The cytochrome bc1 complex as an antipathogenic target von Fisher, Nicholas, Meunier, Brigitte, Biagini, Giancarlo A.

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Artemisinin activity-based probes identify multiple molecular targets within the asexual stage of the malaria parasites Plasmodium falciparum 3D7 von Ismail, Hanafy M., Barton, Victoria, Phanchana, Matthew, Charoensutthivarakul, Sitthivut, Wong, Michael H. L., Hemingway, Janet, Biagini, Giancarlo A., O’Neill, Paul M., Ward, Stephen A.

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The cytochrome bc 1 complex as an antipathogenic target von Fisher, Nicholas, Meunier, Brigitte, Biagini, Giancarlo A

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Antimalarial activity of primaquine operates via a two-step biochemical relay von Camarda, Grazia, Jirawatcharadech, Piyaporn, Priestley, Richard S., Saif, Ahmed, March, Sandra, Wong, Michael H. L., Leung, Suet, Miller, Alex B., Baker, David A., Alano, Pietro, Paine, Mark J. I., Bhatia, Sangeeta N., O’Neill, Paul M., Ward, Stephen A., Biagini, Giancarlo A.

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Prioritization of Anti‐SARS‐Cov‐2 Drug Repurposing Opportunities Based on Plasma and Target Site Concentrations Derived from their Established Human Pharmacokinetics von Arshad, Usman, Pertinez, Henry, Box, Helen, Tatham, Lee, Rajoli, Rajith K. R., Curley, Paul, Neary, Megan, Sharp, Joanne, Liptrott, Neill J., Valentijn, Anthony, David, Christopher, Rannard, Steve P., O’Neill, Paul M., Aljayyoussi, Ghaith, Pennington, Shaun H., Ward, Stephen A., Hill, Andrew, Back, David J., Khoo, Saye H., Bray, Patrick G., Biagini, Giancarlo A., Owen, Andrew

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Dose prediction for repurposing nitazoxanide in SARS‐CoV‐2 treatment or chemoprophylaxis von Rajoli, Rajith K. R., Pertinez, Henry, Arshad, Usman, Box, Helen, Tatham, Lee, Curley, Paul, Neary, Megan, Sharp, Joanne, Liptrott, Neill J., Valentijn, Anthony, David, Christopher, Rannard, Steven P., Aljayyoussi, Ghaith, Pennington, Shaun H., Hill, Andrew, Boffito, Marta, Ward, Steve A., Khoo, Saye H., Bray, Patrick G., O'Neill, Paul M., Hong, W. David, Biagini, Giancarlo A., Owen, Andrew

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Rapid kill of malaria parasites by artemisinin and semi-synthetic endoperoxides involves ROS-dependent depolarization of the membrane potential von Antoine, Thomas, Fisher, Nicholas, Amewu, Richard, O'Neill, Paul M., Ward, Stephen A., Biagini, Giancarlo A.

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A Click Chemistry-Based Proteomic Approach Reveals that 1,2,4-Trioxolane and Artemisinin Antimalarials Share a Common Protein Alkylation Profile von Ismail, Hanafy M., Barton, Victoria E., Panchana, Matthew, Charoensutthivarakul, Sitthivut, Biagini, Giancarlo A., Ward, Stephen A., O'Neill, Paul M.

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SARS‐CoV‐2 infects an upper airway model derived from induced pluripotent stem cells von Djidrovski, Ivo, Georgiou, Maria, Hughes, Grant L., Patterson, Edward I., Casas‐Sanchez, Aitor, Pennington, Shaun H., Biagini, Giancarlo A., Moya‐Molina, Marina, Bor, Jelle, Smit, Martine J., Chung, Git, Lako, Majlinda, Armstrong, Lyle

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Antimalarial 4(1H)-pyridones bind to the Qi site of cytochrome bc1 von Capper, Michael J, O'Neill, Paul M, Fisher, Nicholas, Strange, Richard W, Moss, Darren, Ward, Stephen A, Berry, Neil G, Lawrenson, Alexandre S, Hasnain, S Samar, Biagini, Giancarlo A, Antonyuk, Svetlana V

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Treatment responses to Azithromycin and Ciprofloxacin in uncomplicated Salmonella Typhi infection: A comparison of Clinical and Microbiological Data from a Controlled Human Infecti... von Jin, Celina, Gibani, Malick M, Pennington, Shaun H, Liu, Xinxue, Ardrey, Alison, Aljayyoussi, Ghaith, Moore, Maria, Angus, Brian, Parry, Christopher M, Biagini, Giancarlo A, Feasey, Nicholas A, Pollard, Andrew J

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Antimalarial pharmacology and therapeutics of atovaquone von Nixon, Gemma L, Moss, Darren M, Shone, Alison E, Lalloo, David G, Fisher, Nicholas, O'Neill, Paul M, Ward, Stephen A, Biagini, Giancarlo A

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Measurement of the Intracellular Mycobacterium tuberculosis Drug Effect and Prediction of the Clinical Dose–Response Relationship Using Intracellular Pharmacodynamic Modeling (PDi)... von Donnellan, Samantha, Martínez-Rodríguez, Carmen, Aljayyoussi, Ghaith, Biagini, Giancarlo A.

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Attaching protein-adsorbing silica particles to the surface of cotton substrates for bioaerosol capture including SARS-CoV-2 von Collings, Kieran, Boisdon, Cedric, Sham, Tung-Ting, Skinley, Kevin, Oh, Hyun-Kyung, Prince, Tessa, Ahmed, Adham, Pennington, Shaun H., Brownridge, Philip J., Edwards, Thomas, Biagini, Giancarlo A., Eyers, Claire E., Lamb, Amanda, Myers, Peter, Maher, Simon

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The relative rate of kill of the MMV Malaria Box compounds provides links to the mode of antimalarial action and highlights scaffolds of medicinal chemistry interest von Ullah, Imran, Sharma, Raman, Mete, Antonio, Biagini, Giancarlo A, Wetzel, Dawn M, Horrocks, Paul D

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A Quantitative Method for the Study of HIV-1 and Mycobacterium tuberculosis Coinfection von Donnellan, Samantha, Pennington, Shaun H, Ruggiero, Alessandra, Martinez-Rodriguez, Carmen, Pouget, Marion, Thomas, Jordan, Ward, Steve A, Pollakis, Georgios, Biagini, Giancarlo A, Paxton, William A

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A validated bioluminescence-based assay for the rapid determination of the initial rate of kill for discovery antimalarials von Ullah, Imran, Sharma, Raman, Biagini, Giancarlo A, Horrocks, Paul

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Quantitation of tizoxanide in multiple matrices to support cell culture, animal and human research von Neary, Megan, Arshad, Usman, Tatham, Lee, Pertinez, Henry, Box, Helen, Rajoli, Rajith K.R., Valentijn, Anthony, Sharp, Joanne, Rannard, Steve P., Biagini, Giancarlo A., Curley, Paul, Owen, Andrew

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Pharmacokinetic-Pharmacodynamic modelling of intracellular Mycobacterium tuberculosis growth and kill rates is predictive of clinical treatment duration von Aljayyoussi, Ghaith, Jenkins, Victoria A., Sharma, Raman, Ardrey, Alison, Donnellan, Samantha, Ward, Stephen A., Biagini, Giancarlo A.

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Intracellular Pharmacodynamic Modeling Is Predictive of the Clinical Activity of Fluoroquinolones against Tuberculosis von Donnellan, Samantha, Aljayyoussi, Ghaith, Moyo, Emmanuel, Ardrey, Alison, Martinez-Rodriguez, Carmen, Ward, Stephen A., Biagini, Giancarlo A.

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