Elacestrant (RAD1901), a Selective Estrogen Receptor Degrader (SERD), Has Antitumor Activity in Multiple ER + Breast Cancer Patient-derived Xenograft Models von Bihani, Teeru, Patel, Hitisha K, Arlt, Heike, Tao, Nianjun, Jiang, Hai, Brown, Jeffrey L, Purandare, Dinesh M, Hattersley, Gary, Garner, Fiona

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Elacestrant (RAD1901) exhibits anti-tumor activity in multiple ER+ breast cancer models resistant to CDK4/6 inhibitors von Patel, Hitisha K, Tao, Nianjun, Lee, Kyung-Min, Huerta, Mariela, Arlt, Heike, Mullarkey, Tara, Troy, Steven, Arteaga, Carlos L, Bihani, Teeru

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AZD2014, an Inhibitor of mTORC1 and mTORC2, Is Highly Effective in ER+ Breast Cancer When Administered Using Intermittent or Continuous Schedules von Guichard, Sylvie M, Curwen, Jon, Bihani, Teeru, D'Cruz, Celina M, Yates, James W T, Grondine, Michael, Howard, Zoe, Davies, Barry R, Bigley, Graham, Klinowska, Teresa, Pike, Kurt G, Pass, Martin, Chresta, Christine M, Polanska, Urszula M, McEwen, Robert, Delpuech, Oona, Green, Stephen, Cosulich, Sabina C

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Cyclin D1 activity regulates autophagy and senescence in the mammary epithelium von Brown, Nelson E, Jeselsohn, Rinath, Bihani, Teeru, Hu, Miaofen G, Foltopoulou, Parthena, Kuperwasser, Charlotte, Hinds, Philip W

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Selective estrogen receptor modulators (SERMs) and selective estrogen receptor degraders (SERDs) in cancer treatment von Patel, Hitisha K., Bihani, Teeru

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protein kinase Akt1 regulates the interferon response through phosphorylation of the transcriptional repressor EMSY von Ezell, Scott A, Polytarchou, Christos, Hatziapostolou, Maria, Guo, Ailan, Sanidas, Ioannis, Bihani, Teeru, Comb, Michael J, Sourvinos, George, Tsichlis, Philip N

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Synergistic induction of apoptosis by combination of BTK and dual mTORC1/2 inhibitors in diffuse large B cell lymphoma von Ezell, Scott A, Mayo, Michele, Bihani, Teeru, Tepsuporn, Suprawee, Wang, Suping, Passino, Melissa, Grosskurth, Shaun E, Collins, Mike, Parmentier, Julie, Reimer, Corinne, Byth, Kate F

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Elacestrant demonstrates strong anti-estrogenic activity in PDX models of estrogen-receptor positive endocrine-resistant and fulvestrant-resistant breast cancer von Pancholi, Sunil, Simigdala, Nikiana, Ribas, Ricardo, Schuster, Eugene, Leal, Mariana Ferreira, Nikitorowicz-Buniak, Joanna, Rega, Camilla, Bihani, Teeru, Patel, Hitisha, Johnston, Stephen R., Dowsett, Mitch, Martin, Lesley-Ann

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Dissecting the Senescence-like Program in Tumor Cells Activated by Ras Signaling von Bihani, Teeru, Chicas, Agustin, Lo, Crystal Pui-Kwan, Lin, Athena W.

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EMERALD: Phase III trial of elacestrant (RAD1901) vs endocrine therapy for previously treated ER+ advanced breast cancer von Bardia, Aditya, Aftimos, Philippe, Bihani, Teeru, Anderson-Villaluz, Alfred T, Jung, JungAh, Conlan, Maureen G, Kaklamani, Virginia G

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Phase 1/2 dose escalation study of NUV-422, a potent inhibitor of cyclin-dependent kinases 2, 4, and 6, in recurrent or refractory (r/r) high-grade gliomas (HGG) and solid tumors von Wen, Patrick Y., Rodon Ahnert, Jordi, Powderly, John D., Colman, Howard, Matheny, Shannon L., Golsorkhi, Anthony A., Bihani, Teeru, Zhang, Yan, Kaley, Thomas Joseph

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Differential Oncogenic Ras Signaling and Senescence in Tumor Cells von Bihani, Teeru, Mason, Douglas X., Jackson, Tonya, Chen, Shang Chiung, Boettner, Benjamin, Lin, Athena W.

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EMERALD: A randomized, open label, phase III trial to evaluate the efficacy and safety of elacestrant (RAD1901) versus investigator’s choice (IC) of endocrine therapy (ET) for ER+/... von Bardia, Aditya, Aftimos, Philippe Georges, Jiang, Hai, Bihani, Teeru, Anderson-Villaluz, Alfred T, Conlan, Maureen G., Kaklamani, Virginia G.

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Abstract OT1-04-04: EMERALD: A randomized, open-label, phase 3 trial to evaluate the efficacy and safety of elacestrant (RAD1901), a novel oral selective estrogen receptor degrader... von Aftimos, Philippe, Bardia, Aditya, Kaklamani, Virginia G, Lu, Janice, Bihani, Teeru, Jung, JungAh, Anderson-Villaluz, Alfred T, Conlan, Maureen G, Cortes, Javier

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Abstract PR10: RAD1901, an orally available selective estrogen receptor downregulator, has potent anti-tumor activity in in vitro and in vivo models of ER+ breast cancer von Bihani, Teeru, Brown, Jeffrey, Hattersley, Gary, Garner, Fiona

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Modeling the novel SERD elacestrant in cultured fulvestrant-refractory HR-positive breast circulating tumor cells von Dubash, Taronish D., Bardia, Aditya, Chirn, Brian, Reeves, Brittany A., LiCausi, Joseph A., Burr, Risa, Wittner, Ben S., Rai, Sumit, Patel, Hitisha, Bihani, Teeru, Arlt, Heike, Bidard, Francois-Clement, Kaklamani, Virginia G., Aftimos, Philippe, Cortés, Javier, Scartoni, Simona, Fiascarelli, Alessio, Binaschi, Monica, Habboubi, Nassir, Iafrate, A. John, Toner, Mehmet, Haber, Daniel A., Maheswaran, Shyamala

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Abstract 1814: RAD1901, an orally available SERD, as an effective combination partner in ER+ breast cancer von Bihani, Teeru, Brown, Jeffrey L., Purandare, Dinesh M., Hattersley, Gary, Garner, Fiona

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Abstract PD7-07: Final analysis of phase 1 study of elacestrant (RAD1901), a novel selective estrogen receptor degrader (SERD), in estrogen receptor positive (ER+), human epidermal... von Kaklamani, Virginia, Bardia, Aditya, Wilks, Sharon, Weise, Amy, Richards, Donald, Harb, Wael, Osborne, Cynthia, Wesolowski, Robert, Karuturi, Meghan, Conkling, Paul, Bagley, Rebecca, Jung, JungAh, Bihani, Teeru, Conlan, Maureen, Kabos, Peter

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Abstract P4-01-06: Elacestrant (RAD1901) inhibits growth of ex vivo cultured circulating tumor cells derived from hormone receptor-positive metastatic breast cancer (mBC) patients... von Dubash, Taronish Dorab, Bardia, Aditya, Reeves, Brittany A, Chirn, Brian, Szabolcs, Annamaria, Wittner, Ben S, Iafrate, John, Ting, David, Patel, Hitisha K, Bihani, Teeru, Toner, Mehmet, Haber, Daniel A, Maheswaran, Shyamala

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Resistance to everolimus driven by epigenetic regulation of MYC in ER+ breast cancers von Bihani, Teeru, Ezell, Scott A, Ladd, Brendon, Grosskurth, Shaun E, Mazzola, Anne Marie, Pietras, Mark, Reimer, Corinne, Zinda, Michael, Fawell, Stephen, D'Cruz, Celina M

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