew K, Carballo-Jane, Ester, Hammond, Milton, Colletti, Steven L, Tata, James R, Connolly, Daniel T, Waters, M. Gerard, Richman, Jeremy G

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3-(1H-Tetrazol-5-yl)-1,4,5,6-tetrahydro-cyclopentapyrazole (MK-0354): A Partial Agonist of the Nicotinic Acid Receptor, G-Protein Coupled Receptor 109a, with Antilipolytic but No V... von Semple, Graeme, Skinner, Philip J, Gharbaoui, Tawfik, Shin, Young-Jun, Jung, Jae-Kyu, Cherrier, Martin C, Webb, Peter J, Tamura, Susan Y, Boatman, P. Douglas, Sage, Carleton R, Schrader, Thomas O, Chen, Ruoping, Colletti, Steven L, Tata, James R, Waters, M. Gerard, Cheng, Kang, Taggart, Andrew K, Cai, Tian-Quan, Carballo-Jane, Ester, Behan, Dominic P, Connolly, Daniel T, Richman, Jeremy G

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Potent tricyclic pyrazole tetrazole agonists of the nicotinic acid receptor (GPR109a) von Boatman, P. Douglas, Schrader, Thomas O., Kasem, Michelle, Johnson, Benjamin R., Skinner, Philip J., Jung, Jae-Kyu, Xu, Jerry, Cherrier, Martin C., Webb, Peter J., Semple, Graeme, Sage, Carleton R., Knudsen, Jens, Chen, Ruoping, Taggart, Andrew K., Carballo-Jane, Ester, Richman, Jeremy G.

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Analogues of Acifran:  Agonists of the High and Low Affinity Niacin Receptors, GPR109a and GPR109b von Jung, Jae-Kyu, Johnson, Benjamin R, Duong, Tracy, Decaire, Marc, Uy, Jane, Gharbaoui, Tawfik, Boatman, P. Douglas, Sage, Carleton R, Chen, Ruoping, Richman, Jeremy G, Connolly, Daniel T, Semple, Graeme

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First total synthesis of taxol. 2. Completion of the C and D rings von Holton, Robert A, Kim, Hyeong Baik, Somoza, Carmen, Liang, Feng, Biediger, Ronald J, Boatman, P. Douglas, Shindo, Mitsuru, Smith, Chase C, Kim, Soekchan

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First total synthesis of taxol. 1. Functionalization of the B ring von Holton, Robert A, Somoza, Carmen, Kim, Hyeong Baik, Liang, Feng, Biediger, Ronald J, Boatman, P. Douglas, Shindo, Mitsuru, Smith, Chase C, Kim, Soekchan

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Agonist lead identification for the high affinity niacin receptor GPR109a von Gharbaoui, Tawfik, Skinner, Philip J., Shin, Young-Jun, Averbuj, Claudia, Jung, Jae-Kyu, Johnson, Benjamin R., Duong, Tracy, Decaire, Marc, Uy, Jane, Cherrier, Martin C., Webb, Peter J., Tamura, Susan Y., Zou, Ning, Rodriguez, Nathalie, Boatman, P. Douglas, Sage, Carleton R., Lindstrom, Andrew, Xu, Jerry, Schrader, Thomas O., Smith, Brian M., Chen, Ruoping, Richman, Jeremy G., Connolly, Daniel T., Colletti, Steven L., Tata, James R., Semple, Graeme

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High-throughput synthesis and optimization of thrombin inhibitors via urazole α-addition and Michael addition von Boatman, P.Douglas, Urban, Jan, Nguyen, Minh, Qabar, Maher, Kahn, Michael

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Clinically validated peptides as templates for de novo peptidomimetic drug design at G-protein-coupled receptors von Jones, Robert M, Boatman, P Douglas, Semple, Graeme, Shin, Young-Jun, Tamura, Susan Y

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(1a R ,5a R )1a,3,5,5a-Tetrahydro-1 H -2,3-diaza-cyclopropa[ a ]pentalene-4-carboxylic Acid (MK-1903): A Potent GPR109a Agonist that Lowers Free Fatty Acids in Humans von Boatman, P. Douglas, Lauring, Brett, Schrader, Thomas O., Kasem, Michelle, Johnson, Benjamin R., Skinner, Philip, Jung, Jae-Kyu, Xu, Jerry, Cherrier, Martin C., Webb, Peter J., Semple, Graeme, Sage, Carleton R., Knudsen, Jens, Chen, Ruoping, Luo, Wen-Lin, Caro, Luzelena, Cote, Josee, Lai, Eseng, Wagner, John, Taggart, Andrew K., Carballo-Jane, Ester, Hammond, Milton, Colletti, Steven L., Tata, James R., Connolly, Daniel T., Waters, M. Gerard, Richman, Jeremy G.

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Inhibition of Mas G-protein signaling improves coronary blood flow, reduces myocardial infarct size, and provides long-term cardioprotection von TONG ZHANG, ZHUANGJIE LI, HUONG DANG, RUOPING CHEN, LIAW, Chen, TRAN, Thuy-Anh, DOUGLAS BOATMAN, P, CONNOLLY, Daniel T, ADAMS, John W

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A stereoselective route to the spirobicyclic ring system of oscillatoxin D von Walkup, Robert D., Boatman, P. Douglas, Kane, Robert R., Cunningham, Raymond T.

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Secondary Structure Peptide Mimetics:  Design, Synthesis, and Evaluation of β-Strand Mimetic Thrombin Inhibitors von Boatman, P. Douglas, Ogbu, Cyprian O, Eguchi, Masakatsu, Kim, Hwa-Ok, Nakanishi, Hiroshi, Cao, Bolong, Shea, J. Paul, Kahn, Michael

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Expeditious synthesis of a key C9–C21 subunit of the aplyslatoxine and oscillatoxins von Walkup, Robert D., Kane, Robert R., Douglas Boatman, P., Cunningham, Raymond T.

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Highly efficient and versatile synthesis of libraries of constrained β-strand mimetics von Ogbu, Cyprian O., Qabar, Maher N., Boatman, P.Douglas, Urban, Jan, Meara, Joseph P., Ferguson, Mark D., Tulinsky, John, Lum, Chris, Babu, Suresh, Blaskovich, Mark A., Nakanishi, Hiroshi, Ruan, Fuqiang, Cao, Bolong, Minarik, Ryan, Little, Tom, Nelson, Sherry, Nguyen, Minh, Gall, Anna, Kann, Michael

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ChemInform Abstract: Nicotinic Acid Receptor Agonists von Boatman, P. Douglas, Richman, Jeremy G., Semple, Graeme

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