A Phase I Dose-Escalation Study of Antibody BI-505 in Relapsed/Refractory Multiple Myeloma von Hansson, Markus, Gimsing, Peter, Badros, Ashraf, Niskanen, Titti Martinsson, Nahi, Hareth, Offner, Fritz, Salomo, Morten, Sonesson, Elisabeth, Mau-Sorensen, Morten, Stenberg, Yvonne, Sundberg, Annika, Teige, Ingrid, Van Droogenbroeck, Jan, Wichert, Stina, Zangari, Maurizio, Frendeus, Björn, Korsgren, Magnus, Poelman, Martine, Tricot, Guido

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Antibodies to Costimulatory Receptor 4-1BB Enhance Anti-tumor Immunity via T Regulatory Cell Depletion and Promotion of CD8 T Cell Effector Function von Buchan, Sarah L., Dou, Lang, Remer, Marcus, Booth, Steven G., Dunn, Stuart N., Lai, Chester, Semmrich, Monika, Teige, Ingrid, Mårtensson, Linda, Penfold, Christine A., Chan, H.T. Claude, Willoughby, Jane E., Mockridge, C. Ian, Dahal, Lekh N., Cleary, Kirstie L.S., James, Sonya, Rogel, Anne, Kannisto, Päivi, Jernetz, Mats, Williams, Emily L., Healy, Eugene, Verbeek, J. Sjef, Johnson, Peter W.M., Frendéus, Björn, Cragg, Mark S., Glennie, Martin J., Gray, Juliet C., Al-Shamkhani, Aymen, Beers, Stephen A.

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Antagonistic Human FcγRIIB (CD32B) Antibodies Have Anti-Tumor Activity and Overcome Resistance to Antibody Therapy In Vivo von Roghanian, Ali, Teige, Ingrid, Mårtensson, Linda, Cox, Kerry L., Kovacek, Mathilda, Ljungars, Anne, Mattson, Jenny, Sundberg, Annika, Vaughan, Andrew T., Shah, Vallari, Smyth, Neil R., Sheth, Bhavwanti, Chan, H.T. Claude, Li, Zhan-Chun, Williams, Emily L., Manfredi, Giusi, Oldham, Robert J., Mockridge, C. Ian, James, Sonya A., Dahal, Lekh N., Hussain, Khiyam, Nilsson, Björn, Verbeek, J. Sjef, Juliusson, Gunnar, Hansson, Markus, Jerkeman, Mats, Johnson, Peter W.M., Davies, Andrew, Beers, Stephen A., Glennie, Martin J., Frendéus, Björn, Cragg, Mark S.

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LILRB3 (ILT5) is a myeloid cell checkpoint that elicits profound immunomodulation von Yeboah, Muchaala, Papagregoriou, Charys, Jones, Des C, Chan, H T Claude, Hu, Guangan, McPartlan, Justine S, Schiött, Torbjörn, Mattson, Ulrika, Mockridge, C Ian, Tornberg, Ulla-Carin, Hambe, Björn, Ljungars, Anne, Mattsson, Mikael, Tews, Ivo, Glennie, Martin J, Thirdborough, Stephen M, Trowsdale, John, Frendeus, Björn, Chen, Jianzhu, Cragg, Mark S, Roghanian, Ali

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FDG-PET Imaging for Oxidized LDL in Stable Atherosclerotic Disease: A Phase II Study of Safety, Tolerability, and Anti-Inflammatory Activity von Lehrer-Graiwer, Joshua, MPhil, MD, Singh, Parmanand, MD, Abdelbaky, Amr, MD, Vucic, Esad, MD, Korsgren, Magnus, MD, PhD, Baruch, Amos, PhD, Fredrickson, Jill, PhD, van Bruggen, Nick, PhD, Tang, Meina T., PhD, Frendeus, Bjorn, PhD, Rudd, James H.F., PhD, Hsieh, Frank, PhD, Ballantyne, Christie M., MD, Ghoshhajra, Brian, MD, MBA, Rosenson, Robert S., MD, Koren, Michael, MD, Roth, Eli M., MD, Duprez, Daniel A., MD, PhD, Fayad, Zahi A., PhD, Tawakol, Ahmed A., MD

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Domain binding and isotype dictate the activity of anti-human OX40 antibodies von Griffiths, Jordana, Hussain, Khiyam, Smith, Hannah L, Sanders, Theodore, Cox, Kerry L, Semmrich, Monika, Mårtensson, Linda, Kim, Jinny, Inzhelevskaya, Tatyana, Penfold, Chris A, Tutt, Alison L, Mockridge, C Ian, Chan, HT Claude, English, Vikki, French, Ruth F, Teige, Ingrid, Al-Shamkhani, Aymen, Glennie, Martin J, Frendeus, Bjorn L, Willoughby, Jane E, Cragg, Mark S

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Upregulation of FcγRIIb on monocytes is necessary to promote the superagonist activity of TGN1412 von Hussain, Khiyam, Hargreaves, Chantal E., Roghanian, Ali, Oldham, Robert J., Chan, H. T. Claude, Mockridge, C. Ian, Chowdhury, Ferdousi, Frendéus, Bjorn, Harper, Kirsty S., Strefford, Jonathan C., Cragg, Mark S., Glennie, Martin J., Williams, Anthony P., French, Ruth R.

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Development and Characterization of Monoclonal Antibodies Specific for Mouse and Human Fcγ Receptors von Tutt, Alison L, James, Sonya, Laversin, Stéphanie A, Tipton, Thomas R W, Ashton-Key, Margaret, French, Ruth R, Hussain, Khiyam, Vaughan, Andrew T, Dou, Lang, Earley, Alexander, Dahal, Lekh N, Lu, Chen, Dunscombe, Melanie, Chan, H T Claude, Penfold, Christine A, Kim, Jinny H, Potter, Elizabeth A, Mockridge, C Ian, Roghanian, Ali, Oldham, Robert J, Cox, Kerry L, Lim, Sean H, Teige, Ingrid, Frendéus, Bjorn, Glennie, Martin J, Beers, Stephen A, Cragg, Mark S

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A single-arm, open-label, phase 2 clinical trial evaluating disease response following treatment with BI-505, a human anti-intercellular adhesion molecule-1 monoclonal antibody, in... von Wichert, Stina, Juliusson, Gunnar, Johansson, Åsa, Sonesson, Elisabeth, Teige, Ingrid, Wickenberg, Anna Teige, Frendeus, Björn, Korsgren, Magnus, Hansson, Markus

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Human leukocyte immunoglobulin-like receptors in health and disease von Redondo-García, Silvia, Barritt, Christopher, Papagregoriou, Charys, Yeboah, Muchaala, Frendeus, Björn, Cragg, Mark S, Roghanian, Ali

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Treatment with a human recombinant monoclonal IgG antibody against oxidized LDL in atherosclerosis-prone pigs reduces cathepsin S in coronary lesions von Poulsen, Christian Bo, Al-Mashhadi, Ahmed Ludvigsen, von Wachenfeldt, Karin, Bentzon, Jacob Fog, Nielsen, Lars Bo, Al-Mashhadi, Rozh H, Thygesen, Jesper, Tolbod, Lars, Larsen, Jens Rolighed, Frøkiær, Jørgen, Tawakol, Ahmed, Vucic, Esad, Fredrickson, Jill, Baruch, Amos, Frendéus, Björn, Robertson, Anna-Karin L, Moestrup, Søren Kragh, Drouet, Ludovic, Falk, Erling

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Vectorized Treg-depleting αCTLA-4 elicits antigen cross-presentation and CD8+ T cell immunity to reject ‘cold’ tumors von Semmrich, Monika, Marchand, Jean-Baptiste, Fend, Laetitia, Rehn, Matilda, Remy, Christelle, Holmkvist, Petra, Silvestre, Nathalie, Svensson, Carolin, Kleinpeter, Patricia, Deforges, Jules, Junghus, Fred, Cleary, Kirstie L, Bodén, Mimoza, Mårtensson, Linda, Foloppe, Johann, Teige, Ingrid, Quéméneur, Eric, Frendéus, Björn

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Inhibitory FcγRIIb (CD32b) becomes activated by therapeutic mAb in both cis and trans and drives internalization according to antibody specificity von Vaughan, Andrew T., Iriyama, Chisako, Beers, Stephen A., Chan, Claude H.T., Lim, Sean H., Williams, Emily L., Shah, Vallari, Roghanian, Ali, Frendéus, Bjorn, Glennie, Martin J., Cragg, Mark S.

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Transepithelial Neutrophil Migration Is CXCR1 Dependent In Vitro and Is Defective in IL-8 Receptor Knockout Mice von Godaly, Gabriela, Hang, Long, Frendeus, Bjorn, Svanborg, Catharina

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Evaluating Anti-CD32b F(ab) Conformation Using Molecular Dynamics and Small-Angle X-Ray Scattering von Sutton, Emma J., Bradshaw, Richard T., Orr, Christian M., Frendéus, Bjorn, Larsson, Gunilla, Teige, Ingrid, Cragg, Mark S., Tews, Ivo, Essex, Jonathan W.

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Interleukin-8 Receptor Knockout Mice Have Subepithelial Neutrophil Entrapment and Renal Scarring following Acute Pyelonephritis von Hang, Long, Frendéus, Björn, Godaly, Gabriela, Svanborg, Catharina

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Targeting the Antibody Checkpoints to Enhance Cancer Immunotherapy-Focus on FcγRIIB von Teige, Ingrid, Mårtensson, Linda, Frendéus, Björn L

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757 Phase 1/2a clinical trial of BI-1808, a monoclonal antibody to tumor necrosis factor receptor 2 (TNFR2) as single agent and in combination with pembrolizumab von Kristoffer Staahl Rohrberg, Papai, Zsuzsanna, Carneiro, Ana, Lang, Istvan, Yachnin, Jeffrey, Lim, Sean, Ny, Lars, Rikke H Lovendahl Eefsen, Walter, Harriet, Abel, Edvard, Cleary, Kirstie, Oldham, Robert, Cragg, Mark, Borggren, Marie, Gertsson, Susanne, Holmkvist, Petra, Karlsson, Ingrid, Martensson, Linda, Nilsson, Jan Anders, Wallin, Johan E, Chisamore, Michael, Frendeus, Bjorn, Teige, Ingrid, McAllister, Andres

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1368 Preclinical development of an agonistic anti-TNFR2 antibody (BI-1910) for cancer immunotherapy von Martensson, Linda, Holmkvist, Petra, Kovacek, Mathilda, Svensson, Carolin, Bodén, Mimoza, Cleary, Kirstie, Dadas, Osman, Blidberg, Therese, Duell, Benjamin, Semmrich, Monika, Nilsson, Jan Anders, Beers, Stephen, Lim, Sean, Wallin, Johan E, Borggren, Marie, McAllister, Andres, Cragg, Mark, Karlsson, Ingrid, Frendeus, Bjorn, Teige, Ingrid

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Escherichia coli P fimbriae utilize the Toll‐like receptor 4 pathway for cell activation von Frendéus, Björn, Wachtler, Caroline, Hedlund, Maria, Fischer, Hans, Samuelsson, Patrik, Svensson, Majlis, Svanborg, Catharina

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