Gene essentiality and synthetic lethality in haploid human cells von Blomen, Vincent A., Májek, Peter, Jae, Lucas T., Bigenzahn, Johannes W., Nieuwenhuis, Joppe, Staring, Jacqueline, Sacco, Roberto, van Diemen, Ferdy R., Olk, Nadine, Stukalov, Alexey, Marceau, Caleb, Janssen, Hans, Carette, Jan E., Bennett, Keiryn L., Colinge, Jacques, Superti-Furga, Giulio, Brummelkamp, Thijn R.

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TASL is the SLC15A4-associated adaptor for IRF5 activation by TLR7–9 von Heinz, Leonhard X., Lee, JangEun, Kapoor, Utkarsh, Kartnig, Felix, Sedlyarov, Vitaly, Papakostas, Konstantinos, César-Razquin, Adrian, Essletzbichler, Patrick, Goldmann, Ulrich, Stefanovic, Adrijana, Bigenzahn, Johannes W., Scorzoni, Stefania, Pizzagalli, Mattia D., Bensimon, Ariel, Müller, André C., King, F. James, Li, Jun, Girardi, Enrico, Mbow, M. Lamine, Whitehurst, Charles E., Rebsamen, Manuele, Superti-Furga, Giulio

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The Bicarbonate Transporter SLC4A7 Plays a Key Role in Macrophage Phagosome Acidification von Sedlyarov, Vitaly, Eichner, Ruth, Girardi, Enrico, Essletzbichler, Patrick, Goldmann, Ulrich, Nunes-Hasler, Paula, Srndic, Ismet, Moskovskich, Anna, Heinz, Leonhard X., Kartnig, Felix, Bigenzahn, Johannes W., Rebsamen, Manuele, Kovarik, Pavel, Demaurex, Nicolas, Superti-Furga, Giulio

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Metabolic drug survey highlights cancer cell dependencies and vulnerabilities von Pemovska, Tea, Bigenzahn, Johannes W., Srndic, Ismet, Lercher, Alexander, Bergthaler, Andreas, César-Razquin, Adrián, Kartnig, Felix, Kornauth, Christoph, Valent, Peter, Staber, Philipp B., Superti-Furga, Giulio

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Systematic genetic mapping of necroptosis identifies SLC39A7 as modulator of death receptor trafficking von Fauster, Astrid, Rebsamen, Manuele, Willmann, Katharina L., César-Razquin, Adrian, Girardi, Enrico, Bigenzahn, Johannes W., Schischlik, Fiorella, Scorzoni, Stefania, Bruckner, Manuela, Konecka, Justyna, Hörmann, Katrin, Heinz, Leonhard X., Boztug, Kaan, Superti-Furga, Giulio

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Recent advances in combinatorial drug screening and synergy scoring von Pemovska, Tea, Bigenzahn, Johannes W, Superti-Furga, Giulio

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An Inducible Retroviral Expression System for Tandem Affinity Purification Mass-Spectrometry-Based Proteomics Identifies Mixed Lineage Kinase Domain-like Protein (MLKL) as an Heat... von Bigenzahn, Johannes W., Fauster, Astrid, Rebsamen, Manuele, Kandasamy, Richard K., Scorzoni, Stefania, Vladimer, Gregory I., Müller, André C., Gstaiger, Matthias, Zuber, Johannes, Bennett, Keiryn L., Superti-Furga, Giulio

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The Comparability of Anti-Spike SARS-CoV-2 Antibody Tests is Time-Dependent: a Prospective Observational Study von Perkmann, Thomas, Mucher, Patrick, Perkmann-Nagele, Nicole, Radakovics, Astrid, Repl, Manuela, Koller, Thomas, Schmetterer, Klaus G, Bigenzahn, Johannes W, Leitner, Florentina, Jordakieva, Galateja, Wagner, Oswald F, Binder, Christoph J, Haslacher, Helmuth

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Identifying Kinase Substrates via a Heavy ATP Kinase Assay and Quantitative Mass Spectrometry von Müller, André C., Giambruno, Roberto, Weißer, Juliane, Májek, Peter, Hofer, Alexandre, Bigenzahn, Johannes W., Superti-Furga, Giulio, Jessen, Henning J., Bennett, Keiryn L.

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SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1 von Rebsamen, Manuele, Pochini, Lorena, Stasyk, Taras, de Araújo, Mariana E. G., Galluccio, Michele, Kandasamy, Richard K., Snijder, Berend, Fauster, Astrid, Rudashevskaya, Elena L., Bruckner, Manuela, Scorzoni, Stefania, Filipek, Przemyslaw A., Huber, Kilian V. M., Bigenzahn, Johannes W., Heinz, Leonhard X., Kraft, Claudine, Bennett, Keiryn L., Indiveri, Cesare, Huber, Lukas A., Superti-Furga, Giulio

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LZTR1 is a regulator of RAS ubiquitination and signaling von Bigenzahn, Johannes W, Collu, Giovanna M, Kartnig, Felix, Pieraks, Melanie, Vladimer, Gregory I, Heinz, Leonhard X, Sedlyarov, Vitaly, Schischlik, Fiorella, Fauster, Astrid, Rebsamen, Manuele, Parapatics, Katja, Blomen, Vincent A, Müller, André C, Winter, Georg E, Kralovics, Robert, Brummelkamp, Thijn R, Mlodzik, Marek, Superti-Furga, Giulio

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Identification and Characterization of Novel Small-Molecule Enhancers of the CUL3 LZTR1 E3 Ligase KRAS Complex von Piech, Sophie, Brüschweiler, Sven, Westphalen, Josepha, Siess, Katharina M, García Murias, Julio, Konrat, Robert, Bigenzahn, Johannes W, Superti-Furga, Giulio

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Identification and Characterization of Novel Small-Molecule Enhancers of the CUL3LZTR1 E3 Ligase KRAS Complex von Piech, Sophie, Brüschweiler, Sven, Westphalen, Josepha, Siess, Katharina M., García Murias, Julio, Konrat, Robert, Bigenzahn, Johannes W., Superti-Furga, Giulio

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Global survey of the immunomodulatory potential of common drugs von Vladimer, Gregory I, Snijder, Berend, Krall, Nikolaus, Bigenzahn, Johannes W, Huber, Kilian V M, Lardeau, Charles-Hugues, Sanjiv, Kumar, Ringler, Anna, Berglund, Ulrika Warpman, Sabler, Monika, de la Fuente, Oscar Lopez, Knöbl, Paul, Kubicek, Stefan, Helleday, Thomas, Jäger, Ulrich, Superti-Furga, Giulio

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JAGN1 deficiency causes aberrant myeloid cell homeostasis and congenital neutropenia von Boztug, Kaan, Järvinen, Päivi M, Salzer, Elisabeth, Racek, Tomas, Mönch, Sebastian, Garncarz, Wojciech, Gertz, E Michael, Schäffer, Alejandro A, Antonopoulos, Aristotelis, Haslam, Stuart M, Schieck, Lena, Puchałka, Jacek, Diestelhorst, Jana, Appaswamy, Giridharan, Lescoeur, Brigitte, Giambruno, Roberto, Bigenzahn, Johannes W, Elling, Ulrich, Pfeifer, Dietmar, Conde, Cecilia Domínguez, Albert, Michael H, Welte, Karl, Brandes, Gudrun, Sherkat, Roya, van der Werff ten Bosch, Jutte, Rezaei, Nima, Etzioni, Amos, Bellanné-Chantelot, Christine, Superti-Furga, Giulio, Penninger, Josef M, Bennett, Keiryn L, von Blume, Julia, Dell, Anne, Donadieu, Jean, Klein, Christoph

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Image-based ex-vivo drug screening for patients with aggressive haematological malignancies: interim results from a single-arm, open-label, pilot study von Snijder, Berend, Vladimer, Gregory I, Krall, Nikolaus, Miura, Katsuhiro, Schmolke, Ann-Sofie, Kornauth, Christoph, Lopez de la Fuente, Oscar, Choi, Hye-Soo, van der Kouwe, Emiel, Gültekin, Sinan, Kazianka, Lukas, Bigenzahn, Johannes W, Hoermann, Gregor, Prutsch, Nicole, Merkel, Olaf, Ringler, Anna, Sabler, Monika, Jeryczynski, Georg, Mayerhoefer, Marius E, Simonitsch-Klupp, Ingrid, Ocko, Katharina, Felberbauer, Franz, Müllauer, Leonhard, Prager, Gerald W, Korkmaz, Belgin, Kenner, Lukas, Sperr, Wolfgang R, Kralovics, Robert, Gisslinger, Heinz, Valent, Peter, Kubicek, Stefan, Jäger, Ulrich, Staber, Philipp B, Superti-Furga, Giulio

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The RNA‐binding protein HuR/ELAVL1 regulates IFN‐β mRNA abundance and the type I IFN response von Herdy, Barbara, Karonitsch, Thomas, Vladimer, Gregory I., Tan, Chris S.H., Stukalov, Alexey, Trefzer, Claudia, Bigenzahn, Johannes W., Theil, Tamara, Holinka, Johannes, Kiener, Hans P., Colinge, Jacques, Bennett, Keiryn L, Superti‐Furga, Giulio

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Cell-surface SLC nucleoside transporters and purine levels modulate BRD4-dependent chromatin states von Li, Kai-Chun, Girardi, Enrico, Kartnig, Felix, Grosche, Sarah, Pemovska, Tea, Bigenzahn, Johannes W., Goldmann, Ulrich, Sedlyarov, Vitaly, Bensimon, Ariel, Schick, Sandra, Lin, Jung-Ming G., Gürtl, Bettina, Reil, Daniela, Klavins, Kristaps, Kubicek, Stefan, Sdelci, Sara, Superti-Furga, Giulio

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A time-resolved molecular map of the macrophage response to VSV infection von Kandasamy, Richard K, Vladimer, Gregory I, Snijder, Berend, Müller, André C, Rebsamen, Manuele, Bigenzahn, Johannes W, Moskovskich, Anna, Sabler, Monika, Stefanovic, Adrijana, Scorzoni, Stefania, Brückner, Manuela, Penz, Thomas, Cleary, Ciara, Kralovics, Robert, Colinge, Jacques, Bennett, Keiryn L, Superti-Furga, Giulio

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Abstract A08: Genetic drug resistance screen identifies LZTR1 as regulator of RAS ubiquitination and signaling von Bigenzahn, Johannes W., Collu, Giovanna M., Kartnig, Felix, Pieraks, Melanie, Vladimer, Gregory I., Heinz, Leonhard X., Sedlyarov, Vitaly, Schischlik, Fiorella, Fauster, Astrid, Rebsamen, Manuele, Parapatics, Katja, Blomen, Vincent A., Müller, André C., Winter, Georg E., Kralovics, Robert, Brummelkamp, Thijn R., Mlodzik, Marek, Superti-Furga, Giulio

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