The translation of cell-based therapies: clinical landscape and manufacturing challenges von Heathman, Thomas RJ, Nienow, Alvin W, McCall, Mark J, Coopman, Karen, Kara, Bo, Hewitt, Christopher J

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Development of a process control strategy for the serum-free microcarrier expansion of human mesenchymal stem cells towards cost-effective and commercially viable manufacturing von Heathman, Thomas R.J., Nienow, Alvin W., Rafiq, Qasim A., Coopman, Karen, Bo Kara, Hewitt, Christopher J.

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Characterization of human mesenchymal stem cells from multiple donors and the implications for large scale bioprocess development von Heathman, Thomas R.J., Rafiq, Qasim A., Chan, Alexander K.C., Coopman, Karen, Nienow, Alvin W., Kara, Bo, Hewitt, Christopher J.

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Generation and characterization of multipotent stem cells from established dermal cultures von Hill, Rebecca P, Gledhill, Karl, Gardner, Aaron, Higgins, Claire A, Crawford, Heather, Lawrence, Clifford, Hutchison, Christopher J, Owens, William A, Kara, Bo, James, S Elizabeth, Jahoda, Colin A B

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Assessment of Protocol Impact on Subjectivity Uncertainty When Analyzing Peripheral Blood Mononuclear Cell Flow Cytometry Data Files von Grant, Rebecca, Coopman, Karen, Silva-Gomes, Sandro, Campbell, Jonathan J, Kara, Bo, Braybrook, Julian, Petzing, Jon

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Multivariate data analysis in cell gene therapy manufacturing von Emerson, Joseph, Kara, Bo, Glassey, Jarka

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Human hair follicle dermal sheath and papilla cells support keratinocyte growth in monolayer coculture von Hill, Rebecca P., Gardner, Aaron, Crawford, Heather C., Richer, Rachel, Dodds, Anna, Owens, William A., Lawrence, Clifford, Rao, Sam, Kara, Bo, James, S. Elizabeth, Jahoda, Colin A.

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Lentiviral vector bioprocess economics for cell and gene therapy commercialization von Comisel, Ruxandra-Maria, Kara, Bo, Fiesser, Frederick H., Farid, Suzanne S.

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Gene therapy process change evaluation framework: Transient transfection and stable producer cell line comparison von Comisel, Ruxandra-Maria, Kara, Bo, Fiesser, Frederick H., Farid, Suzanne S.

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Expansion, harvest and cryopreservation of human mesenchymal stem cells in a serum-free microcarrier process von Heathman, Thomas R. J., Glyn, Veronica A. M., Picken, Andrew, Rafiq, Qasim A., Coopman, Karen, Nienow, Alvin W., Kara, Bo, Hewitt, Christopher J.

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Agitation and aeration of stirred-bioreactors for the microcarrier culture of human mesenchymal stem cells and potential implications for large-scale bioprocess development von Heathman, Thomas R.J., Nienow, Alvin W., Rafiq, Qasim A., Coopman, Karen, Kara, Bo, Hewitt, Christopher J.

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Understanding the contribution of operator measurement variability within Flow Cytometry data analysis for Quality Control of Cell and Gene Therapy manufacturing von Grant, Rebecca, Coopman, Karen, Medcalf, Nicholas, Silva-Gomes, Sandro, Campbell, Jonathan J., Kara, Bo, Braybrook, Julian, Petzing, Jon

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Serum-free process development: improving the yield and consistency of human mesenchymal stromal cell production von Heathman, Thomas R.J, Stolzing, Alexandra, Fabian, Claire, Rafiq, Qasim A, Coopman, Karen, Nienow, Alvin W, Kara, Bo, Hewitt, Christopher J

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Scalability and process transfer of mesenchymal stromal cell production from monolayer to microcarrier culture using human platelet lysate von Heathman, Thomas R.J, Stolzing, Alexandra, Fabian, Claire, Rafiq, Qasim A, Coopman, Karen, Nienow, Alvin W, Kara, Bo, Hewitt, Christopher J

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Rapid analysis of the expression of heterologous proteins in Escherichia coli using pyrolysis mass spectrometry and Fourier transform infrared spectroscopy with chemometrics: appli... von McGovern, Aoife C, Ernill, Richard, Kara, Bo V, Kell, Douglas B, Goodacre, Royston

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Studies related to antibody fragment (Fab) production in Escherichia coli W3110 fed-batch fermentation processes using multiparameter flow cytometry von Want, Andrew, Thomas, Owen R.T, Kara, Bo, Liddell, John, Hewitt, Christopher J

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Novel systems for rapid fermentation process development of biopharmaceuticals von Hodgson, Ian, Kara, Bo, Baumgartner, Philippe, Lennon, Chris

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Utilisation of key descriptors from protein sequence data to aid bioprocess route selection von O’Malley, Christopher J., Montague, Gary A., Martin, Elaine B., Liddell, John M., Kara, Bo, Titchener-Hooker, Nigel J.

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Assessment of protocol impact on subjectivity uncertainty when analyzing peripheral blood mononuclear cell flow cytometry data files von Rebecca Grant, Karen Coopman, Sandro Silva-Gomes, Jonathan Campbell, Bo Kara, Julian Braybrook, Jon Petzing

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Quantifying operator subjectivity within flow cytometry data analysis as a source of measurement uncertainty and the impact of experience on results von Rebecca Grant, Karen Coopman, Nick Medcalf, Sandro Silva-Gomes, Jonathan J Campbell, Bo Kara, Julian Braybrook, Jon Petzing

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