Expression and Localization of Rat Aldo-Keto Reductases and Induction of the 1B13 and 1D2 Isoforms by Phenolic Antioxidants von MACLEOD, A. Kenneth, KELLY, Vincent P, HIGGINS, Larry G, KELLEHER, Michael O, PRICE, Sally A, BIGLEY, Alison L, BETTON, Graham R, HAYES, John D

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ZD6474 inhibits vascular endothelial growth factor signaling, angiogenesis, and tumor growth following oral administration von WEDGE, Stephen R, OGILVIE, Donald J, GRAHAM, George A, HUGHES, Gareth D, THOMAS, Andrew P, STOKES, Elaine S. E, CURRY, Brenda, RICHMOND, Graham H. P, WADSWORTH, Peter F, BIGLEY, Alison L, HENNEQUIN, Laurent F, DUKES, Michael, KENDREW, Jane, CHESTER, Rosemary, JACKSON, Janet A, BOFFEY, Sarah J, VALENTINE, Paula J, CURWEN, Jon O, MUSGROVE, Helen L

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Using Automated Image Analysis Algorithms to Distinguish Normal, Aberrant, and Degenerate Mitotic Figures Induced by Eg5 Inhibition von Bigley, Alison L., Klein, Stephanie K., Davies, Barry, Williams, Leigh, Rudmann, Daniel G.

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Gammaherpesvirus infection modulates the temporal and spatial expression of SCGB1A1 (CCSP) and BPIFA1 (SPLUNC1) in the respiratory tract von Leeming, Gail H, Kipar, Anja, Hughes, David J, Bingle, Lynne, Bennett, Elaine, Moyo, Nathifa A, Tripp, Ralph A, Bigley, Alison L, Bingle, Colin D, Sample, Jeffery T, Stewart, James P

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Quantitative Histopathological Assessment of Retardation of Islets of Langerhans Degeneration in Rosiglitazone-dosed Obese ZDF Rats Using Combined Insulin and Collagens (I and III)... von Jones, Huw B., Bigley, Alison L., Pemberton, John, Randall, Kevin J.

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Islets of Langerhans from prohormone convertase-2 knockout mice show α-cell hyperplasia and tumorigenesis with elevated α-cell neogenesis von Jones, Huw B., Reens, Jaimini, Brocklehurst, Simon R., Betts, Catherine J., Bickerton, Sue, Bigley, Alison L., Jenkins, Richard P., Whalley, Nicky M., Morgan, Derrick, Smith, David M.

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Abstract 4986: Utilizing image analysis to characterize an 8-plex immunofluorescence immune checkpoint biomarker panel within the tumor tissue microenvironment von Bigley, Alison L., Sherry, Lorcan A., Stillie, Nicole, Wood, Douglas, Downing, Sean

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Tissue-specific Expression and Subcellular Distribution of Murine Glutathione S-transferase Class Kappa von Thomson, Rachel E, Bigley, Alison L, Foster, John R, Jowsey, Ian R, Elcombe, Clifford R, Orton, Terry C, Hayes, John D

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Abstract 5686: Utilization of fluorescent multiplex IHC and digital image analysis for studying LAG-3, CD3 and CD8 positive TIL subsets in NSCLC tissue von Khenkhar, Malik, Biljes, Daniel, Winkler, Nickels, Uhlig, Philipp C., Juhl, Hartmut, Bigley, Alison L., Sherry, Lorcan

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AZD2171 : A highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer von WEDGE, Stephen R, KENDREW, Jane, CHESTER, Rosemary, JACKSON, Janet A, BOFFEY, Sarah J, KILBURN, Lyndsey L, BARNETT, Sharon, RICHMOND, Graham H. P, WADSWORTH, Peter F, WALKER, Mike, BIGLEY, Alison L, TAYLOR, Sian T, HENNEQUIN, Laurent F, COOPER, Lee, BECK, Sarah, JÜRGENSMEIER, Juliane M, OGILVIE, Donald J, VALENTINE, Paula J, BARRY, Simon T, BRAVE, Sandra R, SMITH, Neil R, JAMES, Neil H, DUKES, Michael, CURWEN, Jon O

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Using Skin Biopsies to Measure Target Occupancy of a Renal Antifibrotic Monoclonal Antibody (mAb) in a Phase 1 Clinical Study: PO2267 von Bowcutt, Rowann, Johnston, Geoffrey I., Huang, Linghong, Song, James Z., Schmidt, Tim S., Bigley, Alison L., Ogg, Graham, Wong, Eric, Thomson, Elizabeth S., Chan, Jane Y., Raievska, Anastasiia, Johnson, Timothy S.

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Digital image analysis of automated mRNA in situ hybridization and immunohistochemistry to quantify HER3 expression in cancer tissues von Khenkhar, Malik, Uhlig, Philipp C., David, Kerstin A., Bigley, Alison L., Sherry, Lorcan

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Miscellaneous: P22: The value of automated cellular imaging on tissue microarrays in the drug-discovery process von Bigley, Alison L., Brocklehurst, Simon R., Randall, Kevin J., Jenkins, Richard P., Wilkinson, Robert W., Heaton, Simon P., Foster, John, Hughes, Gareth D., McKay, Jennifer S.

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Miscellaneous von Bigley, Alison L., Brocklehurst, Simon R., Randall, Kevin J., Jenkins, Richard P., Wilkinson, Robert W., Heaton, Simon P., Foster, John, Hughes, Gareth D., McKay, Jennifer S.

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A pilot evaluation of the use of tissue microarrays for quantitation of target distribution in drug discovery pathology von McKay, Jennifer S., Bigley, Alison, Bell, Alex, Jenkins, Richard, Somers, Rebecca, Brocklehurst, Simon, White, Anne, Goodwin, Louise

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