The Development of Hsp90β-Selective Inhibitors to Overcome Detriments Associated with pan-Hsp90 Inhibition von Mishra, Sanket J, Liu, Weiya, Beebe, Kristin, Banerjee, Monimoy, Kent, Caitlin N, Munthali, Vitumbiko, Koren, John, Taylor, John A, Neckers, Leonard M, Holzbeierlein, Jeffrey, Blagg, Brian S. J

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Engineering an Antibiotic to Fight Cancer: Optimization of the Novobiocin Scaffold to Produce Anti-proliferative Agents von Zhao, Huiping, Donnelly, Alison C, Kusuma, Bhaskar R, Brandt, Gary E. L, Brown, Douglas, Rajewski, Roger A, Vielhauer, George, Holzbeierlein, Jeffrey, Cohen, Mark S, Blagg, Brian S. J

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Structure Based Design of a Grp94-Selective Inhibitor: Exploiting a Key Residue in Grp94 To Optimize Paralog-Selective Binding von Que, Nanette L. S, Crowley, Vincent M, Duerfeldt, Adam S, Zhao, Jinbo, Kent, Caitlin N, Blagg, Brian S. J, Gewirth, Daniel T

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Development of Phenyl Cyclohexylcarboxamides as a Novel Class of Hsp90 C‐terminal Inhibitors von Garg, Gaurav, Forsberg, Leah K, Zhao, Huiping, Blagg, Brian S. J

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Gambogic Acid, a Natural Product Inhibitor of Hsp90 von Davenport, Jason, Manjarrez, Jacob R, Peterson, Laura, Krumm, Brian, Blagg, Brian S. J, Matts, Robert L

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Development of Hsp90 C-terminal inhibitors with noviomimetics that manifest anti-proliferative activities von Amatya, Eva, Subramanian, Chitra, Cohen, Mark S, Blagg, Brian S. J

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A first-in-class polymerase theta inhibitor selectively targets homologous-recombination-deficient tumors von Zhou, Jia, Gelot, Camille, Pantelidou, Constantia, Li, Adam, Yucel, Hatice, Davis, Rachel E., Farkkila, Anniina, Kochupurakkal, Bose, Syed, Aleem, Shapiro, Geoffrey, Tainer, John A., Blagg, Brian S. J., Ceccaldi, Raphael, D'Andrea, Alan D.

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Inhibiting spinal cord-specific hsp90 isoforms reveals a novel strategy to improve the therapeutic index of opioid treatment von Duron, David I., Tanguturi, Parthasaradhireddy, Campbell, Christopher S., Chou, Kerry, Bejarano, Paul, Gabriel, Katherin A., Bowden, Jessica L., Mishra, Sanket, Brackett, Christopher, Barlow, Deborah, Houseknecht, Karen L., Blagg, Brian S. J., Streicher, John M.

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Structure-guided design of an Hsp90β N-terminal isoform-selective inhibitor von Khandelwal, Anuj, Kent, Caitlin N., Balch, Maurie, Peng, Shuxia, Mishra, Sanket J., Deng, Junpeng, Day, Victor W., Liu, Weiya, Subramanian, Chitra, Cohen, Mark, Holzbeierlein, Jeffery M., Matts, Robert, Blagg, Brian S. J.

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Exploiting Conformational Dynamics in Drug Discovery: Design of C‑Terminal Inhibitors of Hsp90 with Improved Activities von Moroni, Elisabetta, Zhao, Huiping, Blagg, Brian S. J, Colombo, Giorgio

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Click chemistry to probe Hsp90: Synthesis and evaluation of a series of triazole-containing novobiocin analogues von Peterson, Laura B., Blagg, Brian S.J.

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Development of a Grp94 inhibitor von Duerfeldt, Adam S, Peterson, Laura B, Maynard, Jason C, Ng, Chun Leung, Eletto, Davide, Ostrovsky, Olga, Shinogle, Heather E, Moore, David S, Argon, Yair, Nicchitta, Christopher V, Blagg, Brian S. J

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Development of Glucose Regulated Protein 94-Selective Inhibitors Based on the BnIm and Radamide Scaffold von Crowley, Vincent M, Khandelwal, Anuj, Mishra, Sanket, Stothert, Andrew R, Huard, Dustin J. E, Zhao, Jinbo, Muth, Aaron, Duerfeldt, Adam S, Kizziah, James L, Lieberman, Raquel L, Dickey, Chad A, Blagg, Brian S. J

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Transformation of the Non-Selective Aminocyclohexanol-Based Hsp90 Inhibitor into a Grp94-Seletive Scaffold von Mishra, Sanket J, Ghosh, Suman, Stothert, Andrew R, Dickey, Chad A, Blagg, Brian S. J

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Synthesis and Structure–Activity Relationships of EGCG Analogues, a Recently Identified Hsp90 Inhibitor von Khandelwal, Anuj, Hall, Jessica A, Blagg, Brian S. J

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From Bacteria to Cancer: A Benzothiazole-Based DNA Gyrase B Inhibitor Redesigned for Hsp90 C‑Terminal Inhibition von Pugh, Kyler W, Zhang, Zheng, Wang, Jian, Xu, Xiuzhi, Munthali, Vitumbiko, Zuo, Ang, Blagg, Brian S. J

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Hsp90 activator Aha1 drives production of pathological tau aggregates von Shelton, Lindsey B., Baker, Jeremy D., Zheng, Dali, Sullivan, Leia E., Solanki, Parth K., Webster, Jack M., Sun, Zheying, Sabbagh, Jonathan J., Nordhues, Bryce A., Koren, John, Ghosh, Suman, Blagg, Brian S. J., Blair, Laura J., Dickey, Chad A.

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Modulating Molecular Chaperones Improves Mitochondrial Bioenergetics and Decreases the Inflammatory Transcriptome in Diabetic Sensory Neurons von Ma, Jiacheng, Pan, Pan, Anyika, Mercy, Blagg, Brian S. J, Dobrowsky, Rick T

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Novologue Therapy Requires Heat Shock Protein 70 and Thioredoxin-Interacting Protein to Improve Mitochondrial Bioenergetics and Decrease Mitophagy in Diabetic Sensory Neurons von Rodriguez, Yssa A, Kaur, Sukmanjit, Nolte, Erika, Zheng, Zhang, Blagg, Brian S. J, Dobrowsky, Rick T

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Identification and initial SAR of silybin: An Hsp90 inhibitor von Zhao, Huiping, Brandt, Gary E., Galam, Lakshmi, Matts, Robert L., Blagg, Brian S.J.

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