Persistent challenges in the development of an mGlu7 PAM in vivo tool compound: The discovery of VU6046980 von Kalbfleisch, Jacob J., Rodriguez, Alice L., Lei, Xia, Weiss, Kelly, Blobaum, Annie L., Boutaud, Olivier, Niswender, Colleen M., Lindsley, Craig W.

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Discovery of VU6024578/BI02982816: An mGlu1 Positive Allosteric Modulator with Efficacy in Preclinical Antipsychotic and Cognition Models von Reed, Carson W., Kalbfleisch, Jacob F., Turkett, Jeremy A., Trombley, Trevor A., Nastase, Anthony F., Spearing, Paul K., Haymer, Daniel H., Sarwar, Mohammad Moshin, Quitalig, Marc, Dickerson, Jonathan W., Blobaum, Annie L., Boutaud, Olivier, Voehringer, Patrizia, Schuelert, Niklas, Cho, Hyekyung P., Niswender, Colleen M., Rook, Jerri M., Priepke, Henning, Ursu, Daniel, Conn, P. Jeffrey, Melancon, Bruce J., Lindsley, Craig W.

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Lead optimization of the VU0486321 series of mGlu 1 PAMs. Part 4: SAR reveals positive cooperativity across multiple mGlu receptor subtypes leading to subtype unselective PAMs von Davis, Dexter C, Bungard, Joseph D, Chang, Sichen, Rodriguez, Alice L, Blobaum, Annie L, Boutaud, Olivier, Melancon, Bruce J, Niswender, Colleen M, Jeffrey Conn, P, Lindsley, Craig W

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Lead optimization of the VU0486321 series of mGlu1 PAMs. Part 4: SAR reveals positive cooperativity across multiple mGlu receptor subtypes leading to subtype unselective PAMs von Davis, Dexter C., Bungard, Joseph D., Chang, Sichen, Rodriguez, Alice L., Blobaum, Annie L., Boutaud, Olivier, Melancon, Bruce J., Niswender, Colleen M., Jeffrey Conn, P., Lindsley, Craig W.

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Synthesis and SAR of a series of mGlu7 NAMs based on an ethyl-8-methoxy-4-(4-phenylpiperazin-1-yl)quinoline carboxylate core von Kalbfleisch, Jacob J., Reed, Carson W., Park, Charlotte, Spearing, Paul K., Quitalig, Marc C., Jenkins, Matthew T., Rodriguez, Alice L., Blobaum, Anna L., Conn, P. Jeffrey, Niswender, Colleen M., Lindsley, Craig W.

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Persistent challenges in the development of an mGlu 7 PAM in vivo tool compound: The discovery of VU6046980 von Kalbfleisch, Jacob J, Rodriguez, Alice L, Lei, Xia, Weiss, Kelly, Blobaum, Annie L, Boutaud, Olivier, Niswender, Colleen M, Lindsley, Craig W

Volltext

Discovery of VU6024578/BI02982816: An mGlu 1 Positive Allosteric Modulator with Efficacy in Preclinical Antipsychotic and Cognition Models von Reed, Carson W, Kalbfleisch, Jacob F, Turkett, Jeremy A, Trombley, Trevor A, Nastase, Anthony F, Spearing, Paul K, Haymer, Daniel H, Sarwar, Mohammad Moshin, Quitalig, Marc, Dickerson, Jonathan W, Blobaum, Annie L, Boutaud, Olivier, Voehringer, Patrizia, Schuelert, Niklas, Cho, Hyekyung P, Niswender, Colleen M, Rook, Jerri M, Priepke, Henning, Ursu, Daniel, Conn, P Jeffrey, Melancon, Bruce J, Lindsley, Craig W

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Solution-Phase Parallel Synthesis and SAR of Homopiperazinyl Analogs as Positive Allosteric Modulators of mGlu4 von Cheung, Yiu-Yin, Zamorano, Rocio, Blobaum, Anna L, Weaver, C. David, Conn, P. Jeffrey, Lindsley, Craig W, Niswender, Colleen M, Hopkins, Corey R

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