Simple and Rapid In Vivo Generation of Chromosomal Rearrangements using CRISPR/Cas9 Technology von Blasco, Rafael B., Karaca, Elif, Ambrogio, Chiara, Cheong, Taek-Chin, Karayol, Emre, Minero, Valerio G., Voena, Claudia, Chiarle, Roberto

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c-Raf, but Not B-Raf, Is Essential for Development of K-Ras Oncogene-Driven Non-Small Cell Lung Carcinoma von Blasco, Rafael B., Francoz, Sarah, Santamaría, David, Cañamero, Marta, Dubus, Pierre, Charron, Jean, Baccarini, Manuela, Barbacid, Mariano

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Combined inhibition of DDR1 and Notch signaling is a therapeutic strategy for KRAS-driven lung adenocarcinoma von Ambrogio, Chiara, Gómez-López, Gonzalo, Falcone, Mattia, Vidal, August, Nadal, Ernest, Crosetto, Nicola, Blasco, Rafael B, Fernández-Marcos, Pablo J, Sánchez-Céspedes, Montserrat, Ren, Xiaomei, Wang, Zhen, Ding, Ke, Hidalgo, Manuel, Serrano, Manuel, Villanueva, Alberto, Santamaría, David, Barbacid, Mariano

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Genomic and biological study of fusion genes as resistance mechanisms to EGFR inhibitors von Kobayashi, Yoshihisa, Oxnard, Geoffrey R., Cohen, Elizabeth F., Mahadevan, Navin R., Alessi, Joao V., Hung, Yin P., Bertram, Arrien A., Heppner, David E., Ribeiro, Mauricio F., Sacardo, Karina P., Saddi, Rodrigo, Macedo, Mariana P., Blasco, Rafael B., Li, Jiaqi, Kurppa, Kari J., Nguyen, Tom, Voligny, Emma, Ananda, Guruprasad, Chiarle, Roberto, Katz, Artur, Tolstorukov, Michael Y., Sholl, Lynette M., Jänne, Pasi A.

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Parp3 promotes long-range end joining in murine cells von Layer, Jacob V., Cleary, J. Patrick, Brown, Alexander J., Stevenson, Kristen E., Morrow, Sara N., Van Scoyk, Alexandria, Blasco, Rafael B., Karaca, Elif, Meng, Fei-Long, Frock, Richard L., Tivey, Trevor, Kim, Sunhee, Fuchs, Hailey, Chiarle, Roberto, Alt, Frederick W., Roberts, Steven A., Weinstock, David M., Day, Tovah A.

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Phosphatidylinositol 3-kinase δ blockade increases genomic instability in B cells von Compagno, Mara, Wang, Qi, Pighi, Chiara, Cheong, Taek-Chin, Meng, Fei-Long, Poggio, Teresa, Yeap, Leng-Siew, Karaca, Elif, Blasco, Rafael B., Langellotto, Fernanda, Ambrogio, Chiara, Voena, Claudia, Wiestner, Adrian, Kasar, Siddha N., Brown, Jennifer R., Sun, Jing, Wu, Catherine J., Gostissa, Monica, Alt, Frederick W., Chiarle, Roberto

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ALK inhibitors increase ALK expression and sensitize neuroblastoma cells to ALK.CAR-T cells von Bergaggio, Elisa, Tai, Wei-Tien, Aroldi, Andrea, Mecca, Carmen, Landoni, Elisa, Nüesch, Manuel, Mota, Ines, Metovic, Jasna, Molinaro, Luca, Ma, Leyuan, Alvarado, Diego, Ambrogio, Chiara, Voena, Claudia, Blasco, Rafael B, Li, Tongqing, Klein, Daryl, Irvine, Darrell J, Papotti, Mauro, Savoldo, Barbara, Dotti, Gianpietro, Chiarle, Roberto

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High Levels of miR-7-5p Potentiate Crizotinib-Induced Cytokilling and Autophagic Flux by Targeting RAF1 in NPM-ALK Positive Lymphoma Cells von Sorrentino, Domenico, Frentzel, Julie, Mitou, Geraldine, Blasco, Rafael B., Torossian, Avedis, Hoareau-Aveilla, Coralie, Pighi, Chiara, Farce, Manon, Meggetto, Fabienne, Manenti, Stephane, Espinos, Estelle, Chiarle, Roberto, Giuriato, Sylvie

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Epitope mapping of spontaneous autoantibodies to anaplastic lymphoma kinase (ALK) in non-small cell lung cancer von Awad, Mark M, Mastini, Cristina, Blasco, Rafael B, Mologni, Luca, Voena, Claudia, Mussolin, Lara, Mach, Stacy L, Adeni, Anika E, Lydon, Christine A, Sholl, Lynette M, Jänne, Pasi A, Chiarle, Roberto

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ALK peptide vaccination restores the immunogenicity of ALK-rearranged non-small cell lung cancer von Mota, Ines, Patrucco, Enrico, Mastini, Cristina, Mahadevan, Navin R, Thai, Tran C, Bergaggio, Elisa, Cheong, Taek-Chin, Leonardi, Giulia, Karaca-Atabay, Elif, Campisi, Marco, Poggio, Teresa, Menotti, Matteo, Ambrogio, Chiara, Longo, Dario L, Klaeger, Susan, Keshishian, Hasmik, Sztupinszki, Zsófia M, Szallasi, Zoltan, Keskin, Derin B, Duke-Cohan, Jonathan S, Reinhold, Bruce, Carr, Steven A, Wu, Catherine J, Moynihan, Kelly D, Irvine, Darrell J, Barbie, David A, Reinherz, Ellis L, Voena, Claudia, Awad, Mark M, Blasco, Rafael B, Chiarle, Roberto

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Abstract A021: Development of an ALK vaccine to treat ALK-rearranged non-small cell lung cancers von Blasco, Rafael B.

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Phosphatidylinositol 3-kinase blockade increases genomic instability in B cells von Compagno, Mara, Wang, Qi, Pighi, Chiara, Cheong, Taek-Chin, Meng, Fei-Long, Poggio, Teresa, Yeap, Leng-Siew, Karaca, Elif, Blasco, Rafael B, Langellotto, Fernanda, Ambrogio, Chiara, Voena, Claudia, Wiestner, Adrian, Kasar, Siddha N, Brown, Jennifer R, Sun, Jing, Wu, Catherine J, Gostissa, Monica, Alt, Frederick W, Chiarle, Roberto

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ANAPLASTIC LYMPHOMA KINASE (ALK) SPECIFIC T CELL RECEPTORS AND METHODS OF USE THEREOF von MECCA, Carmen, CHIARLE, Roberto, BLASCO-PATINO, Rafael B

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Phosphatidylinositol 3-Kinase (PI3K) δ blockade increases genomic instability in B cells von Compagno, Mara, Wang, Qi, Pighi, Chiara, Cheong, Taek-Chin, Meng, Fei-Long, Poggio, Teresa, Yeap, Leng-Siew, Karaca, Elif, Blasco, Rafael B, Langellotto, Fernanda, Ambrogio, Chiara, Voena, Claudia, Wiestner, Adrian, Kasar, Siddha N, Brown, Jennifer R, Sun, Jing, Wu, Catherine J, Gostissa, Monica, Alt, Frederick W, Chiarle, Roberto

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VCN-01 disrupts pancreatic cancer stroma and exerts antitumor effects von Bazan-Peregrino, Miriam, Garcia-Carbonero, Rocio, Laquente, Berta, Álvarez, Rafael, Mato-Berciano, Ana, Gimenez-Alejandre, Marta, Morgado, Sara, Rodríguez-García, Alba, Maliandi, Maria V, Riesco, M Carmen, Moreno, Rafael, Ginestà, Mireia M, Perez-Carreras, Mercedes, Gornals, Joan B, Prados, Susana, Perea, Sofía, Capella, Gabriel, Alemany, Ramon, Salazar, Ramon, Blasi, Emma, Blasco, Carmen, Cascallo, Manel, Hidalgo, Manuel

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Targeted Next Generation Sequencing in Patients with Inborn Errors of Metabolism von Yubero, Dèlia, Brandi, Núria, Ormazabal, Aida, Garcia-Cazorla, Àngels, Pérez-Dueñas, Belén, Campistol, Jaime, Ribes, Antonia, Palau, Francesc, Artuch, Rafael, Armstrong, Judith

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Intensive care adult patients with severe respiratory failure caused by Influenza A (H1N1)v in Spain von Rello, Jordi, Rodríguez, Alejandro, Ibañez, Pedro, Socias, Lorenzo, Cebrian, Javier, Marques, Asunción, Guerrero, José, Ruiz-Santana, Sergio, Marquez, Enrique, Del Nogal-Saez, Frutos, Alvarez-Lerma, Francisco, Martínez, Sergio, Ferrer, Miquel, Avellanas, Manuel, Granada, Rosa, Maraví-Poma, Enrique, Albert, Patricia, Sierra, Rafael, Vidaur, Loreto, Ortiz, Patricia, Prieto del Portillo, Isidro, Galván, Beatriz, León-Gil, Cristóbal

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EFFECTIVENESS OF ZERO SURGICAL INFECTION PROJECT (ZSIP) IN SPANISH HOSPITALS 2017-2021. A PROSPECTIVE COHORT STUDY von Lozano-García, F.J., Ortí-Lucas, R., Delgado-De los Reyes, J.A., Fernández-Prada, M., Herruzo-Cabrera, R., Cachinero, Carlos Millán, García de la Vega, Manuel, Hernández Navarrete, María Jesús, Blazquez, Sonia Cantín, Prada, María Fernández, Fernández, Yanet Pedroso, Monserrat Blasco, María Teresa, Moya García, Isabel María, Orozco, Rafael Gil, Fernández, María Lecuona, Sanz Salanova, Juan Antonio, Rodrigo, Henar Rebollo, Masip, Joan Masip, Domínguez, Lara Pino, Jiménez, Mercedes Arencibia, Abad, Isidro García, Álvarez, Alejandra Rodríguez, Ramírez, Yaiza García, Quintana, Corina Pérez, Gómez García, José Manuel, Brugger, María Bononad, Armijo, Daniel Jaime, Galán, María del Mar Díez, Hernández, María González, Martínez, Natividad Tolosa, Steinbauer, Cristina González, Morel, Héctor Martínez, Román, Vicente García, Valentí, Paula Gras, Payá, José Sánchez, Franco, Empar Carbonell, Monterde, Ricard Bou, Pérez, Antonio Valdivia, López Poma, Juan Carlos, Vicente de Vera, Beatriz Navarro, Alfonso Sánchez, José Luis, Valencia, Miguel Calvo, Cantero, Alberto Torres, Aguilá, Mercedes Salvador, Quintero, Alberto Cabrera, Pajares, Fernando Gómez, Cuenca Giner, María Ángeles, Vicente de Vera, Hector Navarro, León Espinosa, Iraida Fe, Martínez, Sergio Fernández, Rius Muñoz, Miquel Antoni, Sanchiz, Pilar Soriano, Collado, Ana Bediaga, Blesa Algas, María Teresa, Santillana, Mar Gómez, Caballero Martínez, María Victoria, Juárez, Ana Gómez, Jiménez, María ángeles González, Guerrero, Jesús García, Haro Pérez, Ana María, González, César de la Hoz, Fernández, Antonio Quiroga, Garcia crespo, Julio Antonio, Belzunce, Adriana del Villar, Espinilla, Virginia Fernández, Montes Villameriel, Francisco Javier, Domingo, Eduardo Pinto, García, Irene Andrés, Callejo, Elena Jiménez, Salgado, Aurora Sacristán, Arcal, Dolores García, Encinas, Silvia tejero, Conde, Javier Mateos, Pereira Rodríguez, María José, Meijide, María Sande, Gallardo, Inmaculada Sanz, Fernández, Beatriz Isidoro, Valderas X, Sofía, Herreros, Felisa Jaén, Martínez, Ascensión Sánchez, Pérez Romero, Shirley Beatriz, Campayo Rojas, Francisco Javier, Uruena Tincani, Elena Melisa, Barrachina, Ruth López, Coro, Ingrid Estévez, Hualde, Amaya Bacaicoa, Torres Fernández-Gil, María Antonia, Diego, Paulino González, Blasco, Cristina Belio, García, Margarita Viciola, Páez, Daysi Delgado, Adham, Adrián Abeal, Martín, Higinio Gómez, Cogollo, Ronald Rodríguez, López, Jesús Vioque, Varela, Yolanda Agra, Sierra Moros, María José, Berciano, Pilar Gallego, Badía Pérez, Josep María, Sebastián, Antonio Arroyo

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Postoperative Critical Care Admission Was Not Associated with Improved Postoperative Outcomes in Elective Colorectal Surgery: Secondary Analysis Of POWER Trial von Suárez-de-la-Rica, Alejandro, Ripollés-Melchor, Javier, Aldecoa, César, Abad-Motos, Ane, Ferrando, Carlos, Abad-Gurumeta, Alfredo, Díaz-Almirón, Mariana, Gil-Lapetra, Cristina, García-Miguel, Francisco Javier, Pedregosa-Sanz, Ana, Esteve-Pérez, Neus, Rodríguez-Jiménez, Rita, Gimeno Fernandez, Pablo, Maseda, Emilio

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Variability in protein binding of teicoplanin and achievement of therapeutic drug monitoring targets in critically ill patients: Lessons from the DALI Study von Roberts, J.A, Stove, V, De Waele, J.J, Sipinkoski, B, McWhinney, B, Ungerer, J.P.J, Akova, M, Bassetti, M, Dimopoulos, G, Kaukonen, K.-M, Koulenti, D, Martin, C, Montravers, P, Rello, J, Rhodes, A, Starr, T, Wallis, S.C, Lipman, J

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