The Functional Amyloid Curli Protects Escherichia coli against Complement-Mediated Bactericidal Activity von Biesecker, Steven G, Nicastro, Lauren K, Wilson, R Paul, Tükel, Çağla

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Microbial Amyloids Induce Interleukin 17A (IL-17A) and IL-22 Responses via Toll-Like Receptor 2 Activation in the Intestinal Mucosa von NISHIMORI, Jessalyn H, NEWMAN, Tiffanny N, GANEA, Doina, TÜKEL, Cagla, OPPONG, Gertrude O, RAPSINSKI, Glenn J, YEN, Jui-Hung, BIESECKER, Steven G, WILSON, R. Paul, BUTLER, Brian P, WINTER, Maria G, TSOLIS, Renee M

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Epithelial Cells Augment Barrier Function via Activation of the Toll-Like Receptor 2/Phosphatidylinositol 3-Kinase Pathway upon Recognition of Salmonella enterica Serovar Typhimuri... von Oppong, Gertrude O, Rapsinski, Glenn J, Newman, Tiffanny N, Nishimori, Jessalyn H, Biesecker, Steven G, Tükel, Çagla

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Biofilm-associated bacterial amyloids dampen inflammation in the gut: oral treatment with curli fibres reduces the severity of hapten-induced colitis in mice von Oppong, Gertrude O, Rapsinski, Glenn J, Tursi, Sarah A, Biesecker, Steven G, Klein-Szanto, Andres J P, Goulian, Mark, McCauley, Christine, Healy, Catherine, Wilson, R Paul, Tükel, Cagla

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Recommendations for interpreting the loss of function PVS1 ACMG/AMP variant criterion von Abou Tayoun, Ahmad N., Pesaran, Tina, DiStefano, Marina T., Oza, Andrea, Rehm, Heidi L., Biesecker, Leslie G., Harrison, Steven M.

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Calibration of computational tools for missense variant pathogenicity classification and ClinGen recommendations for PP3/BP4 criteria von Pejaver, Vikas, Byrne, Alicia B., Feng, Bing-Jian, Pagel, Kymberleigh A., Mooney, Sean D., Karchin, Rachel, O’Donnell-Luria, Anne, Harrison, Steven M., Tavtigian, Sean V., Greenblatt, Marc S., Biesecker, Leslie G., Radivojac, Predrag, Brenner, Steven E., Biesecker, Leslie G., Harrison, Steven M., Tayoun, Ahmad A., Berg, Jonathan S., Brenner, Steven E., Cutting, Garry R., Ellard, Sian, Greenblatt, Marc S., Kang, Peter, Karbassi, Izabela, Karchin, Rachel, Mester, Jessica, O’Donnell-Luria, Anne, Pesaran, Tina, Plon, Sharon E., Rehm, Heidi L., Strande, Natasha T., Tavtigian, Sean V., Topper, Scott

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Modeling the ACMG/AMP variant classification guidelines as a Bayesian classification framework von Tavtigian, Sean V, Greenblatt, Marc S, Harrison, Steven M, Nussbaum, Robert L, Prabhu, Snehit A, Boucher, Kenneth M, Biesecker, Leslie G

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The ACMG/AMP reputable source criteria for the interpretation of sequence variants von Biesecker, Leslie G., Harrison, Steven M.

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Fitting a naturally scaled point system to the ACMG/AMP variant classification guidelines von Tavtigian, Sean V., Harrison, Steven M., Boucher, Kenneth M., Biesecker, Leslie G.

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A taxonomy of medical uncertainties in clinical genome sequencing von Han, Paul K.J., Umstead, Kendall L., Bernhardt, Barbara A., Green, Robert C., Joffe, Steven, Koenig, Barbara, Krantz, Ian, Waterston, Leo B., Biesecker, Leslie G., Biesecker, Barbara B.

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Updated recommendation for the benign stand‐alone ACMG/AMP criterion von Ghosh, Rajarshi, Harrison, Steven M., Rehm, Heidi L., Plon, Sharon E., Biesecker, Leslie G.

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Recommendations for application of the functional evidence PS3/BS3 criterion using the ACMG/AMP sequence variant interpretation framework von Brnich, Sarah E, Abou Tayoun, Ahmad N, Couch, Fergus J, Cutting, Garry R, Greenblatt, Marc S, Heinen, Christopher D, Kanavy, Dona M, Luo, Xi, McNulty, Shannon M, Starita, Lea M, Tavtigian, Sean V, Wright, Matt W, Harrison, Steven M, Biesecker, Leslie G, Berg, Jonathan S

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Overview of Specifications to the ACMG/AMP Variant Interpretation Guidelines von Harrison, Steven M., Biesecker, Leslie G., Rehm, Heidi L.

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Using the ACMG/AMP framework to capture evidence related to predicted and observed impact on splicing: Recommendations from the ClinGen SVI Splicing Subgroup von Walker, Logan C., Hoya, Miguel de la, Wiggins, George A.R., Lindy, Amanda, Vincent, Lisa M., Parsons, Michael T., Canson, Daffodil M., Bis-Brewer, Dana, Cass, Ashley, Tchourbanov, Alexander, Zimmermann, Heather, Byrne, Alicia B., Pesaran, Tina, Karam, Rachid, Harrison, Steven M., Spurdle, Amanda B., Biesecker, Leslie G., Harrison, Steven M., Tayoun, Ahmad A., Berg, Jonathan S., Brenner, Steven E., Cutting, Garry R., Ellard, Sian, Greenblatt, Marc S., Kang, Peter, Karbassi, Izabela, Karchin, Rachel, Mester, Jessica, O’Donnell-Luria, Anne, Pesaran, Tina, Plon, Sharon E., Rehm, Heidi L., Strande, Natasha T., Tavtigian, Sean V., Topper, Scott

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ClinGen guidance for use of the PP1/BS4 co-segregation and PP4 phenotype specificity criteria for sequence variant pathogenicity classification von Biesecker, Leslie G., Byrne, Alicia B., Harrison, Steven M., Pesaran, Tina, Schäffer, Alejandro A., Shirts, Brian H., Tavtigian, Sean V., Rehm, Heidi L.

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Individualized Iterative Phenotyping for Genome-wide Analysis of Loss-of-Function Mutations von Johnston, Jennifer J., Lewis, Katie L., Ng, David, Singh, Larry N., Wynter, Jamila, Brewer, Carmen, Brooks, Brian P., Brownell, Isaac, Candotti, Fabio, Gonsalves, Steven G., Hart, Suzanne P., Kong, Heidi H., Rother, Kristina I., Sokolic, Robert, Solomon, Benjamin D., Zein, Wadih M., Cooper, David N., Stenson, Peter D., Mullikin, James C., Biesecker, Leslie G.

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Correspondence on “The role of clinical response to treatment in determining pathogenicity of genomic variants” by Shen et al von Biesecker, Leslie G., Harrison, Steven M., Rehm, Heidi L.

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Redefining the Etiologic Landscape of Cerebellar Malformations von Aldinger, Kimberly A., Timms, Andrew E., Thomson, Zachary, Mirzaa, Ghayda M., Bennett, James T., Rosenberg, Alexander B., Roco, Charles M., Hirano, Matthew, Abidi, Fatima, Haldipur, Parthiv, Cheng, Chi V., Collins, Sarah, Park, Kaylee, Zeiger, Jordan, Overmann, Lynne M., Alkuraya, Fowzan S., Biesecker, Leslie G., Braddock, Stephen R., Cathey, Sara, Cho, Megan T., Chung, Brian H.Y., Everman, David B., Zarate, Yuri A., Jones, Julie R., Schwartz, Charles E., Goldstein, Amy, Hopkin, Robert J., Krantz, Ian D., Ladda, Roger L., Leppig, Kathleen A., McGillivray, Barbara C., Sell, Susan, Wusik, Katherine, Gleeson, Joseph G., Nickerson, Deborah A., Bamshad, Michael J., Gerrelli, Dianne, Lisgo, Steven N., Seelig, Georg, Ishak, Gisele E., Barkovich, A. James, Curry, Cynthia J., Glass, Ian A., Millen, Kathleen J., Doherty, Dan, Dobyns, William B.

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Mapping the human genetic architecture of COVID-19 von Niemi, Mari E. K., Karjalainen, Juha, Daly, Mark, Ganna, Andrea, Mehtonen, Juha, Cordioli, Mattia, Kaunisto, Mari, Pigazzini, Sara, Donner, Kati, Kivinen, Katja, Palotie, Aarno, Daly, Mark J., Liao, Rachel G., Kanai, Masahiro, Veerapen, Kumar, Minica, Camelia, Trankiem, Amy, Balaconis, Mary K., Nguyen, Huy, Solomonson, Matthew, Francioli, Laurent, Wang, Qingbo, Green, Robert C., Bryant, Sam, Finucane, Hilary, Martin, Alicia R., Zhou, Wei, Nkambule, Lindokuhle, Karczewski, Konrad J., Atkinson, Elizabeth G., Tsuo, Kristin, Baya, Nikolas, Turley, Patrick, Gupta, Rahul, Walters, Raymond K., Palmer, Duncan S., Sarma, Gopal, Cheng, Nathan, Lu, Wenhan, Churchhouse, Claire, Goldstein, Jacqueline, King, Daniel, Seed, Cotton, Neale, Benjamin M., Satterstrom, F. Kyle, Pathak, Gita A., Wendt, Frank R., Polimanti, Renato, Andrews, Shea J., Sloofman, Laura, Sealfon, Stuart C., Fernandez-Cadenas, Israel, Schulte, Eva C., Protzer, Ulrike, Striano, Pasquale, Coviello, Domenico A., Zara, Federico, Salpietro, Vincenzo, Iacomino, Michele, Scudieri, Paolo, Bocciardi, Renata, Minetti, Carlo, Vari, Maria Stella, Madia, Francesca, Marouli, Eirini, Kanoni, Stavroula, Moutsianas, Loukas, Karim, Mohd Anisul, Ghoussaini, Maya, Schwartzentruber, Jeremy, Dunham, Ian, Savage, Jeanne, Posthuma, Danielle, Tissink, Elleke, Uffelmann, Emil, Butler-Laporte, Guillaume, Richards, J. Brent, Nakanishi, Tomoko, Morrison, David R., Forgetta, Vincenzo, Ghosh, Biswarup, Laurent, Laetitia, Henry, Danielle, Abdullah, Tala, Adeleye, Olumide, Mamlouk, Noor, Kimchi, Nofar, Afrasiabi, Zaman, Rezk, Nardin, Vulesevic, Branka, Bouab, Meriem, Guzman, Charlotte, Petitjean, Louis, Tselios, Chris, Xue, Xiaoqing, Afilalo, Jonathan, Adra, Darin, Kim, Han-Na, Okada, Yukinori, Byun, Jinyoung

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Assessment of the evidence yield for the calibrated PP3/BP4 computational recommendations von Stenton, Sarah L., Pejaver, Vikas, Bergquist, Timothy, Biesecker, Leslie G., Byrne, Alicia B., Nadeau, Emily A.W., Greenblatt, Marc S., Harrison, Steven M., Tavtigian, Sean V., Radivojac, Predrag, Brenner, Steven E., O’Donnell-Luria, Anne, Biesecker, Leslie G., Harrison, Steven M., Tayoun, Ahmad A., Berg, Jonathan S., Brenner, Steven E., Cutting, Garry R., Ellard, Sian, Greenblatt, Marc S., Kang, Peter, Karbassi, Izabela, Karchin, Rachel, Mester, Jessica, O’Donnell-Luria, Anne, Pesaran, Tina, Plon, Sharon E., Rehm, Heidi L., Strande, Natasha T., Tavtigian, Sean V., Topper, Scott

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