Performance assessment of the Illumina massively parallel sequencing platform for deep sequencing analysis of viral minority variants von Thys, Kim, Verhasselt, Peter, Reumers, Joke, Verbist, Bie M.P., Maes, Bart, Aerssens, Jeroen

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VirVarSeq: a low-frequency virus variant detection pipeline for Illumina sequencing using adaptive base-calling accuracy filtering von Verbist, Bie M P, Thys, Kim, Reumers, Joke, Wetzels, Yves, Van der Borght, Koen, Talloen, Willem, Aerssens, Jeroen, Clement, Lieven, Thas, Olivier

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Integrating High-Dimensional Transcriptomics and Image Analysis Tools into Early Safety Screening: Proof of Concept for a New Early Drug Development Strategy von Verbist, Bie M. P, Verheyen, Geert R, Vervoort, Liesbet, Crabbe, Marjolein, Beerens, Dominiek, Bosmans, Cindy, Jaensch, Steffen, Osselaer, Steven, Talloen, Willem, Van den Wyngaert, Ilse, Van Hecke, Geert, Wuyts, Dirk, Van Goethem, Freddy, Göhlmann, Hinrich W. H

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5-Sulfonyl-benzimidazoles as selective CB2 agonists-Part 2 von Gijsen, Harrie J.M., De Cleyn, Michel A.J., Surkyn, Michel, Van Lommen, Guy R.E., Verbist, Bie M.P., Nijsen, Marjoleen J.M.A., Meert, Theo, Wauwe, Jean Van, Aerssens, Jeroen

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Using transcriptomics to guide lead optimization in drug discovery projects: Lessons learned from the QSTAR project von Verbist, Bie, Klambauer, Günter, Vervoort, Liesbet, Talloen, Willem, Shkedy, Ziv, Thas, Olivier, Bender, Andreas, Göhlmann, Hinrich W.H., Hochreiter, Sepp

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Analyzing magnetic bead QuantiGene® Plex 2.0 gene expression data in high throughput mode using QGprofiler von Verbist, Bie, Adriaensen, Eva, Keersmaekers, Vikki, Putri, Dea, Crabbe, Marjolein, Derks, Maarten, Bagdziunas, Rytis, Laenen, Griet, De Wolf, Hans

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Automated quality control tool for high-content imaging data by building 2D prediction intervals on reference biosignatures von Assefa, Alemu Takele, Verbist, Bie, Gustin, Emmanuel, Peeters, Danielle

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5-Sulfonyl-benzimidazoles as selective CB2 agonists von Verbist, Bie M.P., De Cleyn, Michel A.J., Surkyn, Michel, Fraiponts, Erwin, Aerssens, Jeroen, Nijsen, Marjoleen J.M.A., Gijsen, Harrie J.M.

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Daratumumab depletes CD38+ immune regulatory cells, promotes T-cell expansion, and skews T-cell repertoire in multiple myeloma von Krejcik, Jakub, Casneuf, Tineke, Nijhof, Inger S., Verbist, Bie, Bald, Jaime, Plesner, Torben, Syed, Khaja, Liu, Kevin, van de Donk, Niels W.C.J., Weiss, Brendan M., Ahmadi, Tahamtan, Lokhorst, Henk M., Mutis, Tuna, Sasser, A.Kate

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A web application for sample size and power calculation in case-control microbiome studies von Mattiello, Federico, Verbist, Bie, Faust, Karoline, Raes, Jeroen, Shannon, William D, Bijnens, Luc, Thas, Olivier

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Discovery and Pharmacological Characterization of JNJ-64619178, a Novel Small-Molecule Inhibitor of PRMT5 with Potent Antitumor Activity von Brehmer, Dirk, Beke, Lijs, Wu, Tongfei, Millar, Hillary J, Moy, Christopher, Sun, Weimei, Mannens, Geert, Pande, Vineet, Boeckx, An, van Heerde, Erika, Nys, Thomas, Gustin, Emmanuel M, Verbist, Bie, Zhou, Longen, Fan, Yue, Bhargava, Vipul, Safabakhsh, Pegah, Vinken, Petra, Verhulst, Tinne, Gilbert, Angelique, Rai, Sumit, Graubert, Timothy A, Pastore, Friederike, Fiore, Danilo, Gu, Junchen, Johnson, Amy, Philippar, Ulrike, Morschhäuser, Barbara, Walker, David, De Lange, Desiree, Keersmaekers, Vikki, Viellevoye, Marcel, Diels, Gaston, Schepens, Wim, Thuring, Jan Willem, Meerpoel, Lieven, Packman, Kathryn, Lorenzi, Matthew V, Laquerre, Sylvie

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Preclinical Efficacy of the Menin-KMT2A Inhibitor JNJ-75276617 in Combination with Venetoclax and Azacitidine in AML von Kwon, Min Chul, Verhulst, Tinne, Goffin, Dries, Marien, Ann, Verbist, Bie, Guttke, Christina, Thuring, Jan Willem, Ferrante, Lucille, Daskalakis, Nikki, Pietsch, E. Christine, Elsayed, Yusri, Packman, Kathryn, Philippar, Ulrike

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Controlling the Reproducibility of AC50 Estimation during Compound Profiling through Bayesian β-Expectation Tolerance Intervals von Tendong, Wilson, Lebrun, Pierre, Verbist, Bie

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Synergy detection: A practical guide to statistical assessment of potential drug combinations von Makariadou, Elli, Wang, Xuechen, Hein, Nicholas, Deresa, Negera W, Mutambanengwe, Kathy, Verbist, Bie, Thas, Olivier

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Statistical detection of synergy: New methods and a comparative study von Thas, Olivier, Tourny, Annelies, Verbist, Bie, Hawinkel, Stijn, Nazarov, Maxim, Mutambanengwe, Kathy, Bijnens, Luc

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Abstract 1267: Combination therapy of JNJ-67856633, a novel, first-in-class MALT1 protease inhibitor, and JNJ-64264681, a novel BTK inhibitor, for the treatment of B-cell lymphomas von Philippar, Ulrike, Fontan, Lorena, Cornelissen, Ivo, Rui, Haopeng, Balasubramanian, Sriram, Gaudiano, Marcello, Bekkers, Mariette, Van Nuffel, Luc, Lu, Tianbao, Wiener, John, Tichenor, Mark, Greway, Tony, Packman, Kathryn, Verbist, Bie, Elsayed, Yusri, Attar, Ricardo, Bussolari, Jacqueline, Gerecitano, John

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BIGL: Biochemically Intuitive Generalized Loewe null model for prediction of the expected combined effect compatible with partial agonism and antagonism von Van der Borght, Koen, Tourny, Annelies, Bagdziunas, Rytis, Thas, Olivier, Nazarov, Maxim, Turner, Heather, Verbist, Bie, Ceulemans, Hugo

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Pharmacological Characterization of JNJ-75276617, a Menin-KMT2A Inhibitor, As Targeted Treatment for KMT2A-Altered and NPM1-Mutant Acute Leukemia von Kwon, Min Chul, Querolle, Olivier, Dai, Xuedong, Thuring, Jan Willem, Verhulst, Tinne, Marien, Ann, Goffin, Dries, Cai, Wei, Keersmaekers, Vikki, Eyassu, Filmon, Verstraeten, Karin, El Ashkar, Sara, Hogeling, Shanna M, Jacob, Frank, Vinken, Petra, Darville, Nicolas, Pande, Vineet, Krosky, Daniel, Urbanietz, Gregor, Verbist, Bie, Ferrante, Lucille A., Drenberg, Christina Diane, Wilson, David, Attar, Ricardo M., Schuringa, Jan Jacob, Daskalakis, Nikki, Packman, Kathryn, Pietsch, Christine, Elsayed, Yusri, Philippar, Ulrike

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Principal bicorrelation analysis: Unraveling associations between three data sources von Mattiello, Federico, Thas, Olivier, Verbist, Bie

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A web application for sample size and power calculation in case-control microbiome studies von Mattiello, Federico, Verbist, Bie, Faust, Karoline, Raes, Jeroen, Shannon, William D, Bijnens, Luc, Thas, Olivier

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