ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response von Blackford, Andrew N., Jackson, Stephen P.

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Targeting DNA damage response pathways in cancer von Groelly, Florian J., Fawkes, Matthew, Dagg, Rebecca A., Blackford, Andrew N., Tarsounas, Madalena

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How Cells Respond to DNA Breaks in Mitosis von Blackford, Andrew N., Stucki, Manuel

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Regulation of DNA-End Resection by hnRNPU-like Proteins Promotes DNA Double-Strand Break Signaling and Repair von Polo, Sophie E., Blackford, Andrew N., Chapman, J. Ross, Baskcomb, Linda, Gravel, Serge, Rusch, Andre, Thomas, Anoushka, Blundred, Rachel, Smith, Philippa, Kzhyshkowska, Julia, Dobner, Thomas, Taylor, A. Malcolm R., Turnell, Andrew S., Stewart, Grant S., Grand, Roger J., Jackson, Stephen P.

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USP4 Auto-Deubiquitylation Promotes Homologous Recombination von Wijnhoven, Paul, Konietzny, Rebecca, Blackford, Andrew N., Travers, Jonathan, Kessler, Benedikt M., Nishi, Ryotaro, Jackson, Stephen P.

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The Bloom syndrome complex senses RPA-coated single-stranded DNA to restart stalled replication forks von Shorrocks, Ann-Marie K., Jones, Samuel E., Tsukada, Kaima, Morrow, Carl A., Belblidia, Zoulikha, Shen, Johanna, Vendrell, Iolanda, Fischer, Roman, Kessler, Benedikt M., Blackford, Andrew N.

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BOD1L Is Required to Suppress Deleterious Resection of Stressed Replication Forks von Higgs, Martin R., Reynolds, John J., Winczura, Alicja, Blackford, Andrew N., Borel, Valérie, Miller, Edward S., Zlatanou, Anastasia, Nieminuszczy, Jadwiga, Ryan, Ellis L., Davies, Nicholas J., Stankovic, Tatjana, Boulton, Simon J., Niedzwiedz, Wojciech, Stewart, Grant S.

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TOPBP1 recruits TOP2A to ultra-fine anaphase bridges to aid in their resolution von Broderick, Ronan, Nieminuszczy, Jadwiga, Blackford, Andrew N., Winczura, Alicja, Niedzwiedz, Wojciech

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Mitotic DNA synthesis is caused by transcription-replication conflicts in BRCA2-deficient cells von Groelly, Florian J., Dagg, Rebecca A., Petropoulos, Michalis, Rossetti, Giacomo G., Prasad, Birbal, Panagopoulos, Andreas, Paulsen, Teressa, Karamichali, Angeliki, Jones, Samuel E., Ochs, Fena, Dionellis, Vasilis S., Puig Lombardi, Emilia, Miossec, Matthieu J., Lockstone, Helen, Legube, Gaëlle, Blackford, Andrew N., Altmeyer, Matthias, Halazonetis, Thanos D., Tarsounas, Madalena

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The ASCIZ-DYNLL1 axis promotes 53BP1-dependent non-homologous end joining and PARP inhibitor sensitivity von Becker, Jordan R., Cuella-Martin, Raquel, Barazas, Marco, Liu, Rui, Oliveira, Catarina, Oliver, Antony W., Bilham, Kirstin, Holt, Abbey B., Blackford, Andrew N., Heierhorst, Jörg, Jonkers, Jos, Rottenberg, Sven, Chapman, J. Ross

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ATR activation and replication fork restart are defective in FANCM-deficient cells von Schwab, Rebekka A, Blackford, Andrew N, Niedzwiedz, Wojciech

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PAXX, a paralog of XRCC4 and XLF, interacts with Ku to promote DNA double-strand break repair von Ochi, Takashi, Blackford, Andrew N., Coates, Julia, Jhujh, Satpal, Mehmood, Shahid, Tamura, Naoka, Travers, Jon, Wu, Qian, Draviam, Viji M., Robinson, Carol V., Blundell, Tom L., Jackson, Stephen P.

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TopBP1 Interacts with BLM to Maintain Genome Stability but Is Dispensable for Preventing BLM Degradation von Blackford, Andrew N., Nieminuszczy, Jadwiga, Schwab, Rebekka A., Galanty, Yaron, Jackson, Stephen P., Niedzwiedz, Wojciech

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Specific Roles of XRCC4 Paralogs PAXX and XLF during V(D)J Recombination von Lescale, Chloé, Lenden Hasse, Hélène, Blackford, Andrew N., Balmus, Gabriel, Bianchi, Joy J., Yu, Wei, Bacoccina, Léa, Jarade, Angélique, Clouin, Christophe, Sivapalan, Rohan, Reina-San-Martin, Bernardo, Jackson, Stephen P., Deriano, Ludovic

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Treacle controls the nucleolar response to rDNA breaks via TOPBP1 recruitment and ATR activation von Mooser, Clémence, Symeonidou, Ioanna-Eleni, Leimbacher, Pia-Amata, Ribeiro, Alison, Shorrocks, Ann-Marie K., Jungmichel, Stephanie, Larsen, Sara C., Knechtle, Katja, Jasrotia, Arti, Zurbriggen, Diana, Jeanrenaud, Alain, Leikauf, Colin, Fink, Daniel, Nielsen, Michael L., Blackford, Andrew N., Stucki, Manuel

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MDC1 Interacts with TOPBP1 to Maintain Chromosomal Stability during Mitosis von Leimbacher, Pia-Amata, Jones, Samuel E., Shorrocks, Ann-Marie K., de Marco Zompit, Mara, Day, Matthew, Blaauwendraad, Jordy, Bundschuh, Diana, Bonham, Sarah, Fischer, Roman, Fink, Daniel, Kessler, Benedikt M., Oliver, Antony W., Pearl, Laurence H., Blackford, Andrew N., Stucki, Manuel

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The CIP2A-TOPBP1 complex safeguards chromosomal stability during mitosis von De Marco Zompit, Mara, Esteban, Mònica Torres, Mooser, Clémence, Adam, Salomé, Rossi, Silvia Emma, Jeanrenaud, Alain, Leimbacher, Pia-Amata, Fink, Daniel, Shorrocks, Ann-Marie K., Blackford, Andrew N., Durocher, Daniel, Stucki, Manuel

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BLM and BRCA1-BARD1 coordinate complementary mechanisms of joint DNA molecule resolution von Tsukada, Kaima, Jones, Samuel E., Bannister, Julius, Durin, Mary-Anne, Vendrell, Iolanda, Fawkes, Matthew, Fischer, Roman, Kessler, Benedikt M., Chapman, J. Ross, Blackford, Andrew N.

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Synthetic lethality between PAXX and XLF in mammalian development von Balmus, Gabriel, Barros, Ana C, Wijnhoven, Paul W G, Lescale, Chloé, Hasse, Hélène Lenden, Boroviak, Katharina, le Sage, Carlos, Doe, Brendan, Speak, Anneliese O, Galli, Antonella, Jacobsen, Matt, Deriano, Ludovic, Adams, David J, Blackford, Andrew N, Jackson, Stephen P

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Mechanism of Bloom syndrome complex assembly required for double Holliday junction dissolution and genome stability von Hodson, Charlotte, Low, Jason K K, van Twest, Sylvie, Jones, Samuel E, Swuec, Paolo, Murphy, Vincent, Tsukada, Kaima, Fawkes, Matthew, Bythell-Douglas, Rohan, Davies, Adelina, Holien, Jessica K, O'Rourke, Julienne J, Parker, Benjamin L, Glaser, Astrid, Parker, Michael W, Mackay, Joel P, Blackford, Andrew N, Costa, Alessandro, Deans, Andrew J

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