The Oncogenic Transcription Factor RUNX1/ETO Corrupts Cell Cycle Regulation to Drive Leukemic Transformation von Martinez-Soria, Natalia, McKenzie, Lynsey, Draper, Julia, Ptasinska, Anetta, Issa, Hasan, Potluri, Sandeep, Blair, Helen J., Pickin, Anna, Isa, Asmida, Chin, Paulynn Suyin, Tirtakusuma, Ricky, Coleman, Daniel, Nakjang, Sirintra, Assi, Salam, Forster, Victoria, Reza, Mojgan, Law, Ed, Berry, Philip, Mueller, Dorothee, Osborne, Cameron, Elder, Alex, Bomken, Simon N., Pal, Deepali, Allan, James M., Veal, Gareth J., Cockerill, Peter N., Wichmann, Christian, Vormoor, Josef, Lacaud, Georges, Bonifer, Constanze, Heidenreich, Olaf

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Phase II-like murine trial identifies synergy between dexamethasone and dasatinib in T-cell acute lymphoblastic leukemia von Shi, Yuzhe, Beckett, Melanie C., Blair, Helen J., Tirtakusuma, Ricky, Nakjang, Sirintra, Enshaei, Amir, Halsey, Christina, Vormoor, Josef, Heidenreich, Olaf, Krippner-Heidenreich, Anja, van Delft, Frederik W.

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Leukemic stem cells activate lineage inappropriate signalling pathways to promote their growth von Kellaway, Sophie G., Potluri, Sandeep, Keane, Peter, Blair, Helen J., Ames, Luke, Worker, Alice, Chin, Paulynn S., Ptasinska, Anetta, Derevyanko, Polina K., Adamo, Assunta, Coleman, Daniel J. L., Khan, Naeem, Assi, Salam A., Krippner-Heidenreich, Anja, Raghavan, Manoj, Cockerill, Peter N., Heidenreich, Olaf, Bonifer, Constanze

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Disruption to the FOXO-PRDM1 axis resulting from deletions of chromosome 6 in acute lymphoblastic leukaemia von Sinclair, Paul B., Cranston, Ruth E., Raninga, Prahlad, Cheng, Joanna, Hanna, Rebecca, Hawking, Zoe, Hair, Steven, Ryan, Sarra L., Enshaei, Amir, Nakjang, Sirintra, Rand, Vikki, Blair, Helen J., Moorman, Anthony V., Heidenreich, Olaf, Harrison, Christine J.

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Targeting WEE1 kinase as a p53-independent therapeutic strategy in high-risk and relapsed acute lymphoblastic leukemia von Bell, Hayden L, Blair, Helen J, Singh, Mankaran, Moorman, Anthony V, Heidenreich, Olaf, van Delft, Frederik W, Lunec, John, Irving, Julie A E

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Evc is a positive mediator of Ihh-regulated bone growth that localises at the base of chondrocyte cilia von Ruiz-Perez, Victor L, Blair, Helen J, Rodriguez-Andres, M Elena, Blanco, Maria Jose, Wilson, Amy, Liu, Yu-Ning, Miles, Colin, Peters, Heiko, Goodship, Judith A

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Evc2 is a positive modulator of Hedgehog signalling that interacts with Evc at the cilia membrane and is also found in the nucleus von Blair, Helen J, Tompson, Stuart, Liu, Yu-Ning, Campbell, Jennifer, MacArthur, Katie, Ponting, Chris P, Ruiz-Perez, Victor L, Goodship, Judith A

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Inhibition of ATR acutely sensitizes acute myeloid leukemia cells to nucleoside analogs that target ribonucleotide reductase von Fordham, Sarah E., Blair, Helen J., Elstob, Claire J., Plummer, Ruth, Drew, Yvette, Curtin, Nicola J., Heidenreich, Olaf, Pal, Deepali, Jamieson, David, Park, Catherine, Pollard, John, Fields, Scott, Milne, Paul, Jackson, Graham H., Marr, Helen J., Menne, Tobias, Jones, Gail L., Allan, James M.

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Fusion transcripts are present in early progenitor cells in KMT2A-rearranged B-ALL von Tirtakusuma, Ricky, Milne, Paul, Blair, Helen J., Shi, Yuzhe, Bomken, Simon, Heidenreich, Olaf

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Mutations in Two Nonhomologous Genes in a Head-to-Head Configuration Cause Ellis-van Creveld Syndrome von Ruiz-Perez, Victor L., Stuart Tompson, W.J., Helen Blair, J., Espinoza-Valdez, Cecilia, Lapunzina, Pablo, Silva, Elias O., Hamel, Ben, Gibbs, John L., Young, Ian D., Wright, Michael J., Goodship, Judith A.

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Sequencing EVC and EVC2 identifies mutations in two-thirds of Ellis-van Creveld syndrome patients von TOMPSON, Stuart W. J, RUIZ-PEREZ, Victor L, BLAIR, Helen J, BARTON, Stephanie, NAVARRO, Victoria, ROBSON, Joanne L, WRIGHT, Michael J, GOODSHIP, Judith A

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Synthesis and In Vivo Evaluation of a Site-specifically Labeled Radioimmunoconjugate for Dual-Modal (PET/NIRF) Imaging of MT1-MMP in Sarcomas von Pringle, Toni A., Chan, Corey D., Luli, Saimir, Blair, Helen J., Rankin, Kenneth S., Knight, James C.

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Epigenetic regulator genes direct lineage switching in MLL/AF4 leukemia von Tirtakusuma, Ricky, Szoltysek, Katarzyna, Milne, Paul, Grinev, Vasily V., Ptasinska, Anetta, Chin, Paulynn S., Meyer, Claus, Nakjang, Sirintra, Hehir-Kwa, Jayne Y., Williamson, Daniel, Cauchy, Pierre, Keane, Peter, Assi, Salam A., Ashtiani, Minoo, Kellaway, Sophie G., Imperato, Maria R., Vogiatzi, Fotini, Schweighart, Elizabeth K., Lin, Shan, Wunderlich, Mark, Stutterheim, Janine, Komkov, Alexander, Zerkalenkova, Elena, Evans, Paul, McNeill, Hesta, Elder, Alex, Martinez-Soria, Natalia, Fordham, Sarah E., Shi, Yuzhe, Russell, Lisa J., Pal, Deepali, Smith, Alex, Kingsbury, Zoya, Becq, Jennifer, Eckert, Cornelia, Haas, Oskar A., Carey, Peter, Bailey, Simon, Skinner, Roderick, Miakova, Natalia, Collin, Matthew, Bigley, Venetia, Haniffa, Muzlifah, Marschalek, Rolf, Harrison, Christine J., Cargo, Catherine A., Schewe, Denis, Olshanskaya, Yulia, Thirman, Michael J., Cockerill, Peter N., Mulloy, James C., Blair, Helen J., Vormoor, Josef, Allan, James M., Bonifer, Constanze, Heidenreich, Olaf, Bomken, Simon

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Combination p53 activation and BCL-xL/BCL-2 inhibition as a therapeutic strategy in high-risk and relapsed acute lymphoblastic leukemia von Bell, Hayden L., Blair, Helen J., Jepson Gosling, Samantha J., Galler, Martin, Astley, Daniel, Moorman, Anthony V., Heidenreich, Olaf, Veal, Gareth J., van Delft, Frederik W., Lunec, John, Irving, Julie A. E.

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A Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Assay Identifies Nilotinib as an Inhibitor of Inflammation in Acute Myeloid Leukemia von Marín-Rubio, José Luis, Peltier-Heap, Rachel E., Dueñas, Maria Emilia, Heunis, Tiaan, Dannoura, Abeer, Inns, Joseph, Scott, Jonathan, Simpson, A. John, Blair, Helen J., Heidenreich, Olaf, Allan, James M., Watt, Jessica E., Martin, Mathew P., Saxty, Barbara, Trost, Matthias

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The Oncogenic Transcription Factor RUNX1/ETO Corrupts Cell Cycle Regulation to Drive Leukemic Transformation von Martinez-Soria, Natalia, McKenzie, Lynsey, Draper, Julia, Ptasinska, Anetta, Issa, Hasan, Potluri, Sandeep, Blair, Helen J., Pickin, Anna, Isa, Asmida, Chin, Paulynn Suyin, Tirtakusuma, Ricky, Coleman, Daniel, Nakjang, Sirintra, Assi, Salam, Forster, Victoria, Reza, Mojgan, Law, Ed, Berry, Philip, Mueller, Dorothee, Osborne, Cameron, Elder, Alex, Bomken, Simon N., Pal, Deepali, Allan, James M., Veal, Gareth J., Cockerill, Peter N., Wichmann, Christian, Vormoor, Josef, Lacaud, Georges, Bonifer, Constanze, Heidenreich, Olaf

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Dual Targeting of MDM2 and BCL2/Bclxl Demonstrates Potent Synergistic Activity in High-Risk Adult Acute Lymphoblastic Leukemia von Bell, Hayden L, Singh, Mankaran, Blair, Helen J, Heidenreich, Olaf, van Delft, Frederik W., Moorman, Anthony V., Lunec, John, Irving, Julie

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Preclinical Investigation of the p53-MDM2 Antagonist Idasanutlin (RG7388) Demonstrates Significant Activity in High Risk Adult Acute Lymphoblastic Leukemia von Bell, Hayden L, Singh, Mankaran, Blair, Helen J, van Delft, Frederik W., Moorman, Anthony V., Lunec, John, Irving, Julie

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MDB-74. SERINE/GLYCINE METABOLISM REPRESENTS A NOVEL TARGETABLE THERAPEUTIC VULNERABILITY IN MYC-AMPLIFIED MEDULLOBLASTOMA von Adiamah, Magretta, Poole, Bethany, Lindsey, Janet C, Swartz, Shanel, Morcavallo, Alaide, Gosling, Samantha Jepson, Singh, Mankaran, Blair, Helen J, Kohe, Sarah, Zhang, Tong, Maddocks, Oliver, Peet, Andrew, Chesler, Louis, Hickson, Ian, Maxwell, Ross, Hill, Rebecca M, Clifford, Steven C

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Exploring Pre-B Cell Receptor Signalling As a Therapeutic Target in Acute Lymphoblastic Leukaemia von Alhammer, Ali, Case, Marian, Blair, Helen J, Vormoor, Josef, Irving, Julie

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