Multiple Roles of Cyclin-Dependent Kinase 4/6 Inhibitors in Cancer Therapy von ROBERTS, Patrick J, BISI, John E, STRUM, Jay C, COMBEST, Austin J, DARR, David B, USARY, Jerry E, ZAMBONI, William C, WONG, Kwok-Kin, PEROU, Charles M, SHARPLESS, Norman E

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CDK4/6 Inhibition Augments Antitumor Immunity by Enhancing T-cell Activation von Deng, Jiehui, Wang, Eric S, Jenkins, Russell W, Li, Shuai, Dries, Ruben, Yates, Kathleen, Chhabra, Sandeep, Huang, Wei, Liu, Hongye, Aref, Amir R, Ivanova, Elena, Paweletz, Cloud P, Bowden, Michaela, Zhou, Chensheng W, Herter-Sprie, Grit S, Sorrentino, Jessica A, Bisi, John E, Lizotte, Patrick H, Merlino, Ashley A, Quinn, Max M, Bufe, Lauren E, Yang, Annan, Zhang, Yanxi, Zhang, Hua, Gao, Peng, Chen, Ting, Cavanaugh, Megan E, Rode, Amanda J, Haines, Eric, Roberts, Patrick J, Strum, Jay C, Richards, William G, Lorch, Jochen H, Parangi, Sareh, Gunda, Viswanath, Boland, Genevieve M, Bueno, Raphael, Palakurthi, Sangeetha, Freeman, Gordon J, Ritz, Jerome, Haining, W Nicholas, Sharpless, Norman E, Arthanari, Haribabu, Shapiro, Geoffrey I, Barbie, David A, Gray, Nathanael S, Wong, Kwok-Kin

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Preclinical Characterization of G1T28: A Novel CDK4/6 Inhibitor for Reduction of Chemotherapy-Induced Myelosuppression von Bisi, John E, Sorrentino, Jessica A, Roberts, Patrick J, Tavares, Francis X, Strum, Jay C

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CDK4/6 inhibition induces epithelial cell cycle arrest and ameliorates acute kidney injury von DiRocco, Derek P, Bisi, John, Roberts, Patrick, Strum, Jay, Wong, Kwok-Kin, Sharpless, Norman, Humphreys, Benjamin D

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G1T48, an oral selective estrogen receptor degrader, and the CDK4/6 inhibitor lerociclib inhibit tumor growth in animal models of endocrine-resistant breast cancer von Andreano, Kaitlyn J., Wardell, Suzanne E., Baker, Jennifer G., Desautels, Taylor K., Baldi, Robert, Chao, Christina A., Heetderks, Kendall A., Bae, Yeeun, Xiong, Rui, Tonetti, Debra A., Gutgesell, Lauren M., Zhao, Jiong, Sorrentino, Jessica A., Thompson, Delita A., Bisi, John E., Strum, Jay C., Thatcher, Gregory R. J., Norris, John D.

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Discrete vulnerability to pharmacological CDK2 inhibition is governed by heterogeneity of the cancer cell cycle von Kumarasamy, Vishnu, Wang, Jianxin, Roti, Michelle, Wan, Yin, Dommer, Adam P., Rosenheck, Hanna, Putta, Sivasankar, Trub, Alec, Bisi, John, Strum, Jay, Roberts, Patrick, Rubin, Seth M., Frangou, Costakis, McLean, Karen, Witkiewicz, Agnieszka K., Knudsen, Erik S.

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Preclinical development of G1T38: A novel, potent and selective inhibitor of cyclin dependent kinases 4/6 for use as an oral antineoplastic in patients with CDK4/6 sensitive tumors von Bisi, John E, Sorrentino, Jessica A, Jordan, Jamie L, Darr, David D, Roberts, Patrick J, Tavares, Francis X, Strum, Jay C

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Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis von Holt, Jason A, Luo, Guizhen, Billin, Andrew N, Bisi, John, McNeill, Y Yvette, Kozarsky, Karen F, Donahee, Mary, Wang, Da Yuan, Mansfield, Traci A, Kliewer, Steven A, Goodwin, Bryan, Jones, Stacey A

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PML-dependent apoptosis after DNA damage is regulated by the checkpoint kinase hCds1/Chk2 von Yang, Shutong, Kuo, Christin, Bisi, John E., Kim, Myung K.

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Regulation of survivin by ErbB2 signaling : Therapeutic implications for ErbB2-overexpressing breast cancers von WENLE XIA, BISI, John, WESTLUND, Ron E, SUMIN ZHAO, BACUS, Sarah, SPECTOR, Neil L, STRUM, Jay, LEIHUA LIU, CARRICK, Kevin, GRAHAM, Katherine M, TREECE, Amanda L, HARDWICKE, Mary Ann, DUSH, Michael, QIAOYIN LIAO

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Identification of Liver Receptor Homolog-1 as a Novel Regulator of Apolipoprotein AI Gene Transcription von Delerive, Philippe, Galardi, Cristin M, Bisi, John E, Nicodeme, Edwige, Goodwin, Bryan

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Antisense and Antigene Properties of Peptide Nucleic Acids von Hanvey, Jeffery C., Peffer, Nancy J., Bisi, John E., Thomson, Stephen A., Cadilla, Rodolfo, Josey, John A., Ricca, Daniel J., Hassman, C. Fred, Bonham, Michele A., Au, Karin G., Carter, Stephen G., Bruckenstein, David A., Boyd, Ann L., Noble, Stewart A., Babiss, Lee E.

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Abstract 4414: Inhibition of CDK2 overcomes primary and acquired resistance to CDK4/6 inhibitors von Hall, Claire R., Bisi, John E., Strum, Jay C.

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Human tumor suppressor ARF impedes S-phase progression independent of p53 von Yarbrough, Wendell G, Bessho, Mika, Zanation, Adam, Bisi, John E, Xiong, Yue

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Abstract 4426: Selective inhibition of CDK9 induces apoptosis of TNBC cells independent of Rb status von Brighton, Hailey E., Hall, Claire R., Dillon, Kerry A., Bisi, John E., Strum, Jay C.

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Impact of PPARγ overexpression and activation on pancreatic islet gene expression profile analyzed with oligonucleotide microarrays von Parton, Laura E., Diraison, Frédérique, Neill, Suzanne E., Ghosh, Sujoy K., Rubino, Mark A., Bisi, John E., Briscoe, Celia P., Rutter, Guy A.

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Abstract 1522: The CDK4/6 inhibitor G1T38 enhances response to targeted therapies in preclinical models of non-small cell lung cancer von Sorrentino, Jessica A., Freed, Daniel M., Bisi, John E., Strum, Jay C., Roberts, Patrick J.

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Strand-Invasion of Duplex DNA by Peptide Nucleic Acid Oligomers von Peffer, Nancy J., Hanvey, Jeffrey C., Bisi, John E., Thomson, Stephen A., Hassman, C. Fred, Noble, Stewart A., Babiss, Lee E.

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Upstream stimulatory factor regulates expression of the cell cycle-dependent cyclin B1 gene promoter von Cogswell, John P., Godlevski, Michele M., Bonham, Michele, Bisi, John, Babiss, Lee

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Abstract 2824: G1T38, a novel, oral, potent and selective CDK4/6 inhibitor for the treatment of Rb competent tumors von Sorrentino, Jessica A., Bisi, John E., Roberts, Patrick J., Strum, Jay C.

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